The Internet Age: on the face of it, an era of unprecedented freedom in both communication and culture. Yet in the past, each major new medium, from telephone to satellite television, has crested on a wave of similar idealistic optimism, before succumbing to the inevitable undertow of industrial consolidation. Every once free and open technology has, in time, become centralized and closed; as corporate power has taken control of the 'master switch.' Today a similar struggle looms over the Internet, and as it increasingly supersedes all other media the stakes have never been higher. Part industrial expos, part examination of freedom of expression, The Master Switch reveals a crucial drama - full of indelible characters - as it has played out over decades in the shadows of global communication.

The must-read summary of Tim Wu's book: “The Master Switch: The Rise and Fall of Information Empires”. This complete summary of "The Master Switch" by Tim Wu, a renowned professor of law, presents his argument that information technology started as an open playing field and then eventually became dominated by a big entity exercising monopoly. He states that the world’s information is now traveling in a single network; the Internet, therefore he says that great information powers are locked in a battle over the Internet’s future. Added-value of this summary: • Save time • Understand the potential fate of the Internet to an information empire • Expand your knowledge of business politics and information wars To learn more, read "The Master Switch" and discover how information empires are set to be locked into a battle for the Internet's future.

Master Switch explores the terrifying consequences of a breach of security that puts the United States forces and Israeli defenses at risk.General Jeff Weyland has overseen the top secret development of the PATRIOT missle system since its beginning. But during a crucial stage of testing, he makes the horrifying discovery that someone has infiltrated the system.With the Gulf War looming and the lives of American and Israeli citizens at stake, Weyland must find out who is responsible for the missile's failure. With the assistance of Suzy Morris, a Senate staffer, and two old army buddies--Fish, a computer programmer, and Billy, a CIA operative--Weyland sets out through a maze of murder, intrigue, and terrorism to discover who has the most to gain if the PATRIOT missile system fails, and who controls the Master Switch.

Your hands-on guide to materials handling and product movement methods for today's competitive facilities. With your staff, let this book show you how to dramatically improve the movement of materials in any warehouse, distribution, or manufacturing facility. This book will introduce you to the latest methods for designing, organizing, operating, and maintaining a state-of-the-art materials handling/product movement system. You'll learn about horizontal and vertical transportation techniques for items of all sizes--and get full details on inventory control...identification systems...cost estimates...site selection...product security...the use of consultants...and much more. This essential logistics tool features: insights and tips from plant and warehouse pros that will make your materials handling operations more efficient and cost effective; scores of illustrations, forms, and tables to assist you in developing product movement strategies that can be implemented immediately; complete information on the requirements of manual, mechanized, and automated systems.

The functions of the brain that allow us to think, feel, move, and perceive the world are the result of an exchange of information within a network composed of millions of specialized cells called neurons and glia. Neurons use neurotransmitters and other extracellular messengers to communicate with each other, and to constantly update and re-organize their network of connections in a process known as neural plasticity. In order to respond to these extracellular signals, neurons are equipped with specialized receptors that can recognize a single neurotransmitter a bit like a lock would recognize a key. They do this by activating or inhibiting a class of specialized signaling proteins and second messengers. Typically, signaling proteins are themselves organized in networks or pathways in which they activate or inhibit each other in order to integrate the mass of information received by a single cell and to regulate the biological functions of this cell. As we can see, rather than simply being a network of neurons, the brain can be seen as a sort of “Russian doll” in which each neuron is at the same time a part of networks with other neurons and the receptacle of many networks composed of signaling proteins. Two individual genes encode two paralogous signaling proteins: Glycogen Synthase Kinase -3 alpha and beta (GSK-3a, GSK-3b), named for its ability to phosphorylate a key metabolic enzyme of glycogen synthesis, glycogen synthase. This unique “glamour and gloom” protein kinase, has been intriguing many researches for over 30 years by its unusual features, still unknown mechanisms of its activation, its regulation by multiple “key” intracellular pathways, and its capacity to influence the functions of many substrates. Since GSK-3 was discovered, there has been significant progress in elucidating its regulatory roles in the neuron and the structure and functions of the brain. Lithium has been used as a gold standard in the treatment of bipolar disorder for 60 years; and “GSK-3’s renaissance” in psychiatry began with the discovery of GSK-3 as lithium's intracellular target. Since then, GSK3 has been implicated in the pathogenesis of mood disorders, schizophrenia, Alzheimer’s disease, ADHD, multiple sclerosis, Fragile X syndrome and Huntington disease. Connections to these and other diseases has led over the last 10 years to the generation of multiple types of GSK-3 inhibitors as promising therapeutic treatments for the aforementioned pathological conditions. During last couple years new genetic models have been generated, including conventional and conditional mouse models, allowing the discovery of new roles of GSK-3 in the mechanism of neurotransmitter action, neurodevelopment, learning and memory formation, GSK-3’s gene - effect on mouse behavior, and other functions. Thus, GSK-3 has been well-established as an intracellular second messenger for several neurotransmitter systems, and as an important therapeutic target of mood stabilizers, antipsychotics and psychomimetic drugs. The proposed Specific Topic for Frontiers in Neuroscience will be focused on the latest advances from leading laboratories in this area, subdivided into 5 topics: (1) GSK-3 history, mechanism of regulation, substrate specificity and comparison between the brain function of two GSK-3 genes through new animal models and cell biology approaches; (2) role of GSK-3 in neurodevelopment and neuronal structure; (3) involvement of GSK-3 in synaptic functions, learning and memory, and in serotonin and dopamine pathways; (4) role of GSK-3 in neuroinflammation, and application to the pathogenesis of multiple sclerosis, AD, schizophrenia, Fragile X, brain tumors, stroke and bipolar disorder; (5) development of GSK-3 inhibitors and their application in psychiatry, including special discussion about the mechanism of lithium action.