Over the past few decades an exceedingly large number of experimental and clinical investigations have been performed in an attempt to analyze the way in which the kidney functions. The basis for all this work was established during the nineteenth and the early twentieth century by morphologists (Bowman 1842; Hyrtl1863, 1872; Heidenhain 1874; Peter 1909; von Mollendorf 1930). All these investigators clearly outlined the extremely heterogeneous assembly of renal tissue and also defined the nephron as the smallest morphological unit. It was further the merit of these anato mists and histologists to preclude quite a number of nephron functions based merely on their careful observations. Contemporary histologists have been able to add little to these observations. Unfortunately with the introduction of physiologic in vivo et situ studies on kidneys the interest in heterogeneity waned. This lack of attention was aggravated by the introduction of the clearance techniques which cannot account for regional differences in the function of the smallest unit, the nephron. That ana tomic heterogeneity has a functional correlate was strongly suggested by Trueta et al. (1947) and vigorously stimulated a number of studies. The development of physiologic microtechniques, like micropuncture and microperfusion of single nephrons, or the perfusion of isolated nephron portions and electrophysiologic studies, enormously expanded our knowledge concerning details regarding nephron and total renal func tion.

The third edition of The Laboratory Rat features updated information on a variety of topics, including rats as research models for basic and translational research in areas such as genomics, alcoholism, diabetes, metabolic syndrome, obesity, neuroscience, spinal cord injury, traumatic brain injury, regenerative medicine, and infectious disease. New information related to the husbandry and veterinary care of rats is provided including topics related to nutrition, reproduction, anesthesia and surgery, infectious and noninfectious disease, and the care of surgical and other fragile models. It is a premier source of information on the laboratory rat, this book will be of interest to veterinary and medical students, senior graduate students, postdocs and researchers who utilize animals in biomedical research. New chapters on the care of surgical and fragile models and on the use of rats in research areas such as alcoholism, regenerative medicine, spinal cord injury, traumatic brain injury, and others are included. All chapters were written by scientific and veterinary experts. This book condenses information from many sources on topics related to the care and use of rats in research. It is the premier source of information on the laboratory rat.

There is no dearth of high-quality books on renal biopsy and pathology in the market. These are either single author or multi-author books, written by world authorities in their respective areas, mostly from the developed world. The vast scholarly potential of authors in the developing countries remains underutilized. Most of the books share the classical monotony of the topics or subjects covered in the book. The current book is a unique adventure in that it bears a truly international outlook and incorporates a variety of topics, which make the book a very interesting project. The authors of the present book hail not only from the developed world, but also many developing countries. The authors belong not only to US but also to Europe as well as to Pakistan and Japan. The scientific content of the book is equally varied, spanning the spectrum of technical issues of biopsy procurement, to pathological examination, to individual disease entities, renal graft pathology, pathophysiology of renal disorders, to practice guidelines.

Put the world’s most well-known kidney reference to work in your practice with the 11th Edition of Brenner & Rector’s The Kidney. This two-volume masterwork provides expert, well-illustrated information on everything from basic science and pathophysiology to clinical best practices. Addressing current issues such as new therapies for cardiorenal syndrome, the increased importance of supportive or palliative care in advanced chronic kidney disease, increasing live kidney donation in transplants, and emerging discoveries in stem cell and kidney regeneration, this revised edition prepares you for any clinical challenge you may encounter. Extensively updated chapters throughout, providing the latest scientific and clinical information from authorities in their respective fields. Lifespan coverage of kidney health and disease from pre-conception through fetal and infant health, childhood, adulthood, and old age. Discussions of today’s hot topics, including the global increase in acute kidney injury, chronic kidney disease of unknown etiology, cardiovascular disease and renal disease, and global initiatives for alternatives in areas with limited facilities for dialysis or transplant. New Key Points that represent either new findings or "pearls" of information that are not widely known or understood. New Clinical Relevance boxes that highlight the information you must know during a patient visit, such as pertinent physiology or pathophysiology. Hundreds of full-color, high-quality photographs as well as carefully chosen figures, algorithms, and tables that illustrate essential concepts, nuances of clinical presentation and technique, and clinical decision making. A new editor who is a world-renowned expert in global health and nephrology care in underserved populations, Dr. Valerie A. Luyckx from University of Zürich. Board review-style questions to help you prepare for certification or recertification.

Overcome the toughest clinical challenges in nephrology with Brenner & Rector’s The Kidney -- the most well-known nephrology resource in the world. A diverse team of more than 200 international contributors brings you the latest knowledge and best practices on every front in nephrology worldwide. From basic science and pathophysiology to clinical best practices, Brenner & Rector’s The Kidney is your go-to resource for any stage of your career. Review of the basic science that underpins clinical nephrology, comprehensive selection of the most important bibliographical sources in nephrology, and Board Review-style questions help you prepare for certification or recertification. Coverage of kidney health and disease from pre-conception through fetal and infant health, childhood, adulthood, and into old age. Expanded sections and chapter on global perspective and ethical considerations. Uniform terminology and nomenclature in line with emerging consensus in world kidney community. More than 700 full-color high-quality photographs as well as carefully chosen figures, algorithms, and tables to illustrate essential concepts, nuances of clinical presentation and technique, and decision making provide a visual grasp and better understanding of critical information. Internationally diverse, trusted guidance and perspectives from a team of well-respected global contributors . An editorial team headed by Dr. Skorecki and handpicked by Dr. Brenner ensures the ongoing adherence to previous standards of excellence. All chapters have been extensively updated or entirely rewritten by authorities in their respective fields. The latest clinical information including recent clinical trials, genetic causes of kidney disease, cardiovascular and renal risk prediction in chronic kidney disease, new paradigms in fluid and electrolyte management, and pediatric kidney disease, keep you current with the rapid development of care and research worldwide.

The only up-to-date compilation of renal methods available, this book is the definitive resource for any renal researcher eager to stay ahead. Methods in Renal Toxicology presents a vast array of methods for the study of renal cellular and tubular structure, function, and biochemistry under physiological, toxicological, and pathological conditions. It provides detailed descriptions in easy-to-understand language of methods designed to enhance your research efforts. Methods in Renal Toxicology puts you on the cutting edge with valuable chapters detailing molecular methods and transgene and gene targeting - the most recent approaches to the study of renal toxicology. Overall, the book's topics range from non-invasive assessments of renal function in the whole animal and clinical settings to cellular and molecular approaches. Specifically, the book delves into measurements of clearance and urinary markers, histopathology, and methods to assess renal carcinogenesis, mutagenesis, oxidative stress, mitochondria injury, cellular repair, and drug metabolism and transport. A variety of in vitro methods are also described, including the isolated perfused kidney, micropuncture, microperfusion, microdissection, renal slices, isolated perfused tubules, suspensions of tubules and isolated cells, and primary cell cultures and cell lines. Methods in Renal Toxicology is a must-have resource for all renal investigators. Nowhere else can you find concise descriptions of traditional and up-to-the-minute renal toxicology methods in such a practical, well-written single-volume guide.

A classic nephrology reference for over 25years, Seldin and Giebisch’s The Kidney, is the acknowledged authority on renal physiology and pathophysiology. In this 5th edition, such new and powerful disciplines as genetics and cell biology have been deployed to deepen and widen further the explanatory framework. Not only have previous chapters been extensively updated, but new chapters have been added to incorporate additional disciplines. Individual chapters, for example, now provide detailed treatment of the significance of cilia; the role of stem cells is now given special consideration. Finally, there has been a significant expansion of the section of pathophysiology, incorporating the newer findings of cell biology and genetics. If you research the development of normal renal function or the mechanisms underlying renal disease, Seldin and Giebisch’s The Kidney is your number one source for information. Offers the most comprehensive coverage on the market of fluid and electrolyte regulation and dysregulation in 85 completely revised chapters and 10 new chapters Includes 4sections, 62 chapters, devoted to regulation and disorders of acid-base homeostasis, and epithelial and nonepithelial transport regulation Includes foreword by Donald Seldin and Gerhard Giebisch, world renowned names in nephrology and editors of the previous three editions