Search results for: stem-cells-from-mechanisms-to-technologies

Stem Cells

Author : Michal K. Stachowiak
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Fast-moving and ever-changing, stem cell science and research presents ongoing ethical and legal challenges in many countries. Each development and innovation throws up new challenges. This is the case even where new developments initially seem to solve old dilemmas. Sometimes it becomes evident that new science does not in fact solve old problems and, for that reason, the ethical issues remain. In recognition of this, this book presents innovative and creative analyses of a range of ethical and legal challenges raised by stem cell research and its potential and actual application. The editors.

Biology and Engineering of Stem Cell Niches

Author : Ajaykumar Vishwakarma
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Biology and Engineering of Stem Cell Niches covers a wide spectrum of research and current knowledge on embryonic and adult stem cell niches, focusing on the understanding of stem cell niche molecules and signaling mechanisms, including cell-cell/cell-matrix interactions. The book comprehensively reviews factors regulating stem cell behavior and the corresponding approaches for understanding the subsequent effect of providing the proper matrix molecules, mechanical cues, and/or chemical cues. It encompasses a variety of tools and techniques for developing biomaterials-based methods to model synthetic stem cell niches in vivo, or to enhance and direct stem cell fate in vitro. A final section of the book discusses stem cell niche bioengineering strategies and current advances in each tissue type. Includes the importance of Cell-Cell and Cell Matrix Interactions in each specific tissue and system Authored and edited by authorities in this emerging and multidisciplinary field Includes valuable links to 5-10 minute YouTube© author videos that describe main points

Advances in Stem Cell Research

Author : Hossein Baharvand
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Advances in Stem Cell Research discusses recent advances in stem cell science, including therapeutic applications. This volume covers such topics as biomanufacturing iPS cells for therapeutic applications, techniques for controlling stem cell fate decisions, as well as current basic research in such areas as germ line stem cells, genomics and proteomics in stem cell research. It is a useful book for biology and clinical scientists, especially young investigators and stem cell biology students who are newly entering the world of stem cells research. The editors hope that the new knowledge and research outlined in this book will help contribute to new therapies for a wide variety of diseases that presently afflict humanity.

Stem Cell Biology and Tissue Engineering in Dental Sciences

Author : Ajaykumar Vishwakarma
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Stem Cell Biology and Tissue Engineering in Dental Sciences bridges the gap left by many tissue engineering and stem cell biology titles to highlight the significance of translational research in this field in the medical sciences. It compiles basic developmental biology with keen focus on cell and matrix biology, stem cells with relevance to tissue engineering biomaterials including nanotechnology and current applications in various disciplines of dental sciences; viz., periodontology, endodontics, oral & craniofacial surgery, dental implantology, orthodontics & dentofacial orthopedics, organ engineering and transplant medicine. In addition, it covers research ethics, laws and industrial pitfalls that are of particular importance for the future production of tissue constructs. Tissue Engineering is an interdisciplinary field of biomedical research, which combines life, engineering and materials sciences, to progress the maintenance, repair and replacement of diseased and damaged tissues. This ever-emerging area of research applies an understanding of normal tissue physiology to develop novel biomaterial, acellular and cell-based technologies for clinical and non-clinical applications. As evident in numerous medical disciplines, tissue engineering strategies are now being increasingly developed and evaluated as potential routine therapies for oral and craniofacial tissue repair and regeneration. Diligently covers all the aspects related to stem cell biology and tissue engineering in dental sciences: basic science, research, clinical application and commercialization Provides detailed descriptions of new, modern technologies, fabrication techniques employed in the fields of stem cells, biomaterials and tissue engineering research including details of latest advances in nanotechnology Includes a description of stem cell biology with details focused on oral and craniofacial stem cells and their potential research application throughout medicine Print book is available and black and white, and the ebook is in full color

Essentials of Stem Cell Biology

Author : Robert Lanza
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First developed as an accessible abridgement of the successful Handbook of Stem Cells, Essentials of Stem Cell Biology serves the needs of the evolving population of scientists, researchers, practitioners, and students embracing the latest advances in stem cells. Representing the combined effort of 7 editors and more than 200 scholars and scientists whose pioneering work has defined our understanding of stem cells, this book combines the prerequisites for a general understanding of adult and embryonic stem cells with a presentation by the world's experts of the latest research information about specific organ systems. From basic biology/mechanisms, early development, ectoderm, mesoderm, endoderm, and methods to the application of stem cells to specific human diseases, regulation and ethics, and patient perspectives, no topic in the field of stem cells is left uncovered. Contributions by Nobel Laureates and leading international investigators Includes two entirely new chapters devoted exclusively to induced pluripotent stem (iPS) cells written by the scientists who made the breakthrough Edited by a world-renowned author and researcher to present a complete story of stem cells in research, in application, and as the subject of political debate Presented in full color with a glossary, highlighted terms, and bibliographic entries replacing references

Patenting Stem Cell Technologies

Author : Antoinette F. Konski
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Are stem cells patentable? What is the patenting process? What rights does a patent provide? Why should I patent? Applying for and obtaining a patent is a process that can be unpredictable and intimidating, although it does not necessarily need to be. Novice and experienced inventors often have questions regarding patenting and the patenting process. This e-book is provided to answer many questions regarding the patenting process before the United States Patent and Trademark Office (“USPTO”). It also generally describes the technologies typically patented in connection with regenerative medicine. This e-book is provided for informational purposes only and should not replace legal advice, which is necessary to anticipate and address the nuances of the patenting process. In addition, there are issues that should be considered and addressed when considering patenting isolated stem cells and associated technologies—such as the process for obtaining patent rights outside the United States, post-grant procedures for challenging patents, non-patent protection of intellectual property, and enforcement of patents through litigation—which are beyond the scope of this chapter.

Progenitor and Stem Cell Technologies and Therapies

Author : Anthony Atala
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Progenitor and stem cells have the ability to renew themselves and change into a variety of specialised types, making them ideal materials for therapy and regenerative medicine. Progenitor and stem cell technologies and therapies reviews the range of progenitor and stem cells available and their therapeutic application. Part one reviews basic principles for the culture of stem cells before discussing technologies for particular cell types. These include human embryonic, induced pluripotent, amniotic and placental, cord and multipotent stem cells. Part two discusses wider issues such as intellectual property, regulation and commercialisation of stem cell technologies and therapies. The final part of the book considers the therapeutic use of stem and progenitor cells. Chapters review the use of adipose tissue-derived stem cells, umbilical cord blood (UCB) stem cells, bone marrow, auditory and oral cavity stem cells. Other chapters cover the use of stem cells in therapies in various clinical areas, including lung, cartilage, urologic, nerve and cardiac repair. With its distinguished editor and international team of contributors, Progenitor and stem cell technologies and therapies is a standard reference for both those researching in cell and tissue biology and engineering as well as medical practitioners investigating the therapeutic use of this important technology. Reviews the range of progenitor and stem cells available and outlines their therapeutic application Examines the basic principles for the culture of stem cells before discussing technologies for particular cell types, including human embryonic, induced pluripotent, amniotic and placental, cord and multipotent stem cells Includes a discussion of wider issues such as intellectual property, regulation and commercialisation of stem cell technologies and therapies

Regenerative Medicine from Protocol to Patient

Author : Gustav Steinhoff
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Regenerative medicine is the main field of groundbreaking medical development and therapy using knowledge from developmental and stem cell biology, as well as advanced molecular and cellular techniques. This collection of volumes on Regenerative Medicine: From Protocol to Patient, aims to explain the scientific knowledge and emerging technology as well as the clinical application in different organ systems and diseases. International leading experts from all over the world describe the latest scientific and clinical knowledge of the field of regenerative medicine. The process of translating science of laboratory protocols into therapies is explained in sections on regulatory, ethical and industrial issues. This collection is organized into five volumes: (1) Biology of Tissue Regeneration, (2) Stem Cell Science and Technology, (3) Tissue Engineering, Biomaterials and Nanotechnology, (4) Regenerative Therapies I, and (5) Regenerative Therapies II. The textbook gives the student, the researcher, the health care professional, the physician and the patient a complete survey on the current scientific basis, therapeutical protocols, clinical translation and practiced therapies in regenerative medicine. Volume 2 contains sixteen chapters addressing advanced knowledge on “Stem Cell Science and Technology” addressing basic classification technology, cell biology of stemness state and regulatory molecular pathways. Mechanisms and technology of cell programming are explained, as well as the pathology of cancer cells and dedifferentiation signalling. Pluripotent, multipotent germline and tissue specific human stem cells are classified and qualified according to their respective biological function or tissue regeneration. Leading stem cell scientists from all over the world explain advanced technology, latest knowledge, and clinical implications of human stem cell science in a unique, comprehensive and detailed outline.

Stem Cell Biology

Author : Dr. Indumathi Somasundaram
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Stem cell research and therapeutics has been captivating in recent decades due to its versatile discoveries on its potential to treat myriad of diseases. This is due to its properties of being undifferentiated, yet self-renews and differentiates into any type of cells, upon physiological signaling mechanisms. These sole attributes of stem cells, has created inquisitiveness in the minds of scientists and young researchers to explore every aspects of stem cells. This has opened a single doorway to the world of regenerative medicine, thereby saving millions of lives from wide diseases. Although stem cell is creating a new revolution in recent decades, due to its wider hypes and advancement in technologies, it is not becoming cost-effective for young generation University/college students to actually understand what stem cells are? Now-a-days, almost every life science course in College/ University either UG, PG or Specialized Diploma, has either a Unit on Stem cell or a full subject/paper on stem cell biology. Unfortunately, although learning about this new emerging field is imperative, academicians are unable to fulfill the stem cell practical due to the hype created about its tedious, costly coupled with advanced instrumentation facility. Thus, youngsters, being the future scientists are unaware about basic techniques of stem cell biology. Wide job opportunities are increasing day by day for youngsters in biotech industries, healthcare sectors, stem cell companies and banking sectors. Nevertheless, the students are unable to make the best use of these jobs, due to lack of basic know-how on stem cell biology or their basic laboratory techniques. This book is created to remove the bottleneck involved and help students to learn all the stem cell laboratory technique in a simple and easy fashion. We explain over here, the practical manual stem cell techniques that can be done with a basic culture laboratory set up. With such simple manual techniques coupled with shorter time and cost-effectiveness, students can understand all underlying principles and procedures involved in collection, isolation, enumeration, culturing, differentiation and in-vitro characterization of stem cells from various adult stem cell sources in a step-wise easy to understand manner. Although flowcytometry plays an important role in characterization of stem cells, due to cost of the machine, techniques of flowcytometry cannot be a part of lab manual in course of various Universities. However, to help the students, the authors are soon coming out with a new book on "Characterization of stem cells using flowcytometry: An easy Guide".

Stem Cell Engineering

Author : Robert M. Nerem
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This book describes a global assessment of stem cell engineering research, achieved through site visits by a panel of experts to leading institutes, followed by dedicated workshops. The assessment made clear that engineers and the engineering approach with its quantitative, system-based thinking can contribute much to the progress of stem cell research and development. The increased need for complex computational models and new, innovative technologies, such as high-throughput screening techniques, organ-on-a-chip models and in vitro tumor models require an increasing involvement of engineers and physical scientists. Additionally, this book will show that although the US is still in a leadership position in stem cell engineering, Asian countries such as Japan, China and Korea, as well as European countries like the UK, Germany, Sweden and the Netherlands are rapidly expanding their investments in the field. Strategic partnerships between countries could lead to major advances of the field and scalable expansion and differentiation of stem cells. This study was funded by the National Science Foundation (NSF), the National Institutes of Health (NIH) and the National Institute of Standards and Technology (NIST).

Emerging Technologies for Heart Diseases

Author : Udi Nussinovitch
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The increasing pace of advances in cardiology throughout the last few decades has fundamentally altered the natural course of heart patients. In the last few years, available therapies have been revolutionized completely by new transcatheter therapeutic approaches, novel ventricular assist devices, and new drugs. Also, molecular biology and genetics have a rapidly growing impact on cardiovascular diseases, enabling the field of regenerative medicine to become increasingly closer to routine clinical implementation. Emerging Technologies for Heart Diseases was conceived to cover the recent extensive literature on current and novel therapeutic options for cardiac patients. The first volume is dedicated to heart failure and valvular disorders, and the second covers myocardial ischemia and arrhythmias. The clinical topic is addressed in several chapters divided according to the therapeutic approach (mechanical or electrical device-based, or cell and gene-based). Each of the 46 chapters focuses on clinically available solutions, new therapies currently under evaluation in clinical trials, promising preclinical technologies, and emerging concepts and innovations that have not yet been tested in a preclinical model. Also, the book discusses future challenges and opportunities for clinical implementation. Lessons learned from abandoned experimental practices are also covered, giving the readers the widest possible perspective of current therapeutic dilemmas. Overall, this textbook was designed for physicians who want to stay up-to-date with current therapies and those of the future, for biomedical companies, and for those who wish to broaden their knowledge of new cardiovascular therapeutic options. Provides a comprehensive review of the latest therapeutic developments for heart failure, valvular disorders, myocardial ischemia and arrhythmias, and their clinical implications Written by both specialists in the field and established researchers, it delivers a review of emerging medical technologies and presents insight into their therapeutic promise Chapters are arranged according to disease pathogeneses and relevance and include coverage of the mechanical, electrophysiological, and biological approaches for the management of patients with heart failure should be replaced with heart failure and valvular disorders

Cell Culture Technology

Author : Cornelia Kasper
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This textbook provides an overview on current cell culture techniques, conditions, and applications specifically focusing on human cell culture. This book is based on lectures, seminars and practical courses in stem cells, tissue engineering, regenerative medicine and 3D cell culture held at the University of Natural Resources and Life Sciences Vienna BOKU and the Gottfried Wilhelm Leibniz University Hannover, complemented by contributions from international experts, and therefore delivers in a compact and clear way important theoretical, as well as practical knowledge to advanced graduate students on cell culture techniques and the current status of research. The book is written for Master students and PhD candidates in biotechnology, tissue engineering and biomedicine working with mammalian, and specifically human cells. It will be of interest to doctoral colleges, Master- and PhD programs teaching courses in this area of research.

Human Stem Cell Toxicology

Author : James L Sherley
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Toxicity against tissue stem cells (TSCs) is a major problem in drug development and environmental health science. Despite their essential function in all human cellular tissues, the nature of tissue stem cells is not fully understood. The small fraction of stem cells in tissues and the lack of specific biomarkers for their quantification present a formidable challenge to developing tools for their study and assays that can identify stem cell-toxic agents. Human Stem Cell Toxicology reveals TSC toxicity as a biomedical reality that is now well under siege by newly emerging ideas and technologies, despite these challenges. Chapters consider stem cell toxicity by environmental agents, pharmaceutical drug candidates, and marketed therapeutic medicines with adverse side effects. New insights to cellular, molecular, biochemical and chemical mechanisms of human tissue stem cell toxicity are brought together. Experimental and theoretical treatments are of specific topics, including approaches to monitoring TSC function, newly discovered TSC types and TSC toxicity resistance mechanisms are covered by expert authors. This book informs and champions the continued development of innovative technologies to predict the TSC toxicity of compounds before their use, whether in patients or the environment, by addressing emerging new cell-based approaches and concepts for technical innovation. This publication will be a useful reference for postgraduate students and researchers working in toxicology, pharmaceutical science, tissue cell biology and stem cell biology.

Stem Cell Engineering

Author : Gerhard M. Artmann
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The potential of stem cells for healing and disease prevention in all fields of medicine is tremendous and has revolutionized the high-tech biomedical research. In this book, many of the most prominent researchers discuss the challenging topics of stem cell engineering, for example: Ethical issues of stem cell research; technological challenges, stem cell growth and differentiation, therapeutic applications, bioreactors and bioprocesses, high throughput and microfluidic screening platforms, stem cell identification and sorting, intercellular signaling and engineered niches, novel approaches for embryonic and adult stem cell growth and differentiation, stem cells and drug discovery, screening platforms. Stem Cell Engineering offers valuable background and reference for both the public and professionals including industrial staffers, faculty, researchers, engineers, students and scientific journalists.

Stem Cell Biology and Regenerative Medicine

Author : Charles Durand
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The study of stem cell biology is under intensive investigations. Because stem cells have the unique capability to self-renew and differentiate into one or several cell types, they play a critical role in development, tissue homeostasis and regeneration. Stem cells also constitute promising cell candidates for cell therapy. The aim of this book is to provide an accurate knowledge on stem cell biology and regenerative medicine. This book will cover many topics in the field and is based on seminars given by recognized scientists involved the international master program on stem cell biology at the University Pierre and Marie Curie (UPMC) in Paris. Content Preface. Pierre Charbord and Charles Durand. 1) General concepts 1.Stem cell concepts. Charles Durand and Pierre Charbord. 2.Transcriptional regulation in stem cells. Eric Soler and Frank Grosveld. 3.DNA repair in stem cells. Leyla Vahidi Ferdousi and Miria Ricchetti. 4. Stem cells and epigenetic regulation. Emma L. Walton and Claire Francastel. 5. Hydra and the evolution of stem cells. Alexander Klimovich, Anna Marei Böhm and Thomas C.G. Bosch. 6. Ontogeny of stem cells. Thierry Jaffredo. 7. Regeneration in anamniotic vertebrates. Dunja Knapp. 8. Computational models of spatio-temporal stem cell organization. Peter Buske and Joerg Galle. 2) Pluripotent stem cells 9. X chromosome inactivation in stem cells and development. Agnese Loda, Friedemann Loos and Joost Gribnau. 10. Molecular machinery of reprogramming. Romain Desprat, Ollivier Milhavet and Jean-Marc Lemaitre. 11. Modeling human genetic disorders using induced pluripotent stem cells. Franck Lebrin. 3) Adult stem cells 12. Developmental biology of hematopoietic stem cells : Cellular aspects. Laurent Yvernogeau, Jean-Charles Boisset and Catherine Robin. 13. Developmental biology of haematopoietic stem cells: Cell intrinsic and extrinsic regulators of their emergence. Katrin Ottersbach. 14. Biology of hematopoietic stem cells in the adult. Marie-Laure Arcangeli, Rima Haddad, Francoise Pflumio. 15. Epithelial stem cells in the skin. Romain Fontaine, Mathieu Castela and Selim Aractingi. 16. Skeletal muscle stem cells. Elisa Negroni, Maximilien Bencze, Stéphanie Duguez, Gillian Butler-Browne and Vincent Mouly. 17. Mammary stem cells. Marie-Ange Deugnier, Marisa M. Faraldo and Marina A. Glukhova. 18. Intestinal stem cells. Silvia Fre. 19. Neural stem cells. Nathalie Kubis and Martin Catala. 20. Dental stem cells. Anne Poliard. 21. Bone marrow Mesenchymal Stem Cells: from stemness to stromal property of hematopoietic support. Pierre Charbord and Bruno Delorme. 22. Retinal stem cells. Olivier Goureau, Angélique Terray, Katherine S. Matho, Sacha Reichman, and Gael Orieux. 4) Stem cell-related diseases and therapy using stem cells 23. Leukemic stem cells: what the concept brings to disease and patient management. Berent Lunden and Christine Chomienne. 24. Stem cells for cardiac repair. Philippe Menasché. 25. Stem cells for red blood cell production. Christelle Mazurier, Guillaume F Rousseau, Luc Douay and Hélène Lapillonne. 26. Prospectives for therapy with stem cells in skeletal muscular diseases. Maximilien Bencze, Elisa Negroni, Vincent Mouly and Gillian Butler-Browne. 5) Regulatory and philosophical aspects 27. Legal framework for research on Human Embryonic Stem Cells in France and in Europe. Arnaud de Guerra, Emmanuelle Prada-Bordenave 28. Stem cell epistemological issues. Lucie Laplane. 29. Future outlook. Pierre Charbord and Charles Durand.

Stem Cell Biology and Gene Therapy

Author : Peter J. Quesenberry
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STEM CELL BIOLOGY AND GENE THERAPY Edited by Peter J. Quesenberry, Gary S. Stein, Bernard Forget, and Sherman Weissman Advances in molecular genetics and recombinant DNA technology have ushered in a new era in medical therapeutic research. New insights into the molecular basis of human disease and the role played by biological regulatory mechanisms have precipitated tremendous drug development efforts backed by intensive research into human gene therapy worldwide. Stem Cell Biology and Gene Therapy is the first book to thoroughly cover major advances in the field and their applications to novel molecular therapies. This self-contained volume integrates biological and clinical components of stem cell biology, examines some of the most difficult aspects of gene therapy, and provides a systematic review of advanced gene modification techniques. Twenty essays by leading researchers address some of the most compelling topics in contemporary medical research, including: * Fundamental regulatory mechanisms that operate in stem cells * Stem cells from a therapeutic perspective, including preparations of stem cells and their therapeutic potential as vehicles for gene therapy * Delivery systems for therapeutic genes, including an overview of the most promising vectors * Clinical applications for gene therapy, covering a broad range of diseases such as hemophilia, cancers, neurological disease, and more Complete with illustrations and real-world examples of a variety of disorders, Stem Cell Biology and Gene Therapy is essential for researchers in gene therapy and members of the biotechnology industry who are developing human molecular therapies for commercial use. It is also an important reference for molecular biologists, cell biologists, immunologists, molecular geneticists, hematologists, cancer researchers, biochemists, and anyone working in internal medicine.

Stem Cell Research

Author : United States. Congress. Senate. Committee on Appropriations. Subcommittee on Departments of Labor, Health and Human Services, Education, and Related Agencies
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Mesenchymal Stem Cell Therapy

Author : Lucas G. Chase
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Over the past decade, significant efforts have been made to develop stem cell-based therapies for difficult to treat diseases. Multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs), appear to hold great promise in regards to a regenerative cell-based therapy for the treatment of these diseases. Currently, more than 200 clinical trials are underway worldwide exploring the use of MSCs for the treatment of a wide range of disorders including bone, cartilage and tendon damage, myocardial infarction, graft-versus-host disease, Crohn’s disease, diabetes, multiple sclerosis, critical limb ischemia and many others. MSCs were first identified by Friendenstein and colleagues as an adherent stromal cell population within the bone marrow with the ability to form clonogenic colonies in vitro. In regards to the basic biology associated with MSCs, there has been tremendous progress towards understanding this cell population’s phenotype and function from a range of tissue sources. Despite enormous progress and an overall increased understanding of MSCs at the molecular and cellular level, several critical questions remain to be answered in regards to the use of these cells in therapeutic applications. Clinically, both autologous and allogenic approaches for the transplantation of MSCs are being explored. Several of the processing steps needed for the clinical application of MSCs, including isolation from various tissues, scalable in vitro expansion, cell banking, dose preparation, quality control parameters, delivery methods and numerous others are being extensively studied. Despite a significant number of ongoing clinical trials, none of the current therapeutic approaches have, at this point, become a standard of care treatment. Although exceptionally promising, the clinical translation of MSC-based therapies is still a work in progress. The extensive number of ongoing clinical trials is expected to provide a clearer path forward for the realization and implementation of MSCs in regenerative medicine. Towards this end, reviews of current clinical trial results and discussions of relevant topics association with the clinical application of MSCs are compiled in this book from some of the leading researchers in this exciting and rapidly advancing field. Although not absolutely all-inclusive, we hope the chapters within this book can promote and enable a better understanding of the translation of MSCs from bench-to-bedside and inspire researchers to further explore this promising and quickly evolving field.

Essential Current Concepts in Stem Cell Biology

Author : Beate Brand-Saberi
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This textbook describes the biology of different adult stem cell types and outlines the current level of knowledge in the field. It clearly explains the basics of hematopoietic, mesenchymal and cord blood stem cells and also covers induced pluripotent stem cells. Further, it includes a chapter on ethical aspects of human stem cell research, which promotes critical thinking and responsible handling of the material. Based on the international masters program Molecular and Developmental Stem Cell Biology taught at Ruhr-University Bochum and Tongji University Shanghai, the book is a valuable source for postdocs and researchers working with stems cells and also offers essential insights for physicians and dentists wishing to expand their knowledge. This textbook is a valuable complement to Concepts and Applications of Stem Cell Biology, also published in the Learning Materials in Biosciences textbook series.

Concepts and Applications of Stem Cell Biology

Author : Gabriela Rodrigues
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This textbook will support graduate students with learning materials rich in the basic concepts of stem cell biology, in its most widespread and updated perspective. The chapters are conceived in a way for students to understand the meaning of pluripotency, the definition of embryonic stem cells and the formation of multicellular structures such as organoids together with the underlying principles of their epigenetic. This textbook also discusses adult stem cells and the potential use of these cells, in particular neural, mesenchymal, and several types of muscular cells, in biomedical research and clinical applications. This textbook represents a vital complement to the text on Essential Current Concepts of Stem Cell Biology, also published in the Learning Materials in Biosciences textbook series.