Search results for: stem-cells-from-drug-to-drug-discovery

Stem Cells From Drug to Drug Discovery

Author : Khawaja Husnain Haider
File Size : 50.19 MB
Format : PDF, Docs
Download : 172
Read : 266
Download »
Stem cell based therapy is a 21st century approach of therapeutic intervention which epitomizes a shift from conventional symptomatic treatment strategy to addressing the root cause of the disease process. This is especially a hope for the patients suffering from diseases such as Alzheimer, diabetes, myocardial infarction and other diseases which have always been considered as incurable. Moreover, stem cells provide excellent in vitro disease models for drug development. This book is a compilation of the bench experience of experts from various research labs involved in the cutting edge area of research, describing the use of stem cells both as part of the combinatorial therapeutic intervention approach and as tools (disease model) during drug development.

Applications of Stem Cells in Drug Discovery

Author : Lulu Pickering
File Size : 22.98 MB
Format : PDF
Download : 752
Read : 184
Download »

Stem Cells in Drug Discovery and Preclinical Safety Applications as Tools and Targets

Author : Aaron T. Chuang
File Size : 48.74 MB
Format : PDF, ePub, Mobi
Download : 505
Read : 487
Download »
Divided into three parts, this book covers the applications of stem cells as tools for drug discovery assays, the bioengineering applications of stem cell assays, and as drug targets for regenerative therapy. It includes a focus on stem cell culturing methods and their application to efficacy and safety tests when moving to preclinical drug studies. It also provides a single source for stem cell scientists, pharmacologists/discovery scientists, and bioprocessors. This text is a broad reference tool for those in stem cell science and those interested in where and how it fits in drug discovery.

Stem Cells in Regenerative Medicine

Author : Alain A. Vertes
File Size : 49.92 MB
Format : PDF
Download : 455
Read : 794
Download »
This book is a unique guide to emerging stem cell technologies and the opportunities for their commercialisation. It provides in-depth analyses of the science, business, legal, and financing fundamentals of stem cell technologies, offering a holistic assessment of this emerging and dynamic segment of the field of regenerative medicine. • Reviews the very latest advances in the technology and business of stem cells used for therapy, research, and diagnostics • Identifies key challenges to the commercialisation of stem cell technology and avenues to overcome problems in the pipeline • Written by an expert team with extensive experience in the business, basic and applied science of stem cell research This comprehensive volume is essential reading for researchers in cell biology, biotechnology, regenerative medicine, and tissue engineering, including scientists and professionals, looking to enter commercial biotechnology fields.

Phenotypic screening in the 21st century

Author : Gul Erdemli
File Size : 81.93 MB
Format : PDF, ePub, Docs
Download : 110
Read : 1034
Download »
In the genomic era of 1990s-2000s, pharmaceutical research moved to target-based drug discovery which enabled development of a number of small molecule drugs against a wide range of diseases. In many cases however, drugs that arose from genomics failed, questioning the validity of the targets and the suitability of target-based drug discovery as an optimal strategy for all disease states. For monogenic diseases, target-based approaches may be well-suited to the identification of novel therapies. Most diseases, however, are caused by a combination of several genetic and environmental factors and are likely to require simultaneous modulation of multiple molecular targets/pathways for successful treatment. For such diseases, reductionist approaches focusing on individual targets rather than biological networks are unlikely to succeed and new drug development strategies are required. In search of more successful approaches, the pharmaceutical industry is moving towards phenotypic screening beyond individual genes/targets. However, this requires rethinking of diseases and drug discovery approaches from a network and systems biology perspective. Since returning to the pre-genomics era of screening drug candidates in laborious animal models is not a feasible solution, the industry needs to evolve a new paradigm of phenotypic drug discovery within the context of systems biology. Such a paradigm must combine physiologically and disease relevant biological substrates with sufficient throughput, operational simplicity and statistical vigour. Biomarker strategies for translational medicine, as well as preclinical safety and selectivity assessments, would also need to be revised to adapt to the target agnostic style. This focused issue aims to discuss strategies, key concepts and technologies related to systems-based approaches in drug development. Design and implementation of innovative biological assays, featuring multiple target strategies, and rational drug design in the absence of target knowledge during the early drug discovery are illustrated with examples. Specific topics include: • The need for systems-based approaches in drug development • Phenotypic screening strategies • Compound libraries (natural product inspired compound collections) • Target deconvolution and identification • Target agnostic lead discovery and optimization • Multi-target approaches and decoding the phenotype (understanding biological interactions and multiscale systems modelling) • Translational aspects • Early evaluation of selectivity and safety in a target agnostic manner

Engineering and Application of Pluripotent Stem Cells

Author : Ulrich Martin
File Size : 42.53 MB
Format : PDF, Mobi
Download : 189
Read : 469
Download »
​This book reviews the latest biotechnological advances with pluripotent stem cells, exploring their application in tissue engineering and medicinal chemistry. Chapters from expert contributors cover topics such as the production of transgene-free induced pluripotent stem cells (iPSCs), expansion, controlled differentiation and programming of pluripotent stem cells, and their genetic instability. Particular attention is given to the application of the pluripotent stem cells for vascularision of engineered tissue and for drug screening. This book will appeal to researchers working in regenerative medicine and drug discovery, and to bioengineers and professionals interested in stem cell research.

Stem Cells From Hype to Real Hope

Author : Khawaja Husnain Haider
File Size : 31.58 MB
Format : PDF
Download : 570
Read : 235
Download »
This book is a compilation of the bench experience of leading experts from various research labs involved in the cutting edge area of research. The authors describe the use of stem cells both as part of the combinatorial therapeutic intervention approach and as tools (disease model) during drug development, highlighting the shift from a conventional symptomatic treatment strategy to addressing the root cause of the disease process. The book is a continuum of the previously published book entitled "Stem Cells: from Drug to Drug Discovery" which was published in 2017.

Stem Cells

Author : Khawaja Husnain Haider
File Size : 66.80 MB
Format : PDF, ePub, Mobi
Download : 518
Read : 946
Download »
This book is a continuum of the first two books published in the STEM CELLS series entitled "Stem Cells: From Drug to Drug Discovery" and "Stem Cells: From Hype to Real Hope" which were published in 2017 and 2019, respectively. The scope of the book encompasses a wide range of topics with a latitude from adult stem cells to pluripotent stem cells in regenerative medicine either alone or as part of the combinatorial therapeutic intervention approach as "drug" besides their application as tools (disease model) during drug development process. Written by a leading group of researchers, the book encompasses experimental to clinical aspects of stem/progenitors cells, their biology, and characteristics.

Biotechnology and Biopharmaceuticals

Author :
File Size : 86.69 MB
Format : PDF, Docs
Download : 522
Read : 1095
Download »
Biotechnology and Biopharmaceuticals: Transforming Proteins and Genes into Drugs, Second Edition addresses the pivotal issues relating to translational science, including preclinical and clinical drug development, regulatory science, pharmaco-economics and cost-effectiveness considerations. The new edition also provides an update on new proteins and genetic medicines, the translational and integrated sciences that continue to fuel the innovations in medicine, as well as the new areas of therapeutic development including cancer vaccines, stem cell therapeutics, and cell-based therapies.

Stem Cells

Author : G. Sitta Sittampalam
File Size : 36.36 MB
Format : PDF, ePub, Docs
Download : 527
Read : 490
Download »
This book will focus on the principle non-therapeutic ('superior cell tools') applications of stem cell technology, but will also include the emerging field of soluble, regenerative medicines. The scope will be a broad, contemporary review of the current state of the art for stem cell utilities in the biopharmaceutical research sector, with emphasis on technology strengths, challenges to resolve and prospects for future development. It will provide cutting edge opinion from academic and industrial leaders in the sector. The book's objectives include an overview of the fundamental science and technology components that underpin the utilities, an in depth review of the strength of the technology using a representative biopharmaceutical pipeline and case studies covering key therapeutic/development areas (oncology, cardio-vascular, neuroscience, safety pharmacology) and prediction of advanced applications (disease modelling, regenerative medicine). The book goes beyond the renowned applications and via the inclusion of hot topics such as reprogramming and modelling of tissue function in vitro will conveniently set the scene for further consideration as these fields continue to evolve. The editors collectively have nearly 35 years experience in the biopharmaceutical sector, many spent on direct utilization of stem cells and current affiliations are balanced by this in deployment to cover both academic and industrial perspectives. As the industry expands, investments increase and new international entrants and applications into the sector appear, a book reviewing contemporary and anticipating future stem cell utilities will be in major demand as no single review article can adequately cover the whole sector.

Stem Cells in Toxicology and Medicine

Author : Saura C. Sahu
File Size : 43.76 MB
Format : PDF
Download : 951
Read : 1182
Download »
A comprehensive and authoritative compilation of up-to-date developments in stem cell research and its use in toxicology and medicine Presented by internationally recognized investigators in this exciting field of scientific research Provides an insight into the current trends and future directions of research in this rapidly developing new field A valuable and excellent source of authoritative and up-to-date information for researchers, toxicologists, drug industry, risk assessors and regulators in academia, industry and government

Perspectives in Regenerative Medicine

Author : Ena Ray Banerjee
File Size : 25.12 MB
Format : PDF
Download : 165
Read : 609
Download »
The information given in this book tries to capture the essence of the sheer dynamicity of the cell along with useful tips on how to address critical rate limiting steps in the process of exploration and investigation of its capacity to regenerate, rebuild and replenish from within. The definitions of stem cells, stemness, and the niche concept continue to undergo revisions. In adult vertebrates, hematopoietic and some non-hematopoietic progenitors are synthesized within specialized niches of bone marrow. They migrate to designated tissues, and are either trans-differentiated or become quiescent and settle down. These form the stem cell niche reservoir in all tissues. Not only the primary hematopoietic tissue but all organs and tissues are also capable of generating progenitors which are either synthesized from these migrants or are direct recruits from other tissues. In the niches, the cells settle down and await their turn to either make more clones like themselves or differentiate and mobilize in an exigency. Thus progenitors are important reserves, to be multiplied and deployed or travel as important message bearing molecules via blood as circulating progenitors which can home to their allocated destinations. Upon reaching, specific integrins and selectins help them “dock” and “port” and they may be reprogrammed to induce further differentiation and help repopulate the denuded tissue. In pulmonary fibrosis and asthma, progenitors from both systemic circulation and local stem cell niches have been found to participate in the myriad ramifications of repair, replacement and regeneration of lost or diseased tissue. Whether they are lung specific or global in origin and role remain to be explored. Research tools, fundamental concepts, techniques, methodologies and standard operating protocols and animal models and human extrapolations, have been discussed in a concise way along with detailed description and discussion on the appropriate rationale to introduce the subject to the casual reader and provide valuable tactical information to the specialist in Regenerative Medicine. I sincerely hope you enjoy the work and appreciate the hard work that has gone into designing and executing elegant experiments by many researchers in the field. The branch is multi-disciplinary and I hope that the readers will not be limited to biologists alone.

Primary and Stem Cells

Author : Uma Lakshmipathy
File Size : 23.75 MB
Format : PDF, ePub
Download : 909
Read : 1022
Download »
This book describes basic cell engineering methods, emphasizing stem cell applications, and use of the genetically modified stem cells in cell therapy and drug discovery. Together, the chapters introduce and offer insights on new techniques for engineering of stem cells and the delivery of transgenes into stem cells via various viral and non-viral systems. The book offers a guide to the types of manipulations currently available to create genetically engineered stem cells that suit any investigator's purpose, whether it's basic science investigation, creation of disease models and screens, or cells for therapeutic applications.

Developing stem cell based therapies for neural repair

Author : Clare Parish
File Size : 81.37 MB
Format : PDF
Download : 140
Read : 1117
Download »
Current pharmacotherapies and surgical intervention provide limited benefit in the treatment of neural injuries or halting disease progression and has resulted in significant hope for the successes of stem cell research. The properties of stem cells render them appropriate for cell replacement therapy, endogenous repair, disease modeling as well as high-throughput drug screening and development. Such applications will aide in increasing our knowledge and developing treatments for neurodegenerative disorders such as Parkinson’s disease and Huntington’s diseases as well as neural traumas including ischemic brain damage and traumatic brain injury. This Frontiers Research topic encouraged contributions from the general field of stem cell biology, with a particular emphasis on utilizing these cells to develop new therapies for neural repair. Related articles deal with issues such as: breakthroughs in stem cell proliferation/differentiation methodologies, using pluripotent and neural stem cells for transplantation and endogenous repair, the use of patient derived stem cells for disease modeling, using stem cells for drug discovery as well as the ethical issues related to the use of stem cells.

Cancer Stem Cells

Author :
File Size : 35.2 MB
Format : PDF, Docs
Download : 283
Read : 826
Download »

Cell Press Reviews Stem Cells to Model and Treat Disease

Author : Cell Press
File Size : 72.69 MB
Format : PDF
Download : 718
Read : 218
Download »
Cell Press Reviews: Stem Cells to Model and Treat Disease informs, inspires, and connects stem cell researchers and clinicians at all stages in their careers with timely, comprehensive reviews written by leaders in the field and curated by Cell Press editors. The publication offers a broad view of some of the most compelling topics in stem cell research including: Safety and efficacy of stem cell treatments Stem-cell-based organ regeneration Integrating stem cells into personalized drug discovery Using pluripotent stem cells for treating neurological disease Engineering hematopoietic stem cells for innovative therapies Contributions come from leading voices in the field, including: - Shinya Yamanaka, Recipient of the 2012 Nobel Prize for Physiology or Medicine, Recipient of the 2012 Millennium Technology Prize, Professor and Director of the Center for iPS Cell Research and Application at Kyoto University, Senior Investigator at the Gladstone Institute of Cardiovascular Disease, L.K. Whittier Foundation Investigator in Stem Cell Biology and Professor at the University of California, San Francisco - George Q. Daley, Samuel E. Lux IV Professor of Hematology/Oncology at Harvard Medical School and Director for the Stem Cell Transplantation Program at Boston Children’s Hospital - Irving Weissman, Member of National Academy of Sciences, Virgina & D.K Ludwig Professor for Clinical Investigation in Cancer Research, and Director for Institute of Stem Cell Biology and Regenerative Medicine at Stanford University of Medicine Cell Press Reviews: Stem Cells to Model and Treat Disease is part of the Cell Press Reviews series, which features reviews published in Cell Press primary research and Trends reviews journals. Provides timely overviews on a wide range of stem cell applications Offers insight from experts on the key opportunities and challenges facing the field Features reviews on genetic, cellular, and molecular aspects of stem-cell-based applications Includes articles originally published in Cell, Cell Stem Cell, Neuron, Trends in Molecular Medicine, and Trends in Biotechnology

Human Induced Pluripotent Stem Cells for Modeling Neurodegeneration and Drug Discovery

Author : Peter Reinhardt
File Size : 24.24 MB
Format : PDF, ePub, Mobi
Download : 473
Read : 1074
Download »

Human Pluripotent Stem Cell Applications in Drug Discovery and Toxicology An Overview

Author : Shiva Prasad Potta
File Size : 72.20 MB
Format : PDF, ePub, Docs
Download : 609
Read : 1113
Download »
Human Pluripotent Stem Cell Applications in Drug Discovery and Toxicology - An overview.

Stem Cell Engineering

Author : Gerhard M. Artmann
File Size : 77.66 MB
Format : PDF, Mobi
Download : 553
Read : 472
Download »
The potential of stem cells for healing and disease prevention in all fields of medicine is tremendous and has revolutionized the high-tech biomedical research. In this book, many of the most prominent researchers discuss the challenging topics of stem cell engineering, for example: Ethical issues of stem cell research; technological challenges, stem cell growth and differentiation, therapeutic applications, bioreactors and bioprocesses, high throughput and microfluidic screening platforms, stem cell identification and sorting, intercellular signaling and engineered niches, novel approaches for embryonic and adult stem cell growth and differentiation, stem cells and drug discovery, screening platforms. Stem Cell Engineering offers valuable background and reference for both the public and professionals including industrial staffers, faculty, researchers, engineers, students and scientific journalists.

Stem Cells and Cancer Stem Cells Volume 10

Author : M.A. Hayat
File Size : 28.89 MB
Format : PDF, ePub, Mobi
Download : 245
Read : 401
Download »
Presenting contributions by 66 experts representing 13 countries, Volume 10 of the series Stem Cells and Cancer Stem Cells synthesizes current understanding of the causes, diagnosis, and therapy of major human diseases and debilitating tissue and organ injuries, using cell-based treatment. This volume presents contemporary research into generation, preservation, and uses of stem cells in fighting disease and tissue/organ injuries. The contents of the volume are organized into five sections. Mesenchymal Stem Cells section includes chapters on the use of stem cells in bone regeneration, studies and trials of stem cells in autoimmune diseases, and differences between adipose tissue-derived mesenchymal stem cells and bone marrow-derived mesenchymal stem cells as regulators of immune response. Induced Pluripotent Stem Cells section offers chapters on drug discovery using human IPSC-based disease models, and on generation of antigen-specific lymphocytes from IPSCs. Neural Cells and Neural Stem Cells section discusses use of bacterial artificial chromosomes in the genetic identification of stem cell-derived neural cell types, and use of moderate low temperature to preserve the stemness of neural stem cells. The section, Role of Stem Cells in Disease, discusses stem cell support in high-dose chemotherapy of Non-Hodgkin’s Lymphomas; potential targets for drug resistant leukemic stem cells, bone marrow stem cell therapies for diabetes mellitus. This section also discusses the use of stem cells in treating thyroid, breast and bone cancers, hempophilia and Parkinson’s Disease. The section, Stem Cell Transplantation, includes chapters on reducing fungal infection in allogenic stem cell transplantation patients, use of Bulsufan/Fludarabine for conditioning in haematopoietic stem cell transplantation, and interleukin-7 receptor alpha polymorphisms in allogeneic stem cell transplantation. The editor, M.A. Hayat, is a Distinguished Professor in the Department of Biological, Sciences at Kean University, Union, New Jersey, USA.