Author: P. Armitage
Author: P. Armitage
Author: Peter Armitage,Geoffrey Berry,J. N. S. Matthews
Publisher: John Wiley & Sons
View: 2990The explanation and implementation of statistical methods for themedical researcher or statistician remains an integral part ofmodern medical research. This book explains the use of experimentaland analytical biostatistics systems. Its accessible style allowsit to be used by the non-mathematician as a fundamental componentof successful research. Since the third edition, there have been many developments instatistical techniques. The fourth edition provides the medicalstatistician with an accessible guide to these techniques and toreflect the extent of their usage in medical research. The new edition takes a much more comprehensive approach to itssubject. There has been a radical reorganization of the text toimprove the continuity and cohesion of the presentation and toextend the scope by covering many new ideas now being introducedinto the analysis of medical research data. The authors have triedto maintain the modest level of mathematical exposition thatcharacterized the earlier editions, essentially confining themathematics to the statement of algebraic formulae rather thanpursuing mathematical proofs. Received the Highly Commended Certificate in the PublicHealth Category of the 2002 BMA BooksCompetition.
Author: Charan Singh Rayat
View: 2151This book covers all aspects of statistical methods in detail with applications. It presents solutions to the needs of post-graduate medical students, doctors and basic medical scientists for statistical evaluation of data. In present era, dependency on softwares for statistical analysis is eroding the basic understanding of the statistical methods and their applications. As a result, there are very few basic medical scientists capable of analyzing their research data due to lack of knowledge and ability. This book has been written in systematic way supported by figures and tables for basic understanding of various terms, definitions, formulae and applications of statistical methods with solved examples and graphic presentation of data to create interest in this mathematical science.
Author: Ralph B. D'Agostino
Publisher: John Wiley & Sons
View: 2272The Tutorials in Biostatistics have become a very popular feature of the prestigious Wiley journal, Statistics in Medicine (SIM). The introductory style and practical focus make them accessible to a wide audience including medical practitioners with limited statistical knowledge. This book represents the first of two volumes presenting the best tutorials published in SIM, focusing on statistical methods in clinical studies. Topics include the design and analysis of clinical trials, epidemiology, survival analysis, and data monitoring. Each tutorial is focused on a medical problem, has been fully peer-reviewed and edited, and is authored by leading researchers in biostatistics. Many articles include an appendix on the latest developments since publication in the journal and additional references. This will appeal to statisticians working in medical research, as well as statistically-minded clinicians, biologists, epidemiologists and geneticists. It will also appeal to graduate students of biostatistics.
Author: Xiao-Hua Zhou,Nancy A. Obuchowski,Donna K. McClish
Publisher: John Wiley & Sons
View: 8886Praise for the First Edition " . . . the book is a valuable addition to the literature in thefield, serving as a much-needed guide for both clinicians andadvanced students."—Zentralblatt MATH A new edition of the cutting-edge guide to diagnostic tests inmedical research In recent years, a considerable amount of research has focusedon evolving methods for designing and analyzing diagnostic accuracystudies. Statistical Methods in Diagnostic Medicine, Second Editioncontinues to provide a comprehensive approach to the topic, guidingreaders through the necessary practices for understanding thesestudies and generalizing the results to patient populations. Following a basic introduction to measuring test accuracy andstudy design, the authors successfully define various measures ofdiagnostic accuracy, describe strategies for designing diagnosticaccuracy studies, and present key statistical methods forestimating and comparing test accuracy. Topics new to the SecondEdition include: Methods for tests designed to detect and locate lesions Recommendations for covariate-adjustment Methods for estimating and comparing predictive values andsample size calculations Correcting techniques for verification and imperfect standardbiases Sample size calculation for multiple reader studies when pilotdata are available Updated meta-analysis methods, now incorporating randomeffects Three case studies thoroughly showcase some of the questions andstatistical issues that arise in diagnostic medicine, with allassociated data provided in detailed appendices. A related web sitefeatures Fortran, SAS®, and R software packages so thatreaders can conduct their own analyses. Statistical Methods in Diagnostic Medicine, Second Edition is anexcellent supplement for biostatistics courses at the graduatelevel. It also serves as a valuable reference for clinicians andresearchers working in the fields of medicine, epidemiology, andbiostatistics.
Author: J. Philip Miller
View: 9859Essential Statistical Methods for Medical Statistics presents only key contributions which have been selected from the volume in the Handbook of Statistics: Medical Statistics, Volume 27 (2009). While the use of statistics in these fields has a long and rich history, the explosive growth of science in general, and of clinical and epidemiological sciences in particular, has led to the development of new methods and innovative adaptations of standard methods. This volume is appropriately focused for individuals working in these fields. Contributors are internationally renowned experts in their respective areas. · Contributors are internationally renowned experts in their respective areas · Addresses emerging statistical challenges in epidemiological, biomedical, and pharmaceutical research · Methods for assessing Biomarkers, analysis of competing risks · Clinical trials including sequential and group sequential, crossover designs, cluster randomized, and adaptive designs · Structural equations modelling and longitudinal data analysis
Author: Douglas G. Altman
Publisher: CRC Press
View: 1790Most medical researchers, whether clinical or non-clinical, receive some background in statistics as undergraduates. However, it is most often brief, a long time ago, and largely forgotten by the time it is needed. Furthermore, many introductory texts fall short of adequately explaining the underlying concepts of statistics, and often are divorced from the reality of conducting and assessing medical research. Practical Statistics for Medical Research is a problem-based text for medical researchers, medical students, and others in the medical arena who need to use statistics but have no specialized mathematics background. The author draws on twenty years of experience as a consulting medical statistician to provide clear explanations to key statistical concepts, with a firm emphasis on practical aspects of designing and analyzing medical research. The text gives special attention to the presentation and interpretation of results and the many real problems that arise in medical research.
Author: John C. Bailar,David C. Hoaglin
Publisher: John Wiley & Sons
View: 1602A new edition of the classic guide to the use of statistics inmedicine, featuring examples from articles in the New EnglandJournal of Medicine Medical Uses of Statistics has served as one of the mostinfluential works on the subject for physicians,physicians-in-training, and a myriad of healthcare experts who needa clear idea of the proper application of statistical techniques inclinical studies as well as the implications of theirinterpretation for clinical practice. This Third Editionmaintains the focus on the critical ideas, rather than themechanics, to give practitioners and students the resources theyneed to understand the statistical methods they encounter in modernmedical literature. Bringing together contributions from more than two dozendistinguished statisticians and medical doctors, this volumestresses the underlying concepts in areas such as randomizedtrials, survival analysis, genetics, linear regression,meta-analysis, and risk analysis. The Third Editionincludes: Numerous examples based on studies taken directly from the pagesof the New England Journal ofMedicine Two added chapters on statistics in genetics Two new chapters on the application of statistical methods tostudies in epidemiology New chapters on analyses of randomized trials, linearregression, categorical data analysis, meta-analysis, subgroupanalyses, and risk analysis Updated chapters on statistical thinking, crossover designs,p-values, survival analysis, and reporting research results A focus on helping readers to critically interpret publishedresults of clinical research Medical Uses of Statistics, Third Edition is a valuableresource for researchers and physicians working in anyhealth-related field. It is also an excellent supplemental book forcourses on medicine, biostatistics, and clinical research at theupper-undergraduate and graduate levels. You can also visit the NewEngland Journal of Medicine website for relatedinformation.
Author: Basavarajaiah Dm
Publisher: Educreation Publishing
View: 4604Statistical methods play an essential role in all stages of a quantitative health care and clinical research from design analysis and interpretation of real life data sets. The clinical trial is "the most definitive tool for evaluation of the applicability of clinical research" It represents“ a key research activity with the potential to improve the quality of health care and management through careful comparison of alternative treatments” It has been called on many occasions "the gold standard" against which all other clinical research is measured. Although many clinical trial are of high quality, a careful reader of the medical literature will notice that a large number have deficiencies in design, conduct, analysis, presentation, and /or interpretation of results. Improvements have occurred over the past few decades, but too many trials are still conducted without adequate attention to its fundamental principles. Certainly, numerous studies could have been upgraded if the authors had a better understanding of the fundamentals. This book covers the essential principles and methods required for clinical research. The underlying concepts of statistical analysis including basic and some more advanced analysis techniques are also covered. This book is an attempt to present the recent statistical techniques and tools with suitable examples from real life data sets, which the clinical researchers and academicians need.
Author: Michael R. Chernick
Publisher: John Wiley & Sons
View: 1923A fundamental and straightforward guide to using and understanding statistical concepts in medical research Designed specifically for healthcare practitioners who need to understand basic biostatistics but do not have much time to spare, The Essentials of Biostatistics for Physicians, Nurses and Clinicians presents important statistical methods used in today's biomedical research and provides insight on their appropriate application. Rather than provide detailed mathematics for each of these methods, the book emphasizes what healthcare practitioners need to know to interpret and incorporate the latest biomedical research into their practices. The author draws from his own experience developing and teaching biostatistics courses for physicians and nurses, offering a presentation that is non-technical and accessible. The book begins with a basic introduction to the relationship between biostatistics and medical research, asking the question "why study statistics?," while also exploring the significance of statisitcal methods in medical literature and clinical trials research. Subsequent chapters explore key topics, including: Correlation, regression, and logistic regression Diagnostics Estimating means and proportions Normal distribution and the central limit theorem Sampling from populations Contingency tables Meta-analysis Nonparametric methods Survival analysis Throughout the book, statistical methods that are often utilized in biomedical research are outlined, including repeated measures analysis of variance, hazard ratios, contingency tables, log rank tests, bioequivalence, cross-over designs, selection bias, and group sequential methods. Exercise sets at the end of each chapter allow readers to test their comprehension of the presented concepts and techniques. The Essentials of Biostatistics for Physicians, Nurses, and Clinicians is an excellent reference for doctors, nurses, and other practicing clinicians in the fields of medicine, public health, pharmacy, and the life sciences who need to understand and apply statistical methods in their everyday work. It also serves as a suitable supplement for courses on biostatistics at the upper-undergraduate and graduate levels.