Search results for: repairing-the-damage

DNA Damage DNA Repair and Disease Volume 1

Author : R. Stephen Lloyd
File Size : 84.40 MB
Format : PDF, ePub
Download : 469
Read : 998
Download »
The overall aim of this book is to give scientists in academia and industry a comprehensive overview of the field of DNA damage and DNA repair and related human diseases.

Maintenance of Genome Integrity DNA Damage Sensing Signaling Repair and Replication in Plants

Author : Alma Balestrazzi
File Size : 65.45 MB
Format : PDF, ePub
Download : 182
Read : 846
Download »
Environmental stresses and metabolic by-products can severely affect the integrity of genetic information by inducing DNA damage and impairing genome stability. As a consequence, plant growth and productivity are irreversibly compromised. To overcome genotoxic injury, plants have evolved complex strategies relying on a highly efficient repair machinery that responds to sophisticated damage perception/signaling networks. The DNA damage signaling network contains several key components: DNA damage sensors, signal transducers, mediators, and effectors. Most of these components are common to other eukaryotes but some features are unique to the plant kingdom. ATM and ATR are well-conserved members of PIKK family, which amplify and transduce signals to downstream effectors. ATM primarily responds to DNA double strand breaks while ATR responds to various forms of DNA damage. The signals from the activated transducer kinases are transmitted to the downstream cell-cycle regulators, such as CHK1, CHK2, and p53 in many eukaryotes. However, plants have no homologue of CHK1, CHK2 nor p53. The finding of Arabidopsis transcription factor SOG1 that seems functionally but not structurally similar to p53 suggests that plants have developed unique cell cycle regulation mechanism. The double strand break repair, recombination repair, postreplication repair, and lesion bypass, have been investigated in several plants. The DNA double strand break, a most critical damage for organisms are repaired non-homologous end joining (NHEJ) or homologous recombination (HR) pathway. Damage on template DNA makes replication stall, which is processed by translesion synthesis (TLS) or error-free postreplication repair (PPR) pathway. Deletion of the error-prone TLS polymerase reduces mutation frequencies, suggesting PPR maintains the stalled replication fork when TLS is not available. Unveiling the regulation networks among these multiple pathways would be the next challenge to be completed. Some intriguing issues have been disclosed such as the cross-talk between DNA repair, senescence and pathogen response and the involvement of non-coding RNAs in global genome stability. Several studies have highlighted the essential contribution of chromatin remodeling in DNA repair DNA damage sensing, signaling and repair have been investigated in relation to environmental stresses, seed quality issues, mutation breeding in both model and crop plants and all these studies strengthen the idea that components of the plant response to genotoxic stress might represent tools to improve stress tolerance and field performance. This focus issue gives researchers the opportunity to gather and interact by providing Mini-Reviews, Commentaries, Opinions, Original Research and Method articles which describe the most recent advances and future perspectives in the field of DNA damage sensing, signaling and repair in plants. A comprehensive overview of the current progresses dealing with the genotoxic stress response in plants will be provided looking at cellular and molecular level with multidisciplinary approaches. This will hopefully bring together valuable information for both plant biotechnologists and breeders.

DNA Damage DNA Repair and Disease

Author : Miral Dizdaroglu
File Size : 88.79 MB
Format : PDF, ePub, Mobi
Download : 915
Read : 800
Download »
The DNA of all organisms is constantly being damaged by endogenous and exogenous sources. Oxygen metabolism generates reactive species that can damage DNA, proteins and other organic compounds in living cells. Exogenous sources include ionizing and ultraviolet radiations, carcinogenic compounds and environmental toxins among others. The discovery of multiple DNA lesions and DNA repair mechanisms showed the involvement of DNA damage and DNA repair in the pathogenesis of many human diseases, most notably cancer. These books provide a comprehensive overview of the interdisciplinary area of DNA damage and DNA repair, and their relevance to disease pathology. Edited by recognised leaders in the field, this two-volume set is an appealing resource to a variety of readers including chemists, chemical biologists, geneticists, cancer researchers and drug discovery scientists.

Battlefield Damage Assessment and Repair

Author :
File Size : 38.31 MB
Format : PDF, Kindle
Download : 108
Read : 561
Download »

The Role of DNA Damage and Repair in Cell Aging

Author : B.A. Gilchrest
File Size : 27.49 MB
Format : PDF, ePub, Mobi
Download : 357
Read : 784
Download »
Aging occurs at the level of individual cells, a complex interplay between intrinsic "programming" and exogenous "wear and tear", with genetically-determined cellular capacity to repair environmentally-induced DNA damage playing a central role in the rate of aging and its specific manifestations. In 12 chapters, "The Role of DNA Damage and Repair in Cell Aging" provides an intellectual framework for aging of mitotic and post-mitotic cells, describes a variety of model systems for further studies, and reviews current concepts of DNA responses and their relationship to the phenomenon of aging. As part of a series entitled "Advances in Cell Aging and Gerontology," this volume also summarizes seminal recent discoveries such as the molecular basis for Werner syndrome (a mutant DNA helicase), the complementary roles of telomere shortening and telomerase activity in cell senescence versus immortalization, the role of apoptosis in the homeostasis of aging tissue, and the existence of an inducible SOS-like response in mammalian cells that minimizes DNA damage from repeatedly encountered injurious environmental agents. Insights into the relationship between cellular aging and age-associated diseases, particularly malignancies, are also provided in several chapters. This book is an excellent single source of information for anyone interested in DNA repair, mechanisms of aging, or certainly their intersection. Students will gain a general appreciation of these fields, but even the most senior investigators will benefit from the detailed coverage of rapidly advancing areas.

Repair of Earthquake Damaged Concrete and Masonry Wall Buildings

Author :
File Size : 33.7 MB
Format : PDF, ePub
Download : 815
Read : 1186
Download »

Damage and Repair of Aerospace Composite Materials

Author : Charles Lu
File Size : 85.32 MB
Format : PDF, ePub
Download : 906
Read : 1049
Download »
Damage and Repair of Aerospace Composite Materials reports the latest developments on the detection and repair of composite structures from the perspective of ten SAE technical papers, especially chosen for this book. This micro-collection of papers offers an overview of composite utilization on large-scale commercial aircraft as well as an outline of general damage inspection and repair of composite structures. On the damage detection side, really important techniques are explained, including: Porosity inspection of large composite panels; Damage detection of large composites using acoustic ultrasonic and radio frequency methods; Discrimination of damaged and undamaged composite panels using acoustic emission sensors. Automated defect inspection system integrated in the production line by utilizing laser sensors and cameras. The latest studies in damage repair of composite structures are also presented, including: the design of a bonded repair technique for multilayer laminate composite panels; the analysis on the performance of bolted repair vs. bonded repair; the method for economically repairing the holes on composites; the development of a novel cutting tool for the scarf repair of composites; the use the 3D-printing technology to repair gaps and steps in large composite panels.

Repairing the Damage

Author : Evans Publishing Company
File Size : 37.38 MB
Format : PDF
Download : 194
Read : 1153
Download »

Heat straightening Repair of Damaged Steel Bridge Girders

Author : Robert J. Connor
File Size : 68.28 MB
Format : PDF, Mobi
Download : 400
Read : 899
Download »
TRB¿s National Cooperative Highway Research Program (NCHRP) Report 604: Heat-Straightening Repair of Damaged Steel Bridge Girders: Fatigue and Fracture Performance explores limits, based on fatigue and fracture performance, on the number of damage and repair cycles to which damaged steel bridge girders may be subjected using the heat-straightening procedure.

Battlefield Damage Assessment and Repair for Chemical Defensive Materiel

Author :
File Size : 50.17 MB
Format : PDF
Download : 277
Read : 929
Download »