Search results for: ovarian-cancers

Ovarian Cancers

Author : Eric Pujade-Lauraine
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This book provides an overview of the latest developments in the concepts and management of ovarian cancer. The new data presented throughout opens the way to radically different therapeutic approaches. Surgery remains the core of ovarian cancer treatment, but its ultimate goal and the standard surgical procedure have evolved, giving rise to the question of how to label expert centers for debulking surgery. Neo-adjuvant chemotherapy is becoming more popular and is also a new field for testing novel drug combinations. Over recent years, ovarian cancer management has embraced molecular biology. It is now more correct to talk about cancers of the ovary rather than ovarian cancer, since it is not a unique disease but several entities with different molecular drivers. The significant advances in drugs targeting the microenvironment or the tumor cell DNA repair mechanisms are presented in detail together with exciting future perspectives. All these advances would not have been possible without collaborative groups such as the GINECO group in France and their integration in wider clinical research networks at the European (ENGOT) and international (GCIG) level.

Ovarian Cancer

Author : Anastasia Malek
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Ovarian cancer is the most lethal malignancy of the female reproductive system and is also the fifth leading cause of cancer death in women. Sharing common characteristics of cancer, ovarian malignancy possess several clinical and biological particularities In Ovarian Cancer: Methods and Protocols, expert researchers in the field provide methods that have been created or adapted to study various aspects of ovarian cancer. These methods and techniques are applicable to study genetic alterations present in ovarian cancer, structural and metabolic features of ovarian cancer cells, include in vitro and in vivo models that recapitulate ovarian cancer development and progression, and describe ovarian cancer-oriented drug delivery approaches. Methodological chapters are grouped into seven thematic parts, any of them is introduced by short subject review. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Ovarian Cancer: Methods and Protocols seeks to aid scientist to optimize study designs, to correctly select the most applicable methods, and to produce interesting and novel results.

Ovarian Cancers

Author : National Academies of Sciences, Engineering, and Medicine
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In an era of promising advances in cancer research, there are considerable and even alarming gaps in the fundamental knowledge and understanding of ovarian cancer. Researchers now know that ovarian cancer is not a single disease-several distinct subtypes exist with different origins, risk factors, genetic mutations, biological behaviors, and prognoses. However, persistent questions have impeded progress toward improving the prevention, early detection, treatment, and management of ovarian cancers. Failure to significantly improve morbidity and mortality during the past several decades is likely due to several factors, including the lack of research being performed by specific disease subtype, lack of definitive knowledge of the cell of origin and disease progression, and incomplete understanding of genetic and non-genetic risk factors. Ovarian Cancers examines the state of the science in ovarian cancer research, identifies key gaps in the evidence base and the challenges to addressing those gaps, considers opportunities for advancing ovarian cancer research, and examines avenues for translation and dissemination of new findings and communication of new information to patients and others. This study makes recommendations for public- and private-sector efforts that could facilitate progress in reducing the incidence of morbidity and mortality from ovarian cancers.

Trends in Ovarian Cancer Research

Author : A. P. Bardos
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Ovarian cancer is cancer that begins in the cells that constitute the ovaries, including surface epithelial cells, germ cells, and the sex cord-stromal cells. Cancer cells that metastasize from other organ sites to the ovary (most commonly breast or colon cancers) are not then considered ovarian cancer. According to the American Cancer Society, ovarian cancer accounts for 4 percent of all cancers among women and ranks fifth as a cause of their deaths from cancer. The American Cancer Society statistics for ovarian cancer estimate that there will be 25,400 new cases and 14,300 deaths in 2003. The death rate for this disease has not changed much in the last 50 years. Unfortunately, almost 70 percent of women with the common epithelial ovarian cancer are not diagnosed until the disease is advanced in stage -- i.e., has spread to the upper abdomen (stage III) or beyond (stage IV). The 5-year survival rate for these women is only 15 to 20 percent, whereas the 5-year survival rate for stage I disease patients approaches 90 percent and for stage II disease patients approaches 70 percent. Ovarian tumors are named according to the type of cells the tumor started from and whether the tumor is benign or cancerous. The three main types of ovarian tumors are: Epithelial Tumors, Germ Cell Tumors and Stromal Tumors. This new book brings together new and leading-edge research from around the world.

Ovarian Cancer Biomarkers

Author : Khalid El Bairi
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This book comprehensively summarizes the biology, etiology, and pathology of ovarian cancer and explores the role of deep molecular and cellular profiling in the advancement of precision medicine. The initial chapter discusses our current understanding of the origin, development, progression and tumorigenesis of ovarian cancer. In turn, the book highlights the development of resistance, disease occurrence, and poor prognosis that are the hallmarks of ovarian cancer. The book then reviews the role of deep molecular and cellular profiling to overcome challenges that are associated with the treatment of ovarian cancer. It explores the use of genome-wide association analysis to identify genetic variants for the evaluation of ovarian carcinoma risk and prognostic prediction. Lastly, it highlights various diagnostic and prognostic ovarian cancer biomarkers for the development of molecular-targeted therapy.

The 21st Century Handbook of Clinical Ovarian Cancer

Author : Krishnansu S Tewari
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A thorough review on ovarian cancer, treatment guidelines and emerging therapies available for the disease. The book was originally commissioned due to recent developments in therapies for ovarian cancer. This concise pocket book will review ovarian cancer’s epidemiology, clinical features, diagnosis and medical management. Busy healthcare professionals will benefit from this text, which will not only cover the foundation of ovarian cancer management, but discuss up-to-date national and international treatment guidelines and upcoming therapies.

Frontiers in Ovarian Cancer Science

Author : Hidetaka Katabuchi
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This volume presents the latest advances and the current status of our understanding regarding ovarian cancer, addressing both the basic and clinical aspects of the disease. In terms of basic medicine, the WHO Classification of Tumors of Female Reproductive Organs was revised in 2014, and that version addresses several new concepts and histopathological classifications not previously included. One of the most revolutionary breakthroughs concerns the genesis of epithelial ovarian tumors, shifting the focus from the ovarian surface epithelium to serous tubal intraepithelial carcinomas. Clinically, the mortality rate of epithelial ovarian cancer has gradually increased over the past few decades, making it essential to pursue multidisciplinary treatment and apply novel techniques such as neoadjuvant chemotherapy in daily clinical practice. The primary clinical task is the effective treatment of recurrent ovarian cancer with early palliative medicine. Fertility-sparing surgery may also be pursued depending on histologic subtypes, stage, extent of disease, and preexisting ovarian reserve with the concept of oncofertility. On the basis of the considerations described above, each expert author elucidates the science of ovarian cancer in detail, thus providing a collection that will benefit young medical oncologists and seasoned gynecologists and obstetricians alike.

Clinical Trials in Ovarian Cancer

Author : Christine S. Walsh
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When a patient is diagnosed with a gynecological malignancy, she and her doctors must make urgent, high-risk decisions about her course of treatment. In selecting an appropriate plan of care, physicians must weigh the patient’s individual needs, the tumor’s specific characteristics, and the treatment’s potential side effects. Because there is no one-size-fits-all treatment solution, a plethora of clinical trials have been performed on ovarian cancer patients, but clinicians may struggle to keep up with this ever-growing body of research. Collecting and synthesizing research findings from a wide array of medical journal articles and book chapters, Clinical Trials in Ovarian Cancer provides physicians with an invaluable resource. Gynecologic oncologist Christine S. Walsh systematically outlines each of the seminal Phase III trials that have shaped the treatment of ovarian cancers, detailing the rationale for the trial, the patient population studied, treatment delivery methods, efficacy, toxicity, and trial conclusions. She provides a clear overview of established treatments, as well as still-controversial experimental approaches. The first book to organize this cutting-edge research into an easy-to-use reference, Clinical Trials in Ovarian Cancer should help medical personnel at all levels provide their patients with the highest standard of care.

100 Questions and Answers about Ovarian Cancer

Author : Don S. Dizon
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Ovarian Cancer

Author : Omer Devaja
File Size : 48.13 MB
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Ovarian cancer management is a rapidly changing field with new treatment agents available as a result of a greater understanding of the pathogenesis of this disease. In addition, both surgical and chemotherapeutic treatment strategies are evolving to maximise response in this disease. This book brings together leading specialists from around the world to discuss and outline a variety of new concepts in ovarian cancer, ranging from molecular biology and genetics through screening to both surgical and chemotherapeutic management.

Breast and Ovarian Cancers in Women

Author : Guoqiao Zheng
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Surgery for Ovarian Cancer

Author : Robert E. Bristow
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Updated and expanded, the third edition of Surgery for Ovarian Cancer focuses on essential techniques for the effective management of ovarian cancer. It reflects the most contemporary science and surgical applications for the management of patients with ovarian cancer and related peritoneal surface malignancies. This new edition takes a step-by-step approach and includes new intraoperative photographs and videos illustrating surgical procedures. It is principally devoted to the technical aspects of cytoreductive surgery, with chapters divided according to anatomic region. The chapters cover relevant anatomical considerations, surgical challenges specific to each region, and operative approaches and techniques favored by the authors. The list of contributing authors has been expanded from the previous edition and includes international and world-renowned experts from the fields of gynecologic oncology and surgical oncology. The topics of minimally invasive surgery, secondary cytoreduction, palliative surgery, and postoperative care are also covered in detail. New to the third edition are chapters on preoperative risk stratification, regional therapeutics and peritonectomy procedures, and quality assurance relating to ovarian cancer surgery. This comprehensive text is essential reading for all practitioners working with patients with ovarian cancers.

Ovarian Cancer

Author : M. Sharon Stack
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Ovarian carcinoma continues to be responsible for more deaths than all other gynecologic malignancies combined, due to a continued inability to achieve detection of early (rather than advanced) stage disease and the lack of effective tumor-specific therapeutics. Ovarian carcinogenesis, invasion, and metastatic dissemination require a complex cascade of interrelated genetic, molecular, and biochemical events that regulate the neoplastic transition of normal ovarian surface epithelium. This volume summarizes recent advances in ovarian cancer detection and treatment and provides an analysis of current research into aspects of malignant transformation, growth control, and metastasis. A more detailed understanding of these processes may ultimately translate into the development of novel approaches for the detection and control of ovarian cancer.

Ovarian Cancers

Author : Institute of Medicine (U.S.). Committee on the State of the Science in Ovarian Cancer Research
File Size : 28.89 MB
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Interlysate Comparison Studies of Human Ovarian Cancers

Author : Haixing Wang
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Diagnosis of Colorectal and Ovarian Carcinoma

Author : Robert T. Maguire
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This volume discusses the preclinical and clinical experience with the B72.3 monoclonal anti-body as a tumour targeting agent - emphasizing the results of studies utilizing site-specifically radiolabelled B72.3 (CYT-103-111In; OncoScint CR103). disease in colorectal or ovarian cancer patients, this book: reviews the generation of the B72.3 monoclonal antibody and its development from preclinical trials to the first approved cancer imaging technology; presents the results of clinical trials of radioiodinated and indium-111 labelled material for colorectal cancer patients and considers the contribution of this procedure to their care; describes the use of CYT-103-111In as a presurgical diagnostic agent in ovarian cancer patients and its impact on their surgical management; and offers examples of normal biodistribution, tumour localization, and the potential pitfalls in image interpretation. medicine physicians, gastroenterologists, obstetricians/gynaecologists, immunologists and surgeons.

Ovarian Cancer Molecular Diagnostic Imaging and Treatment Strategies

Author : Heide Schatten
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The present book on Molecular & Diagnostic Imaging and Treatment Strategies of ovarian cancer is one of two companion books with the second one being focused on Cell and Molecular Biology of Ovarian Cancer. Both books include new exciting aspects of ovarian cancer research with chapters written by experts in their respective fields who contributed their unique expertise in specific ovarian cancer research areas and include cell and molecular details that are important for the specific subtopics. Comprehensive and concise reviews are included of key topics in the field.

Ovarian Cancer

Author : Christina Fisanick
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Each year, about 22,000 women will be diagnosed with ovarian cancer, and more than 14,000 women will die from it. This essential guidebook provides information on Ovarian Cancer, but also serves as a historical survey, by providing information on the controversies surrounding its causes, and first-person narratives by people coping with Ovarian Cancer. Readers will learn from the words of patients, family members, or caregivers. The symptoms, causes, treatments, and potential cures are explained in detail. Alternative treatments are also covered. Student researchers and readers will find this book easily accessible through its careful and conscientious editing and a thorough introduction to each essay. Includes charts, graphs, and tables.

Ovarian Cancer

Author : Frank Sharp
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This reference details recent knowledge of ovarian cancer. Areas covered include: the genetic basis and molecular biology of ovarian cancer, analytic approaches to diagnosis and management, experimental therapeutics - gene therapy, methodology for dose intensification, new drugs, and quality of life and ethical issues.


Author : Jing Liu
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This dissertation, "Enhanced cisplatin resistance of ovarian cancer cells in three-dimensional (3D) culture system through activation of Notch1/HES1 signaling" by Jing, Liu, 柳競, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Ovarian cancer is a lethal malignancy among females worldwide. A combination treatment of surgery and chemotherapy has been adopted in clinical practice, however, many patients developed resistance to platinum based regimen even if they responded initially. Conventionally, in vitro studies on chemoresistance have been performed in 2D cell culture systems. Emerging evidence has pointed out the restrictions of 2D system due to its poor imitating in vivo environment with cell-cell and cell-extracellular matrix interactions. Therefore, 3D cell culture system, which recapitulates in vivo structures and reflects more closely the real gene expression pattern and drug responses, has become a reliable tool in cancer researches. Previous studies reported that cancer cells cultured in the 3D system showed higher resistance to cisplatin, a common platinum agent, than cells cultured in the 2D system. In this study, cisplatin-resistance of two main subtypes of ovarian cancer, serous carcinoma and clear cell carcinoma, was found to be enhanced in the 3D system. Gene profiling analysis and q-PCR confirmed that HES1, a key downstream effector of Notch1 signaling with high association with cisplatinresistance and patient survival, was significantly up-regulated in ovarian cancer cells cultured in the 3D system. Notch1 was found to be activated in ovarian cancer cells cultured in the 3D culture system by Western Blot analysis. Inhibition of Notch1 signaling by γ-Secretase Inhibitor (GSI) and knockdown restored cisplatin induced cytotoxicity in ovarian cancer cells in both 2D and 3D systems, suggesting Notch1/HES1 signaling is activated and involved in cisplatin resistance of ovarian cancer cells in 3D system. Previous studies have suggested that low-level of Reactive Oxygen Species (ROS) may increase chemoresistance. In this study, an accumulation of ROS was found in ovarian cancer cells in the 3D system. Consistently, phosphorylation of p38 MAPK, which was activated by ROS, was found to be increased in ovarian cancer cells cultured in the 3D system accompanying with an increased expression of Notch1. These results suggested that ROS might be involved in activation of Notch1 signaling through phosphorylation of p38 MAPK in ovarian cancer cells in 3D system. Taken together, this study demonstrated that the aberrant activation of Notch1/HES1 signaling led to enhanced cisplatin resistance of ovarian cancers in 3D cell culture system and could be a putative target for treatment of ovarian cancers. Subjects: Cisplatin Ovaries - Cancer - Treatment Drug resistance in cancer cells