Search results for: multiple-sclerosis-therapeutics

Multiple Sclerosis Therapeutics

Author : Jeffrey A. Cohen
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This book comprehensively reviews the current state of clinical trial methods in multiple sclerosis treatment, providing investigators, sponsors and specialists with current knowledge of outcome measures and study designs for disease and symptom management. The status of the rapidly evolving field of disease-modifying drugs is presented, with emphasis on the most promising therapies currently being tested. Experts discuss disease and symptom management for MS subtypes, including neuromyelitis optica and pediatric MS. In addition, key scientific advances in MS pathology, genetics, immunology and epidemiology are presented. The fourth edition has been extensively revised, featuring more than 50% new material. All chapters have been substantially updated to provide current information on rapidly evolving topics and this volume contains 15 new chapters, reflecting the growth of the field in recent years. This book is an essential reference for practitioners caring for MS patients, investigators planning or conducting clinical trials, and clinical trial sponsors.

Multiple Sclerosis Therapeutics

Author : Eli Minkoff
File Size : 40.14 MB
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Since the publication of the previous edition of this volume, there has been substantial progress in a number of areas of multiple sclerosis (MS) research. Although immunosuppressive treatments continue to be developed and refined, more targeted immunomodulatory therapies are surfacing as we learn more about how the immune system works in health an

Multiple Sclerosis Therapeutics

Author : Richard Rudick
File Size : 30.98 MB
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This textbook examines the most important aspects of multiple sclerosis that impact on clinical trial design, on the development of new disease therapies and on patient care. The international team of contributors discuss the clinical course of multiple sclerosis, its clinical heterogeneity, the presence of subclinical disease activity which occurs during the early stages of the disease. Multiple sclerosis presents clinical challenges: from unexpected and irregular relapses to profressive deterioration.

Primer on Multiple Sclerosis

Author : Barbara S. Giesser
File Size : 37.24 MB
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Primer on Multiple Sclerosis, 2nd Edition is an updated reference manual for the practicing clinician. It covers the range of information needed to treat persons with MS, beginning with basic science and immunopathology, thorough differential diagnosis, symptom management and disease modifying therapies. This essential book also includes material covering new and experimental strategies as well as a review of commonly used complementary and alternative modalities that are used by persons with MS.Multiple Sclerosis (MS) is the most common demyelinating disease of the CNS and the third most common cause of disability among young adults. The complex management issues that are often present in the care of individuals with MS may demand the participation of health care professionals from a variety of disciplines, although the team is usually led by a neurologist. It is therefore essential for the neurologist to have a thorough grounding in the basic science and clinical phenomenology of MS. In this second edition of Primer on Multiple Sclerosis, the latest updates on therapeutics are provided, including new medications that have been FDA- approved since the first edition. Includes new diagnostic criteria, as well as any advances made in current diagnostic techniques, e.g. new imaging metrics. Important new information in the basic sciences and pathophysiology of MS is provided as well as newer epidemiologic studies. Treatment algorithms for common symptoms will be expanded, as well as any new guidelines for switching medications for Disease Modifying treatment "failures". The chapter on alternative and complimentary therapies discusses new research on CCSVI. The chapter on legal issues includes information on the putative effect of the Affordable Health Care Act on access to neurologic care and treatments. Finally, there is expanded discussion of progressive forms of MS both from a basic science and treatment perspective.

Multiple Sclerosis Therapeutics Third Edition PBK

Author : Jeffrey A. Cohen
File Size : 36.98 MB
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This textbook provides a comprehensive update of clinical trial methodology and current therapeutic modalities in multiple sclerosis.

Multiple Sclerosis Therapeutics Second Edition

Author : Richard A. Rudick
File Size : 61.3 MB
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This revised textbook examines the most important aspects of multiple sclerosis that impact on clinical trial design, on the development of new disease therapies, and, most importantly, on patient care. An international team of contributors discusses the clinical course of multiple sclerosis, its clinical heterogeneity, and the presence of subclinical disease activity which occurs during the early stages of the disease. There have been substantial advances in the field since the first edition was published in 1999. There are new chapters on functional imaging, the issues involved in long-term follow-up studies, cyclophosphamide, sex hormones and pregnancy-related factors, complementary and alternative treatments, management of cognitive impairment, treatment of pain, and rehabilitative approaches. Chapters on MS pathogenesis, imaging, the interferons, glatiramer acetate, mitoxantrone, IVIg, plasma exchange, stem cell transplantation, combination therapies, and newly-emerging treatments have been updated. This book is essential for any clinician who works with MS patients.

Multiple Sclerosis Therapeutics Second Edition

Author : Richard A. Rudick
File Size : 78.4 MB
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This revised textbook examines the most important aspects of multiple sclerosis that impact on clinical trial design, on the development of new disease therapies, and, most importantly, on patient care. An international team of contributors discusses the clinical course of multiple sclerosis, its clinical heterogeneity, and the presence of subclinical disease activity which occurs during the early stages of the disease. There have been substantial advances in the field since the first edition was published in 1999. There are new chapters on functional imaging, the issues involved in long-term follow-up studies, cyclophosphamide, sex hormones and pregnancy-related factors, complementary and alternative treatments, management of cognitive impairment, treatment of pain, and rehabilitative approaches. Chapters on MS pathogenesis, imaging, the interferons, glatiramer acetate, mitoxantrone, IVIg, plasma exchange, stem cell transplantation, combination therapies, and newly-emerging treatments have been updated. This book is essential for any clinician who works with MS patients.

Multiple Sclerosis Therapeutics

Author : Jeffrey A. Cohen
File Size : 67.73 MB
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This revised textbook examines the most important aspects of multiple sclerosis that impact on clinical trial design, on the development of new disease therapies, and, most importantly, on patient care. An international team of contributors discusses the clinical course of multiple sclerosis, its clinical heterogeneity, and the presence of subclinical disease activity which occurs during the early stages of the disease. There have been substantial advances in the field since the first edition was published in 1999. There are new chapters on functional imaging, the issues involved in long-term.

Multiple Sclerosis and Related Disorders

Author : Douglas S. Goodin
File Size : 40.53 MB
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Multiple Sclerosis (MS) is generally understood to be an inflammatory autoimmune disease of the central nervous system. While we still are not certain of the root cause of MS, research results suggest that unknown environmental factors and the presence of specific genes seem the most probable targets. MS causes an inflammatory response in the central nervous system leading to neurodegeneration, oligodendrocyte death, axonal damage, and gliosis. Over the past five years ongoing research has greatly expanded our understanding of the pathogenesis of MS, detailed insight into the epidemiology and genetic factors related to MS, the introduction of new technologies and tests to better diagnose and predict the future course of the disease and the introduction of new treatments targeting MS. This collection of review chapters provides a comprehensive reference into the science and clinical applications of the latest Multiple Sclerosis research and will be a valuable resource for the neuroscience research community and the clinical neurology community of researchers and practitioners. A comprehensive tutorial reference detailing our current foundational understanding of Multiple Sclerosis Includes chapters on key topics including the genetics of MS, MRI imaging and MS, and the latest treatment options Each chapter is translational and focuses on current research and impact on diagnosis and treatment options

Multiple Sclerosis

Author : J. F. Hallpike
File Size : 24.85 MB
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Development of Glycomolecules as Novel Therapeutics for the Treatment of Multiple Sclerosis

Author : George McCanney
File Size : 26.42 MB
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Therapeutics of Nervous Diseases

Author : Charles Porter Hart
File Size : 34.41 MB
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Physiology and Medicine of Hyperbaric Oxygen Therapy E Book

Author : Tom S. Neuman
File Size : 60.31 MB
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Written by internationally recognized leaders in hyperbaric oxygen therapy (HBOT) research and practice, this exciting new book provides evidence-based, practical, useful information for anyone involved in HBOT. It outlines the physiologic principles that constitute the basis for understanding the clinical implications for treatment and describes recent advances and current research, along with new approaches to therapy. This book is an essential tool for anyone who cares for patients with difficult-to-heal wounds, wounds from radiation therapy, carbon monoxide poisoning, and more. Provides comprehensive coverage of pathophysiology and clinically relevant information so you can master the specialty. Covers the relevance of HBOT in caring for diverse populations including critical care patients, infants and pediatric patients, and divers. Features a section on the technical aspects of HBOT to provide insight into the technology and physics regarding HBO chambers. Presents evidence to support the effectiveness of HBOT as well as the possible side effects. Describes situations where HBOT would be effective through indication-specific chapters on chronic wounds, radiation and crush injuries, decompression sickness, and more.

Comparing Quality of Life Outcomes in Patients with Relapsing remitting Multiple Sclerosis Receiving Oral Versus Parenteral Disease modifying Therapy

Author : Dwight Macero
File Size : 35.69 MB
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Problem: Multiple sclerosis (MS) affects over two million people worldwide. Currently, there are two standard disease-modifying therapies (DMT) for the treatment of relapsing-remitting MS, the most common form of the disease. Two novel oral therapeutics have been recently approved for the same indication. Previous studies monitoring treatment efficacy have focused on traditional markers of disease progression such as relapse rates, lesion evolution and disability progression. Quality of life, however, is becoming increasingly important. The purpose of this study is to review the impact of standard and novel DMTs on health-related quality of life. Methods: A narrow, qualitative literature review was conducted focusing on articles published in the last five years on original studies looking at the impact of oral fingolimod, dimethyl fumarate, glatiramer acetate and interferons on health-related quality of life measures. Results: A total of 8 studies were examined. It was determined that there are limited studies demonstrating the impact of both the standard of care and the novel oral therapeutics on quality of life. There are no head-to-head comparisons between the therapy options and most studies were against placebo. Conclusions: The current standards of care; interferon and glatiramer acetate, have to be compared to each other as well as the new oral therapies in a comprehensive study examining health-related quality of life outcomes.

Multiple Sclerosis Disease modifying Therapies

Author : Aseel Bin Sawad
File Size : 62.79 MB
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Apheresis Therapy in Immunopathologically Classified Multiple Sclerosis Patients

Author : Lidia Stork
File Size : 67.45 MB
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Predicting the Efficiency of Interferon Therapy for Multiple Sclerosis Using Genotype based Machine Learning Models

Author : Theresa Elena Schmiedlechner
File Size : 46.49 MB
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Multiple Sclerosis 2

Author : W. Ian McDonald
File Size : 58.71 MB
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"This practical resource encompasses the newest essential information on multiple sclerosis-focusing on those areas where progress has been made in research, bringing about new concepts of patient management"--Back cover.

Manual of Neurologic Therapeutics

Author : Martin A. Samuels
File Size : 64.75 MB
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This pocket-size manual examines essential diagnostic criteria for each neurological disorder, and recommends approaches to treatment. There are charts to help in choosing the correct drug and dosage. This updated edition includes the pharmacologic agents recently approved for the treatment of neurologic disorders including: migraine, epileptic seizures and status epilepticus, acute stroke, Alzheimer disease and neurological manifestations of HIV. Also covered are new stereotactic radiosurgical approaches to brain tumour treatment, pallidotomy and various deep brain stimulation techniques for patients with Parkinson disease and diagnostic testing for genetically determined neurological diseases

Neurorehabilitation Therapy and Therapeutics

Author : Krishnan Padmakumari Sivaraman Nair
File Size : 79.52 MB
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This practical handbook for clinicians covers pharmacological and non-pharmacological treatment options in neurological rehabilitation.