Search results for: molecular-biology-of-aging

Molecular Biology of Aging

Author : Leonard Guarente
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This volume covers the major threads in the molecular genetics of aging, including genes that regulate aging, causes of aging, evolutionary theories of aging, and the relationship between diet and aging. Among specific topics covered are calorie restriction, mitochondria, sirtuins, telomeres, stem cells, and cancer.

Molecular Biology of Aging

Author : University of California, Los Angeles
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This broad ranging study explores the recent findings in the dynamic field of molecular biogerontology. It examines the numerous molecular changes which occur during senescence and pinpoints the basic biological pacemakers of aging. Investigators examine the importance of DNA damage and the extent of differential gene expression during aging. There are discussions of attempts to manipulate the lifespans of various model organisms through gene transfer and regulated gene expression. Throughout, the contributors stress that the genome holds the ultimate key to understanding the limits of lifespan and the determinants of senescence.

Molecular Biology of Aging

Author : Avril D. Woodhead
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It is delightful but humbling to find my face at the start of these Proceedings--there are innumerable other faces which could equally weIl stand there, from among the band who have fore gathered at every gerontology conference since the subject was launched in its present form; but I deeply appreciate being there. Gerontology d. id not grow by accident. Its present standing is the fruit of careful planning, undertaken by European and American scientists back in the 1950's. In those days it was still a "fringe" science, and the conspirators had much the standing of the 1920's Interplanetary Society. The United States itself is the offspring of conspiracy, for when the results of conspiracy are beneficent, the conspirators become Founding Fathers. This has been the case with gerontology. The present meeting is especially gratifying because the papers have been recitals of normal, hard-science investigation. We had to get through the rigors of a long period of semantic argument and a long period of one-shot general theories before this kind of meeting, normal in all other research fields, could take place. It was also necesssary to breed in the menagerie a generation of excellent investigators aware of the theoretical background but unintimidated by it, who share our conviction that human aging is comprehensible and probably controllable, and who go into the laboratory to attack specifics.

Molecular Biology of Aging

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Molecular Biology of Aging, the latest volume in the Progress in Molecular Biology and Translational Science series, focuses on placental development and disease. Contains contributions from leading authorities on the topic Publishes cutting-edge reviews in molecular biology

Molecular Biology of Aging

Author : R. S. Sohal
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The Molecular Genetics of Aging

Author : Siegfried Hekimi
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The molecular genetics of aging or life-span determination is an expanding field. One reason is because many people would consider it desirable if hu man life span could be extended. Indeed, it is difficult not to be fascinated by tales of the life and death of people who have succeeded in living a very long life. Because of this, we have placed at the head of this book the chapter by Perls et al. on Centenerians and the Genetics of Longevity. Perls and his coauthors convincingly argue that, while the average life expectancy might be mostly determined by environmental factors because the average person has an average genotype, extremely long life spans are genetically determined. Of course, studying humans to uncover the genetics of aging is not ideal, not so much because one cannot easily perform experiments as because they live such a long time. This is why most of this book describes the current state of research with model organisms such as yeast, worms, flies, and mice. J aswinski focuses on yeast and how metabolic activity and stress resistance affect the longevity of Saccharomyces cerevisiae. In the process, he discusses the concept of aging as applied to a unicellular organism such as yeast and the importance of metabolism and stress resistance for aging in all organisms.

Evolutionary Biology of Aging

Author : Michael R. Rose
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This unique book looks at the biology of aging from a fundamentally new perspective, one based on evolutionary theory rather than traditional concepts which emphasize molecular and cellular processes. The basis for this approach lies in the fact that natural selection, as a powerful determining force, tends to decline in importance with age. Many of the characteristics we associate with aging, the author argues, are more the result of this decline than any mechanical imperative contained within organic structures. This theory in turn yields the most fruitful avenues for seeking answers to the problem of aging, and should be recognized as the intellectual core of gerontology and the foundation for future research. The author ably surveys the vast literature on aging, presenting mathematical, experimental, and comparative findings to illustrate and support the central thesis. The result is the first complete synthesis of this vital field. Evolutionary biologists, gerontologists, and all those concerned with the science of aging will find it a stimulating, strongly argued account.

Aging at the Molecular Level

Author : Thomas von Zglinicki
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During the last 40 years, the study of the biological basis of aging has progressed tremendously, and is now an independent field of study and research. This volume brings together contributions to the field from an international team of authors.

Biology of Aging

Author : Robert Arking
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Arking (Institute of Gerontology, Wayne State U.) presents an overview of the biological processes underlying aging at the cellular, organism, and population levels. A textbook for the college or graduate level. Annotation copyright Book News, Inc. Portland, Or.

Biology of Aging

Author : Roger B. McDonald
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Biology of Aging, Second Edition presents the biological principles that have led to a new understanding of the causes of aging and describes how these basic principles help one to understand the human experience of biological aging, longevity, and age-related disease. Intended for undergraduate biology students, it describes how the rate of biological aging is measured; explores the mechanisms underlying cellular aging; discusses the genetic pathways that affect longevity in various organisms; outlines the normal age-related changes and the functional decline that occurs in physiological systems over the lifespan; and considers the implications of modulating the rate of aging and longevity. The book also includes end-of-chapter discussion questions to help students assess their knowledge of the material. Roger McDonald received his Ph.D. from the University of Southern California and is Professor Emeritus in the Department of Nutrition at the University of California, Davis. Dr. McDonald’s research focused on mechanisms of cellular aging and the interaction between nutrition and aging. His research addressed two key topics in the field: the relationship between dietary restriction and lifespan, and the effect of aging on circadian rhythms and hypothalamic regulation. You can contact Dr. McDonald at [email protected] Related Titles Ahmad, S. I., ed. Aging: Exploring a Complex Phenomenon (ISBN 978-1-1381-9697-1) Moody, H. R. & J. Sasser. Gerontology: The Basics (ISBN 978-1-1387-7582-4) Timiras, P. S. Physiological Basis of Aging and Geriatrics (ISBN 978-0-8493-7305-3)

Molecular Basis of Aging

Author : A Roy
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Molecular Basis of Aging is a collection of papers that discuss the molecular aspects of aging in the light of molecular biology, biochemical gerontology, and genetics. Each chapter of the book contains a different study about the topic, which includes the effects of aging on DNA synthesis; the amplification of extrachromosomal circular copies and mitochondrial DNA during aging; and the altered actions of hormones and neurotransmitters during aging. The book also encompasses the loss of responsiveness to growth factors in cell senescence; the integration of cellular-molecular and neuroendocrine concepts of aging; changes and inactivation of enzymes during aging; and the relationship of aging with free radicals. The text is recommended for molecular biologists, biochemists, and gerontologists who wish to study further the effects of aging on the body on a molecular level.

HANDBOOK OF CELL BIOLOGY OF AGING

Author : Chemical Rubber Company (Cleveland, Ohio)
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Biological Aging

Author : Trygve O. Tollefsbol
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The goal of Biological Aging: Methods and Protocols is to present some of the most promising and important tools that are currently used in biological aging research. These tools include established protocols such as aging cell culture as well as many more contemporary approaches such as nuclear transfer, microarray and proteomics technologies and the use of ribozymes in aging research. Collectively, these powerful tools combined with the many other techniques that are presented are rapidly advancing the exciting and expanding field of biological aging.

Free Radicals in Molecular Biology Aging and Disease

Author : Donald Armstrong
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Handbook of the Biology of Aging

Author : Finchc
File Size : 25.40 MB
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The Evolution of Progress

Author : C. Owen Paepke
File Size : 32.14 MB
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A look at the end of economic growth and the coming revolution in human engineering draws on history, economics, science, and literature to trace the rise and fall of material progress. 15,000 first printing.

Research Awards Index

Author :
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THE THRESHOLD OF DISCOVERY FUTURE DIRECTIONS FOR RESEARCH ON AGING

Author : US DEPARTMENT OF HEALTH AND HUMAN SERVICES
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Cancer and Aging

Author : Terry V. Zenser
File Size : 52.34 MB
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Advances in Anti aging Medicine

Author : Ronald Klatz
File Size : 66.16 MB
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