Search results for: imaging-drug-action-in-the-brain

Imaging Drug Action in the Brain

Author : Edythe D. London
File Size : 67.72 MB
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Imaging Drug Action in the Brain is an outstanding reference that provides detailed methodological information and presents a current review of information obtained using various methods to delineate the neuroanatomy of drug action. It presents material covering selective lesioning and intracranial injections in intact animals. It examines various applications of receptor binding techniques and their importance in pharmacology. In vivo metabolic mapping studies to delineate the distributions of action of psychoactive drugs in animals are reviewed in detail. Imaging Drug Action in the Brain presents recent advances in extending these types of studies to human investigations, using positron emission tomography (PET) scanning and electrophysiological imaging techniques. Applications of immunocytochemical and molecular biology techniques in studies of drug action are explained. Imaging Drug Action in the Brain is the only book that encompasses all of these techniques with up-to-date examples of their applications. It is an essential resource for researchers in the fields of neuropharmacology, neuroanatomy, neurophysiology, and nuclear medicine.

Imaging Drug Action in the Brain

Author : Edythe D. London
File Size : 32.46 MB
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Imaging Drug Action in the Brain is an outstanding reference that provides detailed methodological information and presents a current review of information obtained using various methods to delineate the neuroanatomy of drug action. It presents material covering selective lesioning and intracranial injections in intact animals. It examines various applications of receptor binding techniques and their importance in pharmacology. In vivo metabolic mapping studies to delineate the distributions of action of psychoactive drugs in animals are reviewed in detail. Imaging Drug Action in the Brain presents recent advances in extending these types of studies to human investigations, using positron emission tomography (PET) scanning and electrophysiological imaging techniques. Applications of immunocytochemical and molecular biology techniques in studies of drug action are explained. Imaging Drug Action in the Brain is the only book that encompasses all of these techniques with up-to-date examples of their applications. It is an essential resource for researchers in the fields of neuropharmacology, neuroanatomy, neurophysiology, and nuclear medicine.

Imaging in Drug Discovery and Early Clinical Trials

Author : Markus Rudin
File Size : 54.17 MB
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This monograph examines the contribution of imaging modalities to the stages of drug discovery and development, from early target validation to their use in clinical development programs. Chapters are devoted to the description of the drug discovery process, to the various imaging modalities preclinically and clinically, to applications of imaging during the optimization of a lead compound, addressing issues such as bioavailability and efficacy, and during drug safety evaluation.

Drug Delivery to the Brain

Author : Elizabeth C.M. de Lange
File Size : 28.49 MB
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The development of new CNS drugs is notoriously difficult. Drugs must reach CNS target sites for action and these sites are protected by a number of barriers, the most important being the blood–brain barrier (BBB). Many factors are therefore critical to consider for CNS drug delivery, e.g. active/passive transport across the BBB, intra-brain distribution, and central/systemic pharmacokinetics, to name a few. Neurological disease and trauma conditions add further complexity because CNS barriers, drug distribution and pharmacokinetics are dynamic and often changed by disease/trauma. Knowledge of all these factors and their interplay in different conditions is of utmost importance for proper CNS drug development and disease treatment. In recent years much information has become available for a better understanding of the many factors important for CNS drug delivery and how they interact to affect drug action. This book describes small and large drug delivery to the brain with an emphasis on the physiology of the BBB and the principles and concepts for drug delivery across the BBB and distribution within the brain. It contains methods descriptions for studying drug delivery, routes and approaches of administering drugs into the brain, the influence of disease, drug industry perspectives, and a primer on neuroanatomy and physiological considerations written specifically for drug delivery scientists. Therewith, it contributes to an in-depth understanding of the interplay between brain (patho)-physiology and drug characteristics. Furthermore, the content is designed to be both cutting-edge and educational, so that the book can be used in high-level training of academic and industry scientists with full references to original publications.

Imaging of the Human Brain in Health and Disease

Author : Philip Seeman
File Size : 68.80 MB
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"Modern imaging techniques have allowed researchers to non-invasively peer into the human brain and investigate, among many other things, the acute effects and long-term consequences of drug abuse. Here, we review the most commonly used and some emerging imaging techniques in addiction research, explain how the various techniques generate their characteristic images and describe the rational that researchers use to interpret them. In addition, examples of seminal imaging findings are highlighted that illustrate the contribution of each imaging modality to the expansion in our understanding of the neurobiological bases of drug abuse and addiction, and how they can be parlayed in the future into clinical and therapeutic applications"--Provided by publisher.

Drug Delivery Applications of Noninvasive Imaging

Author : Chun Li
File Size : 82.27 MB
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Cost-effective strategies for designing novel drug deliverysystems that target a broad range of disease conditions In vivo imaging has become an important tool for thedevelopment of new drug delivery systems, shedding new light on thepharmacokinetics, biodistribution, bioavailability, localconcentration, and clearance of drug substances for the treatmentof human disease, most notably cancer. Written by a team ofinternational experts, this book examines the use of quantitativeimaging techniques in designing and evaluating novel drug deliverysystems and applications. Drug Delivery Applications of Noninvasive Imaging offersa full arsenal of tested and proven methods, practices andguidance, enabling readers to overcome the many challenges increating successful new drug delivery systems. The book begins withan introduction to molecular imaging. Next, it covers: In vivo imaging techniques and quantitativeanalysis Imaging drugs and drug carriers at the site of action,including low-molecular weight radiopharmaceuticals, peptides andproteins, siRNA, cells, and nanoparticles Applications of imaging techniques in administration routesother than intravenous injection, such as pulmonary and oraldelivery Translational research leading to clinical applications Imaging drug delivery in large animal models Clinical applications of imaging techniques to guide drugdevelopment and drug delivery Chapters are based on a thorough review of the currentliterature as well as the authors' firsthand experience workingwith imaging techniques for the development of novel drug deliverysystems. Presenting state-of-the-technology applications of imaging inpreclinical and clinical evaluation of drug delivery systems,Drug Delivery Applications of Noninvasive Imaging offerscost-effective strategies to pharmaceutical researchers andstudents for developing drug delivery systems that accuratelytarget a broad range of disease conditions.

Molecular Nuclear Medicine

Author : L.E. Feinendegen
File Size : 58.32 MB
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Biochemical transparency of the human body is at the doorstep of advanced technology. Toward this goal the book describes relevant isotopic tracer techniques of nuclear medicine. It deals with quantitatively measuring in vivo biochemical reactions as they occur within homeostatic circuits under control by genes and protein interactions. The text indicates how nuclear medicine can aid clinical researchers and practitioners, human geneticists and pharmacologists in understanding (and affecting) gene-phenotype relationships. Experts give background, techniques and examples in an interdisciplinary approach to regional imaging and in vitro analyses of biochemical reactions.

APPNING Animal Population Imaging

Author : Michel Dojat
File Size : 31.79 MB
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A Textbook Of SPECT in Neurology and Psychiatry

Author : De Deyn
File Size : 68.78 MB
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This comprehensive colour atlas provides a state-of-the-art view of Single Photon Emission Computerised Tomography (SPECT) in relation to its application in the fields of nuclear medicine and psychiatry. The broad range of topics covered by experts in the fields of nuclear medicine, neurology and psychiatry from all over the world, reflects the most recent evolution in functional neuroimaging with clinical neuropsychiatric sciences. The book is organised with respect to clinical indication, which implies that whenever possible methodological problems related to clinical indication are categorised under the relevant topic. It is designed to stimulate discussion of some issues of paramount importance for the present and future development of this interdisciplinary modality for the study of patients with diseases of the central nervous system. This textbook is an important tool to all nuclear physicians, neurologists and psychiatrists and will serve as a guide towards the optimal application of SPECT in diagnosis, study of pathophysiology and therapeutic follow-up in neuropsychiatric illnesses.

Frontiers in Clinical Drug Research CNS and Neurological Disorders Volume 9

Author : Atta-ur-Rahman
File Size : 36.48 MB
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Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a book series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of central nervous system (CNS) and other nerve disorders. The scope of the book series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of contemporary molecular targets involved in neurological and CNS disorders. Reviews presented in the series are mainly focused on clinical and therapeutic aspects of novel drugs intended for these targets. Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critical information for developing clinical trials and devising research plans in the field of neurology. The ninth volume of this series features reviews that cover the following topics related to the treatment of a different CNS disorders, related diseases and basic neuropharmacology research: - Integrating imaging and microdialysis into systems neuropharmacology - Depression heterogeneity and the potential of a transdiagnostic and dimensional approach to identify biologically relevant phenotypes - CAR-T cells in brain tumors and autoimmune diseases – from basics to the clinic - Revaluation of thyrotropin-releasing hormone and its mimetics as candidates for treating a wide range of neurological and psychiatric disorders - Natural BACE1 inhibitors: promising drugs for the management of Alzheimer’s disease - The possibilities of safe lithium therapy in the treatment of neurological and psychoemotional disorders - Pharmacotherapy of multiple sclerosis and treatment strategies