Search results for: genetic-hypertension

Experimental and Genetic Models of Hypertension

Author : W. De Jong
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Experimental and Genetic Models of Hypertension

Genetic Approaches to Coronary Heart Disease and Hypertension

Author : Kare Berg
File Size : 75.84 MB
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Cardiovascular diseases are the principal cause of mortality in many developed countries and are increasing in importance in developing countries where communicable diseases are being brought under control. It is estimated that coronary heart disease (CRD) and cerebrovascular diseases are responsible for between 40-50% of all deaths. Righ blood pressure is common in all industrialized societies and contributes importantly to CRD. It is well known that genetic factors play an important role in the etiology and pathogenes es of cardiovascular diseases and contribute to an individual's susceptibility or resistance to the disease. The application of modern genetic techniques has resulted in the identification of polymorphie markers that are involved in the normal regulation and function of the cardiovascular system. Many of these may contribute to the individual differences in the risk for CRD and hypertension. It is now known that several risk factors or protective factors with respect to cardiovascular diseases are strongly influenced by genes, and it is now possible to identify individual genes contributing to cardiovascular risk. A large bank of genetic knowledge relevant to CRD and hypertension has become available during the past years. As a result, it is now believed that CRD, for example, could be a good model for a feasibility study to determine a way by which preventive measures can be applied.

Genetic Immune and Molecular Predisposition to Hypertension

Author : P. M. Frossard
File Size : 39.83 MB
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Genetics of Hypertension

Author : Anna F. Dominiczak
File Size : 53.44 MB
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Classic and modern tools of genetics have been applied to hypertension research for some 20 years. This volume in the Handbook of Hypertension series aims to go beyond a simple summary of discoveries and provides a critical commentary on many controversial issues. It will be particularly useful for clinician scientists at all stages of their careers, graduate students and post-doctoral scientists as well as all those interested in cardiovascular medicine and research throughout the entire spectrum from bench to bedside. As in every relatively young area of research, the initial excitement over the early positive observations has not always been confirmed by subsequent larger studies with greater statistical power. Issues related to current recommendations on design of studies and their analysis are therefore included. Pharmacogenetics and pharmacogenomics have been the subjects of many debates in recent years and are of particular importance in hypertension as life-long treatments, frequently with multiple drugs are given to millions of people world-wide. A critical appraisal of this controversial topic is provided. Several chapters on experimental genetics of hypertension with a special focus on physiological genomics are also included.

Genetics of Hypertension

Author : Xi Cheng
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Hypertension, or elevated blood pressure, is a major risk factor for various cardiovascular, renal diseases, and stroke. The form of hypertension with no identifiable cause is referred to as Essential Hypertension. Familial studies indicate that Essential Hypertension is heritable and, thereby, classical genetic approaches have been applied on both human and other mammalian models of hypertension to map the locations of the allelic variants within quantitative trait loci for blood pressure. The post genome era has further elevated this area of research into large-scale genome-wide association studies of hypertension in humans. Collectively, these studies have resulted in the prioritization and cataloging of several genomic regions containing allelic variants as candidates linked or associated with essential hypertension. Further, they are providing evidence to suggest that the inheritance of hypertension is rather complex, encompassing multiple variants both within protein-coding and non-coding annotations, each of which may act independently or interactively with other genes and/or environmental factors to differentially regulate blood pressure. This book provides an overview of the various methods employed to study the genetics of hypertension and discuss the progress and prospects of this area of research that may contribute towards individualized clinical management of hypertension in the future.

Genetics and Pathophysiology of Essential Hypertension

Author : Madhu Khullar
File Size : 37.76 MB
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This book, authored by renowned researchers in the field of Hypertension Research, details the state of the art knowledge in genetics, genomics and pathophysiology of Essential hypertension, specifically the genetic determinants of hypertension and role of gene variants in response to anti-hypertensive therapy. Two chapters describe mitochondrial mutations in Essential hypertension and in hypertension associated Left ventricular hypertrophy, one chapter reviews in detail the global gene expression in hypertension, and an up to date treatise on pathophysiology of resistant hypertension is detailed in another chapter. Other topics included in the book are end organ damage, baroreceptor sensitivity and role of music therapy in essential hypertension.

Clinical and Experimental Hypertension

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Prophylactic Approach to Hypertensive Diseases

Author : Yukio Yamori
File Size : 68.20 MB
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Manual of Hypertension of the European Society of Hypertension Third Edition

Author : Giuseppe Mancia
File Size : 36.78 MB
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The Manual of Hypertension of the European Society of Hypertension reflects emerging concepts that have the potential to impact diagnostic and therapeutic approaches to hypertension. Updating all material, this new edition also delves into a number of areas that have received heightened interest in recent years or have become a matter of debate due to the controversial interpretation of the available data. FEATURES Reflects emerging concepts impacting diagnostic and therapeutic approaches Explores background, history, epidemiology, and risk factors Describes pharmacological, nonpharmacological, and medical treatments Examines hypertension in special populations and treatment

Practical Management of Hypertension

Author : Willem H. Birkenhäger
File Size : 27.30 MB
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WILLEM H. BIRKENHA. GER This compact guide aims to define the current approach to hypertension in practice, with the focus on the individual whom the physician faces across his desk. In the population, blood pressures are distributed along a Gaussian type of curve, but with some tailing towards the upper range. A systolic blood pressure of 160 mmHg is commonly accepted as the upper limit of the normal range. For diastolic pressure, the gradings are much more detailed: borderline hypertension (90-94 mmHg, mild hypertension (95-104 mmHg), moderate hypertension (105-114 mmHg), and severe hypertension (115 mmHg and over). Despite its skewing to the right, the bell shape of the distribution curve of blood pressures implies that the milder elevations of blood pressure are the most common. Such pressures are observed in 15-20% of the population upon casual measurement. After rechecking - which is mandator- the prevalence of hypertension drops to some 5%, due to psychological and statistical factors. Even this modest segment of the population represents an important proportion in terms of future cardiovascular risk. It is an essential part of preventive and curative health care to identify these people; the more so, because some 40% of the excess risk has already been proven to be reversible by conventional antihypertensive treatment.