Search results for: deoxynucleoside-analogs-in-cancer-therapy

Deoxynucleoside Analogs in Cancer Therapy

Author : Godefridus J Peters
File Size : 21.75 MB
Format : PDF, Mobi
Download : 700
Read : 796
Download »
Successful cancer chemotherapy relies heavily on the application of various deoxynucleoside analogs. Since the very beginning of modern cancer chemotherapy, a number of antimetabolites have been introduced into the clinic and subsequently applied widely for the treatment of many malignancies, both solid tumors and hematological disorders. In the latter diseases, cytarabine has been the mainstay of treatment of acute myeloid leukemia. Although many novel compounds were synthesized in the 1980s and 1990s, no real improvement was made. However, novel technology is now capable of elucidating the molecular basis of several inborn errors as well as some specific malignancies. This has enabled the synthesis of several deoxynucleoside analogs that could be applied for specific malignancies, such as pentostatin and subsequently chlorodeoxyadenosine (cladribine) for the treatment of hairy cell leukemia. Already in the early stage of deoxynucleoside analog development, it was recognized that several of these compounds were very effective in the treatment of various viral infections, such as for the treatment of herpes infections. This formed the basis initially for the design of azidothymidine and subsequently many other analogs, which are currently successfully used for the treatment of HIV infections. As a spin-off of these research lines, some compounds not eligible for development as antiviral agents appeared to be very potent anticancer agents. The classical example is gemcitabine, now one of the most widely applied deoxynucleoside analogs, used for the (combination) treatment of non-small cell lung cancer, pancreatic cancer, bladder cancer, and ovarian cancer.

Regional Cancer Therapy

Author : Peter M. Schlag
File Size : 42.14 MB
Format : PDF, Docs
Download : 466
Read : 487
Download »
This volume provides a biological and pharmacological background for regional cancer therapy, strategies and techniques for regional therapies, and specific indications and results for different tumor entities. Clinical trial concepts and detailed treatment protocols are also presented. This book is essential reading for researchers and clinicians engaged in seeking advanced therapeutic options for cancer patients worldwide.

EGFR Signaling Networks in Cancer Therapy

Author : John D. Haley
File Size : 45.9 MB
Format : PDF, ePub, Docs
Download : 305
Read : 358
Download »
The epidermal gro wth factor (EGF ) receptor and its downstream signal transduction networks have been implicated in the ontology and maintenance of tumor tissues, which has motivated the discovery and development of molecularly targeted anti-EGF receptor therapies. Over decades of study, the EGF receptor structure, its ligand binding domains, the physical biochemistry underlying its intrinsic tyrosine kinase catalytic function and the modular interactions with SH2, PTB, and SH3 domain containing signaling adaptor p- teins required for signal transduction, have been extensively dissected. Not only is the EGF receptor the nexus of many streams of information, but it also forms one part of a calcul- ing device by forming dimers and oligomers with the other three receptors in its family in response to at least eleven ligands (some of which are expressed in multiple forms with overlapping or quite distinct functions). This phenomenon, while recruiting to the inner surface of the cell membrane and activating multiple second messenger proteins, also allows the possibility of cross talk between these systems, permitting a further layer of information to be exchanged. Less well described are the cross re gulation of the EGF receptor and other anti-apoptotic, mitogenic and metabolic signaling systems. The study of these systems has yielded new surprises. One hurdle in these efforts has been that signal transduction pathways have frequently been defined in the generic absence of their tissue-specific or cell-interaction specific context.

Antiangiogenic Agents in Cancer Therapy

Author : Beverly A. Teicher
File Size : 34.48 MB
Format : PDF, Mobi
Download : 246
Read : 908
Download »
This volume represents a compendium of scientific findings and approaches to the study of angiogenesis in cancer. The second edition of Antiangiogenic Agents in Cancer Therapy is intended to give a current perspective on the state-of-the-art of angiogenensis and therapy directed at this process. Antiangiogenesis is a dynamic and evolving field in oncology. New therapeutic targets continue to emerge followed by the rapid development of new therapeutic agents to be investigated in clinical trials. Optimizing the therapeutic potential of antiangiogenic agents in combination with the other therapies in the armamentarium to fight cancer will be an on-going challenge.

Transforming Growth Factor Beta in Cancer Therapy Volume II

Author : Sonia B. Jakowlew
File Size : 83.90 MB
Format : PDF, Mobi
Download : 430
Read : 1327
Download »
Transforming Growth Factor- ß in Cancer Therapy, Vols. 1 and 2, provides a compendium of findings about the role of transforming growth factor- ß (TGF- ß) in cancer treatment and therapy. The second volume, Cancer Treatment in Therapy, is divided into three parts. The companion volume details the role of TGF- ß on basic and clinical biology.

Transforming Growth Factor Beta in Cancer Therapy Volume I

Author : Sonia B. Jakowlew
File Size : 21.39 MB
Format : PDF, Kindle
Download : 282
Read : 249
Download »
Transforming Growth Factor- ß in Cancer Therapy, Vols. 1 and 2, provides a compendium of findings about the role of transforming growth factor- ß (TGF- ß) in cancer treatment and therapy. The first volume, Basic and Clinical Biology, is divided into three parts. This volume’s companion, Cancer Treatment in Therapy, examines transforming growth factor- ß in other developing and advanced cancers and methods of treatment and therapy.

Checkpoint Responses in Cancer Therapy

Author : Wei Dai
File Size : 43.57 MB
Format : PDF, ePub, Docs
Download : 744
Read : 571
Download »
Extensive research has uncovered a set of molecular surveillance mechanisms – commonly called “checkpoints” – which tightly monitor cell-cycle processes. Today’s anticancer drug development has identified many of these cell-cycle checkpoint molecules as effective targets. Research now promises to uncover a new generation of anticancer drugs with improved therapeutic indices based on their ability to target emerging checkpoint components. Checkpoint Responses in Cancer Therapy summarizes the advances made over the past 20 years, identifying components of cell-cycle checkpoints and their molecular regulation during checkpoint activation and validating the use of checkpoint proteins as targets for the development of anticancer drugs. This book’s distinguished panel of authors takes a close look at topics ranging from the major molecular players affecting DNA synthesis and the response to DNA damage to advances made in the identification of chemical compounds capable of inhibiting individual mitotic kinases. Illuminating and authoritative, Checkpoint Responses in Cancer Therapy offers a critical summary of findings for researchers in the pharmaceutical and biotechnology industries and a valuable resource for academic scientists in cancer research and the study of cell-cycle regulation, signal transduction and apoptosis.

Gene Therapy for Cancer

Author : Kelly K. Hunt
File Size : 45.71 MB
Format : PDF, Docs
Download : 487
Read : 1048
Download »
The three sections of this volume present currently available cancer gene therapy techniques. Part I describes the various aspects of gene delivery. In Part II, the contributors discuss strategies and targets for the treatment of cancer. Finally, in Part III, experts discuss the difficulties inherent in bringing gene therapy treatment for cancer to the clinic. This book will prove valuable as the volume of preclinical and clinical data continues to increase.

Molecular Targeting in Oncology

Author : Howard L. Kaufman
File Size : 88.26 MB
Format : PDF, ePub, Docs
Download : 866
Read : 318
Download »
This book presents an overview of the development of targeted therapies for the treatment of cancer with an emphasis on clinical application. The volume covers the complexity of the rapidly developing area of targeted therapies for the treatment of patients with cancer. It is structured in a way so readers may begin with chapters that most interest them and work through the rest of the chapters in the order of their choice.

Cytokines in the Genesis and Treatment of Cancer

Author : Michael A. Caligiuri
File Size : 34.51 MB
Format : PDF, Mobi
Download : 805
Read : 929
Download »
Cytokines in the Genesis and Treatment of Cancer provides a comprehensive picture of the dual role of host responses in promoting and inhibiting tumor progression. This volume represents an important investigation into the emerging intersection of cancer biology and cancer immunology. The book brings together an impressive array of internationally distinguished investigators who are devoted to the study of cytokines and cancer.

The Role of Microtubules in Cell Biology Neurobiology and Oncology

Author : Antonio Tito Fojo
File Size : 56.82 MB
Format : PDF
Download : 243
Read : 920
Download »
This book presents the first comprehensive exploration of the dynamic potential of microtubules anti-cancer targets. Written by leading anti-cancer researchers, this groundbreaking volume collects the most current microtubule research available and investigates the potential of microtubules in cancer therapy.

Cancer Drug Resistance

Author : Beverly A. Teicher
File Size : 40.79 MB
Format : PDF
Download : 657
Read : 927
Download »
Leading experts summarize and synthesize the latest discoveries concerning the changes that occur in tumor cells as they develop resistance to anticancer drugs, and suggest new approaches to preventing and overcoming it. The authors review physiological resistance based upon tumor architecture, cellular resistance based on drug transport, epigenetic changes that neutralize or bypass drug cytotoxicity, and genetic changes that alter drug target molecules by decreasing or eliminating drug binding and efficacy. Highlights include new insights into resistance to antiangiogenic therapies, oncogenes and tumor suppressor genes in therapeutic resistance, cancer stem cells, and the development of more effective therapies. There are also new findings on tumor immune escape mechanisms, gene amplification in drug resistance, the molecular determinants of multidrug resistance, and resistance to taxanes and Herceptin.

Cancer Proteomics

Author : Sayed S. Daoud
File Size : 58.6 MB
Format : PDF, Docs
Download : 516
Read : 1031
Download »
"Over the past 20 years, there have been tremendous advances in our understanding of how normal cells transform to cancer and the importance of signaling pathways in cancer initiation and progression. To keep pace, proteomics technologies must constantly be improved. In Cancer Proteomics, the authors collectively outline the current status of proteomics in cancer therapy and describe the existing technologies used in proteomics that allow for protein profiling and the identification of druggable targets in human samples. Mass spectrometry-based protein characterization and protein microarrays hold great promise for predicting response to specific drugs in cancer therapy. This book offers a broad perspective on topics related to the use of proteomic strategies in cancer therapy and addresses challenges that may arise from its application in daily practice."--Jacket.

Histone Deacetylases

Author : Eric Verdin
File Size : 58.40 MB
Format : PDF, Mobi
Download : 406
Read : 1043
Download »
A panel of leading investigators summarizes and synthesizes the new discoveries in the rapidly evolving field of histone acetylation as a key regulatory mechanism for gene expression. The authors describe what has been learned about these proteins, including the identification of the enzymes, the elucidation of the enzymatic mechanisms of action, and the identification of their substrates and their partners. They also review the structures that have been solved for a number of enzymes-both alone and in complex with small molecule inhibitors-and the biological roles of the several histone deacetylases (HDAC) genes that have been knocked out in mice.

Chemical Synthesis of Nucleoside Analogues

Author : Pedro Merino
File Size : 39.12 MB
Format : PDF, Docs
Download : 396
Read : 431
Download »
Compiles current tested and proven approaches tosynthesize novel nucleoside analogues Featuring contributions from leading synthetic chemists fromaround the world, this book brings together and describes testedand proven approaches for the chemical synthesis of common familiesof nucleoside analogues. Readers will learn to create newnucleoside analogues with desired therapeutic properties by using avariety of methods to chemically modify natural nucleosides,including: Changes to the heterocyclic base Modification of substituents at the sugar ring Replacement of the furanose ring by a different carbo- orheterocyclic ring Introduction of conformational restrictions Synthesis of enantiomers Preparation of hydrolitically stable C-nucleosides Chemical Synthesis of Nucleoside Analogues covers all themajor classes of nucleosides, including pronucleotides,C-nucleosides, carbanucleosides, and PNA monomers which have showngreat promise as starting points for the synthesis of nucleosideanalogues. The book also includes experimental procedures for keyreactions related to the synthesis of nucleoside analogues,providing a valuable tool for the preparation of a number ofdifferent compounds. Throughout the book, chemical schemes and figures help readersbetter understand the chemical structures of nucleoside analoguesand the methods used to synthesize them. Extensive references serveas a gateway to the growing body of original research studies andreviews in the field. Synthetically modified nucleosides have proven their value astherapeutic drugs, in particular as antiviral and antitumor agents.However, many of these nucleoside analogues have undesirable sideeffects. With Chemical Synthesis of Nucleoside Analogues astheir guide, researchers have a new tool for synthesizing a newgeneration of nucleoside analogues that can be used as therapeuticdrugs with fewer unwanted side effects.

Genomics and Pharmacogenomics in Anticancer Drug Development and Clinical Response

Author : Federico Innocenti
File Size : 59.35 MB
Format : PDF
Download : 282
Read : 470
Download »
Genomics and Pharmacogenomics in Anticancer Drug Development and Clinical Response provides the most comprehensive body of knowledge available on the role of genetic and genomic variation in the individualization of drug therapies in cancer patients. As a consequence of the intrinsic chromosomal and genetic instability of the tumor genome, it is generally believed that tailoring of chemotherapy in cancer - tients might be achieved by molecular analysis of patient tumor DNA. In addition, to reduce the toxicity risk of patients, the tumor DNA information should be in- grated with the available data on polymorphic drug-metabolizing enzyme and tra- porter genes mediating the exposure of patients to active drugs and/or their active metabolites. The chapters of this book clearly show how DNA information from both the host (germline) and the tumor should be taken into account for rational selection of drug therapies in cancer patients, an aspect that received little attention, despite its importance. The availability of new molecular approaches to the selection of drug therapy is an emerging need, because the traditional approach based on the evaluation of patient and tumor characteristics is clearly far from optimal. Many treated patients do not experience signi?cant bene?ts from the treatment, while they often experience moderate to severe toxicities. In addition, the development and clinical use of novel molecularly targeted agents (alone or in combination with classical cytotoxic therapy) requires the und- standing of the molecular features of the tumors and the identi?cation of tumor markers of response.

Phycotoxins

Author : Luis M. Botana
File Size : 65.63 MB
Format : PDF, Mobi
Download : 102
Read : 774
Download »
Phycotoxins are a diverse group of poisonous substances produced by certain seaweed and algae in marine and fresh waters. Marine toxins are important to the scientific community for many reasons, the most obvious being that they pose food safety issues which requires a large investment from producing countries to regularly monitor the presence of these compounds in foods. For centuries we have been aware that some edible marine products contain toxins or poisons, and therefore we only eat those that are safe. However, phycotoxins accumulate in fish and shellfish from their diet and these toxins are carried up the food chain in edible aquatic products, which can pose harm to people when they reach a certain level. The presence of marine and aquatic toxins is now identified in geographical areas where they were never detected before, which is becoming a concern for food safety authorities as the expansion of water toxins worldwide is a serious threat. The legal change on the standards to control marine toxins has brought about concerns with regard to what toxins are leaking to food and not being identified by food regulators. Since the publication of the first edition, there have been major advances in the science of marine and aquatic toxins, and advances in toxicology, analytical chemistry and pharmacology suggest an update is much needed. This fully revised and updated edition includes several new chapters, including those on Ciguatoxins, Pinnatoxin, Tetrodotoxin, as well as new chapters on food safety control of marine toxins, climate change and water toxins, and microalgae as a source of nutraceuticals. The book presents the most up to date information available on phycotoxins, giving major emphasis to chemistry and biochemistry but also covering aspects of origin, mechanism of action, toxicology and analytical methodology. Phycotoxins: Chemistry and Biochemistry, second edition, will be of interest to toxicologists, marine, food, and plant scientists, as well as researchers and academics in the areas of food science, medicine, public health, toxicology, pharmacology and marine biology.

Clinical Cardio oncology E Book

Author : Joerg Herrmann
File Size : 72.93 MB
Format : PDF
Download : 132
Read : 226
Download »
Clinical Cardio-oncology is a comprehensive, clinically focused title for cardiologists, oncologists, and specialists in cardio-oncology programs who need up-to-date knowledge about the cardiovascular effects of cancer treatment, especially on long-term cancer survivors. This brand-new resource covers the implementation of cardio-oncology into your practice, while a strong focus on patient management offers helpful information on coordinating care before, during, and after therapy. Its highly organized four-section format allows readers to quickly and easily locate relevant information. Comprised of four sections for quick and easy reference: Oncology and Hematology Principles; Cardiac Complications from Cancer Therapy; Coordination of Care; and Cardio-oncology in Practice. Provides expert wisdom from cardio-oncology authorities around the world, as well as consultation and perspectives from pioneers in the field of oncology. Highlights the principles of cancer therapies, including radiation and tumor therapy, as well as pre-, intra-, and post-therapy cardiology evaluation. Boasts chapters on implementing cardio-oncology into practice: primary cancer centers, comprehensive referral centers, group practices, and educational needs and goals for fellowship programs. Advises on how to coordinate care for the patient at every stage of treatment (pre-therapy, during therapy, after therapy, and end-of-life). Presents detailed information on various cardiac complications from cancer therapy, such as cardiomyopathy, vascular disease, arrhythmias, and hypertension. Teaches the principles of oncology and hematology with coverage of different therapy types and cardiac tumors. Includes a comprehensive drug guide.

Recent Advancement in Prodrugs

Author : Kamal Shah
File Size : 37.90 MB
Format : PDF, Docs
Download : 973
Read : 1255
Download »
Recent Advancement in Prodrugs Drugs used as medicines have many limitations like low chemical stability, aqueous solubility, or oral absorption/bioavailability, rapid presystemic metabolism, toxicity, inadequate site specificity, or poor patient acceptance/compliance (unwanted adverse effects, unacceptable taste or odor, irritation or pain). Prodrugs design is an approach to overcome these limitations. Key features Covers recent advancements in development of prodrugs Presents balanced synthesis and applications of prodrug chemistry Discusses broad spectrum of prodrug categories and outlines industrial applications Reviews prodrugs in cancer nanomedicine, its therapy and treatment Elucidates mathematical models to study the kinetics of prodrugs This book covers recent advances in the design of prodrugs. It contains all the significant recent examples of prodrug chemistry developments and will aid academics and researchers seeking to generate new projects in the field.

PHYSICAL CHEMISTRY 2016

Author : Željko Čupić
File Size : 33.5 MB
Format : PDF, Docs
Download : 263
Read : 1287
Download »