Search results for: current-progress-in-stem-cells-research

Current Progress in Stem Cells Research

Author : Mark Walters
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Stem cell therapy has tremendous scope of treating a range of diseases. The most commonly used stem cell therapy is the transplantation of the bone marrow. It is used in treating patients with diseases like leukemia and lymphoma. Recent research focuses on studying stem cells in order to use them to treat diseases. The objective of this book is to give a general view of the different areas of stem cells research and its applications. Scientists and students actively engaged in this field will find this book full of crucial and unexplored concepts.

Current Progress in iPSC Disease Modeling Volume 14

Author : Alexander Birbrair
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The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. Current Progress in iPSC Disease Modeling, Volume 14 addresses the advances in research of how induced pluripotent stem cells are used for the creation of new tissues and organs. The creation of iPSC technology allowed the development of disease-specific human pluripotent stem cells. These cells allow researchers to study questions impossible before for some human diseases. This volume addresses using iPSCs for vascular tissue engineering, bioprinting, derived lung organoids for pulmonary disorders, skeletal muscle engineering, human kidney organoids and much more. The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation; and is contributed by world-renowned authors in the field. Provides overview of the fast-moving field of stem cell biology and function, regenerative medicine and therapeutics Covers the advances in research of how induced pluripotent stem cells are used to create new tissues/organs Contributed by world-renown experts in the field

Handbook of Stem Cells

Author : Anthony Atala
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This is a complete overview of the field of stem cells, providing the background, tools, methods and experimental protocols needed for further research.

Current Progress in iPSC derived Cell Types

Author : Alexander Birbrair
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The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. Current Progress in iPSC-derived Cell Types, Volume 10 addresses how induced pluripotent stem cells can be differentiated into different cell types. Somatic cells can be reprogrammed into induced pluripotent stem cells by the expression of specific transcription factors. These cells have been transforming biomedical research over the last 15 years. This volume will address the advances in research of how research of induced pluripotent stem cells can be reprogrammed to develop new treatment technologies in regenerative medicine. The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation; and is contributed by world-renowned authors in the field. Provides overview of the fast-moving field of stem cell biology and function, regenerative medicine and therapeutics Covers iPSCs derived cardiomyocytes, skeletal muscles, brown adipocytes, airway epithelial cells, and much more Contributed by world-renown experts in the field

Perinatal Stem Cells

Author : Anthony Atala
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This comprehensive volume is one of the first books to offer the reader detailed insight into sources of perinatal stem cells, their biology, and their potential for disease treatment. It examines the research and therapeutic applications of perinatal stem cells including the treatment of renal disease, hematopoietic regeneration, cardiac disease, inflammatory disease, bone regeneration, pulmonary disease, and the treatment of spinal cord injury. Further, the book discusses current progress in the manufacturing, banking and clinical translation of perinatal stem cells. Through this book, readers will gain a thorough understanding of the current pre-clinical and clinical applications of perinatal stem cells as well as the efforts to support the transition of perinatal stem cell therapies from laboratories to clinics. Perinatal Stem Cells contains thirty-two chapters written by internationally recognized leaders in stem cell research. It is organized into four sections covering amniotic fluid stem cells, placental and placental membrane stem cells, umbilical cord stem cells, and clinical translation. This cohesive structure provides an effective framework for detailed insight into this new frontier. Edited by Dr. Anthony Atala, one of the foremost experts in the field, and his co-editor Dr. Sean V. Murphy, this volume is a definitive work for stem cell research and its future implications. It is a key resource for all stem cell researchers, clinicians, and government and industry staff working in this dynamic and exciting field.

Principles of Stem Cell Biology and Cancer

Author : Tarik Regad
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Principles of Stem Cell Biology and Cancer: Future Applications and Therapeutics Tarik Regad, The John van Geest Cancer Research Centre, Nottingham Trent University, UK, Thomas J. Sayers, Centre for Cancer Research, National Cancer Institute, Frederick, USA and Robert Rees The John van Geest Cancer Research Centre, Nottingham Trent University, UK The field of cancer stem cells is expanding rapidly, with many groups focusing on isolating and identifying cancer stem cell populations. Although some progress has been made developing efficient cancer therapies, targeting cancer stem cells remains one of the important challenges facing the growing stem cell research community. Principles of Stem Cell Biology and Cancer brings together original contributions from international experts in the field to present the very latest information linking stem cell biology and cancer. Divided into two parts, the book begins with a detailed introduction to stem cell biology with a focus on the characterization of these cells, progress that has been made in their identification, as well as future therapeutic applications of stem cells. The second part focuses on cancer stem cells and their role in cancer development, progression and chemo-resistance. This section of the book includes an overview of recent progress concerning therapies targeting cancer stem cells. Features: An authoritative introduction to the link between stem cell biology and cancer. Includes contributions from leading international experts in the field. Well-illustrated with full colour figures throughout. This book will prove an invaluable resource for basic and applied researchers and clinicians working on the development of new cancer treatments and therapies, providing a timely publication of high quality reviews outlining the current progress and exciting future possibilities for stem cell research.

Stem Cell Research

Author : Janet T. Arnes
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Embryonic stem cells have the ability to develop into virtually any cell in the body, and may have the potential to treat medical conditions such as diabetes and Parkinson's disease. In August 2001, President Bush announced that for the first time federal funds would be used to support research on human embryonic stem cells, but funding would be limited to 'existing stem cell lines'. The National Institutes of Health (NIH) has established the Human Embryonic Stem Cell Registry which lists stem cell lines that are eligible for use in federally funded research. Although 78 cell lines are listed, 21 embryonic stem cell lines are currently available. Scientists are concerned about the quality, longevity, and availability of the eligible stem cell lines. For a variety of reasons, many believe research advancement requires new embryonic stem cell lines, and for certain applications, stem cells derived from cloned embryos may offer the best hope for progress in understanding and treating disease. A significant cohort of pro-life advocates support stem cell research; those opposed are concerned that the isolation of stem cells requires the destruction of embryos. Letters from Congress, one signed by 206 Members of the House and a second signed by 58 Senators, have been sent urging President Bush to expand the current federal policy concerning embryonic stem cell research. Some have argued that stem cell research be limited to adult stem cells obtained from tissues such as bone marrow. They argue that adult stem cells should be pursued instead of embryonic stem cells because they believe the derivation of stem cells from either embryos or aborted foetuses is ethically unacceptable. Other scientists believe adult stem cells should not be the sole target of research because of important scientific and technical limitations. Groups make ethical distinctions in the debate on how to proceed with stem cell research based upon embryo protection, relief of suffering, viability, the purpose and timing of embryo creation and destruction, donor consent, scientific alternatives, federal funding, and cloning. Other countries are moving fast with active research programs. This book presents the current confused situation along with a selective bibliography.

Current Progress in Mesenchymal Stem Stromal Cell Research

Author : Lindolfo da Silva Meirelles
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Essentials of Stem Cell Biology

Author : Robert Lanza
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First developed as an accessible abridgement of the successful Handbook of Stem Cells, Essentials of Stem Cell Biology serves the needs of the evolving population of scientists, researchers, practitioners, and students embracing the latest advances in stem cells. Representing the combined effort of 7 editors and more than 200 scholars and scientists whose pioneering work has defined our understanding of stem cells, this book combines the prerequisites for a general understanding of adult and embryonic stem cells with a presentation by the world's experts of the latest research information about specific organ systems. From basic biology/mechanisms, early development, ectoderm, mesoderm, endoderm, and methods to the application of stem cells to specific human diseases, regulation and ethics, and patient perspectives, no topic in the field of stem cells is left uncovered. Contributions by Nobel Laureates and leading international investigators Includes two entirely new chapters devoted exclusively to induced pluripotent stem (iPS) cells written by the scientists who made the breakthrough Edited by a world-renowned author and researcher to present a complete story of stem cells in research, in application, and as the subject of political debate Presented in full color with a glossary, highlighted terms, and bibliographic entries replacing references

Essentials of Stem Cell Biology

Author : Robert Lanza
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This book combines the prerequisites for a general understanding of adult and embryonic stem cells with a presentation of the latest research information about specific organ systems. It covers a wide range of topics, including basic biology/mechanisms, early development, ectoderm, mesoderm, endoderm, and methods to the application of stem cells to specific human diseases, regulation and ethics, and patient perspectives.

Stem Cell Research

Author : David E. Newton
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One of the most controversial debates in scientific research today focuses on the use of embryonic stem cells in medical research. Recent discoveries suggest that stem cells exist within embryos and are even more plastic than adult cells, meaning that they are capable of developing into virtually any type of cell found in a living body. This discovery has raised the possibility of using embryonic stem cells for the treatment of a host of medical conditions, including Parkinson's and Alzheimer's diseases, spinal cord injuries, strokes, burns, heart disease, diabetes, osteoarthritis, and rheumatoid arthritis. In each instance, the transplantation of embryonic stem cells into the patient's body is expected to result in the growth of healthy new tissue or organs that have been damaged by the disease being treated. However, opponents of this scientific procedure doubt the validity of the scientific premises behind these therapeutic uses and oppose the destruction of human embryos for further research. Current federal law and regulations allow researchers to use federal funds to conduct some types of stem cell research using adult stem cells, but not embryonic stem cells, which significantly slows the progress of this possibly life-altering medical study. Exploring the political and ethical issues associated with this area of study, Stem Cell Research gives students and general readers alike a comprehensive look at both the science and the controversy surrounding this groundbreaking research. This first-stop reference provides clear and essential information needed to define, understand, and research this important issue objectively. Covering court cases, legislation, and relevant policies, this volume also includes a chronology; a glossary; a guide to further research; an annotated bibliography, an integral part of the Library in a Book series; appendixes; as well as an index.

Handbook of Stem Cells

Author : Anthony Atala
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New discoveries in the field of stem cells increasingly dominate the news and scientific literature revealing an avalanche of new knowledge and research tools that are producing therapies for cancer, heart disease, diabetes, and a wide variety of other diseases that afflict humanity. The Handbook of Stem Cells integrates this exciting area of life science, combining in two volumes the requisites for a general understanding of adult and embryonic stem cells. Organized in two volumes entitled Pluripotent Stem Cells and Cell Biology and Adult and Fetal Stem Cells, this work contains contributions from the world’s experts in stem cell research to provide a description of the tools, methods, and experimental protocols needed to study and characterize stem cells and progenitor populations as well as a the latest information of what is known about each specific organ system. Provides comprehensive coverage on this highly topical subject Contains contributions by the foremost authorities and premiere names in the field of stem cell research Companion website - http://booksite.elsevier.com/9780123859426/ - contains over 250 color figures in presentation format

The Renin Angiotensin System Current Research Progress in The Pancreas

Author : Po Sing Leung
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Highlighting the role local renin-angiotensin systems (RAS) play in pancreatic disease, this review presents the latest research advances in the field. These findings suggest both preventative measures and treatment for pancreatic disease.

Recent Advances in iPSCs for Therapy Volume 3

Author : Alexander Birbrair
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The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. Recent Advances in iPSCs for Therapy, Volume 3 addresses the use of induced pluripotent stem cells for therapy of several disorders. The volume teaches the reader about the biology of induced pluripotent stem cells and their possible use as cell therapy. Remarkable progress has been made in the obtention of induced pluripotent stem cells and their differentiation into several cell types, tissues and organs using state-of-art techniques. This volume will cover what we know so far about the use of iPSCs for therapy of multiple diseases, such as: hair loss disorders, Parkinson's disease, Huntington's disease, ischemic stroke, Alzheimer's disease, Glaucoma, Optic Neuropathy, Age-Related Macular Degeneration, Type 1 Diabetes, Heart Failure, liver diseases, infertility, Autoimmune Diseases, and more. The volume is written for researchers and scientists interested in cell therapy, stem cell biology, regenerative medicine, and organ transplantation and is contributed by world-renowned authors in the field. . Provides overview of the fast-moving field of stem cell biology and function, regenerative medicine, and therapeutics . Covers the possible use of iPSCs for hair loss disorders, Parkinson's disease, Huntington's disease, ischemic stroke, Alzheimer's disease, Glaucoma, Optic Neuropathy, Age-Related Macular Degeneration, Type 1 Diabetes, Heart Failure, liver diseases, infertility, Autoimmune Diseases, and more . Contributions from stem cell leaders around the world

Monitoring Stem Cell Research

Author : President's Council on Bioethics (U.S.)
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This report summarizes some of the more interesting and significant recent developments, both in the basic science and medical applications of stem cell research and in the related ethical, legal, and policy discussions. It does not attempt to be a definitive or comprehensive study of the whole topic. It contains no proposed guidelines and regulations, nor indeed any specific recommendations for policy change. Rather, it seeks to shed light on where we are now: ethically, legally, scientifically, and medically, in order that the President, the Congress, and the nation may be better informed as they consider where we should go in the future.

Recent Advances in iPSC Technology Volume 5

Author : Alexander Birbrair
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The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. Recent Advances in iPSC Technology, Volume 5 addresses the progress in induced pluripotent stem cells (iPSCs) technologies. Somatic cells can be reprogrammed into iPSCs by the expression of specific transcription factors. These cells are transforming biomedical research in the last 15 years. The volume teaches readers about current advances in the field. This book describes different technologies and strategies to use iPSCs for biological and clinical benefit. In recent years, remarkable progress has been made in the obtention of iPSCs and their differentiation into several cell types, tissues, and organs using state-of-the-art techniques. These advantages facilitated identification of key targets and definition of the molecular basis of several disorders. This volume will cover hot topics in the iPSC field, such as iPSCs for modeling the cardiovascular toxicities of anticancer therapies, iPSC differentiation through the lens of the noncoding genome, modeling of blood–brain barrier with iPSCs, mathematical modeling of iPSCs, iPSCs to study human brain evolution, selfrenewal in iPSCs, differences and similarities between iPSCs and embryonic stem cells, and more. The volume is written for researchers and scientists interested in stem cell therapy, cell biology, regenerative medicine, and organ transplantation and is contributed by world-renowned authors in the field. Provides overview of the fast-moving field of induced pluripotent stem cell technology, regenerative medicine, and therapeutics. Covers the following topics: iPSCs for modeling the cardiovascular toxicities of anticancer therapies, iPSC differentiation through the lens of the non-coding genome, modeling of blood-brain barrier with iPSCs, mathematical modelling of iPSCs, iPSCs to study human brain evolution, self-renewal in iPSCs, differences and similarities between iPSCs and embryonic stem cells, and more. Contributed by world-renown experts in the field

Cloning and Stem Cell Research Legal Documents

Author : Willem-Jan Van Der Wolf
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Stem cells are cells found in most, if not all, multi-cellular organisms. They are characterized by the ability to renew themselves through cell division and differentiation into a diverse range of specialized cell types. Stem cells can now be grown and transformed into specialized cells with characteristics consistent with cells of various tissues, such as muscles or nerves, through cell culture. For this reason, their use in medical therapies has been proposed. In particular, embryonic cell lines, autologous embryonic stem cells generated through therapeutic cloning, and highly plastic adult stem cells from the umbilical cord blood or bone marrow are touted as promising candidates. As promising as this may sound, under the Bush regime, stem cell research in the United States was kept on a very tight leash. Bush limited the various uses of stem cell research enormously through the adaptation of strict legislation. The United States' former president even pronounced that he would use his veto, if the senate would stretch the stem cell legislation beyond his prescribed limits. Now, a whole new era opens for the United States, since Barack Obama already made known he will make important changes to the existing legislation concerning stem cell research. In our viewpoint, this is necessary to put America back on the world map whilst discovering the possibilities of curing diseases with the help of stem cell research. In order to compare the new strategy of Obama to the old path prescribed by Bush regarding stem cell research, insight in existing stem cell legislation is necessary. Therefore, this collection of legislation on stem cell research provides a complete and in-depth overview of the current state of affairs concerning this topic in America. This collection is vital for every legal academic scholar, especially now that the United States are marking the progress of stem cell research as one of their top priorities.

Recent Advances in iPSC Disease Modeling Volume 1

Author : ALEXANDER BIRBRAIR
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Recent Advances in iPSC Disease Modeling, Volume 1 addresses how induced pluripotent stem cells can be used to model various diseases. Somatic cells are reprogrammed into induced pluripotent stem cells by the expression of specific transcription factors. These cells are transforming biomedical research in the last 15 years. This volume teaches readers about current advances in the field. This book describes the use of induced pluripotent stem cells to model several diseases in vitro, enabling us to study the cellular and molecular mechanisms involved in different pathologies. Further insights into these mechanisms will have important implications for our understanding of disease appearance, development, and progression. In recent years, remarkable progress has been made in the obtention of induced pluripotent stem cells and their differentiation into several cell types, tissues, and organs using state-of-art techniques. These advantages facilitated identification of key targets and definition of the molecular basis of several disorders. The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation; and is contributed by world-renowned authors in the field. Provides overview of the fast-moving field of induced pluripotent stem cell technology, regenerative medicine, and therapeutics Covers the following diseases: severe congenital neutropenia, sickle cell and Diamond-Blackfan anemias, muscular dystrophies, Bernard-Soulier syndrome, familial hypercholesterolemia type II A, Werner syndrome, lysosomal storage diseases, and more Contains description of cutting-edge research on the development of disease-specific human pluripotent stem cells. These cells allow us to study cellular and molecular processes involved in several human diseases

Human Mesenchymal and Embryonic Stem Cells

Author : Prasad S. Koka
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This new book presents and discusses current research in the field of stem cell research, with a particular focus on both human mesenchymal and embryonic stem cells. Topics discussed include the effect of the n-terminal peptide of link protein on human mesenchymal stem cells from osteoarthritis patients; bone marrow derived mesenchymal stem cells; derivation of human embryonic stem cell lines; neuronal differentiation of murine embryonic stem cells; acute effect of endothelins on intercellular communication of human embryonic stem cells and commercialization of human stem cells and stem cell-based products.

Stem Cells

Author : Peggy J. Parks
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Scientists believe that stem cell research could eventually lead to cures and treatments for a host of human disorders and disease--but where those stem cells come from is the subject of major controversy. Through objective overviews, primary sources, and full-color illustrations, this title examines: Is Stem Cell Research Necessary? Is Stem Cell Research Ethical? Are Stem Cells the Answer to Prolonged Human Life? and Can the Stem Cell Debate Be Resolved?