Search results for: biological-functions-of-carbohydrates

Biological Functions of Carbohydrates

Author : D.J. Candy
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This text emphasises the metabolic reactions of carbohydrates, and the functions of such reactions in the organism; secondly, the metabolism and functions of carbohydrate polymers.

Biological Functions of Carbohydrates

Author : David M. Conning
File Size : 21.23 MB
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Biological Functions of Carbohydrates

Author : British Nutrition Foundation
File Size : 28.22 MB
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Carbohydrate based Drug Discovery

Author : Chi-Huey Wong
File Size : 36.39 MB
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To exploit the full potential of this diverse compound class for the development of novel active substances, this handbook presents the latest knowledge on carbohydrate chemistry and biochemistry. While it is unique in covering the entire field, particular emphasis is placed on carbohydrates with pharmaceutical potential. Topics include the following: > Chemical Synthesis of Carbohydrates > Carbohydrate Biosynthesis and Metabolism > Carbohydrate Analysis > Cellular Functions of Carbohydrates > Development of Carbohydrate-based Drugs A premier resource for carbohydrate chemists and drug developers, this comprehensive two-volume work contains contributions by more than 50 of the world's leading carbohydrate chemists.

Analysis of Protein Interactions Biological Functions and Immunogenicity of Carbohydrates Using Synthetic Oligosaccharides

Author : Tim Horlacher
File Size : 77.62 MB
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Carbohydrate Nanotechnology

Author : Keith J. Stine
File Size : 36.49 MB
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Introducing the emerging field carbohydrate nanostructures, this book will be a unique resource for interested researchers to learn a range of methods of applying the field to their own work. Greater access, as well as greater collaboration, to this new interdisciplinary field is intended for both synthetic carbohydrate chemists and researchers in nanoscience related fields. It covers: the main types of nanostructures presently under investigation for modification by carbohydrates, including nanoparticles, nanorods, magnetic particles, dendrimers, nanoporous, and surface confined structures overview and introduction to the field of carbohydrate nanotechnology, and especially its applications to its biological systems Provides a unique resource for researchers to learn about the techniques used to characterize the physical and biological properties of carbohydrate-modified nanostructures

Capillary Electrophoresis of Carbohydrates

Author : Nicola Volpi
File Size : 44.23 MB
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Simple carbohydrates, complex oligosaccharides and polysaccharides all belong to a class of ubiquitous (macro)molecules that exhibit a wide range of biological functions, and the recent advent of enhanced enzymatic, chemical and analytical tools used to study these sugars has inaugurated a genuine explosion in the field of glycomics. Specifically, it has led to a deeper understanding of how specific sugar structures modulate cellular phenotypes, and that breakthrough has led to the discovery of new pharmaceuticals for the treatment of many serious diseases, such as cancer. The subsequent rapid expansion of this research holds high promise for future therapeutic regimens, and capillary electrophoresis (CE) refers to the range of related separation techniques that are integral to this vital research. CE uses narrow-bore fused-silica capillaries to separate a complex array of large and small molecules, and Capillary Electrophoresis of Carbohydrates offers a comprehensive look at the latest breakthroughs and improvements in CE and CE techniques applied to monosaccharides up to complex oligosaccharides and polysaccharides. It begins with an overview of the application of CE and CE- mass spectrometric in the analysis of simple carbohydrates without any previous derivatization step before discussing various detection techniques such as spectrophotometric detection, electrochemical detection and other less common techniques. It then covers in detail an array of related topics and numerous applications. It is an essential text for anyone exploring the myriad possibilities of this rapidly expanding field.

Carbohydrate Chemistry Biology and Medical Applications

Author : Hari G. Garg
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The finding by Emil Fischer that glucose and fructose on treatment with phenylhydrazine gave the identical osazone led him to the elucidation of stereochemistry of carbohydrates. Since then, progress in the field of carbohydrates has been amazing with the unraveling their basic structure, biosynthesis, immunology, functions, and clinical uses, for pure carbohydrates and for protein-linked carbohydrates (glycoproteins and proteoglycans). The chapters in Carbohydrate Chemistry, Biology and Medical Applications present a logical sequence leading from the chemistry and biochemistry of carbohydrates, followed by their role in various pathological conditions, to carbohydrates as potential therapeutic and diagnostic agents. This book offers a detailed panoramic review of the chemistry and biology of carbohydrates for chemists, biologists and health professionals. Each chapter is authored by contributors expert in the particular area of research. Explains how carbohydrates are important to life Details the chemistry, biology and medical aspects of carbohydrates Interdisciplinary and international team of authors

Carbohydrate Based Interactions at the Molecular and the Cellular Level

Author : Kieran L. Hudson
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This book offers a clearly written and highly accessible account of two different aspects of carbohydrate chemistry. Carbohydrates are an essential component of life and have many important biological functions, but the details of how carbohydrates interact with other biomolecules to mediate biological signalling remain unclear. Firstly, this thesis details innovative methods to mine protein structural data to uncover new features of carbohydrate-based interactions. It also explains these findings using physical chemistry, specifically CH–pi interactions associated with the properties of the interacting partners. Carbohydrates are also critical for tissue growth and development, yet are underexploited in the materials science that underpins much of regenerative medicine. As such, the second part of this thesis describes a diverse array of techniques ranging from synthetic chemistry and enzymatic synthesis to prepare a wide variety of carbohydrates, and materials chemistry to prepare glycosylated hydrogels, to cell biology to determine the effects on cellular development for tissue engineering applications.

Carbohydrate Recognition

Author : Binghe Wang
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This book contains contributions from interdisciplinary scientists to collectively address the issue of targeting carbohydrate recognition for the development of novel therapeutic and diagnostic agents. The book covers (1) biological problems involving carbohydrate recognition, (2) structural factors mediating carbohydrate recognition, (3) design and synthesis of lectin mimics that recognize carbohydrate ligands with high specificity and affinity, and (4) modulation of biological and pathological processes through carbohydrate recognition.

Bioinformatics for Glycobiology and Glycomics

Author : Claus-Wilhelm von der Lieth
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This book is the first to be dedicated to the bioinformatics of carbohydrates and glycoproteins. It provides an introduction to this emerging field of science both for the experimentalist working in glycobiology and glycomics, and also for the computer scientist looking for background information for the development of highly sophisticated algorithmic approaches. The book provides an overview of the state-of-the-art in the field, with reviews on databases, and the tools in use for analysis, interpretation, and prediction of the structures of complex carbohydrates, and demonstrates the value of bioinformatics for glycobiology. The availability of comprehensive databases and corresponding bioinformatics tools, to access and analyse the large amounts of experimental data relating to the structure of carbohydrates, will be a prerequisite for the success of the large-scale glycomics projects that aim to decipher new, so far unknown, biological functions of glycans. Efficient bioinformatics descriptions and tools can considerably enhance the efficiency of glycomics research, in terms of data quality, analysis and experimental costs. For a complete understanding of the molecular processes in which carbohydrates are involved, such as protein–carbohydrate interactions and the impact of glycosylation on protein function, knowledge of the 3D structure of the carbohydrate, the protein–carbohydrate complex, or the glycoprotein is often indispensable. This book provides a thorough introduction into methods used for conformational analysis of carbohydrates. Key features: Describes bioinformatic approaches to handle carbohydrate-active enzymes and glycosylation. Provides an overview on bioinformatics tools that facilitate analysis of carbohydrate structures. Gives introduction into molecular modelling of carbohydrate 3D structure and carbohydrates contained in the Protein Databank. Assumes only a basic knowledge of biology and bioinformatics.

Carbohydrates Synthetic Methods and Applications in Medicinal Chemistry

Author : Tetsuo Suami
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Carbohydrates play an increasingly important role in medicinal and synthetic organic chemistry. Stimulating and timely this collection of essays introduces the reader to synthetic applications and biological functions of carbohydrates, thus reflecting the state-of-the-art of the subject. This book is intended for researchers in synthetic organic chemistry and medicinal chemistry, who will use it as a reference work as well as a source of new ideas and perspectives.

Carbohydrate based Drug Discovery 2 Volume Set

Author : Chi-Huey Wong
File Size : 61.58 MB
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To exploit the full potential of this diverse compound class for the development of novel active substances, this handbook presents the latest knowledge on carbohydrate chemistry and biochemistry. While it is unique in covering the entire field, particular emphasis is placed on carbohydrates with pharmaceutical potential. Topics include the following: > Chemical Synthesis of Carbohydrates > Carbohydrate Biosynthesis and Metabolism > Carbohydrate Analysis > Cellular Functions of Carbohydrates > Development of Carbohydrate-based Drugs A premier resource for carbohydrate chemists and drug developers, this comprehensive two-volume work contains contributions by more than 50 of the world's leading carbohydrate chemists.

Handbook of Carbohydrate Engineering

Author : Kevin J. Yarema
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The Handbook of Carbohydrate Engineering provides an overview of the basic science, theory, methods, and applications of this broad, interdisciplinary field. The text provides background information along with practical knowledge for current and future research methodologies used in the characterization and synthesis of various carbohydrates. This multidisciplinary perspective involves aspects of basic biology, synthetic chemistry, enzymology, complex instrumentation, and sophisticated modeling. The book presents the fundamentals of carbohydrate engineering, addressing concepts in structure, biosynthesis, and biological functions for a variety of carbohydrates with a particular emphasis on mammalian glycoproteins and their N-linked oligosaccharides, glycolipids, sialic acid, as well as polysaccharides from both eukaryotes and bacteria. It describes glycosylation processes found in nature and surveys methods to manipulate these metabolic systems in living cells both for the improved production of carbohydrates and to give these molecules novel properties. Subsequent sections discuss the various methods of purification, synthesis, modification, and analysis used to create and manipulate carbohydrates in the laboratory; these approaches include chemical-enzymatic synthesis, small-molecule cell-based strategies, as well as complete chemical synthesis. The Handbook of Carbohydrate Engineering also focuses on practical applications for carbohydrates. It emphasizes methods to characterize glycosylation pathways and expounds upon the role of carbohydrates in health and disease, a significant - and rapidly growing - area of research. World-renowned experts discuss biomedical applications, including the development of vaccines, therapeutics, glycomimetics, antibody engineering, drug delivery, tissue engineering and organ regeneration, and diagnostic agents. Several chapters also cover important applications in agriculture, industry, food technology, and environmental remediation.

Handbook Oligosaccharides Trisaccharides

Author : Andras Liptak
File Size : 44.48 MB
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Chemical synthesis of oligosaccharides is important to organic chemistry because of the critical biological functions of carbohydrates. Unfortunately, no handbook has been published on the subject...until now. Volume 1: Disaccharides presents synthetic carbohydrate chemistry, lists the syntheses, and shows the route of each synthesis. Volume 2: Trisaccharides presents schematic figures and references. This series includes all oligosaccharides synthesized between 1960 and 1986. This allows oligosaccharides prepared in their free form to be presented, as well as those produced in protected form. The series contains data regarding glycosylation reaction, namely reaction conditions (solvent, promoter, temperature), the aglycon and the glycosyl donor used, and the structure and physical data of the isolated product. For disaccharides, the names of the reactants and the products are revealed, while with trisaccharides and higher oligomers, schematic figures provide a quick and easy way to access information concerning the entire process. These volumes will provide an important reference source for biochemists, biologists, and organic chemists.

Chemical Glycobiology

Author : Chen, Xi
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Although the process of understanding the biological functions of carbohydrates has developed slowly due to the lack of efficient approaches in obtaining and studying these structures, in the past two decades, remarkable advances have been made in chemical and chemoenzymatic synthesis of carbohydrates and glycoconjugates. The material presented in this volume shows how a better understanding of the structure and the function of carbohydrate-containing bacterial cell wall has revealed that carbohydrate-containing molecules and carbohydrate-like structures are useful as carbohydrate-based anti-microbial vaccines, anti-viral drugs, anti-coagulants, anti-cancer drugs, and potential anti-cancer vaccines. In addition, the text explores the important roles that novel glycolipids have been found to play in the immune system. Metabolic engineering has demonstrated itself as an efficient approach to probe and manipulate biological functions of carbohydrates both in vitro and in vivo. Automated glycan analysis, carbohydrate microarrays, and novel high-throughput screening methods have hastened the analysis and the understanding of carbohydrate-containing structures. Polypeptide-based glycopolymers have been developed for the study of multivalent binding events of carbohydrates and proteins. This text presents examples of these recent developments in using chemical techniques and tools to study glycobiology. This is an excellent reference book for upper-division undergraduate students, graduate students, and researchers who are interested in carbohydrate-related medicinal chemistry, organic chemistry, biology, and chemical biology.

Handbook Oligosaccharides Trisaccharides

Author : Andras Liptak
File Size : 30.37 MB
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Chemical synthesis of oligosaccharides is important to organic chemistry because of the critical biological functions of carbohydrates. Unfortunately, no handbook has been published on the subject...until now. Volume 1: Disaccharides presents synthetic carbohydrate chemistry, lists the syntheses, and shows the route of each synthesis. Volume 2: Trisaccharides presents schematic figures and references. This series includes all oligosaccharides synthesized between 1960 and 1986. This allows oligosaccharides prepared in their free form to be presented, as well as those produced in protected form. The series contains data regarding glycosylation reaction, namely reaction conditions (solvent, promoter, temperature), the aglycon and the glycosyl donor used, and the structure and physical data of the isolated product. For disaccharides, the names of the reactants and the products are revealed, while with trisaccharides and higher oligomers, schematic figures provide a quick and easy way to access information concerning the entire process. These volumes will provide an important reference source for biochemists, biologists, and organic chemists.

CRC Handbook of Oligosaccharides

Author : Andras Liptak
File Size : 81.62 MB
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Chemical synthesis of oligosaccharides is important to organic chemistry because of the critical biological functions of carbohydrates. Unfortunately, no handbook has been published on the subject...until now. CRC Handbook of Oligosaccharides is a series of three volumes that includes all oligosaccharides synthesized between 1960 and 1986. This allows oligosaccharides prepared in their free form to be presented, as well as those produced in protected form. The series contains data regarding glycosylation reaction, namely reaction conditions (solvent, promoter, temperature), the aglycon and the glycosyl donor used, and the structure and physical data of the isolated product. For disaccharides, the names of the reactants and the products are revealed, while with trisaccharides and higher oligomers, schematic figures provide a quick and easy way to access information concerning the entire process. These volumes will provide an important reference source for biochemists, biologists, and organic chemists.

Capillary Electrophoresis of Carbohydrates

Author : Nicola Volpi
File Size : 65.18 MB
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Simple carbohydrates, complex oligosaccharides and polysaccharides all belong to a class of ubiquitous (macro)molecules that exhibit a wide range of biological functions, and the recent advent of enhanced enzymatic, chemical and analytical tools used to study these sugars has inaugurated a genuine explosion in the field of glycomics. Specifically, it has led to a deeper understanding of how specific sugar structures modulate cellular phenotypes, and that breakthrough has led to the discovery of new pharmaceuticals for the treatment of many serious diseases, such as cancer. The subsequent rapid expansion of this research holds high promise for future therapeutic regimens, and capillary electrophoresis (CE) refers to the range of related separation techniques that are integral to this vital research. CE uses narrow-bore fused-silica capillaries to separate a complex array of large and small molecules, and Capillary Electrophoresis of Carbohydrates offers a comprehensive look at the latest breakthroughs and improvements in CE and CE techniques applied to monosaccharides up to complex oligosaccharides and polysaccharides. It begins with an overview of the application of CE and CE- mass spectrometric in the analysis of simple carbohydrates without any previous derivatization step before discussing various detection techniques such as spectrophotometric detection, electrochemical detection and other less common techniques. It then covers in detail an array of related topics and numerous applications. It is an essential text for anyone exploring the myriad possibilities of this rapidly expanding field.

Essentials of Carbohydrate Chemistry and Biochemistry

Author : Thisbe K. Lindhorst
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Thisbe K. Lindhorst Essentials of Carbohydrate Chemistry and Biochemistry Carbohydrates are probably nature’s most common product. Plants and algae biosynthesize millions of tons of them every year. Carbohydrates are stores of energy and structural building blocks; they are versatile enough to serve as encoders of biological information and, last but not least, they are involved in recognition processes at a molecular level. Research into carbohydrate and glycoconjugate functions in cell-to-cell communication processes has even created a new and rapidly developing field of study glycobiology Thisbe K. Lindhorst is one of the leading "next generation" scientists in the area of carbohydrate research. Within her current book she presents a comprehensive introduction to the fascinating world of carbohydrates. In a lucid, explicit language she explains carbohydrate structures and the basic concepts of saccharide chemistry and saccharide biochemistry. With the same clarity she spans the gap to the glycobiological aspects of modern "glyco-science". Sample descriptions of research methods supplement the vital teaching text and open an experienced scientist’s bag of tricks required to synthesize and analyze sugar derivatives easily and successfully. This book offers valuable guidance for students as well as for researchers working in chemistry, biochemistry and biomedicine. Reading it can help everyone become an expert in the field of carbohydrate chemistry.