Search results for: biologic-knee-reconstruction

Mechanical Biological and Structural Interaction in the Development of Osteoarthritis Following Anterior Cruciate Ligament Injury and Reconstruction

Author : Matthew R. Titchenal
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Osteoarthritis (OA) of the knee, characterized primarily by pain and cartilage degeneration, is one of the leading causes of disability worldwide, carrying with it a substantial economic cost and reduced quality of life. The risk factors for knee OA include aging, obesity, and traumatic knee injury. OA is particularly difficult to study because its symptoms, such as pain, stiffness, and swelling, are relatively absent until the disease has already reached an advanced state. Risk factors for OA include aging, obesity, and traumatic joint injury. As one of the most common traumatic knee injuries, anterior cruciate ligament (ACL) tear provides a valuable opportunity to study factors influencing the initiation of OA in an at-risk population. Surgical ACL reconstruction (ACLR) has managed to improve patient outcomes by stabilizing the knee and allowing return to physical activity, but has not reduced this risk of post-traumatic OA where roughly 50% of patients develop OA within 10-15 years after injury. Existing research suggests that this is likely a result of perturbations to the pre-injury knee mechanics that negatively interact with the post-injury biology and structure of the joint to disrupt cartilage homeostasis leading to premature OA in about half of patients. Lack of understanding concerning the nature of these interactions has been a critical barrier to identifying which patients will develop OA. Thus, there is a need for improved understanding of OA risk after ACLR to inform early OA risk assessment (before symptoms) that will support the development of intervention strategies to delay or prevent OA onset. This dissertation provides insight into the interaction between mechanical, biological, and structural factors on the risk of OA following ACL injury and reconstruction, and is focused on three studies completed on patients following ACLR examining relationships between these risk factors. The first study examines changes in knee kinematics occurring from 2 to 4 years after ACLR and relationships to patient reported outcomes much later at 8 years after surgery. The results suggest that a subset (approximately 50%) of patients develop increasingly abnormal kinematics that may contribute to and provide early warning of deteriorating knee function years before the onset of clinical symptoms. The second study demonstrates a relationship between cartilage matrix changes measured using a novel quantitative magnetic resonance imaging (MRI) technique and knee loading parameters known to affect OA progression at only 2 years after ACLR when the articular cartilage appeared healthy on standard clinical MRI. These results suggest that this new MRI metric may be showing early cartilage pathology that is undetectable using standard MRI methods. The final study investigates the biological response to knee loading through a walking exercise and cartilage matrix changes assessed by novel quantitative MRI at 2 years after ACLR. The results show a higher synthetic state in some patients suggestive of a repair response. However, the observed correlations with cartilage matrix changes detectable by quantitative MRI and knee loading suggest that this repair response may be related to a higher risk for future knee OA. All three studies demonstrated potential markers that separated patients into divergent groupings that suggest greater or lesser risk for developing knee OA consistent with the natural history where approximately 50% of individuals with ACL injury develop premature knee OA. The studies provide promising markers for the early detection of post-traumatic OA after ACLR and identify potential targets for intervention. It is important to note that assessing the interaction between multiple markers was an important factor in identifying the sensitivity of specific markers that would not be possible when evaluating markers independently. As such, the results of this thesis also demonstrated the importance of interdisciplinary research in evaluating biomarkers of OA risk in relationship to the complex interactions between mechanical, biological, and structural components in maintaining joint homeostasis. This knowledge will aid in the future development of personalized treatment strategies to delay or prevent the onset of post-traumatic OA after ACLR.

Biologic Joint Reconstruction

Author : Brian J. Cole
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The treatment of chondral damage and early arthritis in active patients remains a challenge. This book has accepted this challenge, providing a comprehensive look into the fast growing area of cartilage repair and early arthritis surgery for virtually every major joint. The text includes a detailed approach to surgical management utilizing procedures relative to all joints such as osteotomy, cartilage repair, cartilage restoration, and limited resurfacing. Treatment indications, surgical techniques, and non-operative treatment in the knee, shoulder, hip and smaller joints are also highlighted in the text. This book is the only orthopedic text on the market that combines discussion of biological and limited prosthetic options for the treatment of chondral damage and early arthritis for the young active adult, as well as for traditional joint replacement patients.

The ACL Deficient Knee

Author : Edward M. Wojtys
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A review of surgical and nonsurgical treatment options of anterior cruciate ligament (ACL) injuries. This text includes a discussion of ACL injuries, procedures and outcome evaluations.

Surgery of the Meniscus

Author : Christophe Hulet
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​This book, published in cooperation with ESSKA, provides an exhaustive review of the meniscus and its pathology, covering all aspects from the basic science of the normal meniscus to clinical and imaging diagnosis, meniscus repair and meniscectomy, outcomes and complications, postoperative management, and emerging technologies. The book opens by examining in depth aspects such as anatomy, histology, physiology, biomechanics, and physiopathology. Clear guidance is offered on arthroscopy and the classification of meniscal lesions, with consideration of the full range of meniscal pathology, including traumatic lesions, degenerative lesions, root tears, meniscal cysts, and congenital lesions. Choice of treatment in different settings is explained, and the various surgical techniques – meniscectomy, meniscal repair, and reconstruction with allografts – are described in detail with the aid of accompanying videos and with presentation of long-term results. The concluding chapter takes a look into the future of meniscus reconstruction, for example through regeneration using mesenchymal stem cells.

Operative Techniques Knee Surgery E Book

Author : Mark D. Miller
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Ideal for orthopaedic residents, fellows, and practicing surgeons alike, Operative Techniques: Knee Surgery offers all the step-by-step guidance you need to perform the latest techniques in knee surgery. As part of the highly visual Operative Techniques series, it boasts brief bulleted descriptions and a clean layout for ease of use, while clinical pearls help you optimize outcomes and obtain the best results. Highly visual atlas-style text features brief bulleted descriptions and a clean layout for ease of use. Clinical pearls help you optimize outcomes and obtain the best results. Outlines positioning, exposures, instrumentation, and implants to give you a step-by-step guide for every procedure. Provides information on post-operative care and expected outcomes, including potential complications. Brief notes and supporting evidence on controversies offers important details about patient-focused surgery. Features combined coverage of sports knee surgery, arthroscopy, and total knee replacement. Discusses trochyioplasty, a controversial new innovation, as well as NPSL technique. Boasts updated coverage of key procedures and techniques in sports knee surgery.

Musculoskeletal Tissue Regeneration

Author : William S. Pietrzak
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The repair of musculoskeletal tissue is a vital concern of all surgical specialties, orthopedics and related disciplines. Written by recognized experts, this book aims to provide both basic and advanced knowledge of the newer methodologies being developed and introduced to the clinical arena. A valuable resource for researchers, developers, and clinicians, the book presents a foundation to propel the technology and integration of the current state of knowledge into the 21st century.

Small Implants in Knee Reconstruction

Author : Norberto Confalonieri
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Minimally invasive joint replacement has become one of the hottest topics in the orthopedic world. In the case of the knee, however, this concept has been widely misunderstood. All too frequently it is taken to mean keyhole surgery in which traditional components are implanted with a shorter surgical time. Such an approach in fact has few benefits and various possible dangers. In this book, international experts discuss truly minimally invasive knee reconstruction techniques that involve tissue-sparing surgery and small implants and permit preservation of both the anterior and the posterior cruciate ligament. These techniques have the key advantage of respecting the physiological joint biomechanics. They also entail minimal removal of bone tissue from the tibia and only a small skin incision that avoids damage to the extensor apparatus. All of the most innovative techniques used in uni- and bicompartmental knee reconstruction are covered in detail, including computer-assisted procedures. Long-term results are reported, and pitfalls, highlighted. The reader will learn how, with careful selection of patients and rigorous surgical technique, compartmental reconstruction offers a valid alternative to total knee replacement.

The Child with a Limb Deficiency

Author : Shriners Hospitals for Crippled Children
File Size : 39.23 MB
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Experts in the field of orthopaedic surgery, physical therapy, child psychology, and prosthetics and orthotics discuss the aetiology, diagnosis and treatment of genetic and traumatic limb deficiencies in children. Topics covered in the book include: classification and treatment of congenital femoral deficiency, including Syme's amputation, rotationplasty, and limb lengthening; classification and treatment of fibular deficiency, tibial deficiency, epidemiology, prevention, and treatment of acquired amputations; prosthetic management; management of upper extremity deficiencies and of multiple amputations; and outcomes measures.

New Biologic and Synthetic Vascular Prostheses

Author : Howard P. Greisler
File Size : 70.93 MB
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3rd Kuala Lumpur International Conference on Biomedical Engineering 2006

Author : F. Ibrahim
File Size : 33.86 MB
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The Kuala Lumpur International Conference on Biomedical Engineering (BioMed 2006) was held in December 2006 at the Palace of the Golden Horses, Kuala Lumpur, Malaysia. The papers presented at BioMed 2006, and published here, cover such topics as Artificial Intelligence, Biological effects of non-ionising electromagnetic fields, Biomaterials, Biomechanics, Biomedical Sensors, Biomedical Signal Analysis, Biotechnology, Clinical Engineering, Human performance engineering, Imaging, Medical Informatics, Medical Instruments and Devices, and many more.

Prosthetic Ligament Reconstruction of the Knee

Author : Marc J. Friedman
File Size : 59.32 MB
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The ACL Handbook

Author : Martha M. Murray
File Size : 57.4 MB
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The new age of biologic treatment of the ACL is coming. In The ACL Handbook: Knee Biology, Mechanics, and Treatment, the authors cover the past and current state of ACL injuries and treatment, and then introduce and explain the key concepts for understanding the new biologic approach to ACL treatment. The use of factors to enhance graft healing are reviewed, as well as an in-depth review of the science of platelet-rich plasma and its cellular components (platelets, white cells, and plasma). Chapters on in vitro models for science as well as the advantages and disadvantages of animal models for ACL research are included, as are chapters on the new technique of bio-enhanced ACL repair. All are discussed in easily readable text aimed at anyone with an interest of what is coming next in ACL surgery.

Noyes Knee Disorders Surgery Rehabilitation Clinical Outcomes E Book

Author : Frank R. Noyes
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Frank R. Noyes, MD—internationally-renowned knee surgeon and orthopaedic sports medicine specialist—presents Noyes’ Knee Disorders, an unparalleled resource on the diagnosis, management, and outcomes analysis for the full range of complex knee disorders. Master the technical details of procedures such as anterior cruciate ligament reconstruction, meniscus repair, articular cartilage restoration, and many others, and implement appropriate post-operative rehabilitation programs and protocols. Analyze and manage gender disparities in anterior cruciate ligament injuries. You can access the full text, as well as downloadable images, PubMed links, and alerts to new research online at Offers online access to the full text, downloadable images, PubMed links, and alerts to new research online at through Expert Consult functionality for convenient reference. Presents step-by-step descriptions on the full range of complex soft tissue knee operative procedures for the anterior cruciate ligament reconstruction, meniscus repair, soft tissue transplants, osseous malalignments, articular cartilage restoration, posterior cruciate ligament reconstruction, and more to provide you with guidance for the management of any patient. Relies on Dr. Noyes’ meticulous published clinical studies and outcomes data from other peer-reviewed publications as a scientifically valid foundation for patient care. Features detailed post-operative rehabilitation programs and protocols so that you can apply proven techniques and ease your patients’ progression from one phase to the next. Bonus video available only from the website provides live presentations from the 2009 Advances on the Knee and Shoulder course, step-by-step surgical demonstration of an opening wedge tibial osteotomy, and a 4-part series on the Diagnosis of Knee Ligament Injuries.

Partial Knee Arthroplasty E Book

Author : Keith R. Berend
File Size : 59.33 MB
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Partial Knee Arthroplasty helps you optimize outcomes using the latest best-practice techniques for this increasingly popular procedure. Drs. Keith R. Berend and Fred D. Cushner discuss recent advances and hot topics—such as custom guided implants, biologics, failed PKA, TKA conversion, and more—along with the challenges of choosing the right technique for each patient. The clear focus on surgical techniques, bulleted key points, and procedural videos online at make this comprehensive, practical reference ideal for learning how to achieve the best results. Access the fully searchable text online at, along with a gallery of procedural videos. Apply recent advances and best-practice techniques effectively thanks to global perspectives and analyses of surgical approaches. Improve patient outcomes with clear, direct, and focused coverage of surgical techniques. Find information quickly and easily with a bulleted format for convenient "at-a-glance" reference to key details and ease of use in a mobile environment.

Surgical Techniques of the Shoulder Elbow and Knee in Sports Medicine E Book

Author : Brian J. Cole
File Size : 89.15 MB
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Surgical Techniques of the Shoulder, Elbow, and Knee in Sports Medicine presents you with a step-by-step approach on performing both open and arthroscopic surgeries for sports-related injuries. This medical reference book offers all of the expert guidance you need on everything from patient positioning and the latest orthopaedic surgery techniques, through pearls and pitfalls and post-operative care. An international group of contributors equips you with a worldwide perspective on the most recent orthopaedic advances, making Surgical Techniques of the Shoulder, Elbow, and Knee in Sports Medicine your go-to digest of today's common procedures. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compatible with Kindle®, nook®, and other popular devices. Ensure optimal outcomes from each shoulder, elbow and knee procedure with this orthopaedic surgery text's consistent, step-by-step approach, coupled with numerous tips, pearls, pitfalls, and images gleaned from surgeons specializing in sports injuries. Apply the latest open and arthroscopic techniques, including arthroscopic rotator cuff repair and hamstring and allograft ACL reconstruction. Access the full text and expanded surgical video collection online at Expert Consult. Broaden your knowledge base with contributions from rising international orthopaedic and sports medicine authorities, who offer a global perspective on today's most common techniques including rotator cuff procedures, shoulder and knee instability, and athletic throwing arm issues. Confidently interpret state-of-the-art diagnostic studies with help from a brand-new chapter on sports medicine imaging for each treated joint. See for yourself how key techniques are performed with an expanded online surgical video collection covering Arthroscopic Rotator Cuff Repair: Double Row Techniques; Arthroscopic Repair of Multidirectional Instability of the Shoulder; Ulnar Collateral Ligament Repair and Reconstruction: DANE Technique; Double Bundle Anterior Cruciate Ligament Reconstruction; and Management of Proximal Tibiofibular Instability.

Anticancer Research

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Insall Scott Surgery of the Knee E Book

Author : W. Norman Scott
File Size : 65.62 MB
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Online and in print, Insall & Scott Surgery of the Knee, edited by W. Norman Scott, MD, and 11 section editors who are experts in their fields, is your complete, multimedia guide to the most effective approaches for diagnosis and management of the full range of knee disorders affecting patients of all ages. From anatomical and biomechanical foundations, to revision total knee replacement, this authoritative reference provides the most up-to-date and complete guidance on cutting-edge surgical procedures, the largest collection of knee videos in one knee textbook. Expanded coverage and rigorous updates—including 40 online-only chapters—keep you current with the latest advances in cartilage repair and regeneration, allograft and autografts, computer robotics in total knee arthroplasty, and other timely topics. This edition is the first book ever endorsed by The Knee Society. Access the full text - including a wealth of detailed intraoperative photographs, a robust video library, additional online-only chapters, a glossary of TKR designs, quarterly updates, and more - at Get all you need to know about the clinical and basic science aspects of the full range of knee surgeries as well as the latest relevant information, including imaging and biomechanics; soft tissue cartilage; ligament/meniscal repair and reconstructions; partial and total joint replacement; fractures; tumors; and the arthritic knee. Master the nuances of each new technique through step-by-step instructions and beautiful, detailed line drawings, intraoperative photographs, and surgical videos. See exactly how it’s done. Watch master surgeons perform Partial and Primary TKR, Revision TKR, Tumor Replacement, Fracture Treatment, and over 160 videos on the Find information quickly and easily thanks to a consistent, highly templated, and abundantly illustrated chapter format and streamlined text with many references and chapters appearing online only. Access the fully searchable contents of the book online at, including 40 online-only chapters, a downloadable image library, expanded video collection, quarterly updates, and a glossary of TKR designs with images and text from various device manufacturers. Grasp and apply the latest knowledge with expanded coverage of cartilage repair and regeneration techniques, expanded ligament techniques in allograft and autografts, computer robotics in surgical prognostics, fitting and techniques in partial and total knee arthroplasty, and more. Consult with the best. Renowned knee surgeon and orthopaedic sports medicine authority Dr. W. Norman Scott leads an internationally diverse team of accomplished specialists—many new to this edition—who provide dependable guidance and share innovative approaches to reconstructive surgical techniques and complications management.

Year Book of Orthopedics 2011 E Book

Author : Bernard F. Morrey
File Size : 48.26 MB
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Year Book of Orthopedics 2011 - E-Book

Anterior Cruciate Ligament Surgery

Author : Kevin B. Freedman
File Size : 70.65 MB
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This monograph aims to help doctors learn how to prevent complications during ACL Surgery, as well as be ready to treat them effectively when they do occur. Each chapter discusses case examples of complications - from initial treatment to how the complication was treated (including rationale).

The Anterior Cruciate Deficient Knee

Author : Douglas W. Jackson
File Size : 64.50 MB
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