Variant Haemoglobins

A Guide to Identification

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Author: Barbara J. Bain,Barbara Wild,Adrian Stephens,Lorraine Phelan

Publisher: John Wiley & Sons

ISBN: 1444347675

Category: Medical

Page: 260

View: 1264

Variant Haemoglobins – A Guide to Identification is based on the premise that any single diagnostic technique offers only a very provisional identification of a variant haemoglobin. In routine diagnostic practice two techniques are needed as a minimum, with the results being interpreted in the light of the clinical details, blood count, blood film and ethnic origin. This book covers 150 normal and variant haemoglobins that have been studied and carefully documented. Variant Haemoglobins has four introductory chapters followed by an invaluable atlas. The introductory chapters cover the genetics of haemoglobin synthesis the principles of tests employed for identification common haemoglobins of major clinical or diagnostic importance thalassaemias and related conditions The atlas section comprises 170 full colour pages in which each variant haemoglobin or combination of haemoglobins is illustrated by cellulose acetate electrophoresis at alkaline pH, agarose gel electrophoresis at acid pH, isoelectric focusing and one or more HPLC traces. For ease of reference, the atlas pages are arranged according to the retention time of each haemoglobin on HPLC, this becoming increasingly the primary technique employed in haemoglobin identification. Bringing a mix of necessary scientific expertise and clinical knowledge, each author has more than 30 years experience in the diagnosis of variant haemoglobins. Providing otherwise unavailable information, this unique and practical guide is illustrated with over 700 high quality colour digital images plus flow charts and line diagrams covers common and important haemoglobin variants, in addition to many rarer ones is an essential reference source for diagnosis in the haematology laboratory A remarkably useful book, Variant Haemoglobins will be valuable for haematopathologists, clinical and laboratory haematologists in practice and in training and all laboratory staff involved in haemoglobinopathy diagnosis.

Haemoglobinopathy Diagnosis

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Author: Barbara J. Bain

Publisher: John Wiley & Sons

ISBN: 0470994231

Category: Medical

Page: 328

View: 4844

This unique book is written by Barbara Bain, a leading haematologist with a reputation for her educational prowess in the field. It provides a concise overview of the haemoglobinopathies and focuses on the selection, performance, and interpretation of relevant laboratory tests. The tests dealt with are mainly those done regularly in diagnostic haematology laboratories. Where more specialist tests are required, the reader is given an overview of what the specialist centre will do, with guidance on what the result will imply. This book is extremely practical in orientation and is an essential reference volume in the haematology laboratory. Haemoglobinopathy Diagnosis is ideal for: Trainees and residents in haematology Hematologists in practice Laboratory scientists Why Buy This Book? New Edition - Fully updated, with 43 new pictures and 37 pages of illustrated clinical cases to use for teaching and self-evaluation Essential reference volume for the haematology laboratory Focuses on diagnosis Very practical in its approach In addition to the self-assessment case studies, contains "test your knowledge" sections at the end of every chapter Remarkably comprehensive for a compact book

Dacie and Lewis Practical Haematology

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Author: Barbara J. Bain,Imelda Bates,Mike A Laffan

Publisher: Elsevier Health Sciences

ISBN: 0702069256

Category: Medical

Page: 600

View: 718

For more than 65 years, this best-selling text by Drs. Barbara J. Bain, Imelda Bates, and Mike A. Laffan has been the worldwide standard in laboratory haematology. The 12th Edition of Dacie and Lewis Practical Haematology continues the tradition of excellence with thorough coverage of all of the techniques used in the investigation of patients with blood disorders, including the latest technologies as well as traditional manual methods of measurement. You’ll find expert discussions of the principles of each test, possible causes of error, and the interpretation and clinical significance of the findings. A unique section on haematology in under-resourced laboratories. Ideal as a laboratory reference or as a comprehensive exam study tool. Each templated, easy-to-follow chapter has been completely updated, featuring new information on haematological diagnosis, molecular testing, blood transfusion- and much more. Complete coverage of the latest advances in the field. An expanded section on coagulation now covers testing for new anticoagulants and includes clinical applications of the tests.

Accurate Results in the Clinical Laboratory

A Guide to Error Detection and Correction

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Author: Amitava Dasgupta,Jorge L. Sepulveda

Publisher: Newnes

ISBN: 0124158587

Category: Science

Page: 382

View: 3571

This practical, easy-to-use guide, named to Doody’s Core Titles 2013, addresses interference issues in all laboratory tests, including patient epigenetics, process of specimen collection, enzymes, biomarkers. Clinicians and laboratory scientists can therefore rely on one reference which speaks to both their needs of accurate specimen analysis and optimal patient care. Erroneous hospital and pathology laboratory results can be confusing and problematic, especially in acute care situations. While some factors creating interference, can be identified in the laboratory, detecting many others is often dependent on clinical details unavailable to the laboratory scientists or pathologists. Therefore, clinicians must become proficient in identifying such erroneous reports, and working with pathologists and laboratory scientists so that they can understand the source of such interferences, correct the results, and then decide what course of action must be followed for proper patient management. Named to Doody’s Core Titles 2013, a collection development tool for health sciences libraries of all sizes, by Doody Enterprises Practical information for both clinicians and laboratory scientists, presented in the form of tables and charts for easy reference Focus on range and sources of interferences rather than details of toxicologic mechanisms which are well covered in toxicology textbooks Covers interferences across endocrine, oncology, hematology, immunohistochemistry, immunology, serology, microbiology, and molecular testing

Multiple Choice Questions for Haematology and Core Medical Trainees

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Author: Barbara J. Bain

Publisher: John Wiley & Sons

ISBN: 1119210526

Category: Medical

Page: 208

View: 2257

Written to help haematology and general medical trainees evaluate their own knowledge, and particularly useful for those preparing for the Part 1 examination of the Royal College of Pathologists. This exam-centered book will also be of use to core medical trainees preparing for the examinations of the Royal College of Physicians and the Royal Australasian College of Physicians and to haematology and general medicine trainees in other countries where methods of examination are similar. The 150 questions are presented in two formats, Single Best Answer and Extended Matching Question, and comes complete with detailed feedback and, when appropriate, relevant references are given for each question so that those who select the wrong answer will understand why another answer is better. Quick reference question book, ideal for examination preparation Includes 50 SBA questions, ideal for the Part 1 and Part 2 MRCP examinations, which although having a general medical slant, are also appropriate for haematology specialist trainees Includes 70Â SBA multiple choice questions appropriate for haematology specialist trainees but also useful to core medical trainees Includes 30Â EMQs suitable for those taking Part 1 of the FRCPath examination Questions come complete with fully referenced answers and discussion points This book provides an educational tool for training as well as an ideal way to prepare for examinations and is also of value to those who examine in haematology and haematopathology.

Blood Cells

A Practical Guide

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Author: Barbara J. Bain

Publisher: John Wiley & Sons

ISBN: 140517160X

Category: Medical

Page: 488

View: 5281

Blood Cells has been written with both the practising haematologist and the trainee in mind. It aims to provide a guide for use in the diagnostic haematology laboratory, covering methods of collection of blood specimens, blood film preparation and staining, the principles of manual and automated blood counts and the assessment of the morphological features of blood cells. The practising haematologist should find this book sufficiently comprehensive to be a reference source while, at the same time, the trainee haematologist and biomedical scientist should find it a straightforward and practical bench manual. Enables both the haematologist and laboratory scientist to identify blood cell features, from the most common to the more obscure Provides essential information on methods of collection, blood film preparation and staining, together with the principles of manual and automated blood counts Completely revised and updated, incorporating much newly published information: now includes advice on further tests when a specific diagnosis is suspected Four hundred high quality photographs to aid with blood cell identification Highlights the purpose and clinical relevance of haematology laboratory tests throughout

Von Willebrand Disease

Basic and Clinical Aspects

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Author: Augusto B. Federici,Christine A. Lee,Erik E. Berntorp,David Lillicrap,Robert R. Montgomery

Publisher: John Wiley & Sons

ISBN: 9781444329940

Category: Medical

Page: 268

View: 6152

Von Willebrand Disease: Basic and Clinical Aspects provides an insight into all aspects of the condition. Since its discovery, von Willebrand disease has been extensively studied and the causative factor deficiency, the understanding of the condition and its treatment has greatly improved. This book summarizes recent research and will help to optimize the management of patients with von Willebrand disease. This valuable book describes the important and complex role of von Willebrand factor in hemostasis and thrombosis. In addition to the current understanding of its molecular biology, this book gives particular focus to the association between genetic variants of von Willebrand factor and different von Willebrand disease phenotypes. It also reviews the important area of the obstetric and gynecological manifestations of von Willebrand disease, as well as the treatment of acute bleeding. Written by an international team of contributors it describes the progress in, and difficulties of diagnosing phenotypes and genotypes. Molecular diagnosis of type 1, type 2 and its subgroups, and type 3 von Willebrand disease are presented as well as discussion of the potential future role of gene therapy. Von Willebrand Disease: Basic and Clinical Aspects is a valuable resource for hematologists in practice and in training, and specialists in thrombosis and hemostasis.

Sickle Cell Disease in Clinical Practice

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Author: Jo Howard,Paul Telfer

Publisher: Springer

ISBN: 1447124731

Category: Medical

Page: 287

View: 6774

Sickle Cell Disease is the most common genetic disease world wide and in the UK. It has marked geographical variation in its distribution in the UK, with a concentration in London and other major conurbations (Birmingham and Manchester). In these areas, specialist centres have become established offering expert, up to date care for both inpatients and out patients with Sickle Cell Disease. Although patient numbers are increasing outside these areas, the expertise of health professionals can be patchy. This book aims to provide a user friendly, accessible resource for areas with smaller numbers of patients, to allow them to provide equitable care with the larger well established centres. Sickle Cell Disease can be associated with acute life threatening complications, when clear, easily available advice is needed, and with chronic long term complications which may need liaison with other health professionals. Clear treatment protocols for all the common complications of sickle cell disease, are outlined here, with summaries of key evidence and references.

A Beginner's Guide to Blood Cells

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Author: Barbara J. Bain

Publisher: John Wiley & Sons

ISBN: 1119367735

Category: Medical

Page: 160

View: 3907

The blood film and count -- Assessing red cells -- Assessing white cells and platelets -- Haematological findings in health and disease -- Emergency morphology -- Self-assessment

Hematopathology E-Book

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Author: Elaine Sarkin Jaffe,Nancy Lee Harris,James Vardiman,Daniel A. Arber,Elias Campo

Publisher: Elsevier Health Sciences

ISBN: 1455706248

Category: Medical

Page: 1072

View: 7588

Introducing HEMATOPATHOLOGY, a definitive new diagnostic reference on diseases of the hematopoietic system by Dr. Elaine S. Jaffe and her fellow editors, all collaborators on the World Health Organization's classification of lymphoid and myeloid disorders. These experts provide you with today's most effective guidance in evaluating specimens from the lymph nodes, bone marrow, peripheral blood, and more, equipping you to deliver more accurate and actionable pathology reports. More than 1,100 high-quality color images mirror the findings you encounter in practice. Overcome the toughest diagnostic challenges with authoritative guidance from the world's leading experts. Make optimal use of the newest diagnostic techniques, including molecular, immunohistochemical, and genetic studies. Compare specimens to more than 1,100 high-quality color images to confirm or challenge your diagnostic interpretations. Search the full contents online and download any of the images at expertconsult.com.

Disorders of Hemoglobin

Genetics, Pathophysiology, and Clinical Management

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Author: Martin H. Steinberg,Bernard G. Forget,Douglas R. Higgs,David J. Weatherall

Publisher: Cambridge University Press

ISBN: 1139480804

Category: Medical

Page: N.A

View: 9283

This book is a completely revised new edition of the definitive reference on disorders of hemoglobin. Authored by world-renowned experts, the book focuses on basic science aspects and clinical features of hemoglobinopathies, covering diagnosis, treatment, and future applications of current research. While the second edition continues to address the important molecular, cellular, and genetic components, coverage of clinical issues has been significantly expanded, and there is more practical emphasis on diagnosis and management throughout. The book opens with a review of the scientific underpinnings. Pathophysiology of common hemoglobin disorders is discussed next in an entirely new section devoted to vascular biology, the erythrocyte membrane, nitric oxide biology, and hemolysis. Four sections deal with α and β thalassemia, sickle cell disease, and related conditions, followed by special topics. The second edition concludes with current and developing approaches to treatment, incorporating new agents for iron chelation, methods to induce fetal hemoglobin production, novel treatment approaches, stem cell transplantation, and progress in gene therapy.

A - Z of Haematology

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Author: Barbara J. Bain,Rajeev Gupta

Publisher: John Wiley & Sons

ISBN: 0470794771

Category: Medical

Page: 248

View: 9107

A–Z of Haematology provides an essential "quick reference guide" to definitions covering the entire spectrum of haematology, from blood transfusion and coagulation through to recent advances in molecular haematology. It is the indispensable guide for all those practising or studying haematology including research scientists and biomedical scientists working in diagnostic laboratories. Scientists working in cytogenetics and immunophenotyping will also find it a valuable repository of relevant knowledge. A–Z of Haematology includes: Definitions cover the entire spectrum of haematology, from blood transfusion and coagulation through to molecular haematology Essential "quick reference guide" for all those practising or studying haematology Over 100 figures to explain and clarify difficult concepts Inclusion of all CD numbers and oncogenes to be encountered in daily practice Appendices of laboratory data and normal values included

The Unofficial Guide to Prescribing

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Author: Zeshan Qureshi,Simon R J Maxwell

Publisher: Elsevier Health Sciences

ISBN: 0702055190

Category: Medical

Page: 448

View: 5012

The Unofficial Guide to Prescribing lays out the practical steps of how to assess, investigate and manage a patient, with a focus on what to prescribe and how to prescribe it. Its aim is to empower newly graduated junior doctors to excel at dealing with emergencies and handling complex prescribing scenarios. Prescribing errors cost healthcare systems millions annually, so early training in prescribing has become an urgent priority of medical education and now forms an essential part of teaching and assessment. The Unofficial Guide to Prescribing (from the same stable as The Unofficial Guide to Passing OSCEs) is a new book designed to address this requirement. It is written by junior doctors still close to the transition from theory to practice, overseen by a review panel of senior clinicians to ensure accuracy, and designed to help medical students practise and learn as much as possible about prescribing, in actual clinical scenarios, before they have to do it for real. Each scenario is presented as you would see it in the hospital setting and covers: Initial step-by-step assessment of the patient: how to assess, assessment findings, and immediate management Initial investigations Initial management Reassessment Treatment Handing over the patient 'Prescribe' alerts throughout Written-up drug charts Blank drug charts for copying and practice

ERS Handbook of Respiratory Medicine

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Author: Paolo Palange,Anita K. Simonds

Publisher: European Respiratory Society

ISBN: 1849840415

Category: HEALTH & FITNESS

Page: 593

View: 4370

The European Respiratory Society (ERS) Handbook of Respiratory Medicine, now in its second edition, is a concise, compact and easy-to-read guide to each of the key areas in respiratory medicine. Its 18 chapters, written by clinicians and researchers at the forefront of the field, explain the structure and function of the respiratory system, its disorders and how to treat them. The Handbook is a must-have for anyone who intends to remain up to date in the field, and to have within arm's reach a reference that covers everything from the basics to the latest developments in respiratory medicine.

Morphology of Blood Disorders

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Author: Giuseppe d'Onofrio,Gina Zini

Publisher: Wiley-Blackwell

ISBN: 9781118442609

Category: Medical

Page: 800

View: 7481

Morphology of Blood Disorders, 2nd edition is an outstanding atlas with over 800 high-quality digital images, covering the whole spectrum of blood and bone marrow morphology, with particular emphasis on malignant haematology. Originally written in the Italian language by two world leaders in the field, the book has been expertly translated by the renowned haematologist and teacher, Barbara Bain. This book explores the major topics of haematological pathology, blending classical teaching with up-to-date WHO classification and terminology. Each image in this book is derived from material obtained for diagnostic purposes from patients with serious haematological conditions. Morphological details are supplemented by detailed descriptions of the output and role of automated instruments in disorders of the blood. Morphology of Blood Disorders, 2nd edition is an essential reference source for diagnosis in the haematology laboratory, designed to be the go-to guide for anyone with an interest in blood cell morphology.

100 Cases in Clinical Medicine, Third Edition

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Author: P John Rees,James Pattison,Christopher Kosky

Publisher: CRC Press

ISBN: 1444174290

Category: Medical

Page: 275

View: 9991

Making speedy and appropriate clinical decisions and then choosing the best course of action is an essential skill for doctors. Exploring initial medical assessment, 100 Cases in Clinical Medicine presents 100 scenarios commonly seen by medical students and junior doctors in the emergency or outpatient department, on the ward, or in the community setting. Each case begins with a succinct summary of the patient's history, examination, and initial investigation. The text includes photographs where relevant and questions on the diagnosis and management of each case. The answers provide a detailed discussion on each topic, with further illustration where appropriate. Most of the cases included are common problems but the book also includes more unusual cases to illustrate specific points and to emphasize that rare things do present. The first 20 cases are arranged by systems; the next 80 are in random order because symptoms such as breathlessness and pain may relate to many different clinical problems in various systems. These true-to-life cases will teach students and junior doctors to recognize important clinical symptoms and signs and to develop the diagnostic and management skills needed for the cases they will encounter on the job.