Variant Haemoglobins

A Guide to Identification

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Author: Barbara J. Bain,Barbara Wild,Adrian Stephens,Lorraine Phelan

Publisher: John Wiley & Sons

ISBN: 1444347675

Category: Medical

Page: 260

View: 7343

Variant Haemoglobins – A Guide to Identification is based on the premise that any single diagnostic technique offers only a very provisional identification of a variant haemoglobin. In routine diagnostic practice two techniques are needed as a minimum, with the results being interpreted in the light of the clinical details, blood count, blood film and ethnic origin. This book covers 150 normal and variant haemoglobins that have been studied and carefully documented. Variant Haemoglobins has four introductory chapters followed by an invaluable atlas. The introductory chapters cover the genetics of haemoglobin synthesis the principles of tests employed for identification common haemoglobins of major clinical or diagnostic importance thalassaemias and related conditions The atlas section comprises 170 full colour pages in which each variant haemoglobin or combination of haemoglobins is illustrated by cellulose acetate electrophoresis at alkaline pH, agarose gel electrophoresis at acid pH, isoelectric focusing and one or more HPLC traces. For ease of reference, the atlas pages are arranged according to the retention time of each haemoglobin on HPLC, this becoming increasingly the primary technique employed in haemoglobin identification. Bringing a mix of necessary scientific expertise and clinical knowledge, each author has more than 30 years experience in the diagnosis of variant haemoglobins. Providing otherwise unavailable information, this unique and practical guide is illustrated with over 700 high quality colour digital images plus flow charts and line diagrams covers common and important haemoglobin variants, in addition to many rarer ones is an essential reference source for diagnosis in the haematology laboratory A remarkably useful book, Variant Haemoglobins will be valuable for haematopathologists, clinical and laboratory haematologists in practice and in training and all laboratory staff involved in haemoglobinopathy diagnosis.

Haemoglobinopathy Diagnosis

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Author: Barbara J. Bain

Publisher: John Wiley & Sons

ISBN: 0470994231

Category: Medical

Page: 328

View: 5653

This unique book is written by Barbara Bain, a leading haematologist with a reputation for her educational prowess in the field. It provides a concise overview of the haemoglobinopathies and focuses on the selection, performance, and interpretation of relevant laboratory tests. The tests dealt with are mainly those done regularly in diagnostic haematology laboratories. Where more specialist tests are required, the reader is given an overview of what the specialist centre will do, with guidance on what the result will imply. This book is extremely practical in orientation and is an essential reference volume in the haematology laboratory. Haemoglobinopathy Diagnosis is ideal for: Trainees and residents in haematology Hematologists in practice Laboratory scientists Why Buy This Book? New Edition - Fully updated, with 43 new pictures and 37 pages of illustrated clinical cases to use for teaching and self-evaluation Essential reference volume for the haematology laboratory Focuses on diagnosis Very practical in its approach In addition to the self-assessment case studies, contains "test your knowledge" sections at the end of every chapter Remarkably comprehensive for a compact book

Blood Cells

A Practical Guide

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Author: Barbara J. Bain

Publisher: John Wiley & Sons

ISBN: 111881729X

Category: Medical

Page: 504

View: 9568

Enables both the haematologist and laboratory scientist to identify blood cell features, from the most common to the more obscure Provides essential information on methods of collection, blood film preparation and staining, together with the principles of manual and automated blood counts Completely revised and updated, incorporating much newly published information: now includes advice on further tests when a specific diagnosis is suspected 400 high quality photographs to aid with blood cell identification Highlights the purpose and clinical relevance of haematology laboratory tests throughout

Dacie and Lewis Practical Haematology

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Author: Barbara J. Bain,Imelda Bates,Mike A Laffan

Publisher: Elsevier Health Sciences

ISBN: 0702069256

Category: Medical

Page: 600

View: 6597

For more than 65 years, this best-selling text by Drs. Barbara J. Bain, Imelda Bates, and Mike A. Laffan has been the worldwide standard in laboratory haematology. The 12th Edition of Dacie and Lewis Practical Haematology continues the tradition of excellence with thorough coverage of all of the techniques used in the investigation of patients with blood disorders, including the latest technologies as well as traditional manual methods of measurement. You’ll find expert discussions of the principles of each test, possible causes of error, and the interpretation and clinical significance of the findings. A unique section on haematology in under-resourced laboratories. Ideal as a laboratory reference or as a comprehensive exam study tool. Each templated, easy-to-follow chapter has been completely updated, featuring new information on haematological diagnosis, molecular testing, blood transfusion- and much more. Complete coverage of the latest advances in the field. An expanded section on coagulation now covers testing for new anticoagulants and includes clinical applications of the tests.

A Beginner's Guide to Blood Cells

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Author: Barbara J. Bain

Publisher: John Wiley & Sons

ISBN: 1119367832

Category: Medical

Page: 160

View: 8962

The third edition of this popular pocket book, A Beginner’s Guide to Blood Cells written by Professor Barbara Bain, provides a concise introduction to normal and abnormal blood cells and blood counts for trainees in haematology. Includes a brand new chapter on emergency morphology, designed to make the clinical significance and urgency of certain laboratory findings clear for biomedical scientists and to assist trainee haematologists in the recognition of major clinically important abnormalities Contains exceptional full colour images throughout Introduces important basic concepts of hematology, setting haematological findings in a clinical context Provides a fully updated self-assessment section An essential resource for trainee haematologists, biomedical scientists, and biomedical science and medical students

Leukaemia Diagnosis

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Author: Barbara J. Bain

Publisher: John Wiley & Sons

ISBN: 111921050X

Category: Medical

Page: 576

View: 4459

UP-TO-DATE PRACTICAL GUIDE TO LEUKAEMIA DIAGNOSIS Written by a renowned expert this practical guide had been fully revised and updated. The book covers recent advances in the fields of immunophenotyping, cytogenetics and molecular genetics. It illustrates how laboratory techniques are used for the diagnosis and classification of leukaemia and includes images of abnormal cells to aid diagnosis. This fifth edition: Incorporates the recommendations of the 2015 WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues Includes 300 high quality full colour digital images of abnormal cells in leukaemia and lymphoma Full colour diagrams and helpful tables clarify and summarise key points throughout Essential reading for every haematologist and haematopathologist.

Accurate Results in the Clinical Laboratory

A Guide to Error Detection and Correction

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Author: Amitava Dasgupta,Jorge L. Sepulveda

Publisher: Newnes

ISBN: 0124158587

Category: Science

Page: 382

View: 5065

This practical, easy-to-use guide, named to Doody’s Core Titles 2013, addresses interference issues in all laboratory tests, including patient epigenetics, process of specimen collection, enzymes, biomarkers. Clinicians and laboratory scientists can therefore rely on one reference which speaks to both their needs of accurate specimen analysis and optimal patient care. Erroneous hospital and pathology laboratory results can be confusing and problematic, especially in acute care situations. While some factors creating interference, can be identified in the laboratory, detecting many others is often dependent on clinical details unavailable to the laboratory scientists or pathologists. Therefore, clinicians must become proficient in identifying such erroneous reports, and working with pathologists and laboratory scientists so that they can understand the source of such interferences, correct the results, and then decide what course of action must be followed for proper patient management. Named to Doody’s Core Titles 2013, a collection development tool for health sciences libraries of all sizes, by Doody Enterprises Practical information for both clinicians and laboratory scientists, presented in the form of tables and charts for easy reference Focus on range and sources of interferences rather than details of toxicologic mechanisms which are well covered in toxicology textbooks Covers interferences across endocrine, oncology, hematology, immunohistochemistry, immunology, serology, microbiology, and molecular testing

Multiple Choice Questions for Haematology and Core Medical Trainees

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Author: Barbara J. Bain

Publisher: John Wiley & Sons

ISBN: 1119210526

Category: Medical

Page: 208

View: 8569

Written to help haematology and general medical trainees evaluate their own knowledge, and particularly useful for those preparing for the Part 1 examination of the Royal College of Pathologists. This exam-centered book will also be of use to core medical trainees preparing for the examinations of the Royal College of Physicians and the Royal Australasian College of Physicians and to haematology and general medicine trainees in other countries where methods of examination are similar. The 150 questions are presented in two formats, Single Best Answer and Extended Matching Question, and comes complete with detailed feedback and, when appropriate, relevant references are given for each question so that those who select the wrong answer will understand why another answer is better. Quick reference question book, ideal for examination preparation Includes 50 SBA questions, ideal for the Part 1 and Part 2 MRCP examinations, which although having a general medical slant, are also appropriate for haematology specialist trainees Includes 70Â SBA multiple choice questions appropriate for haematology specialist trainees but also useful to core medical trainees Includes 30Â EMQs suitable for those taking Part 1 of the FRCPath examination Questions come complete with fully referenced answers and discussion points This book provides an educational tool for training as well as an ideal way to prepare for examinations and is also of value to those who examine in haematology and haematopathology.

Von Willebrand Disease

Basic and Clinical Aspects

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Author: Augusto B. Federici,Christine A. Lee,Erik E. Berntorp,David Lillicrap,Robert R. Montgomery

Publisher: John Wiley & Sons

ISBN: 9781444329940

Category: Medical

Page: 268

View: 7197

Von Willebrand Disease: Basic and Clinical Aspects provides an insight into all aspects of the condition. Since its discovery, von Willebrand disease has been extensively studied and the causative factor deficiency, the understanding of the condition and its treatment has greatly improved. This book summarizes recent research and will help to optimize the management of patients with von Willebrand disease. This valuable book describes the important and complex role of von Willebrand factor in hemostasis and thrombosis. In addition to the current understanding of its molecular biology, this book gives particular focus to the association between genetic variants of von Willebrand factor and different von Willebrand disease phenotypes. It also reviews the important area of the obstetric and gynecological manifestations of von Willebrand disease, as well as the treatment of acute bleeding. Written by an international team of contributors it describes the progress in, and difficulties of diagnosing phenotypes and genotypes. Molecular diagnosis of type 1, type 2 and its subgroups, and type 3 von Willebrand disease are presented as well as discussion of the potential future role of gene therapy. Von Willebrand Disease: Basic and Clinical Aspects is a valuable resource for hematologists in practice and in training, and specialists in thrombosis and hemostasis.

Researching 'Race' and Ethnicity

Methods, Knowledge and Power

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Author: Yasmin Gunaratnam

Publisher: SAGE

ISBN: 9780761972877

Category: Social Science

Page: 218

View: 8854

Drawing upon ethnographic research, the author uses detailed case study examples to show how race and ethnicity is produced, negotiated and resisted in qualitative research encounters.

Protein Electrophoresis in Clinical Diagnosis

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Author: David Keren

Publisher: CRC Press

ISBN: 1444113992

Category: Medical

Page: 422

View: 1400

Since the publication of High-Resolution Electrophorsesis and Immunofixation 2e, there have been ever-increasing advances in the analyses of proteins, by electrophoresis in particular. Protein Electrophoresis in Clinical Diagnosis shows the changes in both techniques and interpretation, presenting a comprehensive review of serum protein techniques, immunofixation techniques, approaches to pattern interpretation, and pattern interpretation in both cerebralspinal fluid and urine. Conditions associated with Monoclunal Gammopathies are considered, as are the appropriate strategies for their detection. David Keren is well-known as the leader in this field, his work on guidelines becoming the benchmark for all those involved in protein detection in serum and urine. Dr Keren's book will be essential in every laboratory, and read by pathologists, chemical chemists, medical technicians and clinicians (particularly hematologists and oncologists).

Population Genetics

A Concise Guide

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Author: John H. Gillespie

Publisher: JHU Press

ISBN: 9781421401706

Category: Science

Page: 232

View: 6187

This book is indispensable for students working in a laboratory setting or studying free-ranging populations.

Hematology

Landmark Papers of the Twentieth Century

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Author: Marshall A. Lichtman,Laurence A. Boxer,Edward Henderson,Sanford J. Shattil,Jerry L. Spivak

Publisher: Elsevier

ISBN: 0080533892

Category: Science

Page: 1065

View: 8679

This book is a centennial volume celebrating the enormous progress made in hematology in the 20th century. It is edited by Marshall Lichtman, a distinguished senior hematologist, past president of the American Society of Hematology, and co-editor of the leading text in the field. Hematology is a compendium, with commentaries, of the most important papers published in the field from 1900-1999. The book will be useful for reference--many of the older papers can no longer be found in most libraries, yet are still referred to in current publications, especially review articles--as well as teaching. The Editor and a team of associate editors have included the most important papers covering eight categories: anemia; phagocytic cells; platelets; coagulation and thrombosis; lymphocytes and immune disorders; transfusion medicine; hematologic malignancies and therapeutics; and laboratory developments. Each paper is accompanied by a 1-2 page commentary explaining its impact, and references to the developments that resulted. Key Features * Contains 86 landmark articles from the last 100 years of research in clinical hematology * Includes expert commentaries discussing the impact of each article * Cites approximately 1000 preceding or subsequent articles of consequence in the commentaries * Includes the English translations of nine articles originally published in other languages * Provides easy access to several papers that may no longer be found in libraries

The Unofficial Guide to Prescribing

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Author: Zeshan Qureshi,Simon R J Maxwell

Publisher: Elsevier Health Sciences

ISBN: 0702055190

Category: Medical

Page: 448

View: 5326

The Unofficial Guide to Prescribing lays out the practical steps of how to assess, investigate and manage a patient, with a focus on what to prescribe and how to prescribe it. Its aim is to empower newly graduated junior doctors to excel at dealing with emergencies and handling complex prescribing scenarios. Prescribing errors cost healthcare systems millions annually, so early training in prescribing has become an urgent priority of medical education and now forms an essential part of teaching and assessment. The Unofficial Guide to Prescribing (from the same stable as The Unofficial Guide to Passing OSCEs) is a new book designed to address this requirement. It is written by junior doctors still close to the transition from theory to practice, overseen by a review panel of senior clinicians to ensure accuracy, and designed to help medical students practise and learn as much as possible about prescribing, in actual clinical scenarios, before they have to do it for real. Each scenario is presented as you would see it in the hospital setting and covers: Initial step-by-step assessment of the patient: how to assess, assessment findings, and immediate management Initial investigations Initial management Reassessment Treatment Handing over the patient 'Prescribe' alerts throughout Written-up drug charts Blank drug charts for copying and practice

Bone Marrow Pathology

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Author: Barbara J. Bain,David M. Clark,Bridget S. Wilkins

Publisher: John Wiley & Sons

ISBN: 1444357514

Category: Medical

Page: 640

View: 6053

Bone Marrow Pathology has been extensively revised to reflect the significant advances which have occurred in the application of cytogenetics and in particular, molecular genetics in the diagnosis, classification and understanding of haematological disorders. This comprehensive book not only provides information on all common disease entities, but also covers rare disorders in which bone marrow examination is useful. It is designed as practical resource with ‘Problems and Pitfalls’ sections throughout to aid laboratory diagnosis. This fourth edition: Incorporates the recommendations of the 2008 WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues Covers key diagnostic techniques such as flow cytometric immunophenotyping, immunohistochemistry and cytogenetic and molecular genetic analysis Includes new diagnostic algorithms and summary boxes Contains 550 colour illustrations including high-quality digital photomicrographs Haematologists and histopathologists will find this book an invaluable desktop reference when performing daily blood and bone marrow investigations.

Sickle Cell Disease in Clinical Practice

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Author: Jo Howard,Paul Telfer

Publisher: Springer

ISBN: 1447124731

Category: Medical

Page: 287

View: 7203

Sickle Cell Disease is the most common genetic disease world wide and in the UK. It has marked geographical variation in its distribution in the UK, with a concentration in London and other major conurbations (Birmingham and Manchester). In these areas, specialist centres have become established offering expert, up to date care for both inpatients and out patients with Sickle Cell Disease. Although patient numbers are increasing outside these areas, the expertise of health professionals can be patchy. This book aims to provide a user friendly, accessible resource for areas with smaller numbers of patients, to allow them to provide equitable care with the larger well established centres. Sickle Cell Disease can be associated with acute life threatening complications, when clear, easily available advice is needed, and with chronic long term complications which may need liaison with other health professionals. Clear treatment protocols for all the common complications of sickle cell disease, are outlined here, with summaries of key evidence and references.

Practical Flow Cytometry in Haematology

100 Worked Examples

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Author: Mike Leach,Mark Drummond,Allyson Doig,Pam McKay,Bob Jackson,Barbara J. Bain

Publisher: John Wiley & Sons

ISBN: 1118747038

Category: Medical

Page: 416

View: 8051

"Provide a practical, example-based resource for flow cytometry"--Provided by publisher.

An Introduction to Forensic Genetics

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Author: William Goodwin,Adrian Linacre,Sibte Hadi

Publisher: John Wiley & Sons

ISBN: 0470010258

Category: Science

Page: 162

View: 3044

An Introduction to Forensic Genetics is a comprehensive introduction to this fast moving area from the collection of evidence at the scene of a crime to the presentation of that evidence in a legal context. The last few years have seen significant advances in the subject and the development and application of genetics has revolutionised forensic science. This book begins with the key concepts needed to fully appreciate the subject and moves on to examine the latest developments in the field, illustrated throughout with references to relevant casework. In addition to the technology involved in generating a DNA profile, the underlying population biology and statistical interpretation are also covered. The evaluation and presentation of DNA evidence in court is discussed as well with guidance on the evaluation process and how court reports and statements should be presented. An accessible introduction to Forensic Genetics from the collection of evidence to the presentation of that evidence in a legal context Includes case studies to enhance student understanding Includes the latest developments in the field focusing on the technology used today and that which is likely to be used in the future Accessible treatment of population biology and statistics associated with forensic evidence This book offers undergraduate students of Forensic Science an accessible approach to the subject that will have direct relevance to their courses. An Introduction to Forensic Genetics is also an invaluable resource for postgraduates and practising forensic scientists looking for a good introduction to the field.

Morphology of Blood Disorders

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Author: Giuseppe d'Onofrio,Gina Zini

Publisher: John Wiley & Sons

ISBN: 111844258X

Category: Medical

Page: 800

View: 9939

Morphology of Blood Disorders, 2nd edition is an outstanding atlas with over 800 high-quality digital images, covering the whole spectrum of blood and bone marrow morphology, with particular emphasis on malignant haematology. Originally written in the Italian language by two world leaders in the field, the book has been expertly translated by the renowned haematologist and teacher, Barbara Bain. This book explores the major topics of haematological pathology, blending classical teaching with up-to-date WHO classification and terminology. Each image in this book is derived from material obtained for diagnostic purposes from patients with serious haematological conditions. Morphological details are supplemented by detailed descriptions of the output and role of automated instruments in disorders of the blood. Morphology of Blood Disorders, 2nd edition is an essential reference source for diagnosis in the haematology laboratory, designed to be the go-to guide for anyone with an interest in blood cell morphology.