Transition Metals in the Synthesis of Complex Organic Molecules

DOWNLOAD NOW »

Author: Louis S. Hegedus

Publisher: University Science Books

ISBN: 9781891389047

Category: Science

Page: 337

View: 9789

This second edition offers easy access to the field of organotransition metal chemistry. The book covers the basics of transition metal chemistry, giving a practical introduction to organotransition reaction mechanisms.

Grundlagen der metallorganischen Komplexkatalyse

DOWNLOAD NOW »

Author: Dirk Steinborn

Publisher: Springer-Verlag

ISBN: 3834893757

Category: Science

Page: 434

View: 7913

Die Katalyse ist als grundlegendes Prinzip zur Überwindung der kinetischen Hemmung chemischer Reaktionen von fundamentaler Bedeutung in der Chemie und die metallorganische Komplexkatalyse ist ein Eckpfeiler der modernen Chemie. Das trifft gleichermaßen für die Grundlagen- und angewandte Forschung wie für industrielle Anwendungen zu. Ausgehend von den Prinzipien der Katalyse und den katalytisch relevanten metallorganischen Elementarschritten werden wichtige metallkomplexkatalysierte Reaktionen behandelt, wobei das mechanistische Verständnis im Vordergrund steht. Besonderer Wert wird dabei auf aktuelle Entwicklungen gelegt. Asymmetrische Synthesen finden ausführlich Berücksichtigung und an ausgewählten Beispielen wird die katalytische Wirkung von Metalloenzymen aufgezeigt. Am Beispiel der Stickstofffixierung werden die drei großen Gebiete der Katalyse – die homogene, die heterogene und die enzymatische Katalyse – vergleichend betrachtet. In der 2. Auflage ist ein neues Kapitel zur Stickstofffixierung hinzugekommen. In diesem werden vergleichend die heterogen katalysierte Reaktion, die enzymatisch katalysierte Reaktion (Nitrogenasen) sowie die homogen katalysierte Reaktion gegenübergestellt.

Transition Metals in Total Synthesis

DOWNLOAD NOW »

Author: Peter J. Harrington

Publisher: Wiley-Interscience

ISBN: N.A

Category: Science

Page: 484

View: 633

Examines the use of transition metal complexes as reagents for the synthesis of complex organic molecules. Presented here are total syntheses whose efficiency depends upon the unique reactivity patterns of organometallic complexes. For each total synthesis, the biological activity of the molecule is presented, followed by discussion of the principles of the organometallic processes involved.

Fundamentals of Molecular Catalysis

DOWNLOAD NOW »

Author: N.A

Publisher: Elsevier

ISBN: 9780080532134

Category: Technology & Engineering

Page: 536

View: 5512

Almost all contemporary organic synthesis involve transition metal complexes as catalysts or particular reagents. The aim of this book is to provide the reader with detailed accounts of elementary processes within molecular catalysis to allow its development and as an aid in designing novel catalytic systems. The book comprises authoritative reviews on elementary processes from experts working at the forefront of organometallic chemistry. · This is the first book that focuses on elementary processes in transition metal complexes for understanding catalytic mechanisms · Provides detailed description of elementary processes involved in catalytic cycles by experts in the field · Provides an overview of the mechanisms of various homogeneous catalyses

Science of Synthesis: Houben-Weyl Methods of Molecular Transformations Vol. 2

Compounds of Groups 7-3 (Mn..., Cr..., V..., Ti..., Sc..., La..., Ac...)

DOWNLOAD NOW »

Author: Tsuneo Imamoto

Publisher: Georg Thieme Verlag

ISBN: 313177911X

Category: Science

Page: 1070

View: 8603

Science of Synthesis provides a critical review of the synthetic methodology developed from the early 1800s to date for the entire field of organic and organometallic chemistry. As the only resource providing full-text descriptions of organic transformations and synthetic methods as well as experimental procedures, Science of Synthesis is therefore a unique chemical information tool. Over 1000 world-renowned experts have chosen the most important molecular transformations for a class of organic compounds and elaborated on their scope and limitations. The systematic, logical and consistent organization of the synthetic methods for each functional group enables users to quickly find out which methods are useful for a particular synthesis and which are not. Effective and practical experimental procedures can be implemented quickly and easily in the lab. // The content of this e-book was originally published in October 2002.

Fundamentals of Organometallic Catalysis

DOWNLOAD NOW »

Author: Dirk Steinborn

Publisher: John Wiley & Sons

ISBN: 3527327177

Category: Science

Page: 456

View: 9699

Catalysis, the basic principle for overcoming the kinetic inhibition of chemical reactions, is fundamental in chemistry. In particular, organometallic catalysis plays an overwhelming role in both research and industry. It opens the way to entirely novel synthetic methods and finds widespread applications ranging from mass-production of everyday polymers to stereocontrolled synthesis of bioactive chemicals used as pharmaceuticals and agrochemicals. The targeted development of improved and novel catalysts demands understanding of the relationships between their structures and catalytic properties. Accordingly, this textbook offers the reader a fundamental understanding of the course of organometallic-catalyzed reactions, starting at the molecular level. The initial chapters explain the principles of catalysis and the elementary steps in organometallic catalysis. The book then explores important organometallic-catalyzed reactions, with a focus on mechanism. Current developments are emphasized throughout. Asymmetric synthesis is covered in depth. Finally, the book examines the catalytic behavior of particular metalloenzymes. A look at nitrogen fixation offers a comparative examination of the three major areas of catalysis - homogeneous, heterogeneous, and enzymatic. In addition to problems, the textbook offers solutions, making the book an invaluable learning tool. It is a must-have for advanced students in chemistry and biochemistry, as well as for inorganic and organic chemists, for those working with organometallics, and for those specializing in catalysis.

Transition Metal Arene P-Complexes in Organic Synthesis and Catalysis

DOWNLOAD NOW »

Author: Peter E. Kündig,A. Böttcher

Publisher: Springer Science & Business Media

ISBN: 9783540016045

Category: Science

Page: 232

View: 5433

Metal-arene p-complexes show a rich and varied chemistry. The metal adds a third dimension to the planar aromatic compounds and coordination of a metal to an arene thus not only altering the reactivity of ring-carbons and substituents but also makes possible reactions that lead to chiral non-racemic products. This book, organized in nine chapters and written by leading scientists in the field provides the reader with an up-to-date treatise on the subject organized according to reaction type and use. It covers the wide spectrum of arene activation: from the electrophilic activation of h6-bound areneï⿬ by p-Lewis acid metal complex fragments, to reactions of nucleophilic h2-coordinated arene complexes. The preparation of complexes is detailed, as are the scope, limitations and challenges of reactions in contemporary p-arene metal chemistry with special attention given to asymmetric transformations. The emphasis of the book is on transformations of interest to organic synthesis and on the use of the complexes as catalysts or as chiral ligands. The book is written for academic and industrial researchers in organic, organometallic, and inorganic chemistry as well as for advanced chemistry students

Transition Metal Catalyzed Carbonylation Reactions

Carbonylative Activation of C-X Bonds

DOWNLOAD NOW »

Author: Matthias Beller,Xiao-Feng Wu

Publisher: Springer Science & Business Media

ISBN: 3642390161

Category: Science

Page: 228

View: 5919

Transition Metal Catalyzed Carbonylation Reactions is a comprehensive monograph focusing on carbon monoxide usage. This book provides students and researchers in organic synthesis with a detailed discussion of carbonylation from the basics through to applications. The authors have structured the book around the types of reactions, based on the different nucleophiles involved. Scientists working in carbonylation or with carbon monoxide, as well as teachers of organic synthesis can use this book to become familiar with this important area of organic chemistry.

Ruthenium in Organic Synthesis

DOWNLOAD NOW »

Author: Shun-Ichi Murahashi

Publisher: John Wiley & Sons

ISBN: 3527605797

Category: Science

Page: 398

View: 9657

In this comprehensive book, one of the leading experts, Shun-Ichi Murahashi, presents all the important facets of modern synthetic chemistry using Ruthenium, ranging from hydrogenation to metathesis. In 14 contributions, written by an international authorship, readers will find all the information they need about this fascinating and extraordinary chemistry. The result is a high quality information source and a indispensable reading for everyone working in organometallic chemistry. From the contents: Introduction (S.-I. Murahashi) Hydrogenation and Transfer Hydrogenation (M. Kitamura and R. Noyori) Oxidations (S.-I. Murahashi and N. Komiya) Carbon-Carbon Bond Formations via Ruthenacycle Intermediates (K. Itoh) Carbon-Carbon Bond Formation via pi-Allylruthenium Intermediates (T. Mitsudo) Olefin Metathesis (R. H. Grubbs) Cyclopropanation (H. Nishiyama) Nucleophilic Addition to Alkynes and Reactions via Vinylidene Intermediates (P. Dixneuf) Reactions via C-H Activation (N. Chatani) Lewis Acid Reactions (E. P. Kundig) Reactions with CO and CO2 (T. Mitsudo) Isomerization of Organic Substrates Catalyzed by Ruthenium Complexes (H. Suzuki) Radical Reactions (H. Nagashima) Bond Cleavage Reactions (S. Komiya)

Multicomponent Reactions in Organic Synthesis

DOWNLOAD NOW »

Author: Jieping Zhu,Qian Wang,Meixiang Wang

Publisher: John Wiley & Sons

ISBN: 3527332375

Category: Science

Page: 512

View: 9428

Comprehensive and up–to–date, this book focuses on the latest advances in the field, such as newly developed techniques, more environmentally benign processes, broadened scopes, and completely novel MCRs. In addition to carbene–promoted MCRs and frequently applied metal–catalyzed MCRs, it also covers recently developed catalytic enantioselective variants as well as MCR in drug discovery and for the synthesis of heterocyclic molecules and macrocycles. Edited by the leading experts and with a list of authors reading like a "who′s who" in multicomponent reaction chemistry, this is definitely a must–have for every synthetic organic chemist as well as medicinal chemists working in academia and pharmaceutical companies.

Chirality in Transition Metal Chemistry

Molecules, Supramolecular Assemblies and Materials

DOWNLOAD NOW »

Author: Hani Amouri,Michel Gruselle

Publisher: John Wiley & Sons

ISBN: 047072160X

Category: Science

Page: 260

View: 1960

Chirality in Transition Metal Chemistry is an essential introduction to this increasingly important field for students and researchers in inorganic chemistry. Emphasising applications and real-world examples, the book begins with an overview of chirality, with a discussion of absolute configurations and system descriptors, physical properties of enantiomers, and principles of resolution and preparation of enantiomers. The subsequent chapters deal with the the specifics of chirality as it applies to transition metals. Some reviews of Chirality in Transition Metal Chemistry "...useful to students taking an advanced undergraduate course and particularly to postgraduates and academics undertaking research in the areas of chiral inorganic supramolecular complexes and materials." Chemistry World, August 2009 “...the book offers an extremely exciting new addition to the study of inorganic chemistry, and should be compulsory reading for students entering their final year of undergraduate studies or starting a Ph.D. in structural inorganic chemistry.” Applied Organometallic Chemistry Volume 23, Issue 5, May 2009 “...In conclusion the book gives a wonderful overview of the topic. It is helpful for anyone entering the field through systematic and detailed introduction of basic information. It was time to publish a new and topical text book covering the important aspect of coordination chemistry. It builds bridges between Inorganic, organic and supramolecular chemistry. I can recommend the book to everybody who is interested in the chemistry of chiral coordination compounds .” Angew. chem. Volume 48, Issue 18, April 2009 About the Series Chirality in Transition Metal Chemistry is the latest addition to the Wiley Inorganic Chemistry Advanced Textbook series. This series reflects the pivotal role of modern inorganic and physical chemistry in a whole range of emerging areas such as materials chemistry, green chemistry and bioinorganic chemistry, as well as providing a solid grounding in established areas such as solid state chemistry, coordination chemistry, main group chemistry and physical inorganic chemistry.

Tin in Organic Synthesis

DOWNLOAD NOW »

Author: Michel Pereyre,Jean-Paul Quintard,Alain Rahm

Publisher: Butterworth-Heinemann

ISBN: 1483161072

Category: Science

Page: 352

View: 5639

Tin in Organic Synthesis is a systematic presentation of the organic chemistry of tin. This book discusses the significant advances that have been made with regard to the applications of organotin compounds as reagents or intermediates in organic synthesis and points out directions for future developments. This monograph is comprised of 17 chapters divided into four sections. Following a brief introduction to organotin chemistry, the production of the organotin reagents, which are most usually employed in organic synthesis, is described. Special emphasis is placed on the creation of a fresh tin-carbon bond, a preliminary step in numerous fruitful applications. The following chapters are devoted to synthetic applications involving tin-hydrogen, tin-carbon, and tin-heteroatom bonds. The reduction of organic halides, carbonyl compounds, thio, nitrogen compounds, unsaturated carbon-carbon bonds, and seleno and telluro compounds is considered. The discussion then turns to electrophilic cleavages of tin-carbon bonds, which are of possible interest in organic synthesis, along with transmetallation and metallation of organotin compounds. The creation of new carbon-carbon bonds through substitution, addition, or elimination reactions is also examined. The remaining chapters focus on organotin alkoxides, organotin enolates, organotin oxides and peroxides, and organotin esters. This book will be of interest to students and researchers in the field of organic chemistry.

Modern Colorants: Synthesis and Structure

DOWNLOAD NOW »

Author: A.T. Peters,H.S. Freeman

Publisher: Springer Science & Business Media

ISBN: 9780751402094

Category: Science

Page: 245

View: 1693

Although the research actIvItIes of dyestuff chemists worldwide have been influenced to a great extent, in recent years, by the need to respond to a variety of environmental issues associated with the manufacture and application of synthetic dyes and pigments, a significant level of targeted research continues to be devoted to new chemistry aimed at enhancing the technical properties of dyes in commerce. This book is a presentation of various aspects of basic research conducted during the past decade but not reported in the recent review literature. The coverage herein is unique in that it emphasizes systematic approaches commonly utilized in the design and synthesis of dyes and pigments and the required intermediates. While it is well known that certain transition metals are important in the synthesis of technically viable metallized dyes for polyamide and protein fibers, these metals are demonstrated in Chapter 1 also to be effective agents in the regiospecific placement of substituents into azo compounds. The scope and limitations of this chemistry are presented. In other synthetic work, a description of the different processes employed to produce the major families of reactive dyes is presented. In Chapter 4, special attention is given to reactive dyes containing more than one reactive group, and to the more recent developments in the field. The two chapters which follow provide a review of the recent literature pertaining to novel chromophores and dyes for the D2T2 process, respectively.

Synthetic Methods of Organometallic and Inorganic Chemistry, Volume 7, 1997

Volume 7: Transition Metals

DOWNLOAD NOW »

Author: W. A. Herrmann

Publisher: Georg Thieme Verlag

ISBN: 3131794712

Category: Science

Page: 306

View: 3493

Designed as a benchtop tool, the series includes detailed and reliable experimental procedures for the preparation of common but imp ortant starting compounds, organized according to the periodic table. Properties of the compounds and additional references are also provided. In most cases, no strict borderline has been drawn between inorganic and organometallic compounds. Instead, the material is conveniently presented so that for every group of elements, the various aspects of the chemistry are combined. Several hundred in ternational specialists with established expertise in their respective fields have contributed, resulting in proven and reliable pre parations. In view of the enormous growth of organometallic chemistry, Synthetic Methods of Organometallic and Inorganic Chemistry p rovides you with a balanced compilation of carefully selected and representative examples for all classes of compounds. // The conte nt of this e-book was originally published in 1997.

Science of Synthesis: Houben-Weyl Methods of Molecular Transformations Vol. 7

Compounds of Groups 13 and 2 (Al, Ga, In, Tl, Be...Ba)

DOWNLOAD NOW »

Author: N.A

Publisher: Georg Thieme Verlag

ISBN: 3131779616

Category: Science

Page: 802

View: 3296

Science of Synthesis provides a critical review of the synthetic methodology developed from the early 1800s to date for the entire field of organic and organometallic chemistry. As the only resource providing full-text descriptions of organic transformations and synthetic methods as well as experimental procedures, Science of Synthesis is therefore a unique chemical information tool. Over 1000 world-renowned experts have chosen the most important molecular transformations for a class of organic compounds and elaborated on their scope and limitations. The systematic, logical and consistent organization of the synthetic methods for each functional group enables users to quickly find out which methods are useful for a particular synthesis and which are not. Effective and practical experimental procedures can be implemented quickly and easily in the lab. // The content of this e-book was originally published in July 2004.

Principles of Asymmetric Synthesis

DOWNLOAD NOW »

Author: R.E. Gawley,J. Aubé

Publisher: Elsevier

ISBN: 9780080514772

Category: Science

Page: 394

View: 7392

The world is chiral. Most of the molecules in it are chiral, and asymmetric synthesis is an important means by which enantiopure chiral molecules may be obtained for study and sale. Using examples from the literature of asymmetric synthesis (more than 1300 references), the aim of this book is to present a detailed analysis of the factors that govern stereoselectivity in organic reactions. It is important to note that the references were each individually checked by the authors to verify relevance to the topics under discussion. The study of stereoselectivity has evolved from issues of diastereoselectivity, through auxiliary-based methods for the synthesis of enantiomerically pure compounds (diastereoselectivity followed by separation and auxiliary cleavage), to asymmetric catalysis. In the latter instance, enantiomers (not diastereomers) are the products, and highly selective reactions and modern purification techniques allow preparation - in a single step - of chiral substances in 99% ee for many reaction types. After an explanation of the basic physical-organic principles of stereoselectivity, the authors provide a detailed, annotated glossary of stereochemical terms. A chapter on "Analytical Methods" provides a critical overview of the most common methods for analysis of stereoisomers. The authors then follow the 'tried-and-true' format of grouping the material by reaction type. Thus, there are four chapters on carbon-carbon bond forming reactions (enolate alkylations, organometal additions to carbonyls, aldol and Michael reactions, and cycloadditions and rearrangements), one chapter on reductions and hydroborations (carbon-hydrogen bond forming reactions), and one on oxidations (carbon-oxygen and carbon-nitrogen bond forming reactions). Leading references are provided to natural product synthesis that have been accomplished using a given reaction as a key step. In addition to tables of examples that show high selectivity, a transition state analysis is presented to explain - to the current level of understanding - the stereoselectivity of each reaction. In one case (Cram's rule) the evolution of the current theory is detailed from its first tentative (1952) postulate to the current Felkin-Anh-Heathcock formalism. For other reactions, only the currently accepted rationale is presented. Examination of these rationales also exposes the weaknesses of current theories, in that they cannot always explain the experimental observations. These shortcomings provide a challenge for future mechanistic investigations.

Perspectives in Organometallic Chemistry

DOWNLOAD NOW »

Author: Constantinos G. Screttas,Barry R. Steele

Publisher: Royal Society of Chemistry

ISBN: 9780854048762

Category: Science

Page: 322

View: 3659

This title presents informed accounts of state-of-the-art research which will be of great interest to readers.

Catalytic Reductive Carbonylation of Organic Nitro Compounds

DOWNLOAD NOW »

Author: S. Cenini,F. Ragaini

Publisher: Springer Science & Business Media

ISBN: 9780792343073

Category: Science

Page: 340

View: 2543

About eight years ago, the catalytic carbonylation of organic nitro compounds was a research field developed enough to justify a rather long review on this subject. Now, we feel that the scientific results and new achievements in this field, very important even from an industrial point of view, require a book in order to be adequately presented. The competition between the catalytic carbonylation of organic nitro compounds and other chemical routes for the synthesis of a variety of organic compounds has not yet come to an end, but many progresses have been done in the former field. We also like to emphasize that this type of research does not only involve relevant industrial problems to be solved, but it opens a research field where the academic interests (mechanism of the reactions, isolation of the intermediates in the catalytic cycles, synthesis of model compounds and so on) can find a lot of opportunities.