The Path to the Double Helix

The Discovery of DNA

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Author: Robert Olby

Publisher: Courier Corporation

ISBN: 0486166597

Category: Science

Page: 560

View: 5858

Written by a noted historian of science, this in-depth account traces how Watson and Crick achieved one of science's most dramatic feats: their 1953 discovery of the molecular structure of DNA.

Francis Crick

Hunter of Life's Secrets

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Author: Robert Cecil Olby

Publisher: N.A

ISBN: N.A

Category: Biography & Autobiography

Page: 538

View: 8434

"In Francis Crick: Hunter of Life's Secrets, Robert Olby presents a full-length intellectual biography of Crick's life in science. After early life in Northampton, Crick gained experience as a scientist for the Royal Navy during World War II, before beginning academic studies in biophysics. His pioneering work in molecular biology in the 1950s and 1960s took place in Cambridge, and was followed by his move to the United States in 1976 and his work in neuroscience at the Salk Institute. Olby's detailed exploration of Crick's scientific life up to the famous 1953 discovery and beyond provides a clear demonstration of how chance does indeed favor the prepared mind.".

Life Explained

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Author: Michel Morange

Publisher: Yale University Press

ISBN: 0300142390

Category: SCIENCE

Page: 222

View: 449

Fifty years ago Francis Crick and James D. Watson proposed the double helix model for the DNA molecule. They believed they had, as Crick put it, discovered the secret of life, and many agreed. But in the intervening years, science has marched sometimes leaped forward, and now the question What is life? must be posed once again.In this accessible and fascinating book, Michel Morange draws on recent advances in molecular genetics, evolutionary biology, astrobiology, and other disciplines to find today s answers to the question of life. He begins by discussing the various answers that have been formulated in the past, setting contemporary definitions of life within a rich philosophical and scientific tradition that reaches back to ancient Greece. Then, with impeccable logic and a wealth of appropriate detail, Morange proceeds to lay out the fundamental characteristics that define life. The road to an understanding of life remains incompletely charted, he concludes, but the nature of its final destination is no longer an enigma."

Maurice Wilkins: The Third Man of the Double Helix

An Autobiography

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Author: Maurice Wilkins

Publisher: OUP Oxford

ISBN: 0191578142

Category: Biography & Autobiography

Page: 314

View: 6092

The Nobel Prize for the discovery of the structure of DNA was given to three scientists - James Watson, Francis Crick, and Maurice Wilkins. It was the experimental work of Wilkins and his colleague Rosalind Franklin that provided the clues to the structure. Here, Wilkins, who died in 2004, gives us his own account of his life, his early work in physics, the tensions and exhilaration of working on DNA, and his much discussed difficult relationship with his colleague Rosalind. This is a highly readable, and often moving account from a highly distinguished scientist who played one of the key roles in the historic discovery of the molecule behind inheritance.

DE EVOLUTION

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Author: Jeff Frank

Publisher: Page Publishing Inc

ISBN: 1684096626

Category: Fiction

Page: N.A

View: 4812

A large sophisticated telescope complex sits atop a dormant volcano in one of Earth's most remote locations. Some incredibly bright but fiercely independent folks operate it much of the time. They detect, map, and perform threat analysis of near-Earth objects. Shortly after the world narrowly escapes an extinction event, they start collecting pieces of a related cosmic puzzle. When they've connected enough of them, an intriguing and disturbing picture emerges. Yet the most revealing pieces don't reveal themselves until after all life on Earth already has begun marching in lockstep toward possible oblivion.

Molecular Biology

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Author: Burton E. Tropp

Publisher: Jones & Bartlett Publishers

ISBN: 0763786632

Category: Science

Page: 1097

View: 8071

"Molecular Biology: Genes to Proteins is a guide through the basic molecular processes and genetic phenomena of both prokaryotic and eukaryotic cells. Written for the undergraduate and first year graduate students within molecular biology or molecular genetics, the text has been updated with the latest data in the field. It incorporates a biochemical approach as well as a discovery approach that provides historical and experimental information within the context of the narrative."--Publisher.

DNA: A Graphic Guide to the Molecule that Shook the World

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Author: Israel Rosenfield,Edward Ziff,Borin Van Loon

Publisher: Columbia University Press

ISBN: 0231512317

Category: Science

Page: 272

View: 5720

With humor, depth, and philosophical and historical insight, DNA reaches out to a wide range of readers with its graphic portrayal of a complicated science. Suitable for use in and out of the classroom, this volume covers DNA's many marvels, from its original discovery in 1869 to early-twentieth-century debates on the mechanisms of inheritance and the deeper nature of life's evolution and variety. Even readers who lack a background in science and philosophy will learn a tremendous amount from this engaging narrative. The book elucidates DNA's relationship to health and the cause and cure of disease. It also covers the creation of new life forms, nanomachines, and perspectives on crime detection, and considers the philosophical sources of classical Darwinian theory and recent, radical changes in the understanding of evolution itself. Already these developments have profoundly affected our notions about living things. Borin Van Loon's humorous illustrations recount the contributions of Gregor Mendel, Frederick Griffith, James Watson, and Francis Crick, among other biologists, scientists, and researchers, and vividly depict the modern controversies surrounding the Human Genome Project and cloning.

Principles of Molecular Biology

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Author: Burton E. Tropp

Publisher: Jones & Bartlett Publishers

ISBN: 144964791X

Category: Science

Page: 752

View: 3168

Includes access to the Student Companion Website with every print copy of the text. Written for the more concise course, Principles of Molecular Biology is modeled after Burton Tropp's successful Molecular Biology: Genes to Proteins and is appropriate for the sophomore level course. The author begins with an introduction to molecular biology, discussing what it is and how it relates to applications in "real life" with examples pulled from medicine and industry. An overview of protein structure and function follows, and from there the text covers the various roles of technology in elucidating the central concepts of molecular biology, from both a historical and contemporary perspective. Tropp then delves into the heart of the book with chapters focused on chromosomes, genetics, replication, DNA damage and repair, recombination, transposition, transcription, and wraps up with translation. Key Features: - Presents molecular biology from a biochemical perspective, utilizing model systems, as they best describe the processes being discussed -Special Topic boxes throughout focus on applications in medicine and technology -Presents "real world" applications of molecular biology that are necessary for students continuing on to medical school or the biotech industry -An end-of-chapter study guide includes questions for review and discussion -Difficult or complicated concepts are called-out in boxes to further explain and simplify

Science Vs. Religion

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Author: Steve Fuller

Publisher: Polity

ISBN: 0745641210

Category: Philosophy

Page: 179

View: 6764

For centuries, science and religion have been portrayed as diametrically opposed. In this provocative new book, Steve Fuller examines the apparent clash between science and religion by focusing on the heated debates about evolution and intelligent design theory. In so doing, he claims that science vs. religion is in fact a false dichotomy. For Fuller, supposedly intellectual disputes, such as those between creationist and evolutionist accounts of life, often disguise other institutionally driven conflicts, such as the struggle between State and Church to be the source of legitimate authority in society. Nowadays many conservative anti-science groups support intelligent design theory, but Fuller argues that the theory's theological roots are much more radical, based on the idea that humans were created to fathom the divine plan, perhaps even complete it. He goes on to examine the unique political circumstances in the United States that make the emergence of intelligent design theory so controversial, yet so persistent. Finally, he considers the long-term prognosis, arguing that the future remains very much undecided as society reopens the question of what it means to be human. This book will appeal to all readers intrigued by the debates about creationism, intelligent design and evolution, especially those looking for an intellectually exciting confrontation with the politics and promise of intelligent design theory.

Synthetic Biology

Science, Business, and Policy

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Author: Lewis D. Solomon

Publisher: Transaction Publishers

ISBN: 1412846471

Category: Science

Page: 174

View: 2253

For nearly forty years, using recombinant DNA tools, researchers, and then businesses, have genetically engineered organisms by transferring naturally occurring genes from one organism into another. Doing so modifies the genetic code of living cells, imparting new traits and achieving desired results; this is done in the production of proteins, pharmaceuticals, and seeds. Synthetic biology, argues Solomon, could free scientists from the need to find natural genes to make such desired modifications. Synthetic biology permits more complex and sophisticated bioengineering than what can be achieved through previous genetic modification techniques. Drawing on non-biological scientific and engineering disciplines, including information technology and nanotechnology, synthetic biology strives to rearrange an organism’s genes on a far wider scale by rewriting its genetic code, the chemical instructions need to design, assemble, and operate a species. By allowing the writing of artificial genetic codes, synthetic biology can transform existing industries and spawn new ones, creating new products as well as radically reshaping existing items. Arguing for self-regulation by the scientific and business communities, Lewis D. Solomon recommends a policy framework that would guard against governmental overregulation, which could create a barrier to innovation. Although synthetic biotechnology holds considerable social and economic potential, absent a nurturing regulatory climate, it may prove difficult to translate research discoveries into commercially viable applications.

What is Life?

With Mind and Matter and Autobiographical Sketches

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Author: Erwin Schrodinger

Publisher: Cambridge University Press

ISBN: 1107604664

Category: Philosophy

Page: 184

View: 5350

"What Is Life?" is Nobel laureate Erwin Schrödinger's exploration of the question which lies at the heart of biology. His essay, "Mind and Matter," investigates what place consciousness occupies in the evolution of life, and what part the state of development of the human mind plays in moral questions. "Autobiographical Sketches" offers a fascinating fragmentary account of his life as a background to his scientific writings.

The Man Who Invented the Chromosome

the life of Cyril Darlington

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Author: Oren Solomon HARMAN,Oren Solomon Harman

Publisher: Harvard University Press

ISBN: 0674038339

Category: Biography & Autobiography

Page: 342

View: 2570

Rosalind Franklin

The Dark Lady of DNA

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Author: Brenda Maddox

Publisher: Harper Collins

ISBN: 0062283502

Category: Biography & Autobiography

Page: 416

View: 9345

In 1962, Maurice Wilkins, Francis Crick, and James Watson received the Nobel Prize, but it was Rosalind Franklin's data and photographs of DNA that led to their discovery. Brenda Maddox tells a powerful story of a remarkably single-minded, forthright, and tempestuous young woman who, at the age of fifteen, decided she was going to be a scientist, but who was airbrushed out of the greatest scientific discovery of the twentieth century.

Genes, Girls and Gamow

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Author: James D. Watson

Publisher: Oxford University Press, USA

ISBN: 0198606931

Category: Molecular biologists

Page: 275

View: 1953

In 1953 Watson and Crick discovered the double helical structure of DNA and Watson's personal account of the discovery, The Double Helix, was published in 1968. Genes, Girls and Gamow is also autobiographical, covering the period from when The Double Helix ends, in 1953, to a few years later, and ending with a Postscript bringing the story up to date. Here is Watson adjusting to new-found fame, carrying out tantalizing experiments on the role of RNA in biology, and falling in love. Thebook is enlivened with copies of handwritten letters from the larger than life character George Gamow, who had made significant contributions to physics but became intrigued by genes, RNA and the elusive genetic code. This is a tale of heartbreak, scientific excitement and ambition, laced with travelogue and '50s atmosphere.

Lehninger Principles of Biochemistry

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Author: Albert L. Lehninger,David L. Nelson,Michael M. Cox

Publisher: Macmillan

ISBN: 9780716743392

Category: Medical

Page: 1119

View: 6614

CD-ROM includes animations, living graphs, biochemistry in 3D structure tutorials.

A Passion for DNA

Genes, Genomes, and Society

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Author: James D. Watson

Publisher: OUP Oxford

ISBN: 9780198604280

Category: Science

Page: 250

View: 5671

In 1953, two young and unknown scientists, James Watson and Francis Crick, sparked a worldwide revolution with their discovery of the molecular composition of DNA. In this collection of outspoken and topical essays, speeches and reports, Watson offers his unique insight into the advance of molecular genetics, the prospect of curing cancer over the next decade, how human genetic knowledge is likely to be used, particularly in relation to cloning and genetically modified food, as well as shedding light on his early life and career.

CRC Handbook of Viruses

Mass-Molecular Weight Values and Related Properties

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Author: Horace M. Mazzone

Publisher: CRC Press

ISBN: 9780849326257

Category: Science

Page: 224

View: 8935

As a distinct class of macromolecules, viruses are continually being studied in order to determine their properties. Following a knowledge of host-range infectivity, the particle mass-molecular weight of the virus and related properties - including size, shape, sedimentation, and diffusion coefficients - are also important characterizations. In the literature, these values have been determined for many viruses, and a variety of techniques are available by which such properties may be analyzed. Until now, there has been no single source for such information that the interested investigator may consult, and no databases provided this kind of information. CRC Handbook of Viruses: Mass-Molecular Weight Values and Related Properties corrects this deficiency by presenting such data for all classes of viruses; centering on viruses, their molecular weight, and their related properties; and acquainting the investigator to many methods for obtaining the mass-molecular weight value of viruses. This singular study explains the variety of methods available to the researcher as well as provides examples of each method. Molecular weight values are accessed directly from the book, saving the investigator a tedious search through the range of literature. Chapters discuss: Viruses as infectious agents and their role in establishing the relatively new discipline of molecular biology Essential components of viruses, protein, and nucleic acid - considering their discovery, nature, structural organization, and the forming of viruses from nucleoproteins Basic aspects of virus purification, preparative centrifuge, and various purification methods Basic aspects of crystallography, including procedures, x-ray analysis of the viral protein component, the arranging of subunits, and the composition of the intact virus Sedimentation experiments and studies used to obtain molecular weight Sedimentation and diffusion coefficients integral to the basic Svedberg equation Sedimentation equilibrium procedures The new Beckman Optima series of analytical ultracentrifuges Scattering studies, including small angle x-ray, small angle neutron, classical light scattering, and electron microscopy The renaissance of instrumentation in classical light scattering techniques Cold neutron facilities currently being set into operation by government laboratories Sizing and solvation of viruses in solution - their "natural environment" Critical modeling experiments Facilities and instrumentation for molecular weight studies - including the high voltage transmission electron microscope for obtaining mass values of viral inclusion bodies CRC Handbook of Viruses serves the: Researcher seeking values of virus molecular weight and related parameters Investigator getting started in virology and seeking information on physical chemical procedures Student interested in viruses as infectious agents

Chemical Achievers

The Human Face of the Chemical Sciences

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Author: Mary Ellen Bowden

Publisher: Chemical Heritage Foundation

ISBN: 9780941901123

Category: Biography & Autobiography

Page: 180

View: 6021

A collection of photographs and biographical information intended to help teachers present "the human face of science. ... The format and special binding of the book allow for easy conversion to overhead transparencies."--Cover.

The Meanings of the Gene

Public Debates about Human Heredity

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Author: Celeste Michelle Condit

Publisher: Univ of Wisconsin Press

ISBN: 9780299163648

Category: Social Science

Page: 325

View: 516

The Meanings of the Gene is a compelling look at societal hopes and fears about genetics in the course of the twentieth century. The work of scientists and doctors in advancing genetic research and its applications has been accompanied by plenty of discussion in the popular press—from Good Housekeeping and Forbes to Ms. and the Congressional Record—about such topics as eugenics, sterilization, DNA, genetic counseling, and sex selection. By demonstrating the role of rhetoric and ideology in public discussions about genetics, Condit raises the controversial question, Who shapes decisions about genetic research and its consequences for humans—scientists, or the public? Analyzing hundreds of stories from American magazines—and, later, television news—from the 1910s to the 1990s, Condit identifies three central and enduring public worries about genetics: that genes are deterministic arbiters of human fate; that genetics research can be used for discriminatory ends; and that advances in genetics encourage perfectionistic thinking about our children. Other key public concerns that Condit highlights are the complexity of genetic decision-making and potential for invasion of privacy; conflict over the human genetic code and experimentation with DNA; and family genetics and reproductive decisions. Her analysis reveals a persistent debate in the popular media between themes of genetic determinism (such as eugenics) and more egalitarian views that place genes within the complexity of biological and social life. The Meanings of the Gene offers an insightful view of our continuing efforts to grapple with our biological natures and to define what it means, and will mean in the future, to be human.

The History and Poetics of Scientific Biography

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Author: Dr Thomas Söderqvist

Publisher: Ashgate Publishing, Ltd.

ISBN: 1409479641

Category: History

Page: 286

View: 4004

Biographies of scientists carry an increasingly prominent role in today's publishing climate. Traditional historical and sociological accounts of science are complemented by narratives that emphasize the importance of the scientific subject in the production of science. Not least is the realization that the role of science in culture is much more accessible when presented through the lives of its practitioners. Taken as a genre, such biographies play an important role in the public understanding of science. In recent years there has been an increasing number of monographs and collections about biography in general and literary biography in particular. However, biographies of scientists, engineers and medical doctors have rarely been the topic of scholarly inquiry. As such this volume of essays will be welcomed by those interested in the genre of science biography, and who wish to re-examine its history, foundational problems and theoretical implications. Borrowing approaches and methods from cultural studies and the history, philosophy and sociology of science, the contributions cover a broad range of subjects, periods and locations. By presenting such a rich diversity of essays, the volume is able to chart the reoccurring conceptual problems and devices that have influenced scientific biographies from classical antiquity to the present day. In so doing it provides a compelling overview of the history of the genre, suggesting that the different valuations given scientific biography over time have been largely fuelled by vested professional interests.