The Minipig in Biomedical Research

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Author: Peter A. McAnulty,Anthony D. Dayan,Niels-Christian Ganderup,Kenneth L. Hastings

Publisher: CRC Press

ISBN: 1439811199

Category: Medical

Page: 662

View: 4778

The Minipig in Biomedical Research is a comprehensive resource for research scientists on the potential and use of the minipig in basic and applied biomedical research, and the development of drugs and chemicals. Written by acknowledged experts in the field, and drawing on the authors’ global contacts and experience with regulatory authorities and the pharmaceutical and other industries, this accessible manual ranges widely over the biological, scientific, and practical uses of the minipig in the laboratory. Its coverage extends from the minipig’s origins, anatomy, genetics, immunology, and physiology to its welfare, health, and husbandry; practical dosing and examination procedures; surgical techniques; and all areas of toxicity testing and the uses of the minipig as a disease model. Regulatory aspects of its use are considered. The reader will find an extensive amount of theoretical and practical information in the pharmacology; ADME and toxicology chapters which will help scientists and managers when deciding which species to use in basic research; drug discovery and pharmacology; and toxicology studies of chemicals, biotechnology products and devices. The book discusses regulatory uses of minipigs in the evaluation of human and veterinary pharmaceuticals, medical devices, and other classes of xenobiotics. It describes features of normal health, normal laboratory values, and common diseases. It also carefully elucidates ethical and legal considerations in their supply, housing, and transport. The result is an all-inclusive and up to date manual about the experimental uses of the minipig that describes ‘How to’ and ‘Why’ and ’What to expect in the normal’, combining enthusiasm and experience with critical assessment of its values and potential problems.

Advances in Swine in Biomedical Research

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Author: Mike E. Tumbleson,Lawrence B. Schook

Publisher: Springer Science & Business Media

ISBN: 9780306454967

Category: Medical

Page: 905

View: 435

Contains papers from the October 1995 symposium, in sections on methods and techniques, and nutrition. Subjects include the Yucatan miniature pig model of ventricular septal defect, the minipig as a model for the study of aging in humans, an external thoracic duct venous shunt to allow for long-term

Animal Models in Toxicology, Third Edition

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Author: Shayne C. Gad

Publisher: CRC Press

ISBN: 1466554290

Category: Medical

Page: 1152

View: 4315

Animal Models in Toxicology is a single-source reference for the use of animal models in toxicology. Chapters cover nine species used in toxicology and experimental biology. With contributions from experts in toxicology, toxicological pathology, and species-specific metabolism, each of these chapters provides an excellent introductory "course" along with guidance to the literature for a more detailed understanding. This edition includes five new chapters. The first of these provides specific and detailed guidance on the humane, efficient, and effective performance of necropsies for laboratory animals. Other new chapters discuss new technologies available for laboratory animal research—imaging technologies, use of telemetry in animal studies, transgenic animal models, and immunology endpoint for assessment. Also provided is an overview of the increasingly complex laws and regulations that govern how laboratory animals are obtained, maintained, and utilized. A helpful appendix provides a quick guide to commercial sources of laboratory animals.

The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment

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Author: Joerg Bluemel,Sven Korte,Emanuel Schenck,Gerhard Weinbauer

Publisher: Academic Press

ISBN: 012417146X

Category: Medical

Page: 716

View: 8885

The Nonhuman Primate in Drug Development and Safety Assessment is a valuable reference dedicated to compiling the latest research on nonhuman primate models in nonclinical safety assessment, regulatory toxicity testing and translational science. By covering important topics such as study planning and conduct, inter-species genetic drift, pathophysiology, animal welfare legislation, safety assessment of biologics and small molecules, immunotoxicology and much more, this book provides scientific and technical insights to help you safely and successfully use nonhuman primates in pharmaceutical toxicity testing. A comprehensive yet practical guide, this book is intended for new researchers or practicing toxicologists, toxicologic pathologists and pharmaceutical scientists working with nonhuman primates, as well as graduate students preparing for careers in this area. Covers important topics such as species selection, study design, experimental methodologies, animal welfare and the 3Rs (Replace, Refine and Reduce), social housing, regulatory guidelines, comparative physiology, reproductive biology, genetic polymorphisms and more Includes practical examples on techniques and methods to guide your daily practice Offers a companion website with high-quality color illustrations, reference values for safety assessment and additional practical information such as study design considerations, techniques and procedures and dosing and sampling volumes

Drug Safety Evaluation

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Author: Shayne Cox Gad

Publisher: John Wiley & Sons

ISBN: 1119097401

Category: Medical

Page: 918

View: 3446

This practical guide presents a road map for safety assessment as an integral part of the development of new drugs and therapeutics. Helps readers solve scientific, technical, and regulatory issues in preclinical safety assessment and early clinical drug development Explains scientific and philosophical bases for evaluation of specific concerns – including local tissue tolerance, target organ toxicity and carcinogenicity, developmental toxicity, immunogenicity, and immunotoxicity Covers the development of new small and large molecules, generics, 505(b)(2) route NDAs, and biosimilars Revises material to reflect new drug products (small synthetic, large proteins and cells, and tissues), harmonized global and national regulations, and new technologies for safety evaluation Adds almost 20% new and thoroughly updates existing content from the last edition

Swine in the Laboratory

Surgery, Anesthesia, Imaging, and Experimental Techniques, Second Edition

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Author: M. Michael Swindle

Publisher: CRC Press

ISBN: 9781420009156

Category: Medical

Page: 496

View: 1200

To diminish the learning curve associated with using swine as models, Swine in the Laboratory: Surgery, Anesthesia, Imaging, and Experimental Techniques, Second Edition provides practical technical information for the use of swine in biomedical research. The book focuses on models produced by surgical and other invasive procedures, supplying the basic principles for performing experiments with an organ or system of interest. New to the Second Edition Updated sections on anesthesia and perioperative care, including practical information for more complex models Expansion of anatomic and physiologic details Additional detail in the endoscopy section Chapters on toxicology and radiobiology Chapters that include angiographic, echocardiographic, CT, MRI, and PET imaging techniques with a corresponding DVD of the images More tables of normal values on the most commonly used minipigs and domestic breeds Beneficial for investigators, veterinarians, and technicians using swine for experimental and agricultural procedures, Swine in the Laboratory is certain to foster the appropriate, humane use of swine in biomedical research.

Sourcebook of Models for Biomedical Research

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Author: P. Michael Conn

Publisher: Springer Science & Business Media

ISBN: 1588299333

Category: Medical

Page: 778

View: 8727

The collection of systems represented in this volume is a unique effort to reflect the diversity and utility of models used in biomedicine. That utility is based on the consideration that observations made in particular organisms will provide insight into the workings of other, more complex systems. This volume is therefore a comprehensive and extensive collection of these important medical parallels.

Molecular and Functional Models in Neuropsychiatry

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Author: Jim J. Hagan

Publisher: Springer Science & Business Media

ISBN: 9783642197031

Category: Medical

Page: 394

View: 3460

The development of more effective treatments for neuropsychiatric disorders requires scientific progress on a broad front. Animal models have a vital role to play in advancing the field. When deployed in conjunction with detailed study of these diseases in man they bring the power to make controlled experimental interventions which allow the functional consequences of genetic variations and polymorphisms to be understood in terms of their cellular, systems and behavioural effects. Further, they provide a means by which complex cognitive and behavioural phenomena may be dissected and understood. Finally, they provide a bridge to understanding the effects of drugs on the functioning of the central nervous system, thereby improving our understanding of the actions of those drugs in man.

Use of Non-human Primates in Biomedical Research

International Symposium Held in New Delhi, India, November 3-8, 1975

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Author: Malur R. Narasimha Prasad,T. C. Anand Kumar

Publisher: N.A

ISBN: N.A

Category: Biological research

Page: 426

View: 7142

The Welfare of Laboratory Animals

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Author: Eila Kaliste

Publisher: Springer Science & Business Media

ISBN: 1402022719

Category: Science

Page: 346

View: 8955

This book examines the general principles of laboratory animal maintenance and experimental use as well as factors that have to be taken into account when good research is done with animals. In addition, it provides species specific coverage, concentrating on the species most used as laboratory animals. The book gives a comprehensive description of the welfare questions considered to be important for each species under laboratory conditions.