The Minipig in Biomedical Research

DOWNLOAD NOW »

Author: Peter A. McAnulty,Anthony D. Dayan,Niels-Christian Ganderup,Kenneth L. Hastings

Publisher: CRC Press

ISBN: 1439811199

Category: Medical

Page: 662

View: 9935

The Minipig in Biomedical Research is a comprehensive resource for research scientists on the potential and use of the minipig in basic and applied biomedical research, and the development of drugs and chemicals. Written by acknowledged experts in the field, and drawing on the authors’ global contacts and experience with regulatory authorities and the pharmaceutical and other industries, this accessible manual ranges widely over the biological, scientific, and practical uses of the minipig in the laboratory. Its coverage extends from the minipig’s origins, anatomy, genetics, immunology, and physiology to its welfare, health, and husbandry; practical dosing and examination procedures; surgical techniques; and all areas of toxicity testing and the uses of the minipig as a disease model. Regulatory aspects of its use are considered. The reader will find an extensive amount of theoretical and practical information in the pharmacology; ADME and toxicology chapters which will help scientists and managers when deciding which species to use in basic research; drug discovery and pharmacology; and toxicology studies of chemicals, biotechnology products and devices. The book discusses regulatory uses of minipigs in the evaluation of human and veterinary pharmaceuticals, medical devices, and other classes of xenobiotics. It describes features of normal health, normal laboratory values, and common diseases. It also carefully elucidates ethical and legal considerations in their supply, housing, and transport. The result is an all-inclusive and up to date manual about the experimental uses of the minipig that describes ‘How to’ and ‘Why’ and ’What to expect in the normal’, combining enthusiasm and experience with critical assessment of its values and potential problems.

Advances in Swine in Biomedical Research

DOWNLOAD NOW »

Author: Mike E. Tumbleson,Lawrence B. Schook

Publisher: Springer Science & Business Media

ISBN: 9780306454967

Category: Medical

Page: 905

View: 3341

Contains papers from the October 1995 symposium, in sections on methods and techniques, and nutrition. Subjects include the Yucatan miniature pig model of ventricular septal defect, the minipig as a model for the study of aging in humans, an external thoracic duct venous shunt to allow for long-term

Sourcebook of Models for Biomedical Research

DOWNLOAD NOW »

Author: P. Michael Conn

Publisher: Springer Science & Business Media

ISBN: 1588299333

Category: Medical

Page: 778

View: 5047

The collection of systems represented in this volume is a unique effort to reflect the diversity and utility of models used in biomedicine. That utility is based on the consideration that observations made in particular organisms will provide insight into the workings of other, more complex systems. This volume is therefore a comprehensive and extensive collection of these important medical parallels.

Animal Models in Toxicology, Third Edition

DOWNLOAD NOW »

Author: Shayne C. Gad

Publisher: CRC Press

ISBN: 1466554290

Category: Medical

Page: 1152

View: 4232

Animal Models in Toxicology is a single-source reference for the use of animal models in toxicology. Chapters cover nine species used in toxicology and experimental biology. With contributions from experts in toxicology, toxicological pathology, and species-specific metabolism, each of these chapters provides an excellent introductory "course" along with guidance to the literature for a more detailed understanding. This edition includes five new chapters. The first of these provides specific and detailed guidance on the humane, efficient, and effective performance of necropsies for laboratory animals. Other new chapters discuss new technologies available for laboratory animal research—imaging technologies, use of telemetry in animal studies, transgenic animal models, and immunology endpoint for assessment. Also provided is an overview of the increasingly complex laws and regulations that govern how laboratory animals are obtained, maintained, and utilized. A helpful appendix provides a quick guide to commercial sources of laboratory animals.

The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment

DOWNLOAD NOW »

Author: Joerg Bluemel,Sven Korte,Emanuel Schenck,Gerhard Weinbauer

Publisher: Academic Press

ISBN: 012417146X

Category: Medical

Page: 716

View: 6300

The Nonhuman Primate in Drug Development and Safety Assessment is a valuable reference dedicated to compiling the latest research on nonhuman primate models in nonclinical safety assessment, regulatory toxicity testing and translational science. By covering important topics such as study planning and conduct, inter-species genetic drift, pathophysiology, animal welfare legislation, safety assessment of biologics and small molecules, immunotoxicology and much more, this book provides scientific and technical insights to help you safely and successfully use nonhuman primates in pharmaceutical toxicity testing. A comprehensive yet practical guide, this book is intended for new researchers or practicing toxicologists, toxicologic pathologists and pharmaceutical scientists working with nonhuman primates, as well as graduate students preparing for careers in this area. Covers important topics such as species selection, study design, experimental methodologies, animal welfare and the 3Rs (Replace, Refine and Reduce), social housing, regulatory guidelines, comparative physiology, reproductive biology, genetic polymorphisms and more Includes practical examples on techniques and methods to guide your daily practice Offers a companion website with high-quality color illustrations, reference values for safety assessment and additional practical information such as study design considerations, techniques and procedures and dosing and sampling volumes

Animal Models in Toxicology, Third Edition

DOWNLOAD NOW »

Author: Shayne C. Gad

Publisher: CRC Press

ISBN: 1466554290

Category: Medical

Page: 1152

View: 8213

Animal Models in Toxicology is a single-source reference for the use of animal models in toxicology. Chapters cover nine species used in toxicology and experimental biology. With contributions from experts in toxicology, toxicological pathology, and species-specific metabolism, each of these chapters provides an excellent introductory "course" along with guidance to the literature for a more detailed understanding. This edition includes five new chapters. The first of these provides specific and detailed guidance on the humane, efficient, and effective performance of necropsies for laboratory animals. Other new chapters discuss new technologies available for laboratory animal research—imaging technologies, use of telemetry in animal studies, transgenic animal models, and immunology endpoint for assessment. Also provided is an overview of the increasingly complex laws and regulations that govern how laboratory animals are obtained, maintained, and utilized. A helpful appendix provides a quick guide to commercial sources of laboratory animals.

The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment

DOWNLOAD NOW »

Author: Joerg Bluemel,Sven Korte,Emanuel Schenck,Gerhard Weinbauer

Publisher: Academic Press

ISBN: 012417146X

Category: Medical

Page: 716

View: 7038

The Nonhuman Primate in Drug Development and Safety Assessment is a valuable reference dedicated to compiling the latest research on nonhuman primate models in nonclinical safety assessment, regulatory toxicity testing and translational science. By covering important topics such as study planning and conduct, inter-species genetic drift, pathophysiology, animal welfare legislation, safety assessment of biologics and small molecules, immunotoxicology and much more, this book provides scientific and technical insights to help you safely and successfully use nonhuman primates in pharmaceutical toxicity testing. A comprehensive yet practical guide, this book is intended for new researchers or practicing toxicologists, toxicologic pathologists and pharmaceutical scientists working with nonhuman primates, as well as graduate students preparing for careers in this area. Covers important topics such as species selection, study design, experimental methodologies, animal welfare and the 3Rs (Replace, Refine and Reduce), social housing, regulatory guidelines, comparative physiology, reproductive biology, genetic polymorphisms and more Includes practical examples on techniques and methods to guide your daily practice Offers a companion website with high-quality color illustrations, reference values for safety assessment and additional practical information such as study design considerations, techniques and procedures and dosing and sampling volumes

Drug Safety Evaluation

DOWNLOAD NOW »

Author: Shayne Cox Gad

Publisher: John Wiley & Sons

ISBN: 1119097401

Category: Medical

Page: 918

View: 3258

This practical guide presents a road map for safety assessment as an integral part of the development of new drugs and therapeutics. Helps readers solve scientific, technical, and regulatory issues in preclinical safety assessment and early clinical drug development Explains scientific and philosophical bases for evaluation of specific concerns – including local tissue tolerance, target organ toxicity and carcinogenicity, developmental toxicity, immunogenicity, and immunotoxicity Covers the development of new small and large molecules, generics, 505(b)(2) route NDAs, and biosimilars Revises material to reflect new drug products (small synthetic, large proteins and cells, and tissues), harmonized global and national regulations, and new technologies for safety evaluation Adds almost 20% new and thoroughly updates existing content from the last edition

Swine in the Laboratory

Surgery, Anesthesia, Imaging, and Experimental Techniques, Second Edition

DOWNLOAD NOW »

Author: M. Michael Swindle

Publisher: CRC Press

ISBN: 9781420009156

Category: Medical

Page: 496

View: 8254

To diminish the learning curve associated with using swine as models, Swine in the Laboratory: Surgery, Anesthesia, Imaging, and Experimental Techniques, Second Edition provides practical technical information for the use of swine in biomedical research. The book focuses on models produced by surgical and other invasive procedures, supplying the basic principles for performing experiments with an organ or system of interest. New to the Second Edition Updated sections on anesthesia and perioperative care, including practical information for more complex models Expansion of anatomic and physiologic details Additional detail in the endoscopy section Chapters on toxicology and radiobiology Chapters that include angiographic, echocardiographic, CT, MRI, and PET imaging techniques with a corresponding DVD of the images More tables of normal values on the most commonly used minipigs and domestic breeds Beneficial for investigators, veterinarians, and technicians using swine for experimental and agricultural procedures, Swine in the Laboratory is certain to foster the appropriate, humane use of swine in biomedical research.

Oink

My Life with Mini-Pigs

DOWNLOAD NOW »

Author: Matt Whyman

Publisher: Simon and Schuster

ISBN: 145161828X

Category: Biography & Autobiography

Page: 314

View: 8216

"The memoir of a family of six living in a quiet part of England who, though not farmers, decide to buy two mini-pigs"--

Haschek and Rousseaux's Handbook of Toxicologic Pathology

DOWNLOAD NOW »

Author: Wanda M. Haschek,Colin G. Rousseaux,Matthew A. Wallig

Publisher: Academic Press

ISBN: 0124157653

Category: Medical

Page: 3054

View: 793

Haschek and Rousseaux's Handbook of Toxicologic Pathology is a key reference on the integration of structure and functional changes in tissues associated with the response to pharmaceuticals, chemicals and biologics. The 3e has been expanded by a full volume, and covers aspects of safety assessment not discussed in the 2e. Completely revised with many new chapters, it remains the most authoritative reference on toxicologic pathology for scientists and researchers studying and making decisions on drugs, biologics, medical devices and other chemicals, including agrochemicals and environmental contaminants. New topics include safety assessment, the drug life cycle, risk assessment, communication and management, carcinogenicity assessment, pharmacology and pharmacokinetics, biomarkers in toxicologic pathology, quality assurance, peer review, agrochemicals, nanotechnology, food and toxicologic pathology, the environment and toxicologic pathology and more. Provides new chapters and in-depth discussion of timely topics in the area of toxicologic pathology and broadens the scope of the audience to include toxicologists and pathologists working in a variety of settings Offers high-quality and trusted content in a multi-contributed work written by leading international authorities in all areas of toxicologic pathology Features hundreds of full color images in both the print and electronic versions of the book to highlight difficult concepts with clear illustrations

Mitochondrial DNA, Mitochondria, Disease and Stem Cells

DOWNLOAD NOW »

Author: Justin C. St. John

Publisher: Springer Science & Business Media

ISBN: 1627031014

Category: Science

Page: 190

View: 1569

This volume investigates how the mitochondrial genome is transmitted, segregated, and inherited. It starts by describing mtDNA mutations and deletions and how these impact on the offspring’s well-being. It progresses to discuss how mutations to the mtDNA-nuclear-encoded transcription, replication and translational factors lead to mtDNA-depletion syndromes and how these affect cellular function and lead to the pathology of human mitochondrial disease. It also highlights the importance of the mitochondrial assembly factors and how mutations to these can lead to mitochondrial disease. The reader is then introduced to how mtDNA is transmitted through the oocyte and how stem cells can be used to study mitochondrial biogenesis and mtDNA replication and transcription in undifferentiated pluripotent and differentiating cells and how mitochondria adapt during this process. It then discusses how diseases like cancer are initiated and regulated by mutations to mitochondrial DNA and dysfunctional mitochondria. Finally, it draws on assisted reproductive technologies to discuss how some of these approaches might be adapted to prevent the transmission of mutant and deleted mtDNA from one generation to the next.

Three Dimensional Microanatomy of Cells and Tissue Surfaces

Proceedings of the Symposium on Three Dimensional Microanatomy held in Mexico City, Mexico, August 17-23, 1980

DOWNLOAD NOW »

Author: Delmas J. Allen,Pietro M. Motta,Liberato J. A. DiDio

Publisher: Elsevier

ISBN: 1483281159

Category: Science

Page: 382

View: 882

Three Dimensional Microanatomy of Cells and Tissue Surfaces focuses on the use of scanning electron microscopy in the study of the microanatomy of cells and tissues, cell relationships, and complex biological relationships. The selection first elaborates on the technical aspects of stereoprojection for electron microscopy; three-dimensional microanatomy of intracellular structures; microcirculation studies by the injection-replica method with special reference to portal circulations; and three-dimensional architecture of the mammalian liver. Discussions focus on the preparation of vascular casts, portal circulations of various organs, scanning electron microscopy, copying and printing stereopair negatives, stereoprojection, and high voltage electron microscopy. The text then takes a look at scanning electron microscope bloodvessel casts analysis, three dimensional microanatomy of reticular tissues, kidney glomerular epithelium in response to different physiological states and experimental conditions, and mammalian renal papilla and pelvis. The manuscript examines the lung in scanning electron microscopy and stereopresentation, surface topography of endocardial endothelium, scanning electron microscopy of endothelium, human vas deferens, and seminal vesicles, and dynamic morphology of the apical membrane of lactating cells viewed by freeze-fracture. The selection is a valuable reference for researchers interested in the use of scanning electron microscopy in the study of the microanatomy of cells and tissues and biological relationships.

The Laboratory Swine

DOWNLOAD NOW »

Author: Peter J. A. Bollen,Axel K. Hansen,Aage K Olsen Alstrup

Publisher: CRC Press

ISBN: 0849310350

Category: Medical

Page: 152

View: 6511

With their representation in research on the rise because of refinement in animal experimentation, swine, and miniature swine in particular, are viewed as an alternative non-rodent species to commonly used non-rodent species, such as dogs and primates. Written to provide a complete source of information on the species, this handy guide addresses the biology, husbandry, management, veterinary care and research application of the laboratory swine. The Laboratory Swine, a volume in the Laboratory Animal Pocket Reference Series, is divided into six parts: Part I, Important Biological Features, examines everything from different breeds and behavior, to anatomical and physiological features, as well as digestive, cardiovascular and pulmonary systems. Husbandry, Part II, addresses housing, nutrition, sanitation, transportation, and more. Management and Quality Assurance looks at the impact of infections on animal research using swine; zoonotic diseases; legal regulations; genetic monitoring and more. Part IV, Veterinary Care, covers a variety of topics, such as clinical examination of swine, diseases of swine, pain recognition in swine, and post-operative management. Restraint, sampling techniques, basic surgical procedures, and other issues are addressed in Experimental Techniques. And Resources, Part VI, provides extensive references, including as handbooks, journals and Internet sites, for further study. Ideal for animal caretakers, technicians, investigators, and laboratory animal veterinarians, The Laboratory Swine is a single source reference that contributes to the humane care and use of swine in research.

Handbook of Fertility

Nutrition, Diet, Lifestyle and Reproductive Health

DOWNLOAD NOW »

Author: Ronald Ross Watson

Publisher: Academic Press

ISBN: 0128009934

Category: Medical

Page: 452

View: 1141

Handbook of Fertility: Nutrition, Diet, Lifestyle and Reproductive Health focuses on the ways in which food, dietary supplements, and toxic agents, including alcohol and nicotine affect the reproductive health of both women and men. Researchers in nutrition, diet, epidemiology, and endocrinology will find this comprehensive resource invaluable in their long-term goal of understanding and improving reproductive health. This book brings together a broad range of experts researching the different aspects of foods and dietary supplements that promote or detract from reproductive health. Section One contains several overview chapters on fertility, how it is assessed, and how it can be affected by different metabolic states, nutritional habits, dietary supplements, the action of antioxidants, and lifestyle choices. Sections Two and Three consider how male and female fertility are affected by obesity, metabolic syndrome, hormonal imbalance, and even bariatric surgery. Section Four explores the ways diet, nutrition, and lifestyle support or retard the success of in vitro fertilization, while Section Five explores how alcohol and other drugs of abuse lower fertility in both women and men. Explores how alcohol, nicotine, and other drugs of abuse disrupt and impair reproductive health Reviews studies of common conditions such as obesity and metabolic syndrome and their effect on fertility and reproductive health Investigates the components of foods and dietary supplements, in particular oxidative stress and antioxidants Presents the nutritional effects of foods and dietary supplements and their benefits and risks relating to reproductive health

Metabolite Safety in Drug Development

DOWNLOAD NOW »

Author: Suzanne L. Iverson

Publisher: John Wiley & Sons

ISBN: 111894965X

Category: Medical

Page: 352

View: 3433

A reference on drug metabolism and metabolite safety in the development phase, this book reviews the analytical techniques and experimental designs critical for metabolite studies. It features case studies of lessons learned and real world examples, along with regulatory perspectives from the US FDA and EMA. • Reviews the analytical techniques and experimental designs critical for metabolite studies • Covers methods including chirality, species differences, mass spectrometry, radiolabels, and in vitro / in vivo correlation • Discusses target pharmacology, in vitro systems aligned to toxicity tests, and drug-drug interactions • Includes perspectives from authors with firsthand involvement in industry and the study of drug metabolites, including viewpoints that have influenced regulatory guidelines

Dynamic Behavior of Materials, Volume 1

Proceedings of the 2016 Annual Conference on Experimental and Applied Mechanics

DOWNLOAD NOW »

Author: Dan Casem,Leslie Lamberson,Jamie Kimberley

Publisher: Springer

ISBN: 3319411322

Category: Technology & Engineering

Page: 290

View: 2918

Dynamic Behavior of Materials, Volume 1 of the Proceedings of the 2016 SEM Annual Conference& Exposition on Experimental and Applied Mechanics, the first volume of ten from the Conference, brings together contributions to this important area of research and engineering. The collection presents early findings and case studies on fundamental and applied aspects of Experimental Mechanics, including papers on: Quantitative Visualization Fracture & Fragmentation Dynamic Behavior of Low Impedance Materials Shock & Blast Dynamic Behavior of Composites Novel Testing Techniques Hybrid Experimental & Computational Methods Dynamic Behavior of Geo-materials General Material Behavior

Biomarkers in Toxicology

DOWNLOAD NOW »

Author: Ramesh C. Gupta

Publisher: Academic Press

ISBN: 0124046495

Category: Medical

Page: 1152

View: 2494

Biomarkers in Toxicology is a timely and comprehensive reference dedicated to all aspects of biomarkers that relate to chemical exposure and their effects on biological systems. This book includes both vertebrate and non-vertebrate species models for toxicological testing and development of biomarkers. Divided into several key sections, this reference volume contains chapters devoted to topics in molecular-cellular toxicology, as well as a look at the latest cutting-edge technologies used to detect biomarkers of exposure and effects. Each chapter also contains several references to the current literature and important resources for further reading. Given this comprehensive treatment, Biomarkers in Toxicology is an essential reference for all those interested in biomarkers across several scientific and biomedical fields. Written by international experts who have evaluated the expansive literature to provide you with one resource covering all aspects of toxicology biomarkers Identifies and discusses the most sensitive, accurate, unique and validated biomarkers used as indicators of exposure and effect of chemicals of different classes Covers special topics and applications of biomarkers, including chapters on molecular toxicology biomarkers, biomarker analysis for nanotoxicology, development of biomarkers for drug efficacy evaluation and much more

The Welfare of Laboratory Animals

DOWNLOAD NOW »

Author: Eila Kaliste

Publisher: Springer Science & Business Media

ISBN: 1402022719

Category: Science

Page: 346

View: 2032

This book examines the general principles of laboratory animal maintenance and experimental use as well as factors that have to be taken into account when good research is done with animals. In addition, it provides species specific coverage, concentrating on the species most used as laboratory animals. The book gives a comprehensive description of the welfare questions considered to be important for each species under laboratory conditions.