Reaction Mechanisms in Organic Synthesis

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Author: Rakesh Kumar Parashar

Publisher: John Wiley & Sons

ISBN: 1118681231

Category: Science

Page: 304

View: 2797

Organic chemistry is a core part of the chemistry curricula, andadvanced levels texts often obscure the essential frameworkunderlying and uniting the vast numbers of reactions as a result ofthe high level of detail presented. The material in this book iscondensed into a manageable text of 350 pages and presented in aclear and logical fashion, focusing purely on the basics of thesubject without going through exhaustive detail or repetitiveexamples. The book aims to bridge the gap between undergraduateorganic chemistry textbooks and advanced level textbooks, beginningwith a basic introductory course and arranging the reactionmechanisms according to an ascending order of difficulty. As such,the author believes the book will be excellent primer for advancedpostgraduates Reaction Mechanisms in Organic Synthesis is written fromthe point of view of the synthetic organic chemist, enablingstudents and researchers to understand and expand on reactionscovered in foundation courses, and to apply them in a practicalcontext by designing syntheses. As a further aid to the practicalresearch student, the content is organized according to theconditions under which a reaction is executed rather than by thetypes of mechanisms. Particular emphasis is placed on controllingstereospecificity and regiospecificity. Topics covered include: Transition metal mediated carbon-carbon bond formationreactions Use of stabilized carbanions, ylides and enamines forcarbon-carbon bond formation reactions, Advanced level use of oxidation and reduction reagents insynthesis. As a modern text, this book stands out from its competitors dueto its comprehensive coverage of recently published research. Thebook contains specific examples from the latest literature,covering modern reactions and the latest procedural modifications.The focus on contemporary and synthetically useful reactionsensures that the contents are specifically relevant and attractiveto postgraduate students and industrial organic chemists.

Electrochemical Reactions and Mechanisms in Organic Chemistry

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Author: J. Grimshaw

Publisher: Elsevier

ISBN: 9780080530727

Category: Science

Page: 416

View: 8425

Electrochemical reactions make significant contributions to organic synthesis either in the laboratory or on an industrial scale. These methods have the potential for developing more "green" chemical synthesis. Over recent years, modern investigations have clarified the mechanisms of important organic electrochemical reactions. Progress has also been made in controlling the reactivity of intermediates through either radical or ionic pathways. Now is the time to gather all the electrochemical work into a textbook. As an essential addition to the armory of synthetic organic chemists, electrochemical reactions give results not easily achieved by many other chemical routes. This book presents a logical development of reactions and mechanisms in organic electrochemistry at a level suited to research scientists and final year graduate students. It forms an excellent starting point from which synthetic organic chemists, in both academia and industry, can appreciate uses for electrochemical methods in their own work. The book is also a reference guide to the literature.

Organic Mechanisms

Reactions, Stereochemistry and Synthesis

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Author: Reinhard Bruckner

Publisher: Springer Science & Business Media

ISBN: 3642036503

Category: Science

Page: 855

View: 6027

This English edition of a best-selling and award-winning German textbook Reaction Mechanisms: Organic Reactions · Stereochemistry · Modern Synthetic Methods is aimed at those who desire to learn organic chemistry through an approach that is facile to understand and easily committed to memory. Michael Harmata, Norman Rabjohn Distinguished Professor of Organic Chemistry (University of Missouri) surveyed the accuracy of the translation, made certain contributions, and above all adapted its rationalizations to those prevalent in the organic chemistry community in the English-speaking world. Throughout the book fundamental and advanced reaction mechanisms are presented with meticulous precision. The systematic use of red "electron-pushing arrows" allows students to follow each transformation elementary step by elementary step. Mechanisms are not only presented in the traditional contexts of rate laws and substituent effects but, whenever possible, are illustrated using practical, useful and state-of-the-art reactions. The abundance of stereoselective reactions included in the treatise makes the reader familiar with key concepts of stereochemistry. The fundamental topics of the book address the needs of upper-level undergraduate students, while its advanced sections are intended for graduate-level audiences. Accordingly, this book is an essential learning tool for students and a unique addition to the reference desk of practicing organic chemists, who as life-long learners desire to keep abreast of both fundamental and applied aspects of our science. In addition, it will well serve ambitious students in chemistry-related fields such as biochemistry, medicinal chemistry and pharmaceutical chemistry. From the reviews: "Professor Bruckner has further refined his already masterful synthetic organic chemistry classic; the additions are seamless and the text retains the magnificent clarity, rigour and precision which were the hallmark of previous editions. The strength of the book stems from Professor Bruckner’s ability to provide lucid explanations based on a deep understanding of physical organic chemistry and to limit discussion to very carefully selected reaction classes illuminated by exquisitely pertinent examples, often from the recent literature. The panoply of organic synthesis is analysed and dissected according to fundamental structural, orbital, kinetic and thermodynamic principles with an effortless coherence that yields great insight and never over-simplifies. The perfect source text for advanced Undergraduate and Masters/PhD students who want to understand, in depth, the art of synthesis ." Alan C. Spivey, Imperial College London "Bruckner’s ‘Organic Mechanisms’ accurately reflects the way practicing organic chemists think and speak about organic reactions. The figures are beautifully drawn and show the way organic chemists graphically depict reactions. It uses a combination of basic valence bond pictures with more sophisticated molecular orbital treatments. It handles mechanisms both from the "electron pushing perspective" and from a kinetic and energetic view. The book will be very useful to new US graduate students and will help bring them to the level of sophistication needed to be serious researchers in organic chemistry." Charles P. Casey, University of Wisconsin-Madison "This is an excellent advanced organic chemistry textbook that provides a key resource for students and teachers alike." Mark Rizzacasa, University of Melbourne, Australia.

Advanced Problems in Organic Reaction Mechanisms

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Author: Alexander McKillop

Publisher: Elsevier

ISBN: 9780080432557

Category: Science

Page: 153

View: 2750

This book is a collection of 300 problems which challenge the user to devise reasonable mechanistic interpretations for sets of experimental observations. Almost all of the problems are taken from the literature of the last twenty years. Each is a separate entity, although similar mechanistic themes occur in several quite different problems. Answers are not given, nor are references to the original literature. The user who fails to solve a particular problem and reaches an appropriate level of frustration should be able, relatively quickly, to locate the original literature from the information given in the problem. For senior undergraduate and graduate students of organic chemistry and all teachers of organic chemistry.

Organic Reaction Mechanisms

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Author: Rakesh Kumar Parashar

Publisher: CRC PressI Llc

ISBN: 9780849381669

Category: Science

Page: 639

View: 3306

This book, written explicitly for graduate and postgraduate students of chemistry, provides an extensive coverage of various organic reactions and rearrangements with emphasis on there application in synthesis. A summary of oxidation and reduction of organic compounds is given in tabular form (correlation tables) for the convenience of students. The most commonly encountered reaction intermediates are dealt with. Applications of organic reagents illustrated with examples and problems at the end of each chapter will enable students to evaluate their understanding of the topic. Book jacket.

Name Reactions and Reagents in Organic Synthesis

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Author: Bradford P. Mundy,Michael G. Ellerd,Frank G. Favaloro, Jr.

Publisher: John Wiley & Sons

ISBN: 0471739863

Category: Science

Page: 950

View: 7547

This Second Edition is the premier name resource in the field. It provides a handy resource for navigating the web of named reactions and reagents. Reactions and reagents are listed alphabetically, followed by relevant mechanisms, experimental data (including yields where available), and references to the primary literature. The text also includes three indices based on reagents and reactions, starting materials, and desired products. Organic chemistry professors, graduate students, and undergraduates, as well as chemists working in industrial, government, and other laboratories, will all find this book to be an invaluable reference.

Strategic Applications of Named Reactions in Organic Synthesis

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Author: Laszlo Kurti,Barbara Czako

Publisher: Elsevier

ISBN: 0080575412

Category: Science

Page: 864

View: 966

Kurti and Czako have produced an indispensable tool for specialists and non-specialists in organic chemistry. This innovative reference work includes 250 organic reactions and their strategic use in the synthesis of complex natural and unnatural products. Reactions are thoroughly discussed in a convenient, two-page layout--using full color. Its comprehensive coverage, superb organization, quality of presentation, and wealth of references, make this a necessity for every organic chemist. * The first reference work on named reactions to present colored schemes for easier understanding * 250 frequently used named reactions are presented in a convenient two-page layout with numerous examples * An opening list of abbreviations includes both structures and chemical names * Contains more than 10,000 references grouped by seminal papers, reviews, modifications, and theoretical works * Appendices list reactions in order of discovery, group by contemporary usage, and provide additional study tools * Extensive index quickly locates information using words found in text and drawings

Name Reactions and Reagents in Organic Synthesis

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Author: Bradford P. Mundy

Publisher: Wiley-Interscience

ISBN: N.A

Category: Science

Page: 546

View: 3395

Current indexing schemes do not list reactions and reagents as commonly as they used to. This volume is an up-to-date and concise compilation of the most commonly used and widely known name reactions and reagents in modern synthetic organic chemistry. Reactions are listed alphabetically, each listing providing either an accepted or proposed mechanism, secondary information, and four to five referenced examples. Reactions are cross-referenced to Jerry March's Advanced Organic Chemistry. The second section lists reagents alphabetically, each entry giving structure, physical properties, major uses, preparation and commercial availability, necessary precautions, secondary information, and four to five referenced examples. Reagents are cross-referenced to the Fieser & Fieser series, Reagents for Organic Synthesis, through volume 12.

Advanced Organic Chemistry

Reaction Mechanisms

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Author: Reinhard Bruckner

Publisher: Academic Press

ISBN: 9780121381103

Category: Science

Page: 636

View: 2195

Contents - Radical Substitution Reactions at the Saturated C Atom. Nucleophilic Substitution Reactions at the Saturated C Atom. Additions to the Olefinic C=C Double Bond. Eliminations Substitution Reactions on Aromatic Compounds. Nucleophilic Substitution Reactions (Except Through Enolates) on the Carboxyl Carbon. Additions of Heteroatom Nucleophiles to Heterocumulenes. Additions of Heteroatom Nucleophiles to Carbonyl Compounds and Their Secondary Reactions. Addition of H Nucleophiles and Metal Organyls to Carbonyl Compounds. Reaction of Ylides with Saturated or Unsaturated Carbonyl Compounds. Chemistry of the Alkaline Earth Metal Enolates. Rearrangements. Thermal Cycloadditions. Transition Metal-Mediated Alkenylations, Arylations and Alkynylations. Oxidations and Reductions.

Organic Reactions And Their Mechanisms

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Author: P S Kalsi

Publisher: New Age International

ISBN: 9788122412680

Category: Chemical reactions

Page: 666

View: 5837

This Revised Edition Includes Several New Topics To Make The Treatment More Comprehensive And Contemporary. The Exposition In Several Chapters Has Also Been Recast To Facilitate An Easier Understanding Of The Subject. * Molecular Orbital And Bonding Thoroughly Explained. * Resonance Structures And Allylic Systems Included. * Organic Acids And Bases Explained In Detail With Additional Examples. * Discussion Of Organic Reactions Considerably Expanded. * Various Additional Dimensions Of Photochemistry Highlighted. * A New Chapter On Special Topics Included.With Its Clear And Systematic Presentation, This Is An Essential Text For B.Sc. And M.Sc. Chemistry Students.

Name Reactions

A Collection of Detailed Reaction Mechanisms

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Author: Jie Jack Li

Publisher: Springer Science & Business Media

ISBN: 3662053365

Category: Science

Page: 465

View: 1609

This book differs from others on name reactions in organic chemistry by focusing on their mechanisms. It covers over 300 classical as well as contemporary name reactions. Biographical sketches for the chemists who discovered or developed those name reactions have been included. Each reaction is delineated by its detailed step-by-step, electron-pushing mechanism, supplemented with the original and the latest references, especially review articles. This book contains major improvements over the previous edition and the subject index is significantly expanded.

Enzymatic Reactions in Organic Media

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Author: A. Koskinen,A. Klibanov

Publisher: Springer Science & Business Media

ISBN: 9401106118

Category: Science

Page: 314

View: 8606

The outlook of organic synthesis has changed many times during its tractable history. The initial focus on the synthesis of substances typical of living matter, exemplified by the first examples of organic chemistry through the synthesis of urea from inorganic substances by Liebig, was accepted as the birth of organic chemistry, and thus also of organic synthesis. Although the early developments in organic synthesis closely followed the pursuit of molecules typical in nature, towards the end of the 19th century, societal pressures placed higher demands on chemical methods appropriate for the emerging age of industrialization. This led to vast amounts of information being generated through the discovery of synthetic reactions, spectroscopic techniques and reaction mechanisms. The basic organic functional group transformations were discovered and improved during the early part of this century. Reaction mechanisms were elucidated at a growing pace, and extremely powerful spectroscopic tools, such as infrared, nuclear magnetic resonance and mass spectrometry were introduced as everyday tools for a practising organic chemist. By the 1950s, many practitioners were ready to agree that almost every molecule could be syn thesized. Some difficult stereochemical problems were exceptions; for example Woodward concluded that erythromycin was a "hopelessly complex target". This frustration led to a hectic phase of development of new and increasingly more ingenious protecting group strategies and functional group transformations, and also saw the emergence of asymmetric synthesis.

Organic Reactions Stereochemistry And Mechanism (Through Solved Problems)

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Author: P S Kalsi

Publisher: New Age International

ISBN: 9788122417661

Category: Physical organic chemistry

Page: 608

View: 4572

The Book Provides A Self-Study Of Different Topics Of Organic Chemistry Viab Problem Solving. The Present 4Th Edition Has Been Completely Rewritten According To The Organic Chemistry Syllabus Of The Net (Csir) Examination. This Necessitated The Deletion Of Several Topics From The Third Edition And Incorporation Of New Ones. Emphasis Has Been Laid On A Variety Of New Reactions, Name Reactions, Reagents In Organic Synthesis And Incorporation Of Their Knowledge In The Entire Coverage Of Organic Chemistry In A Unique Way.A Thorough Study Of The Book Is Expected To Help The Student To Excel Not Only In The University Examination Including The Net Examination, But Also In His Learning Of Various Topics And Before Interview Boards. Several Topics Like Aromaticity, Pericyclic Reactions And Heterocyclic Chemistry Have Now Been Brought Up To Date And The Material Provided Is Complete In Itself.The Presentation Has Been So Designed So As To Thread Through The Entire Organic Chemistry By The Application Of The Knowledge Learnt In One Topic To Newer Situations In Other Topics. The Present Revised Edition Also Includes Numerous Important Developments Since The Third Edition Of The Book Was Published.

Radical Reactions in Organic Synthesis

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Author: Samir Z. Zard

Publisher: Oxford University Press on Demand

ISBN: 9780198502401

Category: Philosophy

Page: 256

View: 7332

Introduction and some general concepts. -- General principles: chain reactions based on stannane chemistry. -- Further chain reactions of stannanes. -- Organo-silicon, -germanium, and -mercury hydrides. -- The Barton decarboxylation and related reactions. -- Atom and group transfer reactions. -- The persistent radical effect: non-chain processes. -- Redox processes. -- Some concluding remarks.

Principles of Organic Synthesis, 3rd Edition

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Author: Richard O.C. Norman

Publisher: Routledge

ISBN: 1351421727

Category: Science

Page: 828

View: 433

This book is designed for those who have had no more than a brief introduction to organic chemistry and who require a broad understanding of the subject. The book is in two parts. In Part I, reaction mechanism is set in its wider context of the basic principles and concepts that underlie chemical reactions: chemical thermodynamics, structural theory, theories of reaction kinetics, mechanism itself and stereochemistry. In Part II these principles and concepts are applied to the formation of particular types of bonds, groupings, and compounds. The final chapter in Part II describes the planning and detailed execution of the multi-step syntheses of several complex, naturally occurring compounds.

Click Reactions in Organic Synthesis

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Author: Srinivasan Chandrasekaran

Publisher: John Wiley & Sons

ISBN: 3527694153

Category: Science

Page: 360

View: 8010

This book on click reactions to focus on organic synthesis, this reference work describes the click concept and underlying mechanisms as well as the main applications in various fields. As such, the chapters cover green chemical synthesis, metal-free click reactions, synthesis of pharmaceuticals, peptides, carbohydrates, DNA, macrocycles, dendrimers, polymers, and supramolecular architectures. By filling a gap in the market, this is the ultimate reference for synthetic chemists in academia and industry aiming for a fast and simple design and synthesis of novel compounds with useful properties.

Organic Reaction Mechanisms

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Author: V. K. Ahluwalia,Rakesh Kumar Parashar

Publisher: Alpha Science International Limited

ISBN: 9781842656785

Category: Science

Page: 749

View: 1226

This book, written for graduate and post-graduate chemistry students, provides an extensive coverage of various organic reactions, rearrangements and reagents, with emphasis on their applications in organic synthesis. In the chapters on oxidation and reduction a summary of oxidation and reduction of organic compounds with the different reagents is given in a tabular form for the convenience of students. The most commonly encountered reaction intermediates are discussed in detail. The applications of organic reagents are illustrated with examples while the chapters on pericyclic reactions and photochemical reactions were included in the second and third editions, respectively. In this fourth edition a new chapter on solved problems in Organic Reaction Mechanisms has been added, to enable students evaluate their understanding of the topic. In this chapter several reagents, reactions and rearrangements, which were not earlier included in this book, have now been included in the form of problems. NEW TO THE FOURTH EDITION: * Large number of new Reagents, Reactions and Rearrangements These are: Baylis-Hillman Reaction, Bucherer Reaction, Corey-Posner and Whitesides-House Synthesis, Corey-Suggs Oxidation, Dess-Martin Reagent, Dienone-Phenol Rearrangement, Friedlander Synthesis, Haller-Bauer Reaction, Heck Reaction, Hofmann-Loeffler-Freytag Reaction, Pauson-Khand Reaction, Mozingo Reaction, Nickel boride, Prins Reaction, Stille Coupling, Suzuki Reaction, Tiffeneau-Demjanov Reaction, Trost-Tsuji Coupling. * Solved Problems on Reaction Mechanism This book is also very useful for students taking competitive examinations.

March's Advanced Organic Chemistry

Reactions, Mechanisms, and Structure

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Author: Michael B. Smith,Jerry March

Publisher: John Wiley & Sons

ISBN: 0470084944

Category: Science

Page: 2250

View: 8125