Reaction Mechanisms in Organic Synthesis

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Author: Rakesh Kumar Parashar

Publisher: John Wiley & Sons

ISBN: 1118681231

Category: Science

Page: 304

View: 8644

Organic chemistry is a core part of the chemistry curricula, and advanced levels texts often obscure the essential framework underlying and uniting the vast numbers of reactions as a result of the high level of detail presented. The material in this book is condensed into a manageable text of 350 pages and presented in a clear and logical fashion, focusing purely on the basics of the subject without going through exhaustive detail or repetitive examples. The book aims to bridge the gap between undergraduate organic chemistry textbooks and advanced level textbooks, beginning with a basic introductory course and arranging the reaction mechanisms according to an ascending order of difficulty. As such, the author believes the book will be excellent primer for advanced postgraduates Reaction Mechanisms in Organic Synthesis is written from the point of view of the synthetic organic chemist, enabling students and researchers to understand and expand on reactions covered in foundation courses, and to apply them in a practical context by designing syntheses. As a further aid to the practical research student, the content is organized according to the conditions under which a reaction is executed rather than by the types of mechanisms. Particular emphasis is placed on controlling stereospecificity and regiospecificity. Topics covered include: Transition metal mediated carbon-carbon bond formation reactions Use of stabilized carbanions, ylides and enamines for carbon-carbon bond formation reactions, Advanced level use of oxidation and reduction reagents in synthesis. As a modern text, this book stands out from its competitors due to its comprehensive coverage of recently published research. The book contains specific examples from the latest literature, covering modern reactions and the latest procedural modifications. The focus on contemporary and synthetically useful reactions ensures that the contents are specifically relevant and attractive to postgraduate students and industrial organic chemists.

Organic Mechanisms

Reactions, Stereochemistry and Synthesis

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Author: Reinhard Bruckner

Publisher: Springer Science & Business Media

ISBN: 3642036503

Category: Science

Page: 855

View: 5009

This English edition of a best-selling and award-winning German textbook Reaction Mechanisms: Organic Reactions · Stereochemistry · Modern Synthetic Methods is aimed at those who desire to learn organic chemistry through an approach that is facile to understand and easily committed to memory. Michael Harmata, Norman Rabjohn Distinguished Professor of Organic Chemistry (University of Missouri) surveyed the accuracy of the translation, made certain contributions, and above all adapted its rationalizations to those prevalent in the organic chemistry community in the English-speaking world. Throughout the book fundamental and advanced reaction mechanisms are presented with meticulous precision. The systematic use of red "electron-pushing arrows" allows students to follow each transformation elementary step by elementary step. Mechanisms are not only presented in the traditional contexts of rate laws and substituent effects but, whenever possible, are illustrated using practical, useful and state-of-the-art reactions. The abundance of stereoselective reactions included in the treatise makes the reader familiar with key concepts of stereochemistry. The fundamental topics of the book address the needs of upper-level undergraduate students, while its advanced sections are intended for graduate-level audiences. Accordingly, this book is an essential learning tool for students and a unique addition to the reference desk of practicing organic chemists, who as life-long learners desire to keep abreast of both fundamental and applied aspects of our science. In addition, it will well serve ambitious students in chemistry-related fields such as biochemistry, medicinal chemistry and pharmaceutical chemistry. From the reviews: "Professor Bruckner has further refined his already masterful synthetic organic chemistry classic; the additions are seamless and the text retains the magnificent clarity, rigour and precision which were the hallmark of previous editions. The strength of the book stems from Professor Bruckner’s ability to provide lucid explanations based on a deep understanding of physical organic chemistry and to limit discussion to very carefully selected reaction classes illuminated by exquisitely pertinent examples, often from the recent literature. The panoply of organic synthesis is analysed and dissected according to fundamental structural, orbital, kinetic and thermodynamic principles with an effortless coherence that yields great insight and never over-simplifies. The perfect source text for advanced Undergraduate and Masters/PhD students who want to understand, in depth, the art of synthesis ." Alan C. Spivey, Imperial College London "Bruckner’s ‘Organic Mechanisms’ accurately reflects the way practicing organic chemists think and speak about organic reactions. The figures are beautifully drawn and show the way organic chemists graphically depict reactions. It uses a combination of basic valence bond pictures with more sophisticated molecular orbital treatments. It handles mechanisms both from the "electron pushing perspective" and from a kinetic and energetic view. The book will be very useful to new US graduate students and will help bring them to the level of sophistication needed to be serious researchers in organic chemistry." Charles P. Casey, University of Wisconsin-Madison "This is an excellent advanced organic chemistry textbook that provides a key resource for students and teachers alike." Mark Rizzacasa, University of Melbourne, Australia.

Electrochemical Reactions and Mechanisms in Organic Chemistry

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Author: J. Grimshaw

Publisher: Elsevier

ISBN: 9780080530727

Category: Science

Page: 416

View: 424

Electrochemical reactions make significant contributions to organic synthesis either in the laboratory or on an industrial scale. These methods have the potential for developing more "green" chemical synthesis. Over recent years, modern investigations have clarified the mechanisms of important organic electrochemical reactions. Progress has also been made in controlling the reactivity of intermediates through either radical or ionic pathways. Now is the time to gather all the electrochemical work into a textbook. As an essential addition to the armory of synthetic organic chemists, electrochemical reactions give results not easily achieved by many other chemical routes. This book presents a logical development of reactions and mechanisms in organic electrochemistry at a level suited to research scientists and final year graduate students. It forms an excellent starting point from which synthetic organic chemists, in both academia and industry, can appreciate uses for electrochemical methods in their own work. The book is also a reference guide to the literature.

Name Reactions and Reagents in Organic Synthesis

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Author: Bradford P. Mundy,Michael G. Ellerd,Frank G. Favaloro, Jr.

Publisher: John Wiley & Sons

ISBN: 0471739863

Category: Science

Page: 950

View: 484

This Second Edition is the premier name resource in the field. It provides a handy resource for navigating the web of named reactions and reagents. Reactions and reagents are listed alphabetically, followed by relevant mechanisms, experimental data (including yields where available), and references to the primary literature. The text also includes three indices based on reagents and reactions, starting materials, and desired products. Organic chemistry professors, graduate students, and undergraduates, as well as chemists working in industrial, government, and other laboratories, will all find this book to be an invaluable reference.

Organic Reaction Mechanisms

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Author: Rakesh Kumar Parashar

Publisher: CRC PressI Llc

ISBN: 9780849381669

Category: Science

Page: 639

View: 615

This book, written explicitly for graduate and postgraduate students of chemistry, provides an extensive coverage of various organic reactions and rearrangements with emphasis on there application in synthesis. A summary of oxidation and reduction of organic compounds is given in tabular form (correlation tables) for the convenience of students. The most commonly encountered reaction intermediates are dealt with. Applications of organic reagents illustrated with examples and problems at the end of each chapter will enable students to evaluate their understanding of the topic. Book jacket.

Advanced Problems in Organic Reaction Mechanisms

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Author: Alexander McKillop

Publisher: Elsevier

ISBN: 9780080432557

Category: Science

Page: 153

View: 306

This book is a collection of 300 problems which challenge the user to devise reasonable mechanistic interpretations for sets of experimental observations. Almost all of the problems are taken from the literature of the last twenty years. Each is a separate entity, although similar mechanistic themes occur in several quite different problems. Answers are not given, nor are references to the original literature. The user who fails to solve a particular problem and reaches an appropriate level of frustration should be able, relatively quickly, to locate the original literature from the information given in the problem. For senior undergraduate and graduate students of organic chemistry and all teachers of organic chemistry.

Click Reactions in Organic Synthesis

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Author: Srinivasan Chandrasekaran

Publisher: John Wiley & Sons

ISBN: 3527694153

Category: Science

Page: 360

View: 473

This book on click reactions to focus on organic synthesis, this reference work describes the click concept and underlying mechanisms as well as the main applications in various fields. As such, the chapters cover green chemical synthesis, metal-free click reactions, synthesis of pharmaceuticals, peptides, carbohydrates, DNA, macrocycles, dendrimers, polymers, and supramolecular architectures. By filling a gap in the market, this is the ultimate reference for synthetic chemists in academia and industry aiming for a fast and simple design and synthesis of novel compounds with useful properties.

Advanced Organic Chemistry

Reaction Mechanisms

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Author: Reinhard Bruckner

Publisher: Academic Press

ISBN: 9780121381103

Category: Science

Page: 636

View: 6793

Contents - Radical Substitution Reactions at the Saturated C Atom. Nucleophilic Substitution Reactions at the Saturated C Atom. Additions to the Olefinic C=C Double Bond. Eliminations Substitution Reactions on Aromatic Compounds. Nucleophilic Substitution Reactions (Except Through Enolates) on the Carboxyl Carbon. Additions of Heteroatom Nucleophiles to Heterocumulenes. Additions of Heteroatom Nucleophiles to Carbonyl Compounds and Their Secondary Reactions. Addition of H Nucleophiles and Metal Organyls to Carbonyl Compounds. Reaction of Ylides with Saturated or Unsaturated Carbonyl Compounds. Chemistry of the Alkaline Earth Metal Enolates. Rearrangements. Thermal Cycloadditions. Transition Metal-Mediated Alkenylations, Arylations and Alkynylations. Oxidations and Reductions.

Enzymatic Reactions in Organic Media

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Author: Ari Koskinen,A. Klibanov

Publisher: Springer Science & Business Media

ISBN: 9401106118

Category: Science

Page: 314

View: 5459

The outlook of organic synthesis has changed many times during its tractable history. The initial focus on the synthesis of substances typical of living matter, exemplified by the first examples of organic chemistry through the synthesis of urea from inorganic substances by Liebig, was accepted as the birth of organic chemistry, and thus also of organic synthesis. Although the early developments in organic synthesis closely followed the pursuit of molecules typical in nature, towards the end of the 19th century, societal pressures placed higher demands on chemical methods appropriate for the emerging age of industrialization. This led to vast amounts of information being generated through the discovery of synthetic reactions, spectroscopic techniques and reaction mechanisms. The basic organic functional group transformations were discovered and improved during the early part of this century. Reaction mechanisms were elucidated at a growing pace, and extremely powerful spectroscopic tools, such as infrared, nuclear magnetic resonance and mass spectrometry were introduced as everyday tools for a practising organic chemist. By the 1950s, many practitioners were ready to agree that almost every molecule could be syn thesized. Some difficult stereochemical problems were exceptions; for example Woodward concluded that erythromycin was a "hopelessly complex target". This frustration led to a hectic phase of development of new and increasingly more ingenious protecting group strategies and functional group transformations, and also saw the emergence of asymmetric synthesis.

Name Reactions in Organic Synthesis

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Author: Arun Parikh,Khyati Parikh

Publisher: Cambridge India

ISBN: 8175963514

Category: Science

Page: 644

View: 8545

The book focuses on main aspects of chemical reaction, i.e. principle, mechanism and applications of synthetic utility. The content is explained in an easy and simple language. It will be a good source of information for fundamental knowledge of organic synthesis to students at undergraduate level as well as industrial chemist.

Name Reactions

A Collection of Detailed Reaction Mechanisms

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Author: Jie Jack Li

Publisher: Springer Science & Business Media

ISBN: 3662048353

Category: Science

Page: 417

View: 8221

This book differs from others on name reactions in organic chemistry by focusing on their mechanisms. It covers over 300 classical as well as contemporary name reactions. Biographical sketches for the chemists who discovered or developed those name reactions have been included. Each reaction is delineated by its detailed step-by-step, electron-pushing mechanism, supplemented with the original and the latest references, especially review articles. This book contains major improvements over the previous edition and the subject index is significantly expanded.

Organic Reactions And Their Mechanisms

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Author: P S Kalsi

Publisher: New Age International

ISBN: 9788122412680

Category: Chemical reactions

Page: 666

View: 2709

This Revised Edition Includes Several New Topics To Make The Treatment More Comprehensive And Contemporary. The Exposition In Several Chapters Has Also Been Recast To Facilitate An Easier Understanding Of The Subject. * Molecular Orbital And Bonding Thoroughly Explained. * Resonance Structures And Allylic Systems Included. * Organic Acids And Bases Explained In Detail With Additional Examples. * Discussion Of Organic Reactions Considerably Expanded. * Various Additional Dimensions Of Photochemistry Highlighted. * A New Chapter On Special Topics Included.With Its Clear And Systematic Presentation, This Is An Essential Text For B.Sc. And M.Sc. Chemistry Students.

Principles of Organic Synthesis, 3rd Edition

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Author: Richard O.C. Norman

Publisher: Routledge

ISBN: 1351421727

Category: Science

Page: 828

View: 6838

This book is designed for those who have had no more than a brief introduction to organic chemistry and who require a broad understanding of the subject. The book is in two parts. In Part I, reaction mechanism is set in its wider context of the basic principles and concepts that underlie chemical reactions: chemical thermodynamics, structural theory, theories of reaction kinetics, mechanism itself and stereochemistry. In Part II these principles and concepts are applied to the formation of particular types of bonds, groupings, and compounds. The final chapter in Part II describes the planning and detailed execution of the multi-step syntheses of several complex, naturally occurring compounds.

Organic Reaction Mechanisms

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Author: V. K. Ahluwalia,Rakesh Kumar Parashar

Publisher: Alpha Science International Limited

ISBN: 9781842656785

Category: Science

Page: 749

View: 6807

This book, written for graduate and post-graduate chemistry students, provides an extensive coverage of various organic reactions, rearrangements and reagents, with emphasis on their applications in organic synthesis. In the chapters on oxidation and reduction a summary of oxidation and reduction of organic compounds with the different reagents is given in a tabular form for the convenience of students. The most commonly encountered reaction intermediates are discussed in detail. The applications of organic reagents are illustrated with examples while the chapters on pericyclic reactions and photochemical reactions were included in the second and third editions, respectively. In this fourth edition a new chapter on solved problems in Organic Reaction Mechanisms has been added, to enable students evaluate their understanding of the topic. In this chapter several reagents, reactions and rearrangements, which were not earlier included in this book, have now been included in the form of problems. NEW TO THE FOURTH EDITION: * Large number of new Reagents, Reactions and Rearrangements These are: Baylis-Hillman Reaction, Bucherer Reaction, Corey-Posner and Whitesides-House Synthesis, Corey-Suggs Oxidation, Dess-Martin Reagent, Dienone-Phenol Rearrangement, Friedlander Synthesis, Haller-Bauer Reaction, Heck Reaction, Hofmann-Loeffler-Freytag Reaction, Pauson-Khand Reaction, Mozingo Reaction, Nickel boride, Prins Reaction, Stille Coupling, Suzuki Reaction, Tiffeneau-Demjanov Reaction, Trost-Tsuji Coupling. * Solved Problems on Reaction Mechanism This book is also very useful for students taking competitive examinations.

Radical Reactions in Organic Synthesis

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Author: Samir Z. Zard

Publisher: Oxford University Press on Demand

ISBN: 9780198502401

Category: Philosophy

Page: 256

View: 4651

Introduction and some general concepts. -- General principles: chain reactions based on stannane chemistry. -- Further chain reactions of stannanes. -- Organo-silicon, -germanium, and -mercury hydrides. -- The Barton decarboxylation and related reactions. -- Atom and group transfer reactions. -- The persistent radical effect: non-chain processes. -- Redox processes. -- Some concluding remarks.

March's Advanced Organic Chemistry

Reactions, Mechanisms, and Structure

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Author: Michael B. Smith,Jerry March

Publisher: John Wiley & Sons

ISBN: 0470084944

Category: Science

Page: 2250

View: 1171

Organic Synthesis

Special Techniques

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Author: V. K. Ahluwalia,Renu Aggarwal

Publisher: CRC Press

ISBN: 9780849310027

Category: Science

Page: 200

View: 5649

Suitable for Master's and Ph.D. level students, as well as for the research scientist, this book describes the use of special techniques in organic synthesis and includes a brief discussion of the principles involved. It provides the methodology and procedures for typical preparations for each of the techniques.

Anorganische Chemie

Prinzipien von Struktur und Reaktivität

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Author: James Huheey,Ellen Keiter,Richard Keiter

Publisher: Walter de Gruyter GmbH & Co KG

ISBN: 3110307952

Category: Science

Page: 1340

View: 2998

This modern textbook stands out from other standard textbooks. The framework for the learning units is based on fundamental principles of inorganic chemistry, such as symmetry, coordination, and periodicity. Specific examples of chemical reactions are presented to exemplify and demonstrate these principles. Numerous new illustrations, a new layout, and large numbers of exercises following each chapter round out this new edition.

Reactive Intermediates in Organic Chemistry

Structure, Mechanism, and Reactions

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Author: Maya Shankar Singh

Publisher: John Wiley & Sons

ISBN: 3527678271

Category: Science

Page: 296

View: 7089

Most reactions in organic chemistry do not proceed in a single step but rather take several steps to yield the desired product. In the course of these multi-step reaction sequences, short-lived intermediates can be generated that quickly convert into other intermediates, reactants, products or side products. As these intermediates are highly reactive, they cannot usually be isolated, but their existence and structure can be proved by theoretical and experimental methods. Using the information obtained, researchers can better understand the underlying reaction mechanism of a certain organic transformation and thus develop novel strategies for efficient organic synthesis. The chapters are clearly structured and are arranged according to the type of intermediate, providing information on the formation, characterization, stereochemistry, stability, and reactivity of the intermediates. Additionally, representative examples and a problem section with different levels of difficulty are included for self-testing the newly acquired knowledge. By providing a deeper understanding of the underlying concepts, this is a musthave reference for PhD and Master Students in organic chemistry, as well as a valuable source of information for chemists in academia and industry working in the field. It is also ideal as primary or supplementary reading for courses on organic chemistry, physical organic chemistry or analytical chemistry.