Peptide-based Drug Discovery

Challenges and New Therapeutics

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Author: Ved Srivastava

Publisher: Royal Society of Chemistry

ISBN: 1782627324

Category: Science

Page: 616

View: 4903

With potentially high specificity and low toxicity, biologicals offer promising alternatives to small-molecule drugs. Peptide therapeutics have again become the focus of innovative drug development efforts backed up by a resurgence of venture funds and small biotechnology companies. What does it take to develop a peptide-based medicine? What are the key challenges and how are they overcome? What are emerging therapeutics for peptide modalities? This book answers these questions with a holistic story from molecules to medicine, combining the themes of design, synthesis and clinical applications of peptide-based therapeutics and biomarkers. Chapters are written and edited by leaders in the field from industry and academia and they cover the pharmacokinetics of peptide therapeutics, attributes necessary for commercially successful metabolic peptides, medicinal chemistry strategies for the design of peptidase-resistant peptide analogues, disease classes for which peptide therapeutic are most relevant, and regulatory issues and guidelines. The critical themes covered provide essential background information on what it takes to develop peptide-based medicine from a chemistry perspective and views on the future of peptide drugs. This book will be a valuable resource not only as a reference book for the researcher engaged in academic and pharmaceutical setting, from basic research to manufacturing and from organic chemistry to biotechnology, but also a valuable resource to graduate students to understand discovery and development process for peptide-based medicine.

Drug Discovery Strategies and Methods

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Author: Alexandros Makriyannis,Diane Biegel

Publisher: CRC Press

ISBN: 082475767X

Category: Medical

Page: 348

View: 5184

Navigate the complex and multidisciplinary path of drug discovery procedures with Drug Discovery Strategies and Methods-a well-organized and timely reference that analyzes methods in target identification and validation, lead detection, compound optimization, and biological testing. This volume addresses challenges encountered during the discovery of new pharmaceutical candidates including the use of cutting-edge techniques utilized in drug design and development. It considers key elements in the drug design cycle ranging from appropriateness of targets and disease models to compound characterization, safety, and efficacy and the role of protein crystallography in structure-based drug design.

Therapies for Retinal Degeneration

Targeting Common Processes

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Author: Enrique J. de la Rosa,Thomas G. Cotter

Publisher: Royal Society of Chemistry

ISBN: 1782629491

Category: Science

Page: 260

View: 9839

Sight loss and blindness is a very prevalent cause of disability. Retinal diseases leading to visual loss affect many people worldwide and the search for adequate drugs remains a challenge and an important area of interest in the drug discovery field. This book addresses approaches to the treatment of retinal diseases, targeting common processes and components. Despite their causative origins, which comprise genetic dystrophies, age-related degenerations, as well as pathologies associated with other diseases, a neurodegenerative component appears, sooner or later, in the course of the disease. As is the case for most neurodegenerative diseases, the available treatments are far from satisfactory. The aim of this book is to highlight research and drug development efforts in targeting such common processes as a potential path to provide treatments to the millions of affected people.

Biophysical Techniques in Drug Discovery

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Author: Angeles Canales

Publisher: Royal Society of Chemistry

ISBN: 1782627332

Category:

Page: 320

View: 445

Biophysical techniques are used in many key stages of the drug discovery process including in screening for new receptor ligands, in characterising drug mechanisms, and in validating data from biochemical and cellular assays. This book provides an overview of the biophysical methods applied in drug discovery today, including traditional techniques and newer developments. Perspectives from academia and industry across a spectrum of techniques are brought together in a single volume. Small and biotherapeutic approaches are covered and strengths and limitations of each technique are presented. Case studies illustrate the application of each technique in real applied examples. Finally, the book covers recent developments in areas such as electron microscopy with discussions of their possible impact on future drug discovery. This is a go-to volume for biophysicists, analytical chemists and medicinal chemists providing a broad overview of techniques of contemporary interest in drug discovery.

Acute Brain Impairment

Scientific Discoveries and Translational Research

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Author: Bridget Martinez

Publisher: Royal Society of Chemistry

ISBN: 1782629505

Category: Science

Page: 348

View: 9204

Hot Zone

Ebola, das tödliche Virus

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Author: Richard Preston

Publisher: Knaur eBook

ISBN: 3426434571

Category: Health & Fitness

Page: 368

View: 1077

Richard Prestons populärwissenschaftlicher Tatsachen-Thriller liest sich spannender als jeder Horror-Roman. Preston berichtet darin über die ersten Infektionen mit dem Ebola-Virus vor über vierzig Jahren. Sein Tatsachenthriller von 1998 ist immer noch hochaktuell, wie die schreckliche Ebola-Epidemie in Zentralafrika gerade zeigt. Ebola gehört zu den gefährlichsten Killerviren. Diese aus dem Afrikanischen Regenwald stammenden sogenannten „Filoviren“, können einen Menschen auf grausamste Art und Weise töten. Das Virus löst innerhalb weniger Tage die inneren Organe auf, und der Erkrankte verblutet von innen. Das Virus ist zudem extrem ansteckend, und weltweit gibt es immer noch kein wirksames Heilmittel dagegen. Deshalb ist es nicht auszuschließen, dass die Menschheit eines Tages einer Seuche wie Ebola erliegen könnte. Preston schildert, wie der Ebola-Erreger über Affen, die für medizinische Versuche importiert wurden, schließlich nach Amerika kommt. In einem kleinen Labor in Reston, USA, verbreitet er Angst und Schrecken. Als sich die Seuche unter den im Quarantänelager zusammengepferchten Affen ausbreitet, rufen die Betreiber der Anlage die Gesundheitsbehörden zu Hilfe. Bald müssen die Wissenschaftler feststellen, dass sich das Virus inzwischen nicht nur durch Kontakt, sondern auch durch die Luft verbreiten kann.

Medicinal Chemistry

A Molecular and Biochemical Approach

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Author: Thomas Nogrady,Donald F. Weaver

Publisher: Oxford University Press

ISBN: 9780195104554

Category: Medical

Page: 649

View: 9725

Fully updated, this textbook takes a receptor-based, target-centred approach, presenting concepts central to the study of drug action in a logical, mechanistic way, grounded on molecular & biochemical principles.

New Therapeutic Agents in Thrombosis and Thrombolysis, Third Edition

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Author: Jane E. Freedman,Joseph Loscalzo

Publisher: CRC Press

ISBN: 1420069241

Category: Medical

Page: 712

View: 8759

As the number of patients with thrombosis and thrombolysis increases, there is a critical need for clinicians to learn the latest scientific discoveries and treatment options. This timely Third Edition is a comprehensive text for cardiologists, hematologists, and pharmacologists in need of a resource on current agent development technology for treating cardiovascular and thromboembolic diseases. New to the Third Edition: a thorough examination of all the agents involved in treating thrombosis chapters on biomarkers, testing, and pharmacogenomics key topics, including new targets for antithrombotics, the development of novel classes of platelet inhibitors, new thrombolytic therapies, and evolving clinical uses of thrombolytics for ischemic stroke and venous thrombosis the hemostatic and thrombotic pathways

Pharmakokinetik

Eine Einführung

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Author: Erich Gladtke,Hans Michael von Hattingberg

Publisher: Springer-Verlag

ISBN: 3662092727

Category: Medical

Page: 148

View: 4542

Die Herausgeber dieses Büchleins sind bzw. waren meine langjährigen Mitarbeiter und haben sich überwiegend mit der praktischen und ange wandten Pharmakokinetik beschäftigt. Aus der gemeinsamen Arbeit ergab sich, daß unsere Arbeitsgruppe immer wieder zu Fortbildungsvor trägen und Einführungskursen über das Gebiet der Pharmakokinetik gebeten wurde. Diese Veranstaltungen waren vor allem für jene gedacht, die sich bisher noch nicht mit der Pharmakokinetik beschäftigt hatten, die also wissen wollten, um was es sich bei dieser Materie überhaupt handelt. Beim ersten Hinsehen erscheinen manchem Mediziner und Biologen die Formulierungen und mathematischen Ableitungen, wie sie in einigen diesbezüglichen Arbeiten verwendet werden und wie ich sie in meinen Grundlagen der Pharmakokinetik ausführlich immer wieder bringen mußte, vielleicht zu kompliziert und zu abschreckend. Deshalb begrüße ich es, daß Herr Gladtke und Herr von Hattingberg bewegt werden konnten, den Inhalt dieser Kurse niederzuschreiben. Es soll eine Orientierung und Einführung sein. Sicher werden einige Leser dadurch angeregt, tiefer in jene Materie einzudringen, die ich seinerzeit (1953) Pharmakokinetik genannt habe, ohne zu wissen, daß diese Be zeichnung inzwischen weltweite Bedeutung erlangt haben würde. Damit wäre das Büchlein von Nutzen. Ich darf dies den Autoren wünschen. Gießen, Dezember 1972 F.H. DOST V Vorwort Diese Schrift ist als Einführung in die Pharmakokinetik gedacht und darf damit nicht als Lehrbuch, Nachschlagewerk oder erschöpfende Dar stellung verstanden werden. Der Vorsteher der Sektion antimikrobielle Chemotherapie der Paul Ehr lich-Gesellschaft und Leiter der Abteilung für antimikrobielle Therapie der Universitäts-Kinderklinik München, Herr Professor Dr. med.

Naturstoffe der chemischen Industrie

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Author: Bernd Schäfer

Publisher: Spektrum Akademischer Verlag

ISBN: 9783827416148

Category: Science

Page: 544

View: 4217

Dieses Buch geht auf eine Vorlesung an der Universität Heidelberg zurück und richtet sich in erster Linie an Studenten, aber auch an Hochschuldozenten, Chemielehrer und Industriechemiker. Es vermittelt Einblicke in die moderne Naturstoffchemie und die Entwicklung komplexer Moleküle (asymmetrische und heterozyklische Verbindungen, polyzyklische Strukturen, makrozyklische und kleine Ringe) in der chemischen Industrie. Ein wichtiges Anliegen des Autors besteht darin, exemplarisch zu belegen, welche Aspekte eine Rolle spielen, wenn man im technischen Maßstab komplexe Verbindungen "auf elegantem Weg" herstellen will. So lernt der Leser die Grundlagen, die für einen jungen Chemiker in der chemischen Industrie unentbehrlich sind. Das Buch deckt ein breites Spektrum von Naturstoffen oder davon abgeleiteten Substanzen ab, darunter Farbstoffe wie etwa Indigo, in der Nahrungsmittelindustrie verwendete Verbindungen wie Coffein, Vanillin, Carotenoide und Aminosäuren, Arzneimittel wie Antibiotika, Opioide, Lipstatin und Steroide, Agrochemikalien wie Herbizide, Fungizide und Insektizide oder auch Duftstoffe wie Moschus und Damascon. Jedes Kapitel liefert auch historische und soziale Hintergrundinformationen zu dem jeweiligen Naturstoff und beschreibt seine biologische Aktivität, seine Entdeckung und seine wichtigsten Modifikationen durch die industrielle Chemie. In vielen Fällen wird die industrielle Synthese mit der Biosynthese verglichen. Überdies beleuchtet das Buch moderne Aspekte und zukünftige Entwicklungen in der Naturstoffsynthese. Ohne auf jeden industriell hergestellten Naturstoff einzugehen - was angesichts der Fülle der Substanzen in einem Lehrbuch auch gar nicht möglich ist -, bietet das verständlich geschriebene Werk einen guten Überblick über das gesamte Gebiet. Dabei kommt die "grüne Chemie" ebenso zur Sprache wie die Atomökonomie und "Eleganz" in der industriellen Naturstoffsynthese.

Biomarker Methods in Drug Discovery and Development

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Author: Feng Wang

Publisher: Springer Science & Business Media

ISBN: 1934115231

Category: Medical

Page: 396

View: 6522

In this book, expert researchers provide a tool box for those who have a general interest in biomarker research and for those currently specializing in certain technologies but desiring an understanding of other available methodologies. Its chapters include validated, mature methods as well as new, incredibly promising protocols. This book is the perfect biomarker technical guideline and reference to stimulate more exciting biomarker research and technology development.

Submicron Emulsions in Drug Targeting and Delivery

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Author: S Benita

Publisher: CRC Press

ISBN: 9789057023491

Category: Medical

Page: 352

View: 3213

It is anticipated that submicron emulsion and lipid suspension will find numerous and novel medical applications in the near future. The purpose of this multi-authore book is to provide the reader with an up-to-date general overview of submicron emulsions and lipid suspensions (solid lipid nanoparticles) as well as to emphasize the various methods of preparation, characerization, evaluation and potential applications in various therapeutic areas. Leading authors have contributed to this unique book which contains all state of the art and detailed knowledge related to the physico-chemical, pharmaceutical and medical aspects of these most interesting but complex dosage forms, thus making this information easily available to the reader. This book will be of interest to scientists working in the field of drug delivery and targeting in universities as well as in the pharmaceutical, food, cosmetic, veterinary and chemical industries.

Frontiers in Drug Design and Discovery

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Author: Gary W. Caldwell,Atta-ur- Rahman,Mohammad Iqbal Choudhary,Michael R. D' Andrea

Publisher: Bentham Science Publishers

ISBN: 1608052001

Category: Medical

Page: 365

View: 7987

"Frontiers in Drug Design and Discovery" is an Ebook series devoted to publishing the latest and the most important advances in drug design and discovery. Eminent scientists write contributions on all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. the Ebook series should prove to be of interest to all the pharmaceutical scientists involved in research in drug design and discovery. Each volume is devoted to the major advances in drug design and discovery. the Ebook series is essential reading to all scientists involved in drug design and discovery who wish to keep abreast of rapid and important developments in the field.

Challenges in Delivery of Therapeutic Genomics and Proteomics

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Author: Ambikanandan Misra

Publisher: Elsevier

ISBN: 9780123849656

Category: Science

Page: 686

View: 7859

Delivery of therapeutic proteomics and genomics represent an important area of drug delivery research. Genomics and proteomics approaches could be used to direct drug development processes by unearthing pathways involved in disease pathogenesis where intervention may be most successful. This book describes the basics of genomics and proteomics and highlights the various chemical, physical and biological approaches to protein and gene delivery. Covers a diverse array of topics from basic sciences to therapeutic applications of proteomics and genomics delivery Of interest to researchers in both academia and industry Highlights what’s currently known and where further research is needed

Amino Acids, Peptides and Proteins in Organic Chemistry, Analysis and Function of Amino Acids and Peptides

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Author: Andrew B. Hughes

Publisher: John Wiley & Sons

ISBN: 3527321047

Category: Science

Page: 490

View: 7632

This is the last of five books in the Amino Acids, Peptides and Proteins in Organic Synthesis series. Closing a gap in the literature, this is the only series to cover this important topic in organic and biochemistry. Drawing upon the combined expertise of the international "who′s who" in amino acid research, these volumes represent a real benchmark for amino acid chemistry, providing a comprehensive discussion of the occurrence, uses and applications of amino acids and, by extension, their polymeric forms, peptides and proteins. The practical value of each volume is heightened by the inclusion of experimental procedures. The 5 volumes cover the following topics: Volume 1: Origins and Synthesis of Amino Acids Volume 2: Modified Amino Acids, Organocatalysis and Enzymes Volume 3: Building Blocks, Catalysis and Coupling Chemistry Volume 4: Protection Reactions, Medicinal Chemistry, Combinatorial Synthesis Volume 5: Analysis and Function of Amino Acids and Peptides Volume 5 of this series presents a wealth of methods to analyze amino acids and peptides. Classical approaches are described, such as X–ray analysis, chromatographic methods, NMR, AFM, mass spectrometry and 2D–gel electrophoresis, as well as newer approaches, including Surface Plasmon Resonance and array technologies. Originally planned as a six volume series, Amino Acids, Peptides and Proteins in Organic Chemistry now completes with five volumes but remains comprehensive in both scope and coverage. Further information about the 5 Volume Set and purchasing details can be viewed here.