Molecules and Medicine

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Author: E. J. Corey,Barbara Czakó,L?szl? K?rti

Publisher: John Wiley & Sons

ISBN: 1118361733

Category: Science

Page: 272

View: 4551

Molecules and Medicine provides, for the first time ever, a completely integrated look at chemistry, biology, drug discovery, and medicine. It delves into the discovery, application, and mode of action of more than one hundred of the most significant molecules in use in modern medicine. Opening sections of the book provide a unique, clear, and concise introduction, which enables readers to understand chemical formulas.

Molecules and Medicine

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Author: E. J. Corey,Barbara Czakó,László Kürti

Publisher: John Wiley & Sons

ISBN: 1118361695

Category: Science

Page: 272

View: 5526

Molecules Of Emotion

Why You Feel The Way You Feel

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Author: Candace Pert

Publisher: Simon and Schuster

ISBN: 1471109704

Category: Science

Page: 384

View: 5454

Why do we feel the way we feel? How do our thoughts and emotions affect our health? Are our bodies and minds distinct from each other or do they function together as part of an interconnected system? In MOLECULES OF EMOTION, neuroscientist Candace Pert provides startling and decisive answers to these long-debated questions, establishing the biomolecular basis for our emotions and explaining these new scientific developments in a clear and accessible way. Her pioneering research on how the chemicals inside us form a dynamic information network, linking mind and body, is not only provocative, it is revolutionary. In her groundbreaking book, Candace Pert offers a new scientific understanding of the power of our minds and our feelings to affect our health and well-being.

Molecules to Medicine with mTOR

Translating Critical Pathways into Novel Therapeutic Strategies

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Author: Kenneth Maiese

Publisher: Academic Press

ISBN: 012802755X

Category: Medical

Page: 472

View: 7196

Molecules to Medicine with mTOR: Translating Critical Pathways into Novel Therapeutic Strategies is a one-stop reference that thoroughly covers the mechanistic target of rapamycin (mTOR). mTOR, also known as the mammalian target of rapamycin, is a 289-kDa serine/threonine protein kinase that is ubiquitous throughout the body and has a critical role in gene transcription and protein formation, stem cell development, cell survival and senescence, aging, immunity, tissue regeneration and repair, metabolism, tumorigenesis, oxidative stress, and pathways of programmed cell death that include apoptosis and autophagy. Incorporating a translational medicine approach, this important reference highlights the basic cellular biology of mTOR pathways, presents the role of mTOR during normal physiologic function and disease, and illustrates how the mechanisms of mTOR can be targeted for current and future therapeutic treatment strategies. Coverage of mTOR signaling includes the entire life cycle of cells that impacts multiple systems of the body including those of nervous, cardiovascular, immune, musculoskeletal, endocrine, reproductive, renal, and respiratory origin. Covers the role of mTOR by internationally recognized expert contributors in the field. Provides a clear picture of the complexity of mTOR signaling as well as of the different approaches that could target this pathway at various levels. Includes analysis of the role of mTOR and in both health and disease. Serves as an important resource for a broad audience of healthcare providers, scientists, drug developers, and students in both clinical and research settings.

Molecules of Death

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Author: Rosemary H. Waring,Glyn B. Steventon,Steve C. Mitchell

Publisher: Imperial College Press

ISBN: 1860948146

Category: Medical

Page: 430

View: 2815

This book has been developed over many years from several popular courses taught to students at both Birmingham and London universities. It provides an important step in introducing principles and concepts within the field of toxicology. The underlying mechanisms of toxicity are highlighted through examples taken from gases, minerals, plants, fungi, bacteria, marine creatures, industrial chemicals and pharmacological agents.In this second edition, the text has been completely revised and expanded with the addition of six new chapters ? carbon monoxide, hydrofluoric acid, lead, mushroom, toxins, paracetamol, paraquat and diquat. Each chapter is self-sufficient, enabling readers to dip into chapters of interest at random without any lack of understanding. The book is informative, with numerous clinical details, and will appeal to those who wish to delve into this fascinating subject.

Bioactive Molecules and Medicinal Plants

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Author: Kishan Gopal Ramawat,Jean-Michel Mérillon

Publisher: Springer Science & Business Media

ISBN: 354074603X

Category: Science

Page: 379

View: 1952

This book on medicinal plant biotechnology covers recent developments in this field. It includes a comprehensive up-to-date survey on established medicinal plants and on molecules which gained importance in recent years. No recently published book has covered these carefully selected topics. The contributing scientists have been selected on the basis of their involvement in the related plant material as evident by their internationally recognised published work.

Molecules of Murder

Criminal Molecules and Classic Cases

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Author: John Emsley

Publisher: Royal Society of Chemistry

ISBN: 1782627995

Category: Science

Page: 252

View: 8796

Molecules of Murder is about infamous murderers and famous victims; about people like Harold Shipman, Alexander Litvinenko, Adelaide Bartlett, and Georgi Markov. Few books on poisons analyse these crimes from the viewpoint of the poison itself, doing so throws a new light on how the murders or attempted murders were carried out and ultimately how the perpetrators were uncovered and brought to justice. Part I includes molecules which occur naturally and were originally used by doctors before becoming notorious as murder weapons. Part II deals with unnatural molecules, mainly man-made, and they too have been dangerously misused in famous crimes. The book ends with the most famous poisoning case in recent years, that of Alexander Litvinenko and his death from polonium chloride. The first half of each chapter starts by looking at the target molecule itself, its discovery, its history, its chemistry, its use in medicine, its toxicology, and its effects on the human body. The second half then investigates a famous murder case and reveals the modus operandi of the poisoner and how some were caught, some are still at large, and some literally got away with murder. Molecules of Murder will explain how forensic chemists have developed cunning ways to detect minute traces of dangerous substances, and explain why some of these poisons, which appear so life-threatening, are now being researched as possible life-savers. Award winning science writer John Emsley has assembled another group of true crime and chemistry stories to rival those of his highly acclaimed Elements of Murder.

More Molecules of Murder

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Author: John Emsley

Publisher: Royal Society of Chemistry

ISBN: 1788011031

Category: Law

Page: 272

View: 521

How can a plant as beautiful as the foxglove be so deadly and yet for more than a century be used to treat heart disease? The same is true of other naturally occurring molecules as will be revealed in this current book by award-winning author and chemist, John Emsley. More Molecules of Murder follows on from his highly-acclaimed earlier book Molecules of Murder, and again it deals with 14 potential poisons; seven of which are man-made and seven of which are natural. It investigates the crimes committed with them, not from the point of view of the murderers, their victims, or the detectives, but from the poison used. In so doing it throws new light on how these crimes were carried out and ultimately how the perpetrators were uncovered and brought to justice. Each chapter starts by looking at the target molecule itself, its discovery, its chemistry, its often-surprising use in medicine, its effects on the human body, and its toxicology. The rest of the chapter is devoted to murders and attempted murders in which it has been used. But, be reassured that murder by poison is not the threat it once was, thanks to laws which restrict access to such materials and to the skills of analytical chemists in detecting their presence in incredibly tiny amounts.

Pharmaceutical Analysis for Small Molecules

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Author: Behnam Davani

Publisher: John Wiley & Sons

ISBN: 1119425018

Category: Science

Page: 256

View: 4943

A comprehensive introduction for scientists engaged in new drug development, analysis, and approvals Each year the pharmaceutical industry worldwide recruits thousands of recent science graduates—especially chemistry, analytical chemistry, pharmacy, and pharmaceutical majors—into its ranks. However, because of their limited background in pharmaceutical analysis most of those new recruits find making the transition from academia to industry very difficult. Designed to assist both recent graduates, as well as experienced chemists or scientists with limited regulatory, compendial or pharmaceutical analysis background, make that transition, Pharmaceutical Analysis for Small Molecules is a concise, yet comprehensive introduction to the drug development process and analysis of chemically synthesized, small molecule drugs. It features contributions by distinguished experts in the field, including editor and author, Dr. Behnam Davani, an analytical chemist with decades of technical management and teaching experience in compendial, regulatory, and industry. This book provides an introduction to pharmaceutical analysis for small molecules (non-biologics) using commonly used techniques for drug characterization and performance tests. The driving force for industry to perform pharmaceutical analyses is submission of such data and supporting documents to regulatory bodies for drug approval in order to market their products. In addition, related required supporting studies including good laboratory/documentation practices including analytical instrument qualification are highlighted in this book. Topics covered include: Drug Approval Process and Regulatory Requirements (private standards) Pharmacopeias and Compendial Approval Process (public standards) Common methods in pharmaceutical analysis (typically compendial) Common Calculations for assays and impurities and other specific tests Analytical Method Validation, Verification, Transfer Specifications including how to handle out of specification (OOS) and out of trend (OOT) Impurities including organic, inorganic, residual solvents and elemental impurities Good Documentation Practices for regulatory environment Management of Analytical Laboratories Analytical Instrument Qualifications including IQ, OQ, PQ and VQ Due to global nature of pharmaceutical industry, other topics on both regulatory (ICH) and Compendial harmonization are also highlighted. Pharmaceutical Analysis for Small Molecules is a valuable working resource for scientists directly or indirectly involved with the drug development process, including analytical chemists, pharmaceutical scientists, pharmacists, and quality control/quality assurance professionals. It also is an excellent text/reference for graduate students in analytical chemistry, pharmacy, pharmaceutical and regulatory sciences.

A Taste of Molecules

In Search of the Secrets of Flavor

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Author: Diane Fresquez

Publisher: The Feminist Press at CUNY

ISBN: 1558618392

Category: Science

Page: 208

View: 3774

A spirited food writer on the trail of obsessive scientists and entrepreneurs who want to titillate our taste buds.

Healing Roots

Anthropology in Life and Medicine

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Author: Julie Laplante

Publisher: Berghahn Books

ISBN: 178238555X

Category: Social Science

Page: 302

View: 8300

Umhlonyane, also known as Artemisia afra, is one of the oldest and best-documented indigenous medicines in South Africa. This bush, which grows wild throughout the sub-Saharan region, smells and tastes like "medicine," thus easily making its way into people's lives and becoming the choice of everyday healing for Xhosa healer-diviners and Rastafarian herbalists. This "natural" remedy has recently sparked curiosity as scientists search for new molecules against a tuberculosis pandemic while hoping to recognize indigenous medicine. Laplante follows umhlonyane on its trails and trials of becoming a biopharmaceutical - from the "open air" to controlled environments - learning from the plant and from the people who use it with hopes in healing.

Molecules at an Exhibition

Portraits of Intriguing Materials in Everyday Life

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Author: John Emsley

Publisher: Oxford Paperbacks

ISBN: 9780192862068

Category: Science

Page: 250

View: 7414

Discusses interesting chemicals, such as the smelliest, most lethal, and most versatile, in a non-technical style that covers each chemical's importance without using formulas, equations, or diagrams

Ion Channels

Molecules in Action

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Author: David J. Aidley,Peter R. Stanfield

Publisher: Cambridge University Press

ISBN: 9780521498821

Category: Medical

Page: 307

View: 7063

Ion channels are crucial components of living cells. Situated in the cell membrane, they allow ions to pass from one side of the membrane to the other. This book provides an overview of ion channel study, including up-to-date coverage of the permeability and selectivity of channels, their gating and modulation, their response to drugs and toxins, and the human diseases that result from channel malfunction. Students of molecular biology, biochemistry, physiology, and neurobiology will benefit from this modern, concise text.

Bioactive Materials in Medicine

Design and Applications

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Author: X. Zhao,J M Courtney,H Qian

Publisher: Elsevier

ISBN: 0857092936

Category: Technology & Engineering

Page: 288

View: 6483

Bioactive materials play an increasingly important role in the biomaterials industry, and are used for a range of applications, including artificial organs, drug delivery systems, nanomedicine, and biosensors. Bioactive materials in medicine reviews the current status and ongoing development of bioactive materials for medical applications. Following an introduction to bioactive materials in medicine, part one covers the process of designing bioactive materials, including chapters on molecular design, nanotechnology, and tissue engineering. Part two focuses on the different applications of bioactive materials in medicine, with chapters discussing applications in orthopaedics, in the circulatory system,and as antibacterials. The final chapters focus on the uses of these materials in gene therapy, plastic surgery and body reconstruction, and in drug delivery systems. With its distinguished editors and international team of contributors, Bioactive materials in medicine is an essential reference for researchers and designers in industry, as well as those with an academic interest in the subject. Discusses the current status and ongoing development of bioactive materials for medical applications Explores the process of designing bioactive materials, including molecular design, nanotechnology, and tissue engineering Assesses different applications of bioactive materials in medicine featuring applications in orthopaedics, in the circulatory system,and as antibacterials

The Molecules of Life

Physical and Chemical Principles

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Author: John Kuriyan,Boyana Konforti,David Wemmer

Publisher: Garland Science

ISBN: 9780815341888

Category: Science

Page: 1008

View: 7560

"Key to making future advances in the areas of biochemistry and molecular medicine is a new generation of molecular biologists and biochemists who are able to harness the tools and insights of physics and chemistry to exploit the emergence of genomic and systems-level information in biology.The basic ideas of energy, entropy, equilibrium thermodynamics, transport processes and reaction kinetics are closely related to exciting issues in contemporary biology, such as protein folding, chaperones and prion diseases, DNA polymerase and ribosome fidelity, DNA recognition, drug design, signal transduction, ion channel function, motor protein action and the versatility of enzyme mechanism. Providing this physical chemistry and biochemical foundation is The "Molecules of Life," a new undergraduate textbook for undergraduate students majoring in biology or pre-med. It deepens our understanding of how life functions by illuminating the physical principles underpinning biological phenomena"--Provided by publisher.

Redox Biochemistry

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Author: Ruma Banerjee

Publisher: John Wiley & Sons

ISBN: 9780470177327

Category: Science

Page: 350

View: 5043

This is the premier, single-source reference on redox biochemistry, a rapidly emerging field. This reference presents the basic principles and includes detailed chapters focusing on various aspects of five primary areas of redox biochemistry: antioxidant molecules and redox cofactors; antioxidant enzymes; redox regulation of physiological processes; pathological processes related to redox; and specialized methods. This is a go-to resource for professionals in pharmaceuticals, medicine, immunology, nutrition, and environmental fields and an excellent text for upper-level students.

Neuroanatomical Tract-Tracing

Molecules, Neurons, and Systems

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Author: Laszlo Zaborszky,Floris G. Wouterlood,José Luis Lanciego

Publisher: Springer Science & Business Media

ISBN: 0387289429

Category: Medical

Page: 698

View: 3603

The first two editions of this title had a tremendous impact in neuroscience. Between the Second edition in 1989 and today, there has been an explosion of information in the field, including advances in molecular techniques, such as genomics and proteomics, which have become increasing important in neuroscience. A renaissance in fluorescence has occurred, driven by the development of new probes, new microscopes, live imagers, and computer processing. The introduction of new markers has enormously stimulated the field, moving it from tissue culture to neurophysiology to functional MRI techniques.

Science is Beautiful: Disease and Medicine

Under the Microscope

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Author: Colin Salter

Publisher: Pavilion Books

ISBN: 1849944857

Category: Science

Page: N.A

View: 5151

Our understanding of disease and the powers of medicine today are unparalleled, and their documentation has increased signficantly. Science is Beautiful collects the most fascinating microscopic photographs of our diseases along with the medicines we use to treat them. These photographs are profoundly fascinating – and also beautiful. Featured are some of the most illuminating microscopic images of bacteria, viruses and cancers ever captured, now made possible by electron micrograph technology. Potentially fatal diseases such as cancer and Ebola are included, and minor complaints such as Staphylococcus bacteria and dental plaque are shown for their surprising beauty. Other photographs reveal what human cells look like when suffering from Alzheimer's, from osteoporosis, or from HIV. It also uncovers some diseases specific to animals. But there are also dazzling images of the crystals, powders and potions that we take to cure ourselves, including magnified versions of aspirin, insulin, morphine and caffeine. This collection of images, as beautiful as any artwork, can be enjoyed purely as a visual voyage but also as a way to understand more of the science behind the image, whether it's the work of a meningitis virus, our chromosomes in a cancer cell or the breakdown of painkillers. Each image includes the scale of the photography as well as the scientific details in layman's terms.

Inorganic and Organometallic Transition Metal Complexes with Biological Molecules and Living Cells

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Author: Kenneth Kam-Wing Lo

Publisher: Academic Press

ISBN: 012803887X

Category: Science

Page: 406

View: 7625

Inorganic and Organometallic Transition Metal Complexes with Biological Molecules and Living Cells provides a complete overview of this important research area that is perfect for both newcomers and expert researchers in the field. Through concise chapters written and edited by esteemed experts, this book brings together a comprehensive treatment of the area previously only available through scattered, lengthy review articles in the literature. Advanced topics of research are covered, with particular focus on recent advances in the biological applications of transition metal complexes, including inorganic medicine, enzyme inhibitors, antiparasital agents, and biological imaging reagents. Geared toward researchers and students who seek an introductory overview of the field, as well as researchers working in advanced areas Focuses on the interactions of inorganic and organometallic transition metal complexes with biological molecules and live cells Foscuses on the fundamentals and their potential therapeutic and diagnostic applications Covers recent biological applications of transition metal complexes, such as anticancer drugs, enzyme inhibitors, bioconjugation agents, chemical biology tools, and bioimaging reagents