Molecular Biology of Cancer

Mechanisms, Targets, and Therapeutics

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Author: Lauren Pecorino

Publisher: Oxford University Press

ISBN: 019957717X

Category: Medical

Page: 342

View: 2376

The third edition of The Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics offers a fresh approach to the study of the molecular basis of cancer, by showing how our understanding of the defective mechanisms which drive cancer is leading to the development of new targeted therapeutic agents.

Molecular Biology of Cancer

Mechanisms, Targets, and Therapeutics

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Author: Principal Lecturer in Cancer Biology Lauren Pecorino

Publisher: N.A

ISBN: 9780198717348

Category:

Page: 368

View: 4100

Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics offers an accessible, engaging, and optimistic account of cancer biology for undergraduate and graduate students. Using the hallmarks of cancer as a starting point, the book looks at the cellular and molecular mechanisms underpinning the transformation of cells into cancer cells. After discussing the theory, each chapter then demonstrates how this knowledge can be directly applied to the development of new targeted therapies, giving the reader a clear appreciation of how the theory translates to tackling the disease. Drawing on the latest research in this dynamic field, the author makes cutting edge science readily accessible. The book features a variety of learning features--'Pause and think', 'How do we know that?', self-tests and activities--to help students engage with, and master, the concepts presented. The emphasis is not on exhaustive coverage of the subject to the point of overwhelming with detail, but on acquiring a solid understanding of the essentials and an appreciation of how a theoretical understanding can be transformed into therapeutic benefit. Online Resource Centre The Online Resource Centre features: For registered adopters of the book: - Figures from the book, ready to download. - A test bank of multiple choice questions, with feedback linked to the book. For students: - Web links to a range of additional cancer biology resources on the internet.

Molecular Biology of Cancer

Mechanisms, Targets, and Therapeutics

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Author: Lauren Pecorino

Publisher: Oxford University Press, USA

ISBN: 9780199211487

Category: Medical

Page: 316

View: 1295

The second edition of The Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics gives a fresh approach to the study of the molecular basis of cancer, by showing how our understanding of the defective mechanisms which drive cancer is leading to the development of new targeted therapeutic agents. Opening with an overview of the key hallmarks of cancer as a disease state, the book then leads us through the principal components of the regulatory machinery through which cell division is controlled, and explains how the failure of these components can lead to the onset of cancer. Uniquely, within each chapter, students are shown how this molecular knowledge is being applied to develop new targeted therapeutic strategies. Written with the student learner in mind, the book features a variety of learning features to help students engage with, and master, the concepts presented. The emphasis is not on exhaustive coverage of the field, but on acquiring a solid understanding of the essentials of the subject - and an appreciation of how a theoretical understanding can be transformed into therapeutic benefit. The Molecular Biology of Cancer is an invaluable resource for any student wishing to gain an insight into the molecular basis of the disease, and possible solutions for its effective control.

Molecular Biology of Cancer

Mechanisms, Targets, and Therapeutics

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Author: Lauren Pecorino

Publisher: Oxford University Press, USA

ISBN: 9780199264728

Category: Medical

Page: 243

View: 5793

Demonstrating how the malfunction of normal molecular pathways and components can lead to cancer, this text explores how our understanding of these defective mechanisms can be harnessed to develop new targeted therapeutic agents.

The Biology of Cancer, Second Edition

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Author: Robert Weinberg

Publisher: Garland Science

ISBN: 1317963466

Category: Science

Page: 960

View: 5881

Thoroughly updated and incorporating the most important advances in the fast-growing field of cancer biology, The Biology of Cancer, Second Edition, maintains all of its hallmark features admired by students, instructors, researchers, and clinicians around the world. The Biology of Cancer is a textbook for students studying the molecular and cellular bases of cancer at the undergraduate, graduate, and medical school levels. The principles of cancer biology are presented in an organized, cogent, and in-depth manner. The clarity of writing, supported by an extensive full-color art program and numerous pedagogical features, makes the book accessible and engaging. The information unfolds through the presentation of key experiments that give readers a sense of discovery and provide insights into the conceptual foundation underlying modern cancer biology.

Introduction to Cancer Biology

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Author: Robin Hesketh

Publisher: Cambridge University Press

ISBN: 1107013984

Category: Medical

Page: 335

View: 734

A concise overview of the fundamental concepts of cancer biology, ideal for those with little or no background in the field. From cancer epidemiology and the underlying mechanisms, through to tumour detection and treatment, the comprehensive picture revealed will enable students to move into the cancer field with confidence.

The Molecular Biology of Cancer

A Bridge from Bench to Bedside

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Author: Stella Pelengaris,Michael Khan

Publisher: John Wiley & Sons

ISBN: 1118430859

Category: Science

Page: 632

View: 2783

The Molecular Biology of Cancer, Stella Pelengaris & Michael Khan This capturing, comprehensive text, extensively revised and updated for its second edition, provides a detailed overview of the molecular mechanisms underpinning the development of cancer and its treatment. “Bench to Bedside”: A key strength of this book that sets it apart from general cancer biology references is the interweaving of all aspects of cancer biology from the causes, development and diagnosis through to the treatment and care of cancer patients – essential for providing a broader view of cancer and its impact. The highly readable presentation of a complex field, written by an international panel of researchers, specialists and practitioners, would provide an excellent text for graduate and undergraduate courses in the biology of cancer, medical students and qualified practitioners in the field preparing for higher exams, and for researchers and teachers in the field. For the teaching of cancer biology, special features have been included to facilitate this use: bullet points at the beginning of each chapter explaining key concepts and controversial areas; each chapter builds on concepts learned in previous chapters, with a list of key outstanding questions remaining in the field, suggestions for further reading, and questions for student review. All chapters contain text boxes that provide additional and relevant information. Key highlights are listed below: An overview of the cancer cell and important new concepts. Selected human cancers: lung, breast, colorectal, prostate, renal, skin, cervix, and hematological malignancies. Key cellular processes in cancer biology including (a) traditionally important areas such as cell cycle control, growth regulation, oncogenes and tumour suppressors apoptosis, as well as (b) more highly topical areas of apoptosis, telomeres, DNA damage and repair, cell adhesion, angiogenesis, immunity, epigenetics, and the proteasome. Clinical oncology: In-depth coverage of important concepts such as screening, risk of cancer and prevention, diagnoses, managing cancer patients from start to palliative care and end-of-life pathways. Chapters highlighting the direct links between cancer research and clinical applications. New coverage on how cancer drugs are actually used in specific cancer patients, and how therapies are developed and tested. Systems Biology and cutting edge research areas covered such as RNA interference (RNAi). Each chapter includes key points, chapter summaries, text boxes, and topical references for added comprehension and review. Quotations have been used in each chapter to introduce basic concepts in an entertaining way. Supported by a dedicated website at www.blackwellpublishing.com/pelengaris We should list the great reviews we got for first edition which are on the back of the 2nd edition: “A capturing, comprehensive, clearly written and absolutely accurate introduction into cancer biology…..This book deserves great praise for the readable presentation of this complex field….the true synthesis of bench and bedside approaches is marvelously achieved.” Christian Schmidt, Molecular Cell “Chapters address the issues of cancer diagnosis, treatment, and patient care and set the book apart from general molecular biology references….This book is applicable to both graduate and undergraduate students, and in the context of a research laboratory, this book would be an excellent resource as a reference guide for scientists at all levels.” V.Emuss, Institute of Cancer Research, London. Also, from the first edition: “Pelengaris, Khan, and the contributing authors are to be applauded. The Molecular Biology of Cancer is a comprehensive and readable presentation of the many faces of cancer from molecular mechanisms to clinical therapies and diagnostics. This book will be welcomed by neophyte students, established scientists in other fields, and curious physicians.” -Dean Felsher, Stanford University

How Cancer Works

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Author: Lauren Sompayrac

Publisher: Jones & Bartlett Learning

ISBN: 9780763718213

Category: Family & Relationships

Page: 110

View: 5806

Lauren Sompayrac explains the basics of cancer: what it is, what it does, and what is being done to try to cure it.

Principles of Cancer Biology

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Author: Lewis J. Kleinsmith

Publisher: Benjamin-Cummings Publishing Company

ISBN: N.A

Category: Health & Fitness

Page: 312

View: 4640

Principles of Cancer Biology,is an engaging book focused on providing readers with a “big picture” view of cancer. Author Lewis Kleinsmith has written an instructional text focusing on key concepts for a general audience. Each chapter contains a list of suggested readings that expand the detail as needed. The text also emphasizes the scientific evidence that underlies cancer biology, and teaches readers to think critically about this evidence- as there are constantly new “breakthroughs” and reports in this field. For readers who need the review, there are brief reviews of several topics related to DNA replication and repair, cell division, cell signaling, and inheritance patterns in chapters where these subjects are relevant. By including these reviews, the text is both accessible and engaging to a broad audience of readers who are studying cancer biology for the first time, as well as an interested general audience.What Is Cancer, Profile of a Cancer Cell, How Cancers Spread, Identifying the Causes of Cancer, Chemicals and Cancer, Radiation and Cancer, Infectious Agents and Cancer, Heredity and Cancer, Oncogenes, Tumor Suppressor Genes and Cancer Overview, Cancer Screening, Diagnosis, and Treatment, Preventing Cancer, Main Types of Cancer, Human Carcinogens.For all readers interested in the big picture view of cancer.

Cancer Biology

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Author: Raymond W. Ruddon

Publisher: Oxford University Press

ISBN: 0195175433

Category: Medical

Page: 530

View: 5604

The fourth edition of this classic text provides a thorough, yet concise review of the cellular and molecular mechanisms involved in the transformation of normal into malignant cells, the invasiveness of cancer cells into host tissues, and the metastatic spread of cancer cells in the host organism. It defines the fundamental pathophysiologic changes that occur in tumor tissue and in the host animal or patient. Each chapter discusses the historical development of a field, citing the key experimental advances to the present day, and evaluates the current evidence that best supports or rules out concepts of the molecular and cellular mechanisms regulating cancer cell behavior. For all the areas of fundamental cancer research, an effort has been made to relate basic research findings to the clinical disease states. The book is well written and well illustrated, with schematic diagrams and actual research data to demonstrate points made in the text. There is also an extensive, up-to-date bibliography, making the book valuable to scientists, and to physicians, students, and nurses interested in the field of cancer biology. The topics covered include pathologic characterization of human tumors, epidemiology of human cancer, regulation of cell proliferation and differentiation, cellular and molecular phenotypic characteristics of the cancer cell, mechanisms of carcinogenesis, tumor initiation and promotion, viral carcinogenesis, oncogenes and oncogene products, growth factors, chromosomal alterations in cancer, mechanisms of tumor metastasis, host-tumor interactions, fundamental aspects of tumor immunology, and the advances in cancer cell biology that will lead to improved diagnosis and treatment of cancer in the future.

Cancer Signaling

From Molecular Biology to Targeted Therapy

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Author: Christoph Wagener,Oliver Müller,Carol Stocking

Publisher: John Wiley & Sons

ISBN: 3527336583

Category: Science

Page: 360

View: 4637

Cancer, which has become the second-most prevalent health issue globally, is essentially resulting from a malfunction of cell signaling. Understanding how the intricate signaling networks of cells and tissues allow a cancer to thrive - and how these networks can be turned into potent weapons against it - is the key to managing cancer in the clinic and improving the outcome of cancer therapies. In their ground-breaking textbook, the authors tell a compelling story of how cancer works at the molecular level, and how targeted therapies - using kinase inhibitors and other modulators of signaling pathways - can contain and eventually cure it. The first part of the book gives an introduction into the cell and molecular biology of cancer, focusing on the key mechanisms of cancer formation. The second part of the book introduces the main signaling transduction mechanisms responsible for carcinogenesis and compares their functions in healthy versus cancer cells. Coloured figures and the text which is written in plain style make the complex topic easy to understand. Specially prepared teaching videos on key concepts and pathways in cancer signaling illustrate the most relevant aspects and are available online.

The Molecular Basis of Cancer

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Author: John Mendelsohn,Peter M. Howley,Mark A. Israel,Joe W. Gray,Craig B. Thompson

Publisher: Elsevier Health Sciences

ISBN: 0323261965

Category: Medical

Page: 730

View: 4399

Stay current with the latest discoveries in molecular and genomic research. Sweeping revisions throughout include eight brand-new chapters on: Tumor Suppressor Genes; Inflammation and Cancer; Cancer Systems Biology: The Future; Biomarkers Assessing Risk of Cancer; Understanding and Using Information About Cancer Genomes; The Technology of Analyzing Nucleic Acids in Cancer; Molecular Abnormalities in Kidney Cancer; and Molecular Pathology.

Fundamentals of Cancer Epidemiology

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Author: Philip C. Nasca,Harris Pastides

Publisher: Jones & Bartlett Learning

ISBN: 9780834217768

Category: Health & Fitness

Page: 368

View: 2228

Public Health

Principles of Development

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Author: Lewis Wolpert,Emeritus Professor of Biology Lewis Wolpert,Cheryll Tickle,Alfonso Martinez Arias

Publisher: Oxford University Press, USA

ISBN: 0198709889

Category: Developmental biology

Page: 652

View: 724

The process of biological development is an amazing feat of tightly regulated cellular behaviours--differentiation, movement, and growth--powerful enough to result in the emergence of a highly complex living organism from a single cell: the fertilized egg. Principles of Development clearlyillustrates the universal principles that govern this process of development in a succinct and accessible style. Cutting-edge science is explained clearly and succinctly, richly illustrated with a variety of custom drawn figures, animations, and online resources. A focus on the key principles of development throughout the text provides a framework on which a richer understanding of specific topics can bebuilt.

Cell and Molecular Biology of Breast Cancer

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Author: Heide Schatten

Publisher: Springer Science & Business Media

ISBN: 1627036342

Category: Science

Page: 383

View: 7943

Highlighting recent advances in our understanding of breast cancer, this book is intended for a wide audience as a reference book. Included are reviews of genetics, epigenetics, various aspects of cell and molecular biology, and several other areas of breast cancer that are aimed at determining new intervention sites for treatments and cures of the disease. The chapters are written by internationally recognized experts and include reviews of key topics in breast cancer research. Each chapter highlights the new aspects of specific research topics and the various impacts of designing new strategies as well as identifies new targets for therapeutic intervention. The topics addressed are selected to be of interest to patients, scientists, students, teachers, and anyone else interested in expanding their knowledge of breast cancer imaging, diagnostics, therapeutics, or basic biomedical research on breast cancer.

Textbook of Cancer Epidemiology

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Author: Hans-Olov Adami,David J. Hunter,Pagona Lagiou,Lorelei Mucci

Publisher: Oxford University Press

ISBN: 0190676841

Category: Medical

Page: 736

View: 9393

"Comprehensive and comprehensible, but also encouraging -- informed by the hope and belief that informed its creation." -Cancer Amid sweeping advances in the science and treatment of cancer, the TEXTBOOK OF CANCER EPIDEMIOLOGY offers students and professionals a definitive, systematic resource for understanding the factors affecting all types of human cancer. This fully updated new edition offers an overview of epidemiology's key concepts and methods as they relate to cancer (including the emerging potential of biomarkers) as well as site-specific chapters on individual cancers' natural history, pathology, descriptive epidemiology, and etiology. Taken together, these chapters forge connections between established science and the ongoing evolution of this dynamic field. Crisply and concisely written by an assembly of internationally recognized researchers, the TEXTBOOK OF CANCER EPIDEMIOLOGY offers a superlative introduction to the subject's consensuses and controversies for those embarking on their careers and a ready reference for seasoned professionals.

A Practical Guide To Cancer Systems Biology

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Author: Juan Hsueh-fen,Huang Hsuan-cheng

Publisher: World Scientific

ISBN: 9813229160

Category: Medical

Page: 152

View: 5795

Systems biology combines computational and experimental approaches to analyze complex biological systems and focuses on understanding functional activities from a systems-wide perspective. It provides an iterative process of experimental measurements, data analysis, and computational simulation to model biological behavior. This book provides explained protocols for high-throughput experiments and computational analysis procedures central to cancer systems biology research and education. Readers will learn how to generate and analyze high-throughput data, therapeutic target protein structure modeling and docking simulation for drug discovery. This is the first practical guide for students and scientists who wish to become systems biologists or utilize the approach for cancer research. Contents: Introduction to Cancer Systems Biology (Hsueh-Fen Juan and Hsuan-Cheng Huang)Transcriptome Analysis: Library Construction (Hsin-Yi Chang and Hsueh-Fen Juan)Quantitative Proteome: The Isobaric Tags for Relative and Absolute Quantitation (iTRAQ) (Yi-Hsuan Wu and Hsueh-Fen Juan)Phosphoproteome: Sample Preparation (Chia-Wei Hu and Hsueh-Fen Juan)Transcriptomic Data Analysis: RNA-Seq Analysis Using Galaxy (Chia-Lang Hsu and Chantal Hoi Yin Cheung)Proteomic Data Analysis: Functional Enrichment (Hsin-Yi Chang and Hsueh-Fen Juan)Phosphorylation Data Analysis (Chia-Lang Hsu and Wei-Hsuan Wang)Pathway and Network Analysis (Chen-Tsung Huang and Hsueh-Fen Juan)Dynamic Modeling (Yu-Chao Wang)Protein Structure Modeling (Chia-Hsien Lee and Hsueh-Fen Juan)Docking Simulation (Chia-Hsien Lee and Hsueh-Fen Juan) Readership: Graduate students and researchers entering the cancer systems biology field. Keywords: Systems Biology;Transcriptomics;Proteomics;Network Biology;Dynamic Modeling;Protein Structure Modeling;Docking Simulation;BioinformaticsReview: Key Features: Written by two active researchers in the fieldCovers both experimental and computational areas in cancer systems biologyStep-by-step instructions help beginners who are interested in creating biological data and analyzing the data by themselvesReaders will gain the skills to generate and analyze omics data and discover potential therapeutic targets and drug candidates

Therapeutic Strategies in Cancer Biology and Pathology

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Author: Gajanan V. Sherbet

Publisher: Elsevier

ISBN: 0124165907

Category: Medical

Page: 310

View: 9414

Currently, intensive effort is being directed toward the identification of molecular targets that can provide approaches to the development of novel therapeutic strategies in cancer management. This book focuses on metastasis-associated genes, metastasis promoter and suppressor genes, which relate specifically to behavioral alterations of cancer cells in epithelial mesenchymal transition, cancer stem cell maintenance and propagation, and to the acquisition of invasive and metastasis faculty. The function of these genes has implications for cell cycle regulation and cell proliferation and so constitute an essential element in cancer growth and dissemination. The emphasis in this book is on how appropriate these genes are as molecular targets and how practicable are the constituents of their signal transduction systems as potential candidates and how accessible they are to targeted therapy. Written in a straightforward and clear style with background information supporting the new research, this book will be useful for students and researchers in cancer therapies. Identifies molecular targets and their accessibility for therapeutic intervention Provides information on biological features of tumor development and dissemination Background information provided for each topic

DNA Repair in Cancer Therapy

Molecular Targets and Clinical Applications

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Author: Mark R. Kelley,Melissa L. Fishel

Publisher: Academic Press

ISBN: 0128035994

Category: Medical

Page: 464

View: 7859

DNA Repair and Cancer Therapy: Molecular Targets and Clinical Applications, Second Edition provides a comprehensive and timely reference that focuses on the translational and clinical use of DNA repair as a target area for the development of diagnostic biomarkers and the enhancement of cancer treatment. Experts on DNA repair proteins from all areas of cancer biology research take readers from bench research to new therapeutic approaches. This book provides a detailed discussion of combination therapies, in other words, how the inhibition of repair pathways can be coupled with chemotherapy, radiation, or DNA damaging drugs. Newer areas in this edition include the role of DNA repair in chemotherapy induced peripheral neuropathy, radiation DNA damage, Fanconi anemia cross-link repair, translesion DNA polymerases, BRCA1-BRCA2 pathway for HR and synthetic lethality, and mechanisms of resistance to clinical PARP inhibitors. Provides a comprehensive overview of the basic and translational research in DNA repair as a cancer therapeutic target Includes timely updates from the earlier edition, including Fanconi Anemia cross-link repair, translesion DNA polymerases, chemotherapy induced peripheral neuropathy, and many other new areas within DNA repair and cancer therapy Saves academic, medical, and pharma researchers time by allowing them to quickly access the very latest details on DNA repair and cancer therapy Assists researchers and research clinicians in understanding the importance of the breakthroughs that are contributing to advances in disease-specific research

Molecular and Cell Biology of Pain

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Author: N.A

Publisher: Academic Press

ISBN: 0128014326

Category: Science

Page: 648

View: 1646

Pain is the number one reason that people seek medical attention but pain is still under- and poorly-treated world-wide. The purpose of this book is to give an up to date picture of what causes pain, how pain becomes chronic and what pharmacological targets might be manipulated to alleviate acute and chronic pain. The book will cover a wide array of topics from gene polymorphisms to voltage-gated ion channels moving from cellular biology to whole animal physiology. Written by future leaders in the pain field Covers a wide range of targets Contains provocative ideas about the future direction of the pain field.