Metallomics

A Primer of Integrated Biometal Sciences

DOWNLOAD NOW »

Author: Wolfgang Maret

Publisher: World Scientific Publishing Company

ISBN: 1783268301

Category: Science

Page: 156

View: 8686

Metallomics is an integrated biometal science as it unifies different disciplines into a mainstream subject that can be taught to students of the biological and biomedical sciences. Metallomics bridges chemistry and the biological sciences from a global and quantitative systems approach, while the biological context provides new insights into the functions of metals in biological cells. The book challenges the traditional view of relating biochemistry only to organic chemistry, and discusses the structure and function of metal ions in the context of their environment in organisms. This is an essential read for undergraduate and graduate students in the fields of biochemistry, cell biology, nutrition (trace element research), toxicology, pharmacology and ecology.

Metallomics

The Science of Biometals

DOWNLOAD NOW »

Author: Marco Aurélio Zezzi Arruda

Publisher: Springer

ISBN: 3319901435

Category: Science

Page: 279

View: 4791

This book covers the new Omics area, Metallomics. As Metallomics is intrinsically a transdisciplinary area, this book is authored by experts in the field on such diverse topics as Environmental, Nuclear, and Human Metallomics. Within these topics metals play important role, as being part of biomolecules, controlling different biochemical process, being signaling agents, being catalyst of biochemical reactions, among others. This volume demonstrates the importance of more investigation about metals and their interactions with biomolecules. As the knowledge in this field is growing and growing daily, then new challenges concerning studies involving Metallomics is appearing, such as comparative metallomics, speciation metallomics, real-time metallomics, new predictions of metals in biomolecules, metalloprotein databank expansion, interactions between metalloprotein-metalloprotein, among others.

Nuclear Analytical Techniques for Metallomics and Metalloproteomics

DOWNLOAD NOW »

Author: Chunying Chen,Zhifang Chai,Yuxi Gao

Publisher: Royal Society of Chemistry

ISBN: 1847559018

Category: Science

Page: 397

View: 9045

This authoritative book provides readers with a comprehensive view of advanced nuclear analytical techniques for metallomics and metalloproteomics.

Metallomics

Recent Analytical Techniques and Applications

DOWNLOAD NOW »

Author: Yasumitsu Ogra,Takafumi Hirata

Publisher: Springer

ISBN: 4431564632

Category: Medical

Page: 364

View: 3602

This book focuses on recent topics in metallomics, a study of the metallome, or metal-containing biomolecules. Metals can induce various physiological and toxicological effects in a very small amounts, in other words, the concentrations of biometals are very low in organisms. Thus, analytical techniques for a trace amount of metal are crucial to understand the biological and toxicological functions of metals.This volume begins with an overview of metallomics including the history and development of the field. Subsequent parts provide basic and advanced techniques for metallomics. Speciation and imaging of metals are basic approaches to reveal the function of the metallome. The applications of speciation using an HPLC hyphenated with inductively coupled plasma mass spectrometry (LC-ICP-MS) and flow cytometry ICP-MS are described. As advanced approaches, the applications using a micro-flow injection-ICP-MS, an ICP-triple quadrupole mass spectrometer, an ICP-sector field mass spectrometer, and an ICP-multi-collector mass spectrometer are mentioned. For the imaging of metals, basic principles and applications of several techniques such as scanning X-ray fluorescence microscopy and ICP-MS equipped with laser ablation (LA-ICP-MS) are presented. Speciation analyses using electrospray ionization mass spectrometry (ESI-MS), X-ray Absorption Spectroscopy (XAS), and nuclear magnetic resonance spectroscopy (NMR) are also introduced. The last part highlights the medical and pharmaceutical applications of metallomics. Molecular biological approaches to reveal the effects of toxic metals, metal functions in brain and neurodegenerative diseases, and metallodrugs are explained. The topic of metal transporters is also presented.

Metallomics

Analytical Techniques and Speciation Methods

DOWNLOAD NOW »

Author: Bernhard Michalke

Publisher: John Wiley & Sons

ISBN: 3527339698

Category: Science

Page: 496

View: 9724

Latest developments, new insights and knowledge derived from speciation analysis in one unique compilation: The reader gets acquainted with relevant instrumental as well as application aspects of metallomics approaches, paving the road to understanding fate, pathway, and action of metals in environment and organisms. Upon an introductory chapter on analytical methods and strategies, the full bandwidth of applications is discussed. Expert chapter authors cast spotlights on recent topics such as metallomics applications to environmental and nutrition studies as well as biology and medicine. Special chapters deal with the impact of manganese and iron on neurodegeneration, and the impact of nanoparticles on health.

Metallomics and the Cell

DOWNLOAD NOW »

Author: Lucia Banci

Publisher: Springer Science & Business Media

ISBN: 9400755619

Category: Science

Page: 609

View: 3113

Metallomics and the Cell provides in an authoritative and timely manner in 16 stimulating chapters, written by 37 internationally recognized experts from 9 nations, and supported by more than 3000 references, several tables, and 110 illustrations, mostly in color, a most up-to-date view of the "metallomes" which, as defined in the "omics" world, describe the entire set of biomolecules that interact with or are affected by each metal ion. The most relevant tools for visualizing metal ions in the cell and the most suitable bioinformatic tools for browsing genomes to identify metal-binding proteins are also presented. Thus, MILS-12 is of relevance for structural and systems biology, inorganic biological chemistry, genetics, medicine, diagnostics, as well as teaching, etc.

Biological Chemistry of Arsenic, Antimony and Bismuth

DOWNLOAD NOW »

Author: Hongzhe Sun

Publisher: John Wiley & Sons

ISBN: 0470976225

Category: Science

Page: 400

View: 4029

Arsenic, antimony and bismuth, three related elements of group 15, are all found in trace quantities in nature and have interesting biological properties and uses. While arsenic is most well known as a poison - and indeed the contamination of groundwater by arsenic is becoming a major health problem in Asia - it also has uses for the treatment of blood cancer and has long been used in traditional chinese medicine. Antimony and bismuth compounds are used in the clinic for the treatment of parasitic and bacterial infections. Biological Chemistry of Arsenic, Antimony and Bismuth is an essential overview of the biological chemistry of these three elements, with contributions from an international panel of experts. Topics covered include: chemistry of As, Sb and Bi biological chemistry of arsenic biological chemistry of Sb and Bi arsenic and antimony speciation in environmental and biological samples arsenic in traditional chinese medicine arsenic in aquifers biomethylation of As, Sb and Bi uptake of metalloids by cells bismuth complexes of porphyrins and their potential in medical applications Helicobacter pylori and bismuth metabolism of arsenic trioxide in blood of the acute promyelocytic leukemia patients anticancer properties of As, Sb and Bi radio-Bi in cancer therapy genotoxicity of As, Sb and Bi metallomics as a new technique for As, Sb and Bi metalloproteomics for As, Sb and Bi Biological Chemistry of Arsenic, Antimony and Bismuth conveys the essential aspects of the bioinorganic chemistry of these three elements, making this book a valuable complement to more general bioinorganic chemistry texts and more specialized topical reviews. It will find a place on the bookshelves of practitioners, researchers and students working in bioinorganic chemistry and medicinal chemistry.

Heavy Metal Stress in Plants

DOWNLOAD NOW »

Author: Dharmendra K. Gupta,Francisco J. Corpas,José M. Palma

Publisher: Springer Science & Business Media

ISBN: 3642384692

Category: Science

Page: 242

View: 8374

Plants possess a range of potential cellular mechanisms that may be involved in the detoxification of heavy metals and thus tolerance to metal stress. Metal toxicity causes multiple direct and indirect effects in plants that concern practically all physiological functions. The main purpose of this book is to present comprehensive and concise information on recent advances in the field of metal transport and how genetic diversity affects heavy metal transport in plants. Other key futures of the book are related to metal toxicity and detoxification mechanisms, biochemical tools for HM remediation processes, molecular mechanisms for HM detoxification, how metallomics and metalloproteomics are affected by heavy metal stress in plants, and the role of ROS metabolism in the alleviation of heavy metals. Some chapters also focus on recent developments in the field of phytoremediation. Overall the book presents in-depth information and the most essential advances in the field of heavy metal toxicity in plants in recent years.

Proceedings

DOWNLOAD NOW »

Author: National Academy of Sciences, India

Publisher: N.A

ISBN: N.A

Category: Science

Page: N.A

View: 2068

Menkes Disease: New Insights for the Healthcare Professional: 2012 Edition

ScholarlyPaper

DOWNLOAD NOW »

Author: N.A

Publisher: ScholarlyEditions

ISBN: 146498977X

Category: Medical

Page: 15

View: 2694

Menkes Disease: New Insights for the Healthcare Professional / 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Menkes Disease in a compact format. The editors have built Menkes Disease: New Insights for the Healthcare Professional / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Menkes Disease in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Menkes Disease: New Insights for the Healthcare Professional / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Advances in Phosphotransferases (Phosphomutases) Research and Application: 2012 Edition

ScholarlyPaper

DOWNLOAD NOW »

Author: N.A

Publisher: ScholarlyEditions

ISBN: 1481643592

Category: Medical

Page: 15

View: 8170

Advances in Phosphotransferases (Phosphomutases) Research and Application / 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Phosphotransferases (Phosphomutases) in a compact format. The editors have built Advances in Phosphotransferases (Phosphomutases) Research and Application / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Phosphotransferases (Phosphomutases) in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Phosphotransferases (Phosphomutases) Research and Application / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Microbial Ecology

DOWNLOAD NOW »

Author: Larry L. Barton,Diana E. Northup

Publisher: John Wiley & Sons

ISBN: 1118015835

Category: Science

Page: 440

View: 1149

This book covers the ecological activities of microbes in the biosphere with an emphasis on microbial interactions within their environments and communities In thirteen concise and timely chapters, Microbial Ecology presents a broad overview of this rapidly growing field, explaining the basic principles in an easy-to-follow manner. Using an integrative approach, it comprehensively covers traditional issues in ecology as well as cutting-edge content at the intersection of ecology, microbiology, environmental science and engineering, and molecular biology. Examining the microbial characteristics that enable microbes to grow in different environments, the book provides insights into relevant methodologies for characterization of microorganisms in the environment. The authors draw upon their extensive experience in teaching microbiology to address the latest hot-button topics in the field, such as: Ecology of microorganisms in natural and engineered environments Advances in molecular-based understanding of microbial phylogeny and interactions Microbially driven biogeochemical processes and interactions among microbial populations and communities Microbial activities in extreme or unusual environments Ecological studies pertaining to animal, plant, and insect microbiology Microbial processes and interactions associated with environmental pollution Designed for use in teaching, Microbial Ecology offers numerous special features to aid both students and instructors, including: Information boxes that highlight key microbial ecology issues "Microbial Spotlights" that focus on how prominent microbial ecologists became interested in microbial ecology Examples that illustrate the role of bacterial interaction with humans Exercises to promote critical thinking Selected reading lists Chapter summaries and review questions for class discussion Various microbial interactions and community structures are presented through examples and illustrations. Also included are mini case studies that address activities of microorganisms in specific environments, as well as a glossary and key words. All these features make this an ideal textbook for graduate or upper-level undergraduate students in biology, microbiology, ecology, or environmental science. It also serves as a highly useful reference for scientists and environmental professionals. PowerPoint slides of figures from the book are available for download at: ftp://ftp.wiley.com/public/sci_tech_med/microbial_ecology