Genomes 3

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Author: Terence A. Brown

Publisher: Garland Science

ISBN: 0815341385

Category: Science

Page: 713

View: 837

The VitalBook e-book version of Genomes 3 is only available in the US and Canada at the present time. To purchase or rent please visit http://store.vitalsource.com/show/9780815341383 Covering molecular genetics from the basics through to genome expression and molecular phylogenetics, Genomes 3is the latest edition of this pioneering textbook. Updated to incorporate the recent major advances, Genomes 3 is an invaluable companion for any undergraduate throughout their studies in molecular genetics. Genomes 3 builds on the achievements of the previous two editions by putting genomes, rather than genes, at the centre of molecular genetics teaching. Recognizing that molecular biology research was being driven more by genome sequencing and functional analysis than by research into genes, this approach has gathered momentum in recent years.

Genome Stability

From Virus to Human Application

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Author: Igor Kovalchuk,Olga Kovalchuk

Publisher: Academic Press

ISBN: 0128033452

Category: Medical

Page: 712

View: 8984

Every species has to preserve the integrity of its genome to ensure faithful passage of genetic information to the progeny. At the same time, there are times during the life of the organism and population in general when a fine balance in genome stability and diversification has to be made to benefit the survival of the species. Genome Stability teaches the reader how various species maintain this fine balance in genome stability and genome diversification in response to their environments. Genome Stability covers a wide range of topics, including the genome stability of DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes and mammals. Topics also include major DNA repair mechanisms, the role of chromatin in genome stability, human diseases associated with genome instability as well as changes in genome stability in response to aging. Finally, Genome Stability covers how epigenetic factors contribute to genome stability and how the species pass the memory of the encounters to the progeny, thus influencing the genome of the progeny in an indirect manner. This volume is an essential resource for geneticists, epigeneticists, and molecular biologists who are looking to gain a deeper understanding of this rapidly-expanding field, and can also be of great use to advanced students who are looking to gain additional expertise in genome stability. Includes a collection of chapters on genome stability research from various kingdoms, including topics such as epigenetics and transgenerational effects Provides the first comprehensive coverage of the differences in the mechanisms utilized by different organisms to maintain genomic stability Contains applications of genome instability and its effect on human diseases Explains how various species maintain the fine balance in genome stability and genome diversification in response to their environments

Genetics, Genomics and Breeding of Stone Fruits

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Author: Chittaranjan Kole,Albert G. Abbott

Publisher: CRC Press

ISBN: 1466565497

Category: Science

Page: 418

View: 9427

The stone fruits—including peaches, apricots, almonds, plums, and cherries—have been bred and grown for thousands of years and today are significant agricultural crops in many local economies worldwide. This volume presents a comprehensive commentary on classical genetics and breeding, molecular mapping and breeding of agronomic traits, and the cloning of genes of interest. It also explores recent advances on omics sciences including structural and functional genomics, proteomics, nd metabolomics. The book enumerates the whole genome sequencing of the model fruit plant peach and discusses bioinformatic strategies and tools for stone fruit research

From Genes to Genomes

Concepts and Applications of DNA Technology

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Author: Jeremy W. Dale,Malcolm von Schantz,Nick Plant

Publisher: John Wiley & Sons

ISBN: 0470683856

Category: Science

Page: 386

View: 633

Rapid advances in a collection of techniques referred to as gene technology, genetic engineering, recombinant DNA technology and gene cloning have pushed molecular biology to the forefront of the biological sciences.

Gentechnologie für Einsteiger

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Author: T. A. Brown

Publisher: Spektrum Akademischer Verlag

ISBN: 9783827428684

Category: Science

Page: 298

View: 6046

Gentechnologie für Einsteiger hat sich weltweit als leicht verständliche Einführung in dieses wichtige und spannende Wissenschaftsgebiet bewährt. Die sechste Auflage bleibt dem Grundkonzept früherer Auflagen treu, widmet sich aber auch neuen, wachsenden Forschungsfeldern. Das Buch bleibt damit ein unentbehrlicher Leitfaden für Studierende in den Biowissenschaften und ihren zahlreichen Teilgebieten. Es eignet sich auch bestens als Einführung für alle, die sich in ihrem Beruf mit den Grundlagen des Themas vertraut machen müssen.

Encyclopedia of Microbiology

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Author: N.A

Publisher: Academic Press

ISBN: 0123739446

Category: Science

Page: 4600

View: 4461

Available as an exclusive product with a limited print run, Encyclopedia of Microbiology, 3e, is a comprehensive survey of microbiology, edited by world-class researchers. Each article is written by an expert in that specific domain and includes a glossary, list of abbreviations, defining statement, introduction, further reading and cross-references to other related encyclopedia articles. Written at a level suitable for university undergraduates, the breadth and depth of coverage will appeal beyond undergraduates to professionals and academics in related fields. 16 separate areas of microbiology covered for breadth and depth of content Extensive use of figures, tables, and color illustrations and photographs Language is accessible for undergraduates, depth appropriate for scientists Links to original journal articles via Crossref 30% NEW articles and 4-color throughout - NEW!

Genetics and Genomics of Rosaceae

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Author: Kevin M. Folta,Susan E. Gardiner

Publisher: Springer Science & Business Media

ISBN: 9780387774916

Category: Science

Page: 636

View: 9276

This is the first book on Rosaceae genomics. It covers progress in recent genomic research among the Rosaceae, grounding this firmly in the historical context of genetic studies and in the application of genomics technologies for crop development.

Biotechnology of Lactic Acid Bacteria

Novel Applications

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Author: Fernanda Mozzi,R?ul R. Raya,Graciela M. Vignolo

Publisher: John Wiley & Sons

ISBN: 0813820952

Category: Technology & Engineering

Page: 352

View: 1198

This title represents a broad review of current research on LAB and their novel applications with contributions from a number of well-known leading scientists. The book encompasses a wide range of topics including both traditional and novel developing fields, and provides unparalleled, comprehensive information on new advances of genomics, proteomics, metabolism and biodiversity of LAB. Chapters contain state-of-the-art discussions of specific LAB applications such as their use as probiotics, live vaccines and starter cultures in old and new fermented products. The safety of these microorganisms and their interactions with diverse ecosystems natural biota are also covered as well as the new applications of well-known (bacteriocins) and novel (vitamins, low-calorie sugars, etc.) metabolites produced by LAB. This book is an essential reference for established researchers and scientists, doctoral and post-doctoral students, university professors and instructors, and food technologists working on food microbiology, physiology and biotechnology of lactic acid bacteria.

Principles and Technical Aspects of PCR Amplification

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Author: Elizabeth van Pelt-Verkuil,Alex van Belkum,John P. Hays

Publisher: Springer Science & Business Media

ISBN: 9781402062414

Category: Science

Page: 330

View: 2302

Kary Mullis was awarded a Nobel Prize for inventing the PCR technique more than a decade ago in 1993. Since its "discovery", multiple adaptations and variations of the standard PCR technique have been described. This publication aims to provide the reader with a guide to the standard PCR technique and its many available variants, with particular emphasis being placed on the role of these PCR techniques in the clinical diagnostic laboratory (the central theme of this book).

Ancestors in Our Genome

The New Science of Human Evolution

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Author: Eugene E. Harris

Publisher: Oxford University Press

ISBN: 0199978204

Category: Science

Page: 200

View: 5563

In 2001, scientists were finally able to determine the full human genome sequence, and with the discovery began a genomic voyage back in time. Since then, we have sequenced the full genomes of a number of mankind's primate relatives at a remarkable rate. The genomes of the common chimpanzee (2005) and bonobo (2012), orangutan (2011), gorilla (2012), and macaque monkey (2007) have already been identified, and the determination of other primate genomes is well underway. Researchers are beginning to unravel our full genomic history, comparing it with closely related species to answer age-old questions about how and when we evolved. For the first time, we are finding our own ancestors in our genome and are thereby gleaning new information about our evolutionary past. In Ancestors in Our Genome, molecular anthropologist Eugene E. Harris presents us with a complete and up-to-date account of the evolution of the human genome and our species. Written from the perspective of population genetics, and in simple terms, the book traces human origins back to their source among our earliest human ancestors, and explains many of the most intriguing questions that genome scientists are currently working to answer. For example, what does the high level of discordance among the gene trees of humans and the African great apes tell us about our respective separations from our common ancestor? Was our separation from the apes fast or slow, and when and why did it occur? Where, when, and how did our modern species evolve? How do we search across genomes to find the genomic underpinnings of our large and complex brains and language abilities? How can we find the genomic bases for life at high altitudes, for lactose tolerance, resistance to disease, and for our different skin pigmentations? How and when did we interbreed with Neandertals and the recently discovered ancient Denisovans of Asia? Harris draws upon extensive experience researching primate evolution in order to deliver a lively and thorough history of human evolution. Ancestors in Our Genome is the most complete discussion of our current understanding of the human genome available.

Gram-Positive Asporogenous Rods—Advances in Research and Application: 2012 Edition

ScholarlyPaper

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Author: N.A

Publisher: ScholarlyEditions

ISBN: 1481626221

Category: Science

Page: 29

View: 8887

Gram-Positive Asporogenous Rods—Advances in Research and Application: 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Gram-Positive Asporogenous Rods in a compact format. The editors have built Gram-Positive Asporogenous Rods—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Gram-Positive Asporogenous Rods in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Gram-Positive Asporogenous Rods—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Bioinformatics Research and Applications

5th International Symposium, ISBRA 2009 Fort Lauderdale, FL, USA, May 13-16, 2009, Proceedings

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Author: Ion Mandoiu

Publisher: Springer Science & Business Media

ISBN: 3642015506

Category: Computers

Page: 336

View: 2391

This book constitutes the refereed proceedings of the 5th International Symposium on Bioinformatics Research and Applications, ISBRA 2009, held in Fort Lauderdale, FL, USA, in May 2009. The 26 revised full papers presented together four invited papers were carefully reviewed and selected from a total of 55 submissions. The papers cover a wide range of topics, including clustering and classification, gene expression analysis, gene networks, genome analysis, motif finding, pathways, protein structure prediction, protein domain interactions, phylogenetics, and software tools.

Modern Genome Annotation

The Biosapiens Network

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Author: D. Frishman,Alfonso Valencia

Publisher: Springer Science & Business Media

ISBN: 3211751238

Category: Science

Page: 490

View: 9835

An accurate description of current scientific developments in the field of bioinformatics and computational implementation is presented by research of the BioSapiens Network of Excellence. Bioinformatics is essential for annotating the structure and function of genes, proteins and the analysis of complete genomes and to molecular biology and biochemistry. Included is an overview of bioinformatics, the full spectrum of genome annotation approaches including; genome analysis and gene prediction, gene regulation analysis and expression, genome variation and QTL analysis, large scale protein annotation of function and structure, annotation and prediction of protein interactions, and the organization and annotation of molecular networks and biochemical pathways. Also covered is a technical framework to organize and represent genome data using the DAS technology and work in the annotation of two large genomic sets: HIV/HCV viral genomes and splicing alternatives potentially encoded in 1% of the human genome.

Tag-based Next Generation Sequencing

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Author: Guenter Kahl

Publisher: John Wiley & Sons

ISBN: 352732819X

Category: Science

Page: 581

View: 2123

Tag-based approaches were originally designed to increase the throughput of capillary sequencing, where concatemers of short sequences were first used in expression profiling. New Next Generation Sequencing methods largely extended the use of tag-based approaches as the tag lengths perfectly match with the short read length of highly parallel sequencing reactions. Tag-based approaches will maintain their important role in life and biomedical science, because longer read lengths are often not required to obtain meaningful data for many applications. Whereas genome re-sequencing and de novo sequencing will benefit from ever more powerful sequencing methods, analytical applications can be performed by tag-based approaches, where the focus shifts from 'sequencing power' to better means of data analysis and visualization for common users. Today Next Generation Sequence data require powerful bioinformatics expertise that has to be converted into easy-to-use data analysis tools. The book's intention is to give an overview on recently developed tag-based approaches along with means of their data analysis together with introductions to Next-Generation Sequencing Methods, protocols and user guides to be an entry for scientists to tag-based approaches for Next Generation Sequencing.

Handbook of Computational Molecular Biology

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Author: Srinivas Aluru

Publisher: CRC Press

ISBN: 9781420036275

Category: Science

Page: 1104

View: 7056

The enormous complexity of biological systems at the molecular level must be answered with powerful computational methods. Computational biology is a young field, but has seen rapid growth and advancement over the past few decades. Surveying the progress made in this multidisciplinary field, the Handbook of Computational Molecular Biology offers comprehensive, systematic coverage of the various techniques and methodologies currently available. Accomplished researcher Srinivas Aluru leads a team of experts from around the world to produce this groundbreaking, authoritative reference. With discussions ranging from fundamental concepts to practical applications, this book details the algorithms necessary to solve novel problems and manage the massive amounts of data housed in biological databases throughout the world. Divided into eight sections for convenient searching, the handbook covers methods and algorithms for sequence alignment, string data structures, sequence assembly and clustering, genome-scale computational methods in comparative genomics, evolutionary and phylogenetic trees, microarrays and gene expression analysis, computational methods in structural biology, and bioinformatics databases and data mining. The Handbook of Computational Molecular Biology is the first resource to integrate coverage of the broad spectrum of topics in computational biology and bioinformatics. It supplies a quick-reference guide for easy implementation and provides a strong foundation for future discoveries in the field.

Bioconsensus

DIMACS Working Group Meetings on Bioconsensus : October 25-26, 2000 and October 2-5, 2001, DIMACS Center

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Author: Melvin F. Janowitz

Publisher: American Mathematical Soc.

ISBN: 9780821871034

Category: Science

Page: 242

View: 7647

This volume is based on two DIMACS working group meetings on ''Bioconsensus''. It provides a valuable introduction and reference to the various aspects of this rapidly developing field. The meetings brought together mathematical and biological scientists to discuss the uses in the biological sciences of methods of consensus and social choice. These two lively meetings contributed much toward establishing the new field of ''bioconsensus''. Yet this book is much more than just a report of two meetings. It includes some historical background, as well as a substantial introduction to the axiomatic foundations of the field of bioconsensus and some practical applications of consensus methods to real data. Also included are contributed papers from experts who were not at the meetings. The book is intended for mathematical biologists, evolutionary biologists, and computer scientists.

Protein Engineering Handbook

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Author: Stefan Lutz,Uwe Theo Bornscheuer

Publisher: John Wiley & Sons

ISBN: 3527667016

Category: Science

Page: 1015

View: 8583

Unparalleled in size and scope, this new major reference integrates academic and industrial knowledge into a single resource, allowing for a unique overview of the entire field. Adopting a systematic and practice-oriented approach, and including a wide range of technical and methodological information, this highly accessible handbook is an invaluable 'toolbox' for any bioengineer. In two massive volumes, it covers the full spectrum of current concepts, methods and application areas.

Issues in Life Sciences: Molecular Biology: 2011 Edition

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Author: N.A

Publisher: ScholarlyEditions

ISBN: 1464963495

Category: Science

Page: 3330

View: 3262

Issues in Life Sciences: Molecular Biology / 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Life Sciences—Molecular Biology. The editors have built Issues in Life Sciences: Molecular Biology: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Life Sciences—Molecular Biology in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Life Sciences: Molecular Biology: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

PCR Cloning Protocols

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Author: Bing-Yuan Chen,Harry W. Janes

Publisher: Springer Science & Business Media

ISBN: 1592591779

Category: Science

Page: 460

View: 4210

Annotation PCR Cloning Protocols, Second Edition, updates and expands Bruce White's best-selling PCR Cloning Protocols (1997) with the newest procedures for DNA cloning and mutagenesis. Here the researcher will find readily reproducible methods for all the major aspects of PCR use, including PCR optimization, computer programs for PCR primer design and analysis, and novel variations for cloning genes of special characteristics or origin, with emphasis on long distance PCR and GC-rich template amplification. Also included are both conventional and novel enzyme-free and restriction site-free procedures to clone PCR products into a range of vectors, as well as state-of-the-art protocols to facilitate DNA mutagenesis and recombination, and to clone the challenging uncharacterized DNA flanking a known DNA fragment.

Multidisciplinary Management of Head and Neck Cancer

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Author: Robert I. Haddad, MD

Publisher: Demos Medical Publishing

ISBN: 1617050121

Category: Medical

Page: 288

View: 8625

Head and neck cancer is a very common cancer worldwide with an estimated 500,000 individuals diagnosed each year. In the United States an average of 39,000 new cases are reported each year representing between 3 to 5% of all new cancer cases diagnosed annually. Head and neck cancers are more common in men and in individuals over the age of 50. The treatment of head and neck cancer is extremely challenging and involves insight and expertise from multiple disciplines. Multidisciplinary Management of Head and Neck Cancer is a comprehensive textbook looking at different aspects of head and neck cancer, including the diagnosis, treatment and outcomes for patients with this disease. The chapters written by world-renowned experts cover the entire discipline of head and neck oncology and include discussion of the role of HPV infections, advances in radiotherapy, new surgical techniques, novel agents in thyroid therapy and more. The book is designed to be both practical and comprehensive for the physicians treating this complex disease. Features of Multidisciplinary Management of Head and Neck Cancer include: A chapter on the role of HPV infections in head and neck cancer A chapter on new advances in radiotherapy for head and neck cancer, including review IMRT, new standards and potential pitfalls Detailed discussion of the role of chemotherapy in head and neck cancer, including commonly used drugs and how to combine them with radiotherapy to improve patient outcomes Detailed discussion on incorporating novel agents with radiotherapy Detailed discussion of novel therapeutics in head and neck cancer, including new drugs and biologics