Epilepsy as a Dynamic Disease

DOWNLOAD NOW »

Author: John Milton,Peter Jung

Publisher: Springer Science & Business Media

ISBN: 366205048X

Category: Science

Page: 417

View: 4497

The first book to bring together experts in epilepsy, bio-engineering and dynamical systems theory, to discuss the possibility of treating epilepsy by controlling mechanisms that cause seizures. It includes a unique reference database with more than 1000 references, including hard-to-access references in the Russian literature.

Quantitative EEG Analysis Methods and Clinical Applications

DOWNLOAD NOW »

Author: Shanbao Tong,Nitish Vyomesh Thakor

Publisher: Artech House

ISBN: 1596932058

Category: Electroencephalography

Page: 421

View: 2362

This authoritative volume provides an overview of basic and advanced techniques used in quantitative EEG (qEEG) analysis. The book provides a wide range of mathematical tools used in qEEG, from single channel discriptors to the interactions among multi-channel EEG analysis. Moreover, you find coverage of the latest and most popular application in the field, including mental and neurological disease detection/monitoring, physiological and cognitive phenomena research, and fMRI.

Seizures

Medical Causes and Management

DOWNLOAD NOW »

Author: Norman Delanty

Publisher: Springer Science & Business Media

ISBN: 1592590942

Category: Medical

Page: 368

View: 2918

Seizures are frightening events. They frighten the patients who experience them; they frighten those who witness them; they also frighten many physicians who have to deal with them. Most individuals with seizures present to family physicians or to emergency room physicians. However, despite the fact that seizures are among the most common neurological conditions, most general practitioners, family practice specialists, and intemists do not see large numbers of patients with seizures. Given the apoplectic appearance of generalized tonic clonic convulsions, it is not difficult to understand why they arouse such emotional responses in those that experience them, those that witness them, and those whose care is sought for them. Seizures are symptoms of something wrong with the brain. Many different kinds of perturbations in brain anatomy, chemistry, or physiology can produce seizures. For many individuals, seizures occur in the context of an acute illness and will not recur once that illness is treated. These individuals do not have epilepsy. They have transient disturbances in brain function attributable to systemic medical conditions. It is important to recognize these issues, because, first, the seizure may be the initial, or even only, manifestation of the underlying medical problem and this needs to be recognized.

Seizure Prediction in Epilepsy

From Basic Mechanisms to Clinical Applications

DOWNLOAD NOW »

Author: Björn Schelter,Jens Timmer,Andreas Schulze-Bonhage

Publisher: John Wiley & Sons

ISBN: 3527625208

Category: Science

Page: 369

View: 311

Comprising some 30 contributions, experts from around the world present and discuss recent advances related to seizure prediction in epilepsy. The book covers an extraordinarily broad spectrum, starting from modeling epilepsy in single cells or networks of a few cells to precisely-tailored seizure prediction techniques as applied to human data. This unique overview of our current level of knowledge and future perspectives provides theoreticians as well as practitioners, newcomers and experts with an up-to-date survey of developments in this important field of research.

Epilepsy: Basic principles and diagnosis

DOWNLOAD NOW »

Author: Hermann Stefan,William H. Theodore

Publisher: Newnes

ISBN: 0444528989

Category: Medical

Page: 548

View: 2742

Volume 1: This book offers a comprehensive review of our knowledge of the field today, including epidemiology, basic mechanisms, animal models, and topics of increasing interest such as the role of inflammation in epilepsy. It provides a comprehensive approach to the description of the clinical, electrographic and imaging aspects of the epilepsies, with a clear outline of contemporary classification and the role of modern diagnostic techniques as well as neuropsychological and psychiatric aspects of epilepsy. Chapters are authored by internationally respected neurologists with varied perspectives, ensuring depth to the content. [Ed.].

Astrocytes and Epilepsy

DOWNLOAD NOW »

Author: Jacqueline A. Hubbard,Devin K. Binder

Publisher: Academic Press

ISBN: 0128026243

Category: Medical

Page: 394

View: 3883

Epilepsy is a devastating group of neurological disorders characterized by periodic and unpredictable seizure activity in the brain. There is a critical need for new drugs and approaches given than at least one-third of all epilepsy patients are not made free of seizures by existing medications and become "medically refractory". Much of epilepsy research has focused on neuronal therapeutic targets, but current antiepileptic drugs often cause severe cognitive, developmental, and behavioral side effects. Recent findings indicate a critical contribution of astrocytes, star-shaped glial cells in the brain, to neuronal and network excitability and seizure activity. Furthermore, many important cellular and molecular changes occur in astrocytes in epileptic tissue in both humans and animal models of epilepsy. The goal of Astrocytes and Epilepsy is to comprehensively review exciting findings linking changes in astrocytes to functional changes responsible for epilepsy for the first time in book format. These insights into astrocyte contribution to seizure susceptibility indicate that astrocytes may represent an important new therapeutic target in the control of epilepsy. Astrocytes and Epilepsy includes background explanatory text on astrocyte morphology and physiology, epilepsy models and syndromes, and evidence from both human tissue studies and animal models linking functional changes in astrocytes to epilepsy. Beautifully labelled diagrams are presented and relevant figures from the literature are reproduced to elucidate key findings and concepts in this rapidly emerging field. Astrocytes and Epilepsy is written for neuroscientists, epilepsy researchers, astrocyte investigators as well as neurologists and other specialists caring for patients with epilepsy. Presents the first comprehensive book to synthesize historical and recent research on astrocytes and epilepsy into one coherent volume Provides a great resource on the field of astrocyte biology and astrocyte-neuron interactions Details potential therapeutic targets, including chapters on gap junctions, water and potassium channels, glutamate and adenosine metabolism, and inflammation

Jasper's Basic Mechanisms of the Epilepsies

DOWNLOAD NOW »

Author: Jeffrey Noebels,Massimo Avoli,Michael Rogawski,Richard Olsen,Antonio Delgado-Escueta

Publisher: Oxford University Press

ISBN: 0199842590

Category: Medical

Page: 1264

View: 5619

H.H. Jasper, A.A. Ward, A. Pope and H.H. Merritt, chair of the Public Health Service Advisory Committee on the Epilepsies, National Institutes of Health, published the first volume on Basic Mechanisms of the Epilepsies (BME) in 1969. Their ultimate goal was to search for a "better understanding of the epilepsies and seek more rational methods of their prevention and treatment." Since then, basic and clinical researchers in epilepsy have gathered together every decade and a half with these goals in mind -- assessing where epilepsy research has been, what it has accomplished, and where it should go. In 1999, the third volume of BME was named in honor of H.H. Jasper. In line with the enormous expansion in the understanding of basic epilepsy mechanisms over the past four decades, this fourth edition of Jasper's BME is the most ambitious yet. In 90 chapters, the book considers the role of interactions between neurons, synapses, and glia in the initiation, spread and arrest of seizures. It examines mechanisms of excitability, synchronization, seizure susceptibility, and ultimately epileptogenesis. It provides a framework for expanding the epilepsy genome and understanding the complex heredity responsible for common epilepsies as it explores disease mechanisms of ion channelopathies and developmental epilepsy genes. It considers the mechanisms of conditions of epilepsy comorbidities. And, for the first time, this 4th edition describes the current efforts to translate the discoveries in epilepsy disease mechanisms into new therapeutic strategies. This book, considered the 'bible' of basic epilepsy research, is essential for the student, the clinician scientist and all research scientists who conduct laboratory-based experimental epilepsy research using cellular, brain slice and animal models, as well as for those interested in related disciplines of neuronal oscillations, network plasticity, and signaling in brain strucutres that include the cortex, hippocampus, and thalamus. In keeping with the 1969 goals, the book is now of practical importance to the clinical neurologist and epileptologist as the progress of research in molecular genetics and modern efforts to design antiepileptic drugs, cures and repairs in the epilepsies converge and impact clinical care.

Epileptic Seizures and the EEG

Measurement, Models, Detection and Prediction

DOWNLOAD NOW »

Author: Andrea Varsavsky,Iven Mareels,Mark Cook

Publisher: CRC Press

ISBN: 1439812047

Category: Medical

Page: 370

View: 4250

Analysis of medical data using engineering tools is a rapidly growing area, both in research and in industry, yet few texts exist that address the problem from an interdisciplinary perspective. Epileptic Seizures and the EEG: Measurement, Models, Detection and Prediction brings together biology and engineering practices and identifies the aspects of the field that are most important to the analysis of epilepsy. Analysis of EEG records The book begins by summarizing the physiology and the fundamental ideas behind the measurement, analysis and modeling of the epileptic brain. It introduces the EEG as a measured signal and explains its use in the study of epilepsy. Next, it provides an explanation of the type of brain activity likely to register in EEG measurements, offering quantitative analysis of the populations of neurons that contribute to both scalp and cortical EEG and discussing the limitations and effects that choices made in the recording process have on the data. The book provides an overview of how these EEG records are and have been analyzed in the past, concentrating on the mathematics relevant to the problem of classification of EEG. The authors use these extracted features to differentiate between or classify inter-seizure, pre-seizure and seizure EEG. The challenge of seizure prediction The book focuses on the problem of seizure detection and surveys the physiologically based dynamic models of brain activity. Finally, the book addresses the fundamental question: can seizures be predicted? Through analysis of epileptic activity spanning from 3 hours to 25 years, it is proposed that seizures may be predictable, but the amount of data required is greater than previously thought. Based on the authors’ extensive research, the book concludes by exploring a range of future possibilities in seizure prediction.

Psychiatry as Medicine

Contemporary Psychotherapies

DOWNLOAD NOW »

Author: A. Fried,Joseph Agassi

Publisher: Springer Science & Business Media

ISBN: 9400968639

Category: Psychology

Page: 192

View: 1851

PREFACE This volume is a sequel to yet independent of our Paranoia: A Study in Diagnosis, Reidel, Dordrecht and Boston, 1976. Whereas our first book centered on diagnosis, this centers on treatment. In our first volume, all discussions of nosology (theory of illness) and of treatment was ancillary to our discussion of diagnosis; similarly all discussion of this volume dealing with nosology - there is very little on diagnosis here - is ancillary to our discussion of psychotherapy. It is still our profoundest conviction that to speak of treatment without diagnosis is meaningless, if not irresponsible, since otherwise one does not know what one is talking about. Hence, our present study, though it centers on theories of treatment, links psychotherapy with psychopathology. It is the rationale of psychotherapy which is of importance, and the rationale dwells in this link. We wish our present study to be self-contained and understood by readers who are not familiar with our first book - or with any specific literature. Our discussion of medicine in general, meaning the rationale of therapy in general, helps the uninitiated reader, as well as the initiated, we hope: it certainly has helped us. We did not see how else can we study a branch of medicine; we felt the need for some idea of how medicine is supposed to work.

Epilepsy

The Intersection of Neurosciences, Biology, Mathematics, Engineering, and Physics

DOWNLOAD NOW »

Author: Ivan Osorio,Hitten P. Zaveri,Mark G. Frei,Susan Arthurs

Publisher: CRC Press

ISBN: 9781439838860

Category: Medical

Page: 578

View: 3528

Epilepsy, one of the most prevalent neurological disorders, affects approximately 1% (greater than 60 million) of the world's population. In an estimated 20 million of these patients, seizures are not controlled even by multiple anti-seizure drugs, and are extremely difficult to predict. Epilepsy: The Intersection of Neurosciences, Biology, Mathematics, Engineering, and Physics seamlessly brings together the neurosciences, mathematics, computational sciences, engineering, physics, and clinical epileptology to present to readers a highly didactic, integrated, clear and practically useful knowledge base and research directions. Laying out the foundations of signal analysis, data conditioning, linear and non-linear analysis, introduction to dynamical systems and fundamental anatomical and neurophysiological concepts, this book: Introduces non-physicians to language and concepts necessary to establish a meaningful dialog with epileptologists Introduces physicians to dynamical theory and signal processing without which interdisciplinary collaborations would not be productive Mines knowledge from fields devoted to the investigation of aperiodic paroxysmal relaxation phenomena, such as earthquakes, which bear dynamical similarities with epilepsy, so as to lay the proper scientific foundations for epileptology and foster much needed therapeutic advances efficiently Reviews spatiotemporal behavior of seizures, mechanisms of epileptogenesis and ictogenesis as well as of seizure control and ancillary technology Calls attention to nocturnal frontal lobe epilepsy as a potentially fruitful paradigm for advancing seizure prediction. Of all neurological disorders, epilepsy demands of investigators the broadest and deepest knowledge of dynamical, control, and system theories, knowledge that cannot be amassed without possessing a certain level of sophistication in relevant areas of neurosciences, physics, mathematics, and engineering. Narrowing the inescapable cultural chasm that commonly fragments multidisciplinary efforts, this book captures and enriches the burgeoning interdisciplinary synergism in the nascent field of dynamical epileptology.

Computational Neuroscience in Epilepsy

DOWNLOAD NOW »

Author: Ivan Soltesz,Kevin Staley

Publisher: Academic Press

ISBN: 9780080559537

Category: Science

Page: 624

View: 9991

Epilepsy is a neurological disorder that affects millions of patients worldwide and arises from the concurrent action of multiple pathophysiological processes. The power of mathematical analysis and computational modeling is increasingly utilized in basic and clinical epilepsy research to better understand the relative importance of the multi-faceted, seizure-related changes taking place in the brain during an epileptic seizure. This groundbreaking book is designed to synthesize the current ideas and future directions of the emerging discipline of computational epilepsy research. Chapters address relevant basic questions (e.g., neuronal gain control) as well as long-standing, critically important clinical challenges (e.g., seizure prediction). Computational Neuroscience in Epilepsy should be of high interest to a wide range of readers, including undergraduate and graduate students, postdoctoral fellows and faculty working in the fields of basic or clinical neuroscience, epilepsy research, computational modeling and bioengineering. Covers a wide range of topics from molecular to seizure predictions and brain implants to control seizures Contributors are top experts at the forefront of computational epilepsy research Chapter contents are highly relevant to both basic and clinical epilepsy researchers

Epilepsy Across the Spectrum

Promoting Health and Understanding

DOWNLOAD NOW »

Author: Committee on the Public Health Dimensions of the Epilepsies,Board on Health Sciences Policy,Institute of Medicine

Publisher: National Academies Press

ISBN: 0309255074

Category: Medical

Page: 521

View: 7274

Although epilepsy is one of the nation's most common neurological disorders, public understanding of it is limited. Many people do not know the causes of epilepsy or what they should do if they see someone having a seizure. Epilepsy is a complex spectrum of disorders that affects an estimated 2.2 million Americans in a variety of ways, and is characterized by unpredictable seizures that differ in type, cause, and severity. Yet living with epilepsy is about much more than just seizures; the disorder is often defined in practical terms, such as challenges in school, uncertainties about social situations and employment, limitations on driving, and questions about independent living. The Institute of Medicine was asked to examine the public health dimensions of the epilepsies, focusing on public health surveillance and data collection; population and public health research; health policy, health care, and human services; and education for people with the disorder and their families, health care providers, and the public. In Epilepsy Across the Spectrum, the IOM makes recommendations ranging from the expansion of collaborative epilepsy surveillance efforts, to the coordination of public awareness efforts, to the engagement of people with epilepsy and their families in education, dissemination, and advocacy for improved care and services. Taking action across multiple dimensions will improve the lives of people with epilepsy and their families. The realistic, feasible, and action-oriented recommendations in this report can help enable short- and long-term improvements for people with epilepsy. For all epilepsy organizations and advocates, local, state, and federal agencies, researchers, health care professionals, people with epilepsy, as well as the public, Epilepsy Across the Spectrum is an essential resource.

From Neuroscience to Neurology

Neuroscience, Molecular Medicine, and the Therapeutic Transformation of Neurology

DOWNLOAD NOW »

Author: Stephen Waxman

Publisher: Elsevier

ISBN: 9780080506982

Category: Medical

Page: 552

View: 6670

The field of neurology is being transformed, from a therapeutically nihilistic discipline with few effective treatments, to a therapeutic specialty which offers new, effective treatments for disorders of the brain and spinal cord. This remarkable transformation has bridged neuroscience, molecular medicine, and clinical investigation, and represents a major triumph for biomedical research. This book, which contains chapters by more than 29 internationally recognized authorities who have made major contributions to neurotherapeutics, tells the stories of how new treatments for disabling disorders of the nervous system, such as stroke, multiple sclerosis, Parkinson’s disease, and migraine, were developed, and explores evolving themes and technologies that offer hope for even more effective treatments and ultimately cures for currently untreatable disorders of the brain and spinal cord. The first part of this book reviews the development of new therapies in neurology, from their inception in terms of basic science to their introduction into the clinical world. It also explores evolving themes and new technologies. This book will be of interest to everyone – clinicians and basic scientists alike – interested in diseases of the brain and spinal cord, and in the quest for new treatments for these disorders. * Presents the evolution of the field of neurology into a therapeutic discipline * Discusses lessons learned from past successes and applications to ongoing work * Explores the future of this field

The Causes of Epilepsy

Common and Uncommon Causes in Adults and Children

DOWNLOAD NOW »

Author: Simon D. Shorvon,Frederick Andermann,Renzo Guerrini

Publisher: Cambridge University Press

ISBN: 113949578X

Category: Medical

Page: N.A

View: 7549

Causation is an aspect of epilepsy neglected in the scientific literature and in the conceptualization of epilepsy at a clinical and experimental level. It was to remedy this deficiency that this book was conceived. The book opens with a draft etiological classification that goes some way to filling the nosological void. The book is divided into four etiological categories: idiopathic, symptomatic, cryptogenic, and provoked epilepsies. Each chapter considers topics in a consistent fashion, dealing with the phenomenon of epilepsy in each etiology, including its epidemiology, clinical features and prognosis, and any specific aspects of treatment. The book is a comprehensive reference work, a catalogue of all important causes of epilepsy, and a clinical tool for all clinicians dealing with patients who have epilepsy. It is aimed at epileptologists and neurologists and provides a distillation of knowledge in a form that is helpful in the clinical setting.

Sleep, Epilepsies, and Cognitive Impairment

DOWNLOAD NOW »

Author: Peter Halasz,Anna Szucs

Publisher: Academic Press

ISBN: 0128125802

Category: Medical

Page: 174

View: 4139

Translational research connects science and clinical medicine from "the bench to the bedside." In Sleep, Epilepsies and Cognitive Impairment, the authors look back from the bedside to the brain function underlying clinical symptoms and reveal mechanisms explored by contemporary neuroimaging and signal analysis in the overlapping fields of sleep and epilepsy. This book will help the reader to see epilepsy from a new viewpoint. The common pathophysiology binding together the diverse manifestations of epilepsies is the exaggeration of plastic functions of the brain involving the hippocampus, the non-specific thalamocortical system and the perisylvian cognitive network. Epileptic derailment seems to be the price for the latest achievements of the mammal and human brain; namely the highly developed ability to change and learn. The contemporary results of sleep research provide new viewpoints to explain why sleep and epilepsy are bedfellows. Converging evidence supports the concept that one of the most important biological roles of NREM sleep is the renewal of synaptic balance ensuring learning ability from one day to the next and consolidation of new memories. Epilepsy and NREM sleep use overlapping structures and functions, therefore epilepsy beginning in early childhood may interfere with sleep plastic functions. NREM sleep, which affects original learning and memory, may become the hidden source of chronic cognitive impairment when epilepsy occurs during sleep and blocks the plastic processes. Sleep, Epilepsies and Cognitive Impairment abandons the academic classification of epilepsy by following the system epilepsy concept, binding major epilepsies with structures and functions of physiological brain systems. It tries to show within this system the close interrelationship between sleep, epilepsy and cognition. Neuroscientists, clinical epileptologists and neurologists interested in brain processes underlying brain plasticity, sleep and epilepsy will find this book thought provoking. It offers good "brain-gymnastics" for reconsidering the ideas on epilepsy. It provides contemporary knowledge about the neurophysiological and functional anatomical background of major epilepsies Treats major epilepsies as system epilepsies of brain networks Reveals the interrelationship of sleep, epilepsy and cognitive impairment showing how epileptic manifestations became facilitated in NREM sleep and interferes with sleep plastic functions

The Last Book in the Universe

DOWNLOAD NOW »

Author: Rodman Philbrick

Publisher: Scholastic Inc.

ISBN: 0545303877

Category: Juvenile Fiction

Page: 240

View: 9739

This fast-paced action novel is set in a future where the world has been almost destroyed. Like the award-winning novel Freak the Mighty, this is Philbrick at his very best. It's the story of an epileptic teenager nicknamed Spaz, who begins the heroic fight to bring human intelligence back to the planet. In a world where most people are plugged into brain-drain entertainment systems, Spaz is the rare human being who can see life as it really is. When he meets an old man called Ryter, he begins to learn about Earth and its past. With Ryter as his companion, Spaz sets off an unlikely quest to save his dying sister -- and in the process, perhaps the world.

The Spirit Catches You and You Fall Down

A Hmong Child, Her American Doctors, and the Collision of Two Cultures

DOWNLOAD NOW »

Author: Anne Fadiman

Publisher: Macmillan

ISBN: 0374533407

Category: Family & Relationships

Page: 368

View: 3414

A study in the collision between Western medicine and the beliefs of a traditional culture focuses on a hospitalized child of Laotian immigrants whose belief that illness is a spiritual matter comes into conflict with doctors' methods.