Design, Analysis, and Interpretation of Genome-Wide Association Scans

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Author: Daniel O. Stram

Publisher: Springer Science & Business Media

ISBN: 1461494435

Category: Medical

Page: 334

View: 3736

This book presents the statistical aspects of designing, analyzing and interpreting the results of genome-wide association scans (GWAS studies) for genetic causes of disease using unrelated subjects. Particular detail is given to the practical aspects of employing the bioinformatics and data handling methods necessary to prepare data for statistical analysis. The goal in writing this book is to give statisticians, epidemiologists, and students in these fields the tools to design a powerful genome-wide study based on current technology. The other part of this is showing readers how to conduct analysis of the created study. Design and Analysis of Genome-Wide Association Studies provides a compendium of well-established statistical methods based upon single SNP associations. It also provides an introduction to more advanced statistical methods and issues. Knowing that technology, for instance large scale SNP arrays, is quickly changing, this text has significant lessons for future use with sequencing data. Emphasis on statistical concepts that apply to the problem of finding disease associations irrespective of the technology ensures its future applications. The author includes current bioinformatics tools while outlining the tools that will be required for use with extensive databases from future large scale sequencing projects. The author includes current bioinformatics tools while outlining additional issues and needs arising from the extensive databases from future large scale sequencing projects.

Bioinformatics and Biomedical Engineering

Third International Conference, IWBBIO 2015, Granada, Spain, April 15-17, 2015. Proceedings

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Author: Francisco Ortuño,Ignacio Rojas

Publisher: Springer

ISBN: 3319164805

Category: Computers

Page: 736

View: 6970

The two volume set LNCS 9043 and 9044 constitutes the refereed proceedings of the Third International Conference on Bioinformatics and Biomedical Engineering, IWBBIO 2015, held in Granada, Spain, in April 2015. The 135 papers presented were carefully reviewed and selected from 268 submissions. The scope of the conference spans the following areas: bioinformatics for healthcare and diseases, biomedical engineering, biomedical image analysis, biomedical signal analysis, computational genomics, computational proteomics, computational systems for modelling biological processes, e Health, next generation sequencing and sequence analysis, quantitative and systems pharmacology, Hidden Markov Model (HMM) for biological sequence modeling, advances in computational intelligence for bioinformatics and biomedicine, tools for next generation sequencing data analysis, dynamics networks in system medicine, interdisciplinary puzzles of measurements in biological systems, biological networks, high performance computing in bioinformatics, computational biology and computational chemistry, advances in drug discovery and ambient intelligence for bio emotional computing.

Human Genome Epidemiology, 2nd Edition

Building the evidence for using genetic information to improve health and prevent disease

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Author: Muin Khoury,Sara Bedrosian,Marta Gwinn,Julian Higgins,John Ioannidis,Julian Little

Publisher: Oxford University Press

ISBN: 9780199749348

Category: Medical

Page: 704

View: 9672

The first edition of Human Genome Epidemiology, published in 2004, discussed how the epidemiologic approach provides an important scientific foundation for studying the continuum from gene discovery to the development, applications and evaluation of human genome information in improving health and preventing disease. Since that time, advances in human genomics have continued to occur at a breathtaking pace. With contributions from leaders in the field from around the world, this new edition is a fully updated look at the ways in which genetic factors in common diseases are studied. Methodologic developments in collection, analysis and synthesis of data, as well as issues surrounding specific applications of human genomic information for medicine and public health are all discussed. In addition, the book focuses on practical applications of human genome variation in clinical practice and disease prevention. Students, clinicians, public health professionals and policy makers will find the book a useful tool for understanding the rapidly evolving methods of the discovery and use of genetic information in medicine and public health in the 21st century.

Explanation in Causal Inference

Methods for Mediation and Interaction

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Author: Tyler VanderWeele

Publisher: Oxford University Press

ISBN: 019932588X

Category: Medical

Page: 248

View: 757

The book provides an accessible but comprehensive overview of methods for mediation and interaction. There has been considerable and rapid methodological development on mediation and moderation/interaction analysis within the causal-inference literature over the last ten years. Much of this material appears in a variety of specialized journals, and some of the papers are quite technical. There has also been considerable interest in these developments from empirical researchers in the social and biomedical sciences. However, much of the material is not currently in a format that is accessible to them. The book closes these gaps by providing an accessible, comprehensive, book-length coverage of mediation. The book begins with a comprehensive introduction to mediation analysis, including chapters on concepts for mediation, regression-based methods, sensitivity analysis, time-to-event outcomes, methods for multiple mediators, methods for time-varying mediation and longitudinal data, and relations between mediation and other concepts involving intermediates such as surrogates, principal stratification, instrumental variables, and Mendelian randomization. The second part of the book concerns interaction or "moderation," including concepts for interaction, statistical interaction, confounding and interaction, mechanistic interaction, bias analysis for interaction, interaction in genetic studies, and power and sample-size calculation for interaction. The final part of the book provides comprehensive discussion about the relationships between mediation and interaction and unites these concepts within a single framework. This final part also provides an introduction to spillover effects or social interaction, concluding with a discussion of social-network analyses. The book is written to be accessible to anyone with a basic knowledge of statistics. Comprehensive appendices provide more technical details for the interested reader. Applied empirical examples from a variety of fields are given throughout. Software implementation in SAS, Stata, SPSS, and R is provided. The book should be accessible to students and researchers who have completed a first-year graduate sequence in quantitative methods in one of the social- or biomedical-sciences disciplines. The book will only presuppose familiarity with linear and logistic regression, and could potentially be used as an advanced undergraduate book as well.

Eine kurze Geschichte der Menschheit

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Author: Yuval Noah Harari

Publisher: DVA

ISBN: 364110498X

Category: History

Page: 528

View: 5938

Krone der Schöpfung? Vor 100 000 Jahren war der Homo sapiens noch ein unbedeutendes Tier, das unauffällig in einem abgelegenen Winkel des afrikanischen Kontinents lebte. Unsere Vorfahren teilten sich den Planeten mit mindestens fünf weiteren menschlichen Spezies, und die Rolle, die sie im Ökosystem spielten, war nicht größer als die von Gorillas, Libellen oder Quallen. Vor 70 000 Jahren dann vollzog sich ein mysteriöser und rascher Wandel mit dem Homo sapiens, und es war vor allem die Beschaffenheit seines Gehirns, die ihn zum Herren des Planeten und zum Schrecken des Ökosystems werden ließ. Bis heute hat sich diese Vorherrschaft stetig zugespitzt: Der Mensch hat die Fähigkeit zu schöpferischem und zu zerstörerischem Handeln wie kein anderes Lebewesen. Anschaulich, unterhaltsam und stellenweise hochkomisch zeichnet Yuval Harari die Geschichte des Menschen nach und zeigt alle großen, aber auch alle ambivalenten Momente unserer Menschwerdung.

Molekulare Humangenetik

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Author: Tom Strachan,Andrew P. Read

Publisher: Spektrum Akademischer Verlag

ISBN: 9783827414939

Category: Science

Page: 802

View: 579

Die vorliegende 3. Auflage der Molekularen Humangenetik ist völlig neu überarbeitet - unter Berücksichtigung der Entdeckungen, die im Zuge und in der Folge des Human Genome Project gemacht wurden. Die einführenden Kapitel (Teil I) beschreiben die Grundlagen wie DNA-Struktur und -Funktion, Chromosomen, Zellen und Entwicklung, Stammbaumanalysen und grundlegende Techniken im Labor. In Teil II werden die verschiedenen Genomsequenzierungsprojekte und die dadurch ermöglichten Einblicke in Organisation, Expression, Variabilität und Evolution des menschlichen Genoms gezeigt. Die Kartierung, Identifizierung und Diagnose der Ursachen von mendelnden und komplexen Krankheiten sowie Krebs ist Schwerpunkt von Teil III. Der letzte Teil gibt Ausblicke auf die funktionelle Genomik und Bioinformatik, auf Tiermodelle und Therapien. Das Buch soll eine Brücke bilden zwischen den grundlegenden Lehrbüchern und der Forschungsliteratur, sodass auch Interessierte mit relativ wenig Hintergrundwissen zum Thema die neuesten Forschungsergebnisse lesen und beurteilen können.

The Lancet

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Author: N.A

Publisher: N.A

ISBN: N.A

Category: Medicine

Page: N.A

View: 5200

Cancer: New Insights for the Healthcare Professional: 2011 Edition

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Author: N.A

Publisher: ScholarlyEditions

ISBN: 1464900027

Category: Medical

Page: 3937

View: 2168

Cancer: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Cancer. The editors have built Cancer: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Cancer in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Cancer: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Genie und Vererbung (Classic Reprint)

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Author: Francis Galton

Publisher: N.A

ISBN: 9781332457298

Category: Biography & Autobiography

Page: 456

View: 8118

Excerpt from Genie und Vererbung Die Bucherei hat es sich zur Aufgabe gemacht, einerseits dem deutschen Publikum die Hauptwerke der auslandischen Philosophie und Soziologie in guten Ubersetzungen nahezubringen, andererseits auch wertvolle deutsche Originalarbeiten in ihren Rahmen aufzunehmen. Wie ihr Erscheinen von den Fachgenossen aufgenommen wurde, zeigt eine Zuschirift Rudolf Euckens der dem Verleger folgendermassen schreibt: "Ich wunsche von Herzen Gluck zu den bedeutenden wissenschaftlichen Unternehmungen, die sie beginnen. Ich glaube, dass hier in Wahrheit eine Lucke besteht, welche dringend der Ausfullung bedarf: wir Deutschen haben zu wenig Beziehung zu den inneren geistigen Bewegungen der anderen Kulturvolker, und wir konnten daraus doch manches gewinnen." Es sollen ausser deutschen Philosophen zunachst die bedeutendsten Vertreter der auslandischen Philosophie mit charakteristischen Werken zu Worte kommen, daneben wird Ruck sieht darauf genommen, dass nicht nur fur den Fachmann interessante Werke zur Verdeutschung kommen, sondern auch solche, die fur ein grosseres philosophisch und soziologisch interessiertes Publikum Wert haben. Die beste Auskunft uber Plan und Ab sichten des Unternehmens gibt ein Blick auf die Titel der schon erschienenen und vorbereiteten Bande. Ein ausfuhrlicher Spezialprospekt uber die Gebiete Philosophie-Soziologie steht jederzeit umsonst zu Diensten. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works."

Issues in Biological and Life Sciences Research: 2011 Edition

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Author: N.A

Publisher: ScholarlyEditions

ISBN: 1464963355

Category: Science

Page: 5106

View: 2559

Issues in Biological and Life Sciences Research: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Biological and Life Sciences Research. The editors have built Issues in Biological and Life Sciences Research: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Biological and Life Sciences Research in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Biological and Life Sciences Research: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Microarray Quality Control

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Author: Wei Zhang,Ilya Shmulevich,Jaakko Astola

Publisher: John Wiley & Sons

ISBN: 9780471726241

Category: Science

Page: 144

View: 5904

Microarray technology provides researchers in the life scienceswith a revolutionary tool for measuring gene expression. However,this highly developed process involves multiple steps, from sampleselection to data analysis, each susceptible to potentially costlyerrors. Without sound quality control, experimental microarrays mayproduce useless or, even worse, misleading results. Microarray Quality Control provides a comprehensive resource forensuring quality control in every step of this complex process.From experimental design to data processing, analysis, andinterpretation, the emphasis in this text remains on practicaladvice for each stage of planning and running a microarray study.Chapters cover: * Quality of biological samples * Quality of DNA * Hybridization protocols Scanning * Data acquisition * Image analysis * Data analysis Written for the broad group of workers-biologists, mathematicians,statisticians, engineers, physicians, and computationalscientists-involved in microarray studies, Microarray QualityControl features a straightforward style easily accessed by variousdisciplines. Useful checklists and tips help ensure the integrityof results, and each chapter contains a thorough review ofpertinent literature. The only complete, systematic treatment of the topic available,Microarray Quality Control offers students and practitioners aninvaluable resource for improving experimental quality andefficiency.

Über Wachstum und Form

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Author: D'Arcy Wentworth Thompson,Anita Albus

Publisher: N.A

ISBN: 9783821845685

Category:

Page: 477

View: 7272

Science

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Author: John Michels (Journalist)

Publisher: N.A

ISBN: N.A

Category: Science

Page: N.A

View: 2139

Schizoaffektive Psychosen

Diagnose, Therapie und Prophylaxe

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Author: Andreas Marneros

Publisher: Springer-Verlag

ISBN: 3642838138

Category: Medical

Page: 217

View: 9906

Die steigende Zahl von Publikationen und internationalen Kongressen über die schizoaffektiven Psychosen waren Anlaß, dieses Thema erstmalig ausführlich und umfassend in Buchform darzustellen. Namhafte Wissenschaftler aus dem In- und Ausland vermitteln praktische, klinisch relevante Informationen über die Diagnose, den Verlauf, die Therapie und die Prophylaxe der schizoaffektiven Psychosen. Angesprochen werden auch genetische und soziale Aspekte sowie Zukunftsperspektiven.

Issues in Biophysics and Geophysics Research and Application: 2011 Edition

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Author: N.A

Publisher: ScholarlyEditions

ISBN: 1464964297

Category: Science

Page: 1698

View: 6360

Issues in Biophysics and Geophysics Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Biophysics and Geophysics Research and Application. The editors have built Issues in Biophysics and Geophysics Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Biophysics and Geophysics Research and Application in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Biophysics and Geophysics Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Instrumentelle Analytik

Grundlagen - Geräte - Anwendungen

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Author: Douglas A. Skoog,James J. Leary

Publisher: Springer-Verlag

ISBN: 366207916X

Category: Science

Page: 900

View: 6587

Mit der deutschsprachigen Ausgabe des Standard-Lehrbuchs zur Instrumentellen Analytik von Skoog und Leary schließt sich endlich eine Lücke im Buchangebot für fortgeschrittene Studenten der Chemie an Universitäten und Fachhochschulen. Aufgrund des multidisziplinären Eindringens der Analytischen Chemie in andere Bereiche richtet sich das Buch auch an Physiker, Ingenieure und Biochemiker. Das Buch führt aktuell und kompetent in die Grundzüge und Feinheiten der heutigen Instrumentellen Analytischen Chemie ein. Über 530 detailreiche, selbsterklärende Abbildungen, Anhänge zu Statistik und Elektronik, Übungsaufgaben mit Lösungen und viele wichtige Originalzitate ergänzen dieses moderne Lehrbuch für Studierende und Praktiker.