Design, Analysis, and Interpretation of Genome-Wide Association Scans

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Author: Daniel O. Stram

Publisher: Springer Science & Business Media

ISBN: 1461494435

Category: Medical

Page: 334

View: 515

This book presents the statistical aspects of designing, analyzing and interpreting the results of genome-wide association scans (GWAS studies) for genetic causes of disease using unrelated subjects. Particular detail is given to the practical aspects of employing the bioinformatics and data handling methods necessary to prepare data for statistical analysis. The goal in writing this book is to give statisticians, epidemiologists, and students in these fields the tools to design a powerful genome-wide study based on current technology. The other part of this is showing readers how to conduct analysis of the created study. Design and Analysis of Genome-Wide Association Studies provides a compendium of well-established statistical methods based upon single SNP associations. It also provides an introduction to more advanced statistical methods and issues. Knowing that technology, for instance large scale SNP arrays, is quickly changing, this text has significant lessons for future use with sequencing data. Emphasis on statistical concepts that apply to the problem of finding disease associations irrespective of the technology ensures its future applications. The author includes current bioinformatics tools while outlining the tools that will be required for use with extensive databases from future large scale sequencing projects. The author includes current bioinformatics tools while outlining additional issues and needs arising from the extensive databases from future large scale sequencing projects.

Bioinformatics and Biomedical Engineering

Third International Conference, IWBBIO 2015, Granada, Spain, April 15-17, 2015. Proceedings

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Author: Francisco Ortuño,Ignacio Rojas

Publisher: Springer

ISBN: 3319164805

Category: Computers

Page: 736

View: 7704

The two volume set LNCS 9043 and 9044 constitutes the refereed proceedings of the Third International Conference on Bioinformatics and Biomedical Engineering, IWBBIO 2015, held in Granada, Spain, in April 2015. The 135 papers presented were carefully reviewed and selected from 268 submissions. The scope of the conference spans the following areas: bioinformatics for healthcare and diseases, biomedical engineering, biomedical image analysis, biomedical signal analysis, computational genomics, computational proteomics, computational systems for modelling biological processes, e Health, next generation sequencing and sequence analysis, quantitative and systems pharmacology, Hidden Markov Model (HMM) for biological sequence modeling, advances in computational intelligence for bioinformatics and biomedicine, tools for next generation sequencing data analysis, dynamics networks in system medicine, interdisciplinary puzzles of measurements in biological systems, biological networks, high performance computing in bioinformatics, computational biology and computational chemistry, advances in drug discovery and ambient intelligence for bio emotional computing.

Springer Handbook of Bio-/Neuro-Informatics

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Author: Nikola Kasabov

Publisher: Springer Science & Business Media

ISBN: 3642305741

Category: Computers

Page: 1229

View: 8998

The Springer Handbook of Bio-/Neuro-Informatics is the first published book in one volume that explains together the basics and the state-of-the-art of two major science disciplines in their interaction and mutual relationship, namely: information sciences, bioinformatics and neuroinformatics. Bioinformatics is the area of science which is concerned with the information processes in biology and the development and applications of methods, tools and systems for storing and processing of biological information thus facilitating new knowledge discovery. Neuroinformatics is the area of science which is concerned with the information processes in biology and the development and applications of methods, tools and systems for storing and processing of biological information thus facilitating new knowledge discovery. The text contains 62 chapters organized in 12 parts, 6 of them covering topics from information science and bioinformatics, and 6 cover topics from information science and neuroinformatics. Each chapter consists of three main sections: introduction to the subject area, presentation of methods and advanced and future developments. The Springer Handbook of Bio-/Neuroinformatics can be used as both a textbook and as a reference for postgraduate study and advanced research in these areas. The target audience includes students, scientists, and practitioners from the areas of information, biological and neurosciences. With Forewords by Shun-ichi Amari of the Brain Science Institute, RIKEN, Saitama and Karlheinz Meier of the University of Heidelberg, Kirchhoff-Institute of Physics and Co-Director of the Human Brain Project.

Human Genome Epidemiology, 2nd Edition

Building the evidence for using genetic information to improve health and prevent disease

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Author: Muin Khoury,Sara Bedrosian,Marta Gwinn,Julian Higgins,John Ioannidis,Julian Little

Publisher: Oxford University Press

ISBN: 9780199749348

Category: Medical

Page: 704

View: 1662

The first edition of Human Genome Epidemiology, published in 2004, discussed how the epidemiologic approach provides an important scientific foundation for studying the continuum from gene discovery to the development, applications and evaluation of human genome information in improving health and preventing disease. Since that time, advances in human genomics have continued to occur at a breathtaking pace. With contributions from leaders in the field from around the world, this new edition is a fully updated look at the ways in which genetic factors in common diseases are studied. Methodologic developments in collection, analysis and synthesis of data, as well as issues surrounding specific applications of human genomic information for medicine and public health are all discussed. In addition, the book focuses on practical applications of human genome variation in clinical practice and disease prevention. Students, clinicians, public health professionals and policy makers will find the book a useful tool for understanding the rapidly evolving methods of the discovery and use of genetic information in medicine and public health in the 21st century.

Rhinology and Skull Base Surgery

From the Lab to the Operating Room - An Evidence-based Approach

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Author: Christos Georgalas,Wytske Fokkens

Publisher: Thieme

ISBN: 3131644613

Category: Medical

Page: 946

View: 1453

Incorporating advanced, up-to-date basic science with current clinical knowledge to set a new standard in the field This major new reference offers the most complete and balanced coverage of modern rhinology and skull base surgery available today by integrating key advances in the basic sciences with modern clinical developments. From the role of genetics, allergy, and immunology in rhinologic disorders to new, evidence-based medical and surgical approaches, the book covers all aspects of this dynamic, multidisciplinary specialty. With nearly 80 videos online–including full patient cases with imaging, endoscopic examinations, and step-by-step surgical techniques– complements the book. Special Features: Highlights basic science developments in anatomy, embryology, pathophysiology, immunology, genetics, and investigative rhinology Includes more than 900 full-color photographs and 120 drawings Structured on evidence-based medicine principles and based on current, evidence-based guidelines (including the EPOS 2012 and Endoscopic Skull Base Tumors consensus document) Shares the medical and surgical expertise of a truly international team of more than 100 clinicians and scientists from 17 countries A learning-focused textbook, with structured chapters, each one including tips and tricks, important notes, key points, summary, and self-assessment questions The only textbook tailored to the curriculum of the British Intercollegiate, FRCS(ORL-HNS), American Board of Otolaryngology, and European Academy exams A world-class clinical reference as well as a comprehensive textbook, Rhinology and Skull Base Surgery: From the Lab to the Operating Room is unrivalled for its breadth of coverage–from basic science breakthroughs to the newest diagnostic tools to the most advanced endoscopic treatment techniques. A book that all practicing rhinologists, otolaryngologists, skull base surgeons as well as residents and fellows in otolaryngology will find indispensable for expanding their surgical and medical expertise–and also for gaining a full understanding of the basic science framework of their multifaceted specialty.

Rheumatology E-Book

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Author: Marc C. Hochberg,Alan J. Silman,Josef S. Smolen,Michael E. Weinblatt,Michael H. Weisman

Publisher: Elsevier Health Sciences

ISBN: 0702063037

Category: Medical

Page: 2112

View: 8963

Stay current in the ever-changing discipline of rheumatology with clear, reliable guidance from Hochberg’s Rheumatology, one of the most respected and trusted sources in the field. Designed to meet the needs of the practicing clinician, this medical reference book provides extensive, authoritative coverage of rheumatic diseases from basic scientific principles to practical points of clinical management in a lucid, logical, user-friendly manner. Track disease progression and treat patients more effectively with the information on genetic findings, imaging outcomes, cell and biologic therapies, rheumatoid arthritis, and SLE. Incorporate recent findings about pathogenesis of disease; imaging outcomes for specific diseases like RA, osteoarthritis, and spondyloarthropathies; cell and biologic therapies; and other timely topics. Remain up to date on the latest information in rheumatology through 13 brand-new chapters covering biomedical and translation science, disease and outcome assessment, new imaging modalities, early emerging disease, clinical therapeutics, patient management, and rehabilitation. Take advantage of expanded coverage of small molecule treatment, biologics, biomarkers, epigenetics, biosimilars, and cell-based therapies. Focus on the core knowledge needed for successful results with each chapter co-authored by an internationally-renowned specialist in the field. Easily find the information you need thanks to a consistent, user-friendly format with templated content and large-scale images.

Molekulare Humangenetik

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Author: Tom Strachan,Andrew P. Read

Publisher: Spektrum Akademischer Verlag

ISBN: 9783827414939

Category: Science

Page: 802

View: 5029

Die vorliegende 3. Auflage der Molekularen Humangenetik ist völlig neu überarbeitet - unter Berücksichtigung der Entdeckungen, die im Zuge und in der Folge des Human Genome Project gemacht wurden. Die einführenden Kapitel (Teil I) beschreiben die Grundlagen wie DNA-Struktur und -Funktion, Chromosomen, Zellen und Entwicklung, Stammbaumanalysen und grundlegende Techniken im Labor. In Teil II werden die verschiedenen Genomsequenzierungsprojekte und die dadurch ermöglichten Einblicke in Organisation, Expression, Variabilität und Evolution des menschlichen Genoms gezeigt. Die Kartierung, Identifizierung und Diagnose der Ursachen von mendelnden und komplexen Krankheiten sowie Krebs ist Schwerpunkt von Teil III. Der letzte Teil gibt Ausblicke auf die funktionelle Genomik und Bioinformatik, auf Tiermodelle und Therapien. Das Buch soll eine Brücke bilden zwischen den grundlegenden Lehrbüchern und der Forschungsliteratur, sodass auch Interessierte mit relativ wenig Hintergrundwissen zum Thema die neuesten Forschungsergebnisse lesen und beurteilen können.

The Design of Everyday Things

Psychologie und Design der alltäglichen Dinge

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Author: Norman Don

Publisher: Vahlen

ISBN: 3800648105

Category: Business & Economics

Page: 320

View: 9700

Apple, Audi, Braun oder Samsung machen es vor: Gutes Design ist heute eine kritische Voraussetzung für erfolgreiche Produkte. Dieser Klassiker beschreibt die fundamentalen Prinzipien, um Dinge des täglichen Gebrauchs umzuwandeln in unterhaltsame und zufriedenstellende Produkte. Don Norman fordert ein Zusammenspiel von Mensch und Technologie mit dem Ziel, dass Designer und Produktentwickler die Bedürfnisse, Fähigkeiten und Handlungsweisen der Nutzer in den Vordergrund stellen und Designs an diesen angepasst werden. The Design of Everyday Things ist eine informative und spannende Einführung für Designer, Marketer, Produktentwickler und für alle an gutem Design interessierten Menschen. Zum Autor Don Norman ist emeritierter Professor für Kognitionswissenschaften. Er lehrte an der University of California in San Diego und der Northwest University in Illinois. Mitte der Neunzigerjahre leitete Don Norman die Advanced Technology Group bei Apple. Dort prägte er den Begriff der User Experience, um über die reine Benutzbarkeit hinaus eine ganzheitliche Erfahrung der Anwender im Umgang mit Technik in den Vordergrund zu stellen. Norman ist Mitbegründer der Beratungsfirma Nielsen Norman Group und hat unter anderem Autohersteller von BMW bis Toyota beraten. „Keiner kommt an Don Norman vorbei, wenn es um Fragen zu einem Design geht, das sich am Menschen orientiert.“ Brand Eins 7/2013 „Design ist einer der wichtigsten Wettbewerbsvorteile. Dieses Buch macht Spaß zu lesen und ist von größter Bedeutung.” Tom Peters, Co-Autor von „Auf der Suche nach Spitzenleistungen“

Regression

Modelle, Methoden und Anwendungen

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Author: Ludwig Fahrmeir,Thomas Kneib,Stefan Lang

Publisher: Springer-Verlag

ISBN: 3642018378

Category: Business & Economics

Page: 502

View: 2744

In dem Band beschreiben die Autoren erstmals klassische Regressionsansätze und moderne nicht- und semiparametrische Methoden in einer integrierten und anwendungsorientierten Form. Um Lesern die Analyse eigener Fragestellungen zu ermöglichen, demonstrieren sie die praktische Anwendung der Konzepte und Methoden anhand ausführlicher Fallstudien. Geeignet für Studierende der Statistik sowie für Wissenschaftler und Praktiker, zum Beispiel in den Wirtschafts- und Sozialwissenschaften, der Bioinformatik und -statistik, Ökonometrie und Epidemiologie.

Basic Science of Oncology, Fifth Edition

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Author: Ian F. Tannock

Publisher: McGraw Hill Professional

ISBN: 0071745203

Category: Medical

Page: 575

View: 8235

Basic Science of Oncology, 5e is an engaging state-of-art review of cancer causation, cancer biology, and the biology underlying cancer treatment. The fifth edition features critical updates in all areas of the fast-moving field of cancer care

Cancer: New Insights for the Healthcare Professional: 2011 Edition

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Author: N.A

Publisher: ScholarlyEditions

ISBN: 1464900027

Category: Medical

Page: 3937

View: 5269

Cancer: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Cancer. The editors have built Cancer: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Cancer in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Cancer: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Issues in Genetic Medicine: 2011 Edition

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Author: N.A

Publisher: ScholarlyEditions

ISBN: 1464963789

Category: Medical

Page: 2671

View: 3968

Issues in Genetic Medicine / 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Genetic Medicine. The editors have built Issues in Genetic Medicine: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Genetic Medicine in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Genetic Medicine: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Angewandte Bioinformatik

Eine Einführung

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Author: Paul M. Selzer,Richard J. Marhöfer,Oliver Koch

Publisher: Springer-Verlag

ISBN: 3662541351

Category: Science

Page: 184

View: 8855

Für Studierende und Wissenschaftler der Lebenswissenschaften schafft dieses Buch einen schnellen, strukturierten Zugang zur Angewandten Bioinformatik ohne Programmierkenntnisse oder tiefgehende Informatikkenntnisse vorauszusetzen. Es bietet eine Einführung in die tägliche Anwendung der vielfältigen bioinformatischen Werkzeuge und gibt einen ersten Überblick über das sehr komplexe Fachgebiet. Die Kontrolle des vermittelten Stoffs wird durch Übungsbeispiele mit Lösungen gewährleistet. Ein Glossar der zugrundeliegenden Fachtermini sowie ein ausführliches Sachverzeichnis runden das Buch ab. Für die 2. Auflage wurde das Werk umfassend aktualisiert.

Über Wachstum und Form

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Author: D'Arcy Wentworth Thompson,Anita Albus

Publisher: N.A

ISBN: 9783821845685

Category:

Page: 477

View: 4834