Anticancer

A New Way of Life

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Author: David Servan-Schreiber

Publisher: Penguin UK

ISBN: 0141970545

Category: Health & Fitness

Page: 336

View: 2489

An updated edition for 2011 including all the latest medical research and up-to-date studies. An approachable, empowering guide to staying healthy and fighting disease. Would it surprise you to hear that one in four people are affected by cancer? If you knew that simple lifestyle changes could significantly reduce your chances of developing the disease, would you take advantage of your natural defences? 'I had cancer. I was diagnosed for the first time 15 years ago. I received conventional treatment and the cancer went into remission, but I relapsed after that. Then I decided to learn everything I could to help my body defend itself against the illness. I've lived cancer free now for seven years. In this book, I'd like to tell you the stories - scientific and personal - behind what I learned.' Author David-Servan Schreiber is an academic physician with a wealth of experience in the field of integrative medicine. He will show you how, through simple alterations in diet, lifestyle and attitude, you can tackle cancer alongside conventional treatments, or even avoid it altogether. This is not a biology textbook, but a practical, insightful and individual guide that will allow you to make the best choices for your own health and well-being.

The Anticancer Drugs

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Author: William B. Pratt,William D. Ensminger,Raymond W. Ruddon

Publisher: Oxford University Press, USA

ISBN: 9780195067392

Category: Medical

Page: 352

View: 8285

This text offers an up-to-date review of the field of cancer chemotherapy, including some of the new approaches to biological treatments of cancer and potential targets for new drug design. A detailed description of the pharmacology, mechanisms of action, toxicity, resistance mechanisms, and clinical usefulness of each class of drugs is given. The authors emphasize concepts involved in determining the mechanism of action and development of resistance, the determinants of drug responsiveness to chemotherapeutic agents, and a rationale for their clinical use in various types of cancer. The text is organized in a way that makes it easy for the reader to conceptualize how drugs work and categorize them by their mechanism of action. It facilitates an understanding of the rationale for chemotherapy with respect to the biology of the cancer cell and to tumor growth kinetics. Drawing on the fields of authors draw on the fields of medicinal chemistry, pharmacology, biochemistry, cell biology, molecular biology, and clinical medicine, this timely book is extensively referenced and provides a historical background for the development of each class of drugs.

Frontiers in Anti-Cancer Drug Discovery

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Author: Atta-ur-Rahman,M. Iqbal Choudhary

Publisher: Bentham Science Publishers

ISBN: 1608059227

Category: Medical

Page: 413

View: 626

Frontiers in Anti-Cancer Drug Discovery is an Ebook series devoted to publishing the latest and the most important advances in Anti-Cancer drug design and discovery. Eminent scientists write contributions on all areas of rational drug design and drug discovery, including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. The Ebook series should prove to be of interest to all pharmaceutical scientists involved in research in Anti-Cancer drug design and discovery. Each volume is devoted to the major advances in Anti-Cancer drug design and discovery. The Ebook series is essential reading for all scientists involved in drug design and discovery who wish to keep abreast of rapid and important developments in the field.

Anticancer

A New Way of Life

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Author: David Servan-Schreiber, MD, PhD

Publisher: Penguin

ISBN: 9781101163054

Category: Health & Fitness

Page: 288

View: 1251

The revolutionary, New York Times bestselling guide to the powerful lifestyle changes that fight and prevent cancer—an integrative approach based on the latest scientific research “A common-sense blueprint for healthy living.” —Chicago Tribune “Resonating with cancer support communities and recommended nationwide.” —Los Angeles Times “Life affirming . . . filled with practical advice.” —The Seattle Times David Servan-Schreiber was a rising neuroscientist with his own brain imaging laboratory when, in the middle of an equipment test, he discovered a tumor the size of a walnut in his own brain. Forced to confront what medicine knows about cancer, and all that we still do not know, Servan-Schreiber marshaled his will to live and set out to understand the complex inner workings of the body’s natural cancer-fighting capabilities. He soon found himself on a decades-long journey from disease and relapse into scientific exploration and, finally, a new view of health. Anticancer is at once the moving story of one doctor’s inner and outer search for wellness and a radical exposition of the roles that lifestyle, environment, and trauma play in our health. Drawing on the latest research in integrative medicine that blends conventional and alternative approaches, Servan-Schreiber concisely explains what makes cancer cells thrive, what inhibits them, and how we can empower ourselves to prevent their growth. His advice details how to develop a science-based anticancer diet (and the small changes that can make a big difference); how to reap the benefits of exercise, yoga, and meditation; which toxic, unsafe products to replace in your home; and how to stave off the effects of helplessness and unhealed wounds to regain balance. Anticancer’s synthesis of science and personal experience marks a transformation in the way we understand and confront cancer. A long-running bestseller that has changed the lives of millions around the world, Anticancer remains a pioneering and peerless resource, an inspirational and revolutionary guide to “a new way of life.”

Medicinal Chemistry of Anticancer Drugs

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Author: Carmen Avendano,J. Carlos Menendez

Publisher: Elsevier

ISBN: 9780080559629

Category: Medical

Page: 400

View: 3952

Antitumor chemotherapy is nowadays a very active field of research, and a huge amount of information on the topic is generated every year. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book addresses the need for an updated treatment from the point of view of medicinal chemistry and drug design. The focus of Medicinal Chemistry of Anticancer Drugs is on the mechanism of action of antitumor drugs from the molecular point of view and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents, aiming at the rationalization of the action of this type of drug, which would allow the design of new active structures. * Explains the biological basis of cancer treatment and the role of chemists in improving anticancer drugs * Provides the historical background and serves as a comprehensive and practical guide on cancer research and anticancer drug development * Includes coverage of different approaches to treating cancer, drug resistance, and a chapter on cancer prevention

Matricellular Receptors as Potential Targets in Anti-Cancer Therapeutic Strategies

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Author: Hervé Emonard,Stéphane Dedieu,Laurent Duca

Publisher: Frontiers Media SA

ISBN: 2889450244

Category:

Page: N.A

View: 2850

The invasive character of a primary cancer is greatly dependent on numerous interactions between tumor cells and their extracellular surroundings. Matricellular receptors are defined as (cell-surface) receptors that bind extracellular matrix (ECM) structural proteins and soluble factors dynamically acting on ECM homeostasis. Matricellular receptors mediate numerous signalings from the extracellular environment to cell nucleus and drive main biological functions that are cell growth, survival and migration. Numerous data from the last decade evidence that matricellular receptors are biosensors that allow to a tumor cell answering to microenvironmental variations, and in this sense they are important contributors to tumor cell malignancy. Matricellular receptors represent thus valuable targets for the development of original anti-cancer strategies. Original reports, bibliographic reviews or hypotheses are welcome to improve the basic knowledge of matricellular receptor properties, their spatio-temporal regulation, the dynamic formation of complex receptors and the impact of such interactions on the invasive properties of tumor cells. Biological, biophysical and pharmacological, as well as in silico contributions will be appreciated.

New Approaches to Natural Anticancer Drugs

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Author: Soodabeh Saeidnia

Publisher: Springer

ISBN: 3319140272

Category: Medical

Page: 106

View: 8116

This book provides an up-to-date review of recently identified natural anti-tumor compounds from various natural origins including plants, fungi, endophytic fungi and marine organisms. It also includes discussion of new areas such as biotechnology and nanoparticles. Chapters explain the challenges and developments in anti-cancer drug discovery approaches, traditional remedies for prevention and treatment of cancer, marine-derived anti-cancer compounds, and antibiotics used as anti-cancer agents, as well as different classes of terpenoids and carbohydrates, which have been the subject of discussion in this field as efficient anti-cancer candidates. This book will be a concise guide for researchers in the field of pharmaceutical sciences, students and residents in pharmacy and medicine as well as those researching phytochemistry and natural products.

Principles of Anticancer Drug Development

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Author: Elizabeth Garrett-Mayer

Publisher: Springer Science & Business Media

ISBN: 9781441973580

Category: Medical

Page: 674

View: 8380

A practical guide to the design, conduction, analysis and reporting of clinical trials with anticancer drugs.

Advances in Anticancer Agents in Medicinal Chemistry

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Author: Michelle Prudhomme

Publisher: Bentham Science Publishers

ISBN: 1608057127

Category: Medical

Page: 470

View: 4324

Advances in Anticancer Agents in Medicinal Chemistry is an exciting eBook series comprising a selection of updated articles previously published in the peer-reviewed journal Anti-Cancer Agents in Medicinal Chemistry. The first volume gathers reviews of many classes of drugs of contemporary interest for cancer therapy and is devoted to small molecules inhibitors of various proteins involved in cancer development such as Casein kinase 2 (CK2), Protein kinase B (PKB), mTOR, Hsp90, P-glycoprotein (P-gp), Kinesin spindle protein (KSP), Cyclooxygenase 2 (COX-2), Histone deacetylase enzymes (HDACs) and Topoisomerase I. Advances in Anticancer Agents in Medicinal Chemistry will be of particular interest to readers interested in anti cancer drug therapy as the series provides additional value to scientific research by entailing an approach of bringing relevant reviews up-to-date and thus more valuable for reference purposes.

Novel Anticancer Drug Protocols

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Author: John K. Buolamwini,Alex A. Adjei

Publisher: Springer Science & Business Media

ISBN: 1592593801

Category: Medical

Page: 372

View: 6679

This book not only surveys the whole arena of novel anticancer drug targets, but also presents a wide-ranging selection of cuttingedge techniques currently being applied throughout novel antitumor drug discovery and development. The methods are applied to experiments involving such topics as immunotherapy, angiogenesis, cancer metastasis, the cell cycle, signal transduction inhibitors, apoptosis, antibodies, antisense molecules, microarray gene expression, flow cytometry, and PET imaging for cancer target validation. There are also proven methods for the preclinical identification of drug targets. Validate new drug targets both preclinically and clinically Identify novel anticancer drug targets in preclinical stages Follow proven instructions to obtain successful results and avoid failure.

Evidence-based Anticancer Materia Medica

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Author: William C.S. Cho

Publisher: Springer Science & Business Media

ISBN: 9789400705265

Category: Medical

Page: 442

View: 9900

Cancer is one of the leading killers in the world and the incidence is increasing, but most cancer patients and cancer survivors suffer much from the disease and its conventional treatments’ side effects. In the past, clinical data showed that some complementary and alternative medicine (CAM) possessed anticancer abilities, but some clinicians and scientists have queried about the scientific validity of CAM due to the lack of scientific evidence. There is great demand in the knowledge gap to explore the scientific and evidence-based knowledge of CAM in the anticancer field. With this aim, a book series is needed to structurally deliver the knowledge to readers. Recently there have been encouraging results from both laboratory experiments and clinical trials demonstrating the anticancer effects of herbal medicine. There is considerable interest among oncologists and cancer researchers to find anticancer agents in herbal medicine. This volume is a specialised book presenting the up-to-date scientific evidence for anticancer herbal medicine. This unique book provides an overview of the anticancer herbal medicines and remedies, as well as a detailed evidence-based evaluation of 18 common anticancer herbal medicines covering their biological and pharmacological properties, efficacies, herb-drug interactions, adverse effects, pre-clinical studies, and clinical applications. Gathering international opinion leaders’ views, this volume will contribute great to the cancer, academic, and clinical community by providing evidence-based information on the anticancer efficacy of herbal medicine. Readership Oncologists, cancer researchers, pharmacologists, pharmaceutical specialists, Chinese medicine practitioners, medical educators, postgraduates and advanced undergraduates in biomedical disciplines, cancer caregivers, cancer patients.

Organ Directed Toxicities of Anticancer Drugs

Proceedings of the First International Symposium on the Organ Directed Toxicities of the Anticancer Drugs Burlington, Vermont, USA-June 4–6, 1987

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Author: Miles P. Hacker,John S. Lazo,Thomas R. Tritton

Publisher: Springer Science & Business Media

ISBN: 1461320232

Category: Medical

Page: 254

View: 641

The addition of chemotherapy as an effective means to treat cancer has had a major impact on selected human malignancies. Due to a general inability to dif ferentiate between normal and neoplastic cells, little selectivity exists in currently used oncolytic drugs. Consequently, significant toxicity to the patient is expected when systemic cancer chemotherapy is chosen as an appropriate therapeutic in tervention. Much of this toxicity, such as damage to the bone marrow, gastroin testinal tract, or hair follicles, is predictable based upon the fact that anticancer drugs kill actively dividing cells. These types of toxicities, while serious, are usually manageable and reversible and are, therefore, not often considered to be dose limiting. Unfortunately, several of the most important anticancer drugs also damage tissues in which the growth fraction is relatively small. Such toxicities can not be predicted based on the chemical structure of the drugs, are often not detected in preclinical studies, and are encountered frequently for the first time in clinical studies. Further, unlike most of the proliferative-dependent toxicities, the unpre dicted toxicities are usually irreversible or only partially reversible upon cessation of drug administration. Because of this, the unpredicted toxicities are referred to as dose limiting. They represent a significant barrier to the ultimate efficacy of several of our most important anticancer drugs.

Anticancer Therapeutics

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Author: Sotiris Missailidis

Publisher: John Wiley & Sons

ISBN: 0470697032

Category: Science

Page: 424

View: 5880

Written by the winner of the 2008 Mike Price Fellowship "This volume provides a comprehensive overview of the wealth of information now available in this important and fast-moving subject." Anticancer Research, November - December 2008 This book provides a clear introduction to the area, with an overview of the various drug design and development approaches for cancer therapeutics and their progress in today’s multidisciplinary approach to cancer treatment. Clearly structured throughout, the book not only provides information on currently used molecular treatment approaches, but also describes the various agents that are currently at various stages of development and clinical trials, thus making them the drugs of tomorrow. The book goes on to present current therapeutic regimes including their indications and side effects, as well as their position in the international market in terms of sales and development costs. Furthermore, coverage of our advancement in the understanding of cancer biology and how this has driven the drug discovery process is clearly discussed. Modern drug discovery aspects, through genomic, proteomic and metabolomic approaches are referred to as well as combinatorial chemistry techniques and discovery of chemotherapeutic agents from plant extracts, re-use of old drugs and drugs from other indications, or de novo rational drug design. Including contributions from leading experts in the field, this book provides the reader with a complete overview of the various types of therapeutic agents, current and emerging, as well as other aspects associated with anticancer therapy, drug design, resistance and clinical trials in oncology.

Anticancer Drug Development

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Author: Bruce C. Baguley,David J. Kerr

Publisher: Elsevier

ISBN: 9780080490441

Category: Medical

Page: 397

View: 7216

Here in a single source is a complete spectrum of ideas on the development of new anticancer drugs. Containing concise reviews of multidisciplinary fields of research, this book offers a wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death. Detailed descriptions of sources for new drugs and methods for testing and clinical trial design are also provided. One work that can be consulted for all aspects of anticancer drug development Concise reviews of research fields, combined with practical scientific detail, written by internationally respected experts A wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death Detailed descriptions of the sources of new anticancer drugs, including combinatorial chemistry, phage display, and natural products Discussion of how new drugs can be tested in preclinical systems, including the latest technology of robotic assay systems, cell culture, and experimental animal techniques Hundreds of references that allow the reader to access relevant scientific and medical literature Clear illustrations, some in color, that provide both understanding of the field and material for teaching

Cytotoxic Anticancer Drugs: Models and Concepts for Drug Discovery and Development

models and concepts for drug discovery and development : proceedings of the Twenty-Second Annual Detroit Cancer Symposium, Detroit, Michigan, USA, April 26-28, 1990

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Author: Frederick A. Valeriote,Thomas H. Corbett,Laurence H. Baker

Publisher: Springer Science & Business Media

ISBN: 9780792316299

Category: Medical

Page: 409

View: 8897

Proceedings of the 22nd Annual Cancer Symposium, Detroit, Michigan, April 26-28, 1990.

Molecular Aspects of Anticancer Drug DNA Interactions

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Author: Stephen Neidle

Publisher: CRC Press

ISBN: 9780849377730

Category: Medical

Page: 336

View: 9737

This cutting-edge book surveys the current knowledge on the mode of action of the major classes of DNA-interactive antitumor agents, providing information that could be crucial for the discovery of new therapeutic substances. It is an important reference for molecular biologists, cancer researchers, biochemists, biophysicists, and pharmacologists.

Novel Anticancer Agents

Strategies for Discovery and Clinical Testing

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Author: Alex A. Adjei,John K. Buolamwini

Publisher: Academic Press

ISBN: 0080537758

Category: Medical

Page: 464

View: 2097

This book offers pertinent basic science information on strategies used for the rational design and discovery of novel anticancer agents, and, in addition, translational studies involving clinical trial design and execution with these novel, mostly cytostatic agents. This book covers basic science strategies that are being used in drug discovery and preclinical evaluation focused on novel molecular targets, as well as clinical trial methodology including clinical pharmacokinetics and imaging to address issues of efficacy evaluation of the new, relatively non-cytotoxic anticancer agents. At present, there is no book that provides such an integration of basic and clinical studies of novel anticancer agents, covering both drug discovery and translational research extensively. * Addresses the critical issues involved in the development of novel agents for cancer therapy by experts in the field * Presents drug discovery strategies * Discusses regulatory issues surrounding drug development *

Anticancer Genes

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Author: Stefan Grimm

Publisher: Springer

ISBN: 144716458X

Category: Science

Page: 283

View: 905

This book discusses the emergence of a new class of genes with a specific anticancer activity. These genes, recently defined as “Anticancer Genes”, are reviewed in individual chapters on their mode of action, the specific cell death signals they induce, and the status of attempts to translate them into clinical application. Anticancer Genes provides an overview of this nascent field, its genesis, current state, and prospect. It discusses how Anticancer Genes might lead to the identification of a repertoire of signaling pathways directed against cellular alterations that are specific for tumor cells. With contributions from experts worldwide, Anticancer Genes is an essential guide to this dynamic topic for researchers and students in cancer research, molecular medicine, pharmacology and toxicology and genetics as well as clinicians and clinical researchers interested in the therapeutic potential of this exciting new field.

Macromolecular Anticancer Therapeutics

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Author: L. Harivardhan Reddy,Patrick Couvreur

Publisher: Springer Science & Business Media

ISBN: 9781441905079

Category: Medical

Page: 500

View: 6641

In spite of the development of various anticancer drugs, the therapy of cancer has remained challenging for decades. The current therapy of cancer is overwhelmed because of the inability to deliver therapeutics to all regions of a tumor in effective therapeutic concentrations, intrinsic or acquired resistance to the treatment with currently available agents via genetic and epigenetic mechanisms, and toxicity. As a result, cancer therapy using conventional therapeutics and different types of treatment regimens using this therapeutics has not led to a convincing survival benefit of the patients. In this context, Macromolecular therapeutics offer several advantages over conventional low molecular therapeutics by various ways such as, enable the use of larger doses of these agents by limiting the toxicity, by enhanced permeability and retention into tumors, by tumor targeting using tumor-specific antibodies, by specific inhibition of oncogenes using anticancer oligonucleotides etc. Cancer treatment using this macromolecular therapeutics has considerably improved the survival benefit for patients. As a result, various macromolecular therapeutics are already commercialized or are under clinical development. Although we are far from a real magic bullet today, looking at the pace of research and current success in this field of macromolecular therapeutics, it appears that we are approaching a magic bullet for the efficient treatment of cancer. Thus, we believe that the subject of this book is very timely, and that the book will fill an unmet need in the market. This book is unique and assembles various types and aspects of macromolecular anticancer therapeutics for cancer therapy in one shell and conveys the importance of this interdisciplinary field to the broad audience. Thus, in a nutshell, this book details the basics of cancer, and various therapeutic strategies such as those based on macromolecular therapeutics hence can become an important reference for practitioners, oncologists, medical pharmacologists, medicinal chemists, biomedical scientists, experimental pharmacologists, pharmaceutical technologists, and particularly it can essentially become a handbook of macromolecular therapeutics for cancer therapy for graduates, post-graduates and Ph.D. students in these fields.