Advanced Practical Organic Chemistry, Third Edition

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Author: John Leonard,Barry Lygo,Garry Procter

Publisher: CRC Press

ISBN: 1439860971

Category: Medical

Page: 356

View: 2380

Any research that uses new organic chemicals, or ones that are not commercially available, will at some time require the synthesis of such compounds. Therefore, organic synthesis is important in many areas of both applied and academic research, from chemistry to biology, biochemistry, and materials science. The third edition of a bestseller, Advanced Practical Organic Chemistry is a guide that explains the basic techniques of organic chemistry, presenting the necessary information for readers to carry out widely used modern organic synthesis reactions. This book is written for advanced undergraduate and graduate students as well as industrial organic chemists, particularly those involved in pharmaceutical, agrochemical, and other areas of fine chemical research. It provides the novice or nonspecialist with the often difficult-to-find information on reagent properties needed to perform general techniques. With over 80 years combined experience training and developing organic research chemists in industry and academia, the authors offer sufficient guidance for researchers to perform reactions under conditions that give the highest chance of success, including the appropriate precautions to take and proper experimental protocols. The text also covers the following topics: Record keeping and equipment Solvent purification and reagent preparation Using gases and working with vacuum pumps Purification, including crystallization and distillation Small-scale and large-scale reactions Characterization, including NMR spectra, melting point and boiling point, and microanalysis Efficient ways to find information in the chemical literature With fully updated text and all newly drawn figures, the third edition provides a powerful tool for building the knowledge on the most up-to-date techniques commonly used in organic synthesis.

Advanced Practical Organic Chemistry, Third Edition

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Author: John Leonard

Publisher: CRC Press

ISBN: 9781138455931

Category:

Page: N.A

View: 7788

Any research that uses new organic chemicals, or ones that are not commercially available, will at some time require the synthesis of such compounds. Therefore, organic synthesis is important in many areas of both applied and academic research, from chemistry to biology, biochemistry, and materials science. The third edition of a bestseller, Advanced Practical Organic Chemistry is a guide that explains the basic techniques of organic chemistry, presenting the necessary information for readers to carry out widely used modern organic synthesis reactions.This book is written for advanced undergraduate and graduate students as well as industrial organic chemists, particularly those involved in pharmaceutical, agrochemical, and other areas of fine chemical research. It provides the novice or nonspecialist with the often difficult-to-find information on reagent properties needed to perform general techniques. With over 80 years combined experience training and developing organic research chemists in industry and academia, the authors offer sufficient guidance for researchers to perform reactions under conditions that give the highest chance of success, including the appropriate precautions to take and proper experimental protocols. The text also covers the following topics: Record keeping and equipment Solvent purification and reagent preparation Using gases and working with vacuum pumps Purification, including crystallization and distillation Small-scale and large-scale reactions Characterization, including NMR spectra, melting point and boiling point, and microanalysis Efficient ways to find information in the chemical literature With fully updated text and all newly drawn figures, the third edition provides a powerful tool for building the knowledge on the most up-to-date techniques commonly used in organic synthesis.

Practical Synthetic Organic Chemistry

Reactions, Principles, and Techniques

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Author: Stéphane Caron

Publisher: John Wiley & Sons

ISBN: 1118093569

Category: Science

Page: 898

View: 1964

A hands-on guide to assist in the planning and execution of synthetic reactions in the laboratory Despite the maturity of organic chemistry, it can still be very challenging to identify optimal methods for synthetic transformations that perform as well in real-world manufacturing processes as they do in the laboratory. This detailed and accessible guide attempts to address this vexing issue and deliver proven methodologies practicing synthetic chemists will find valuable for identifying reaction conditions that work reliably over the broadest possible range of substrates. Practical Synthetic Organic Chemistry: Provides a practical guide to strategically planning and executing chemical syntheses for the bench chemist in industry Discusses information that is not common knowledge beyond the boundaries of process chemistry groups, such as the synthetic routes of selected contemporary pharmaceutical drugs and practical solvents, as well as green chemistry concepts Highlights key reactions, including substitutions, additions, eliminations, rearrangements, oxidations, and reductions Addresses basic principles, mechanisms, advantages and disadvantages of the methodology, and techniques for achieving laboratory success Incorporating such an extraordinary wealth of information on organic chemistry and its related fields into one complete volume distinguishes Practical Synthetic Organic Chemistry as an incomparable desktop reference for professionals—and an invaluable study aid for students.

Modern Organic Synthesis in the Laboratory

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Author: Jie Jack Li,Chris Limberakis,Derek A. Pflum

Publisher: Oxford University Press

ISBN: 9780198040637

Category: Science

Page: 224

View: 7131

Searching for reaction in organic synthesis has been made much easier in the current age of computer databases. However, the dilemma now is which procedure one selects among the ocean of choices. Especially for novices in the laboratory, it becomes a daunting task to decide what reaction conditions to experiment with first in order to have the best chance of success. This collection intends to serve as an "older and wiser lab-mate" one could have by compiling many of the most commonly used experimental procedures in organic synthesis. With chapters that cover such topics as functional group manipulations, oxidation, reduction, and carbon-carbon bond formation, Modern Organic Synthesis in the Laboratory will be useful for both graduate students and professors in organic chemistry and medicinal chemists in the pharmaceutical and agrochemical industries.

High-resolution NMR Techniques in Organic Chemistry

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Author: Timothy D. W. Claridge

Publisher: Newnes

ISBN: 0080546285

Category: Mathematics

Page: 383

View: 2400

"Nuclear Magnetic Resonance (NMR) Spectroscopy remains the foremost analytical technique for the structure elucidation of organic molecules and an indispensable tool for the synthetic, medicinal and natural product chemist. New techniques continue to emerge and the application of NMR methods continues to expand. High-Resolution NMR Techniques in Organic Chemistry is designed for use in academic and industrial NMR facilities, as a text for graduate-level NMR courses, and as an accessible reference for the chemist's or spectroscopist's desk." --Book Jacket.

Advanced Practical Inorganic and Metalorganic Chemistry

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Author: R. John Errington

Publisher: CRC Press

ISBN: 9780751402254

Category: Science

Page: 302

View: 5671

While the boundaries between the areas of chemistry traditionally labeled as inorganic, organic and physical are gradually diffusing, the practical techniques adopted by workers in each of these areas are often radically different. The breadth and variety of research classed as "inorganic chemistry" is readily apparent from an inspection of some of the leading international journals, and can be quite daunting for newcomers to this domain who are likely to have only limited experience of the methodologies involved. This book has therefore been written to provide guidance for those unfamiliar with the techniques most often encountered in synthetic inorganic / metalorganic chemistry, with an emphasis on procedures for handling air-sensitive compounds. One chapter is devoted to more specialized techniques such as metal vapor synthesis, and a review of preparative methods for a selection of starting materials is included as an aid to those planning research projects. While this book is aimed primarily at postgraduate and advanced undergraduate students involved in inorganic research projects, synthetic organic chemists and industrial chemists will also find much useful information within its pages. Similarly, it serves as a useful reference source for materials and polymer scientists who wish to take advantage of recent progress in precursor synthesis and catalyst development.

Writing Reaction Mechanisms in Organic Chemistry

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Author: Kenneth A. Savin

Publisher: N.A

ISBN: 9780124114753

Category: Science

Page: 502

View: 5558

"This book illustrates that understanding organic reactions is based on applying general principles rather than memorizing unrelated processes. This approach helps you understand that writing mechanisms is a practical method of applying knowledge of previously encountered reactions and reaction conditions to new reactions. After explaining basic principles, this book then examines a series of examples representing a broad series of reaction types. A clear background and explanation is provided for the reactions, as well as an illustration of the reaction use and its mechanism." --

Advanced Practical Medicinal Chemistry

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Author: Ashutosh Kar

Publisher: New Age International

ISBN: 8122415393

Category: Drugs

Page: 330

View: 9716

The Present Compendium On Advanced Practical Medicinal Chemistry Is Designed Specifically To Serve As A Text-Cum-Reference Book Not Only Intended For The Advanced Undergraduate And Graduate Students Of Pharmacy Specializing In Pharmaceutical Chemistry But Also For The Bulk-Drug Industrial Researchers And Academics Who Work Intimately With Medicinal Compounds. It Mainly Comprises Of Four Comprehensive Chapters. First Chapter Is Entirely Devoted To Safety In Chemical Laboratory, Which Is An Absolute Must For Each Medicinal Chemist. Second Chapter Is On Drug Synthesis And Concentrates On Three Vital Aspects, Namely : Conceptualization Of A Synthesis, Reaction Variants, And Stereochemistry. Third Chapter Exclusively Deals With Performing The Reactions And Entails The Wide Range Of Latest Laboratory Techniques Used In A Good Chemical Laboratory To Facilitate Synthesis Of Drugs.Fourth Chapter Is Particularly Focused And Earmarked To Synthesis Of Medicinal Compounds, And Essentially Include Various Cardinal Aspects, Such As :Types Of Chemical Reactions, Organic Name Reactions (Onrs), And Selected Medicinal Compounds. A Galaxy Of Eighty Carefully Chosen Medicinal Compounds Have Been Presented In Anoriginal-Unique-Style Comprising Of : Chemical Structure-Synonym (S)/Chemical Name(S)-Theory-Chemicals Required-Procedure-Precautions- Recrystallizatio-Theoretical Yield/Practical Yield-Physical Parameters-Uses, And -Questions For Viva-Voce.It Is Hoped That Advanced Practical Medicinal Chemistry Would Certainly Help To Bridge Existing Gap And Fill Up The Long Needed Vacuum In The Synthesis Of Drugs In Pharmaceutical Chemistry Departments, Academics And Bulk-Drug Industries, And May Provide The Basis For Meaningful Productive Group Discussions Of Synthetic Problems On A Broader Perspective.

Advanced Organic Chemistry

Reaction Mechanisms

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Author: Reinhard Bruckner

Publisher: Academic Press

ISBN: 9780121381103

Category: Science

Page: 636

View: 4735

Contents - Radical Substitution Reactions at the Saturated C Atom. Nucleophilic Substitution Reactions at the Saturated C Atom. Additions to the Olefinic C=C Double Bond. Eliminations Substitution Reactions on Aromatic Compounds. Nucleophilic Substitution Reactions (Except Through Enolates) on the Carboxyl Carbon. Additions of Heteroatom Nucleophiles to Heterocumulenes. Additions of Heteroatom Nucleophiles to Carbonyl Compounds and Their Secondary Reactions. Addition of H Nucleophiles and Metal Organyls to Carbonyl Compounds. Reaction of Ylides with Saturated or Unsaturated Carbonyl Compounds. Chemistry of the Alkaline Earth Metal Enolates. Rearrangements. Thermal Cycloadditions. Transition Metal-Mediated Alkenylations, Arylations and Alkynylations. Oxidations and Reductions.

Organic Syntheses Based on Name Reactions

A Practical Guide to 750 Transformations

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Author: Alfred Hassner,Irishi Namboothiri

Publisher: Elsevier

ISBN: 0080966306

Category: Science

Page: 577

View: 7769

Rev. ed. of: Organic syntheses based on name reactions and unnamed reactions. 1st ed. 1994.

The Art of Writing Reasonable Organic Reaction Mechanisms

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Author: Robert B. Grossman

Publisher: Springer Science & Business Media

ISBN: 0387954686

Category: Science

Page: 360

View: 4646

Intended for students of intermediate organic chemistry, this text shows how to write a reasonable mechanism for an organic chemical transformation. The discussion is organized by types of mechanisms and the conditions under which the reaction is executed, rather than by the overall reaction as is the case in most textbooks. Each chapter discusses common mechanistic pathways and suggests practical tips for drawing them. Worked problems are included in the discussion of each mechanism, and "common error alerts" are scattered throughout the text to warn readers about pitfalls and misconceptions that bedevil students. Each chapter is capped by a large problem set.

Handbook of Synthetic Organic Chemistry

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Author: Michael C. Pirrung

Publisher: Academic Press

ISBN: 0128095040

Category: Science

Page: 288

View: 350

Handbook of Synthetic Organic Chemistry, Second Edition updates and expands the author’s popular 2007 work, Synthetic Organic Chemist’s Companion. This new handbook provides valuable, practical guidance; incorporates corrections, and includes coverage on important topics, such as lyophylization, crystallization, precipitation, HPLC detectors, gases, and microwave reactions. The book maintains the useful organization of the author’s earlier work, beginning with a basic overview and walking through every practical step of the process of organic synthesis, from reagents, solvents, and temperature control, to documentation, implementation, purification, and analytical methods for the product. From planning and setting up reactions, to recording them, the book provides insight and valuable guidance into every step of the process. Practical guidance for planning, working up, documenting, analyzing, and improving reactions in synthetic organic chemistry

Writing Reaction Mechanisms in Organic Chemistry

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Author: Audrey Miller,Philippa H. Solomon

Publisher: Academic Press

ISBN: 9780124967120

Category: Science

Page: 471

View: 6104

Writing Reaction Mechanisms in Organic Chemistry, Second Edition, is an invaluable guide to charting the movements of atoms and electrons in the reactions of organic molecules. Miller and Solomon illustrate that understanding organic reactions is based on applying general principles rather than the rote memorization of unrelated processes, and, in turn, emphasize that writing mechanisms is a practical method of applying knowledge of previously encountered reactions and reaction conditions to new reactions. Students and research chemists alike will find this book useful in providing a method of organizing and synthesizing an oftentimes overwhelming quantity of information into a set of general principles and guidelines for determining and describing organic reaction mechanisms. * Essential for those students who need to have mechanisms explained in greater detail than most organic chemistry textbooks provide. * Illustrated with hundreds of chemical structures * Extensively rewritten and reorganized to make the presentation and format even easier for students to use * Contains many problem sets and answers to all problems to help students work through general principles and applications * Appendixes have been added to this edition that contain easily referenced information on Lewis structures, symbols for chemical notation, and the relative acidities of common substances

Synthesis and Technique in Inorganic Chemistry

A Laboratory Manual

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Author: Gregory S. Girolami,Thomas B. Rauchfuss,Robert J. Angelici

Publisher: University Science Books

ISBN: 9780935702484

Category: Science

Page: 272

View: 1731

This well-known laboratory manual introduces students to modern synthetic and instrumental techniques currently used in inorganic chemistry. The new Third Edition has been updated to reflect the latest developments in inorganic chemistry - giving greater emphasis to applications related to biochemistry and materials science.

Organic Synthesis

Strategy and Control

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Author: Paul Wyatt,Stuart Warren

Publisher: John Wiley & Sons

ISBN: 1118681444

Category: Science

Page: 920

View: 1209

Organic Synthesis: Strategy and Control is the long-awaited sequel to Stuart Warren’s bestseller Organic Synthesis: The Disconnection Approach, which looked at the planning behind the synthesis of compounds. This unique book now provides a comprehensive, practical account of the key concepts involved in synthesising compounds and focuses on putting the planning into practice. The two themes of the book are strategy and control: solving problems either by finding an alternative strategy or by controlling any established strategy to make it work. The book is divided into five sections that deal with selectivity, carbon-carbon single bonds, carbon-carbon double bonds, stereochemistry and functional group strategy. A comprehensive, practical account of the key concepts involved in synthesising compounds Takes a mechanistic approach, which explains reactions and gives guidelines on how reactions might behave in different situations Focuses on reactions that really work rather than those with limited application Contains extensive, up-to-date references in each chapter Students and professional chemists familiar with Organic Synthesis: The Disconnection Approach will enjoy the leap into a book designed for chemists at the coalface of organic synthesis.

Techniques in Organic Chemistry

Miniscale, Standard-Taper Microscale, Williamson Microscale

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Author: Jerry R. Mohrig,Christina Noring Hammond,Paul F. Schatz,Terence C. Morrill

Publisher: W. H. Freeman

ISBN: 9780716766384

Category: Science

Page: 312

View: 5551

Multiscale Operational Organic Chemistry

A Problem-solving Approach to the Laboratory Course

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Author: John W. Lehman

Publisher: Prentice Hall

ISBN: N.A

Category: Science

Page: 970

View: 3701

This comprehensive laboratory text provides a thorough introduction to all of the significant operations used in the organic lab and includes a large selection of traditional-scale and microscale experiments and minilabs. Its unique problem-solving approach encourages students to think in the laboratory by solving a scientific problem in the process of carrying out each experiment. The Second Edition contains a new introductory section, “Chemistry and the Environment,” which includes a discussion of the principles of green chemistry. Several green experiments have been added, and some experiments from the previous editions have been revised to make them greener.

Chemistry of High-Energy Materials

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Author: Thomas M. Klapötke

Publisher: Walter de Gruyter GmbH & Co KG

ISBN: 311053679X

Category: Science

Page: 385

View: 3269

The 4th revised edition expands on the basic chemistry of high energy materials of the precious editions and examines new research developments, including hydrodynamics and ionic liquids. Applications in military and civil fields are discussed. This work is of interest to advanced students in chemistry, materials science and engineering, as well as to all those working in defense technology.