A Primer to Mechanism in Organic Chemistry

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Author: Peter Sykes

Publisher: Prentice Hall

ISBN: 9780582266445

Category: Science

Page: 177

View: 2758

This book marks a significantly different approach to the subject. It has been designed specifically to offer a simpler and less sophisticated treatment of organic reaction mechanisms than that to be found in the Guidebook. It is based on three underlying principles: that there are three types of reaction - substitution, addition and elimination; that there are three types of reagent - nucleophiles, electrophiles and radicals; and that there are two effects - electronic and steric - through which the behaviour of a particular atom or group can be influenced by the rest of the molecule of which it is a constituent part. A Primer to Mechanism in Organic Chemistry is an essential resource for first- and second-year chemistry undergraduates and particularly, though not exclusively, those not then proceeding to further chemical study. It is also a useful reference for sixth-form students.

Reaction Mechanisms in Organic Synthesis

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Author: Rakesh Kumar Parashar

Publisher: John Wiley & Sons

ISBN: 1118681266

Category: Science

Page: 392

View: 4827

Organic chemistry is a core part of the chemistry curricula, and advanced levels texts often obscure the essential framework underlying and uniting the vast numbers of reactions as a result of the high level of detail presented. The material in this book is condensed into a manageable text of 350 pages and presented in a clear and logical fashion, focusing purely on the basics of the subject without going through exhaustive detail or repetitive examples. The book aims to bridge the gap between undergraduate organic chemistry textbooks and advanced level textbooks, beginning with a basic introductory course and arranging the reaction mechanisms according to an ascending order of difficulty. As such, the author believes the book will be excellent primer for advanced postgraduates Reaction Mechanisms in Organic Synthesis is written from the point of view of the synthetic organic chemist, enabling students and researchers to understand and expand on reactions covered in foundation courses, and to apply them in a practical context by designing syntheses. As a further aid to the practical research student, the content is organized according to the conditions under which a reaction is executed rather than by the types of mechanisms. Particular emphasis is placed on controlling stereospecificity and regiospecificity. Topics covered include: Transition metal mediated carbon-carbon bond formation reactions Use of stabilized carbanions, ylides and enamines for carbon-carbon bond formation reactions, Advanced level use of oxidation and reduction reagents in synthesis. As a modern text, this book stands out from its competitors due to its comprehensive coverage of recently published research. The book contains specific examples from the latest literature, covering modern reactions and the latest procedural modifications. The focus on contemporary and synthetically useful reactions ensures that the contents are specifically relevant and attractive to postgraduate students and industrial organic chemists.

The Mechanisms of Reactions at Transition Metal Sites

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Author: Richard A. Henderson

Publisher: Oxford University Press on Demand

ISBN: 9780198557463

Category: Science

Page: 87

View: 8046

Understanding the mechanisms of the reactions at transition metal sites is a key component in designing synthetic methods, developing industrial homogeneous catalysts, and investigating metalloenzymes. These mechanisms are therefore an essential part of undergraduate chemistry courses. This primer provides a broad-based, systematic guide to the fundamentals of transition-metal mechanistic chemistry, including substitution, electron transfer, and reactions of ligands. It serves as an ideal text for undergraduate students with a foundation in basic inorganic chemistry but who are new to inorganic reaction mechanisms.

Mechanisms of Organic Reactions

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Author: Howard Maskill

Publisher: Oxford University Press

ISBN: 9780198558224

Category: Science

Page: 96

View: 2115

Focusing on organic reactions, this text begins by introducing modern technology, definitions, and concepts of mechanisms and reactivity. The following four chapters are accounts of the mechanisms of four of the main classes of reactions of aliphatic compounds.

Reaction Mechanisms in Organic Synthesis

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Author: Rakesh Kumar Parashar

Publisher: John Wiley & Sons

ISBN: 1118681231

Category: Science

Page: 304

View: 2896

Organic chemistry is a core part of the chemistry curricula, and advanced levels texts often obscure the essential framework underlying and uniting the vast numbers of reactions as a result of the high level of detail presented. The material in this book is condensed into a manageable text of 350 pages and presented in a clear and logical fashion, focusing purely on the basics of the subject without going through exhaustive detail or repetitive examples. The book aims to bridge the gap between undergraduate organic chemistry textbooks and advanced level textbooks, beginning with a basic introductory course and arranging the reaction mechanisms according to an ascending order of difficulty. As such, the author believes the book will be excellent primer for advanced postgraduates Reaction Mechanisms in Organic Synthesis is written from the point of view of the synthetic organic chemist, enabling students and researchers to understand and expand on reactions covered in foundation courses, and to apply them in a practical context by designing syntheses. As a further aid to the practical research student, the content is organized according to the conditions under which a reaction is executed rather than by the types of mechanisms. Particular emphasis is placed on controlling stereospecificity and regiospecificity. Topics covered include: Transition metal mediated carbon-carbon bond formation reactions Use of stabilized carbanions, ylides and enamines for carbon-carbon bond formation reactions, Advanced level use of oxidation and reduction reagents in synthesis. As a modern text, this book stands out from its competitors due to its comprehensive coverage of recently published research. The book contains specific examples from the latest literature, covering modern reactions and the latest procedural modifications. The focus on contemporary and synthetically useful reactions ensures that the contents are specifically relevant and attractive to postgraduate students and industrial organic chemists.

Pushing Electrons

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Author: Daniel P. Weeks

Publisher: Cengage Learning

ISBN: 1285633237

Category: Science

Page: 224

View: 8516

This brief guidebook assists you in mastering the difficult concept of pushing electrons that is vital to your success in Organic Chemistry. With an investment of only 12 to 16 hours of self-study you can have a better understanding of how to write resonance structures and will become comfortable with bond-making and bond-breaking steps in organic mechanisms. A paper-on-pencil approach uses active involvement and repetition to teach you to properly push electrons to generate resonance structures and write organic mechanisms with a minimum of memorization. Compatible with any organic chemistry textbook. Important Notice: Media content referenced within the product description or the product text may not be available in the ebook version.

Intermediate Organic Chemistry

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Author: Ann M. Fabirkiewicz,John C. Stowell

Publisher: John Wiley & Sons

ISBN: 1118308816

Category: Science

Page: 384

View: 8786

This book presents key aspects of organic synthesis stereochemistry, functional group transformations, bond formation, synthesis planning, mechanisms, and spectroscopy and a guide to literature searching in a reader–friendly manner. Helps students understand the skills and basics they need to move from introductory to graduate organic chemistry classes Balances synthetic and physical organic chemistry in a way accessible to students Features extensive end–of–chapter problems Updates include new examples and discussion of online resources now common for literature searches Adds sections on protecting groups and green chemistry along with a rewritten chapter surveying organic spectroscopy

Pericyclic Reactions

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Author: Ian Fleming

Publisher: Oxford University Press, USA

ISBN: 0199680906

Category: Addition reactions

Page: 118

View: 5140

Key texts in the renowned Oxford Chemistry Primers series have been fully refreshed and updated to suit the needs of today's students, lecturers, and postgraduate researchers. The rigorous and yet accessible treatment of each subject area is ideal for those wanting to know more about a particular topic not covered comprehensively in existing undergraduate texts. Moreover, cutting-edge examples and applications throughout the texts show the relevance of thechemistry being described to the real world. Pericyclic reactions constitute a fundamental class of organic chemistry, including such commercially important synthetic reactions as theDiels-Alder reaction. This primer gives a concise and accessible account of these reactions, enabling students to recognise the different types of pericyclic reaction and understand their application in organic synthesis.

Protecting Group Chemistry

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Author: Jeremy Robertson

Publisher: Oxford University Press, USA

ISBN: 9780198502753

Category: Science

Page: 96

View: 4660

Protecting Group Chemistry provides an overview of the general methods that are used to block the reactivity of - i.e. protect - specific functional grops thus allowing others, present within the same molecule, to be manipulated unambiguously. An introductory chapter outlines protecting group strategy, relevant aspects of functional group reactivity, temporary protection, and introduces the concept of protecting group devices as an aid to unifying the wide range of available methods. Therest of the book is divided on the basis of broad classes of the experimental conditions that lead to cleavage of each protecting group (acid/electrophile, base/nucleophile, oxidising or reducing agent). The treatment differs from traditional texts in that it places the emphasis on making a connection between the fundamental mechanisms of organic chemsitry - ionisation, substitution, addition, elimination, oxidation and reduction, etc. - and how a particular protecting group can best be selected in a given situation.

Organic Reaction Mechanisms

40 Solved Cases

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Author: Mar Gomez-Gallego,Miguel A. Sierra

Publisher: Springer Science & Business Media

ISBN: 3642187889

Category: Science

Page: 290

View: 7205

Organic Reaction Mechanisms shows readers how to interpret the experimental data obtained from an organic reaction, and specifically how an organic reaction mechanism can be considered or rejected based on the analysis of the experimental evidence. Whilst examining a series of selected examples of mechanisms, the text focuses on real cases and discusses them in detail. The examples are arranged to elucidate key aspects of organic reaction mechanisms. The authors employ all the types of information that the authors of the original work considered useful and necessary, including spectroscopic data, kinetic and thermodynamic data, isotopic labelling and organic reactivity. The book makes an excellent primer for advanced undergraduates in chemistry who are preparing for exams and is also useful for graduate students and instructors.

Medicinal Chemistry

A Molecular and Biochemical Approach

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Author: Thomas Nogrady,Donald F. Weaver

Publisher: Oxford University Press

ISBN: 0190282967

Category: Science

Page: N.A

View: 9565

Fully updated and rewritten by a basic scientist who is also a practicing physician, the third edition of this popular textbook remains comprehensive, authoritative and readable. Taking a receptor-based, target-centered approach, it presents the concepts central to the study of drug action in a logical, mechanistic way grounded on molecular and principles. Students of pharmacy, chemistry and pharmacology, as well as researchers interested in a better understanding of drug design, will find this book an invaluable resource. Starting with an overview of basic principles, Medicinal Chemistry examines the properties of drug molecules, the characteristics of drug receptors, and the nature of drug-receptor interactions. Then it systematically examines the various families of receptors involved in human disease and drug design. The first three classes of receptors are related to endogenous molecules: neurotransmitters, hormones and immunomodulators. Next, receptors associated with cellular organelles (mitochondria, cell nucleus), endogenous macromolecules (membrane proteins, cytoplasmic enzymes) and pathogens (viruses, bacteria) are examined. Through this evaluation of receptors, all the main types of human disease and all major categories of drugs are considered. There have been many changes in the third edition, including a new chapter on the immune system. Because of their increasingly prominent role in drug discovery, molecular modeling techniques, high throughput screening, neuropharmacology and genetics/genomics are given much more attention. The chapter on hormonal therapies has been thoroughly updated and re-organized. Emerging enzyme targets in drug design (e.g. kinases, caspases) are discussed, and recent information on voltage-gated and ligand-gated ion channels has been incorporated. The sections on antihypertensive, antiviral, antibacterial, anti-inflammatory, antiarrhythmic, and anticancer drugs, as well as treatments for hyperlipidemia and peptic ulcer, have been substantially expanded. One new feature will enhance the book's appeal to all readers: clinical-molecular interface sections that facilitate understanding of the treatment of human disease at a molecular level.

Molecular Biology of the Cell

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Author: Bruce Alberts

Publisher: Garland Science

ISBN: 1317563743

Category: Science

Page: 1464

View: 8053

As the amount of information in biology expands dramatically, it becomes increasingly important for textbooks to distill the vast amount of scientific knowledge into concise principles and enduring concepts.As with previous editions, Molecular Biology of the Cell, Sixth Edition accomplishes this goal with clear writing and beautiful illustrations. The Sixth Edition has been extensively revised and updated with the latest research in the field of cell biology, and it provides an exceptional framework for teaching and learning. The entire illustration program has been greatly enhanced.Protein structures better illustrate structure–function relationships, icons are simpler and more consistent within and between chapters, and micrographs have been refreshed and updated with newer, clearer, or better images. As a new feature, each chapter now contains intriguing openended questions highlighting “What We Don’t Know,” introducing students to challenging areas of future research. Updated end-of-chapter problems reflect new research discussed in the text, and these problems have been expanded to all chapters by adding questions on developmental biology, tissues and stem cells, pathogens, and the immune system.

Molecules and Medicine

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Author: E. J. Corey,Barbara Czakó,L?szl? K?rti

Publisher: John Wiley & Sons

ISBN: 1118361733

Category: Science

Page: 272

View: 9565

Molecules and Medicine provides, for the first time ever, a completely integrated look at chemistry, biology, drug discovery, and medicine. It delves into the discovery, application, and mode of action of more than one hundred of the most significant molecules in use in modern medicine. Opening sections of the book provide a unique, clear, and concise introduction, which enables readers to understand chemical formulas.

Organic Chemistry As a Second Language: First Semester Topics

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Author: David R. Klein

Publisher: John Wiley & Sons

ISBN: 1119110661

Category: Science

Page: 400

View: 4712

Readers continue to turn to Klein's Organic Chemistry as a Second Language: First Semester Topics, 4th Edition because it enables them to better understand fundamental principles, solve problems, and focus on what they need to know to succeed. This edition explores the major principles in the field and explains why they are relevant. It is written in a way that clearly shows the patterns in organic chemistry so that readers can gain a deeper conceptual understanding of the material. Topics are presented clearly in an accessible writing style along with numerous hands-on problem solving exercises.

Organic Chemistry

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Author: Marye Anne Fox,James K. Whitesell

Publisher: Jones & Bartlett Learning

ISBN: 9780763721978

Category: Chemistry, Organic.

Page: 1140

View: 8279

Accompanying CD-ROM ... "has been enhanced with updated animated illustrations to accompany the presentations [and] Chem3D files for helpful structure visualization."--Page 4 of cover.

Arrow-Pushing in Organic Chemistry

An Easy Approach to Understanding Reaction Mechanisms

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Author: Daniel E. Levy

Publisher: John Wiley & Sons

ISBN: 1118991346

Category: Science

Page: 424

View: 5669

Organic chemistry is required coursework for degrees in life, food, and medical sciences. To help the students discouraged by the belief that this topic cannot be mastered without significant memorization, Arrow Pushing in Organic Chemistry serves as a handy supplement for understanding the subject. • Includes new chapters, an expanded index, and additional problem sets complete with detailed solutions • Focuses on understanding the mechanics and logic of organic reaction mechanisms • Introduces ionic and non-ionic reactive species and reaction mechanisms • Teaches strategies to predict reactive species, sites of reactions, and reaction products • Provides a solid foundation upon which organic chemistry students can advance with confidence

Thermodynamics, Solubility and Environmental Issues

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Author: Trevor M. Letcher

Publisher: Elsevier

ISBN: 9780080481036

Category: Science

Page: 492

View: 7962

Environmental problems are becoming an important aspect of our lives as industries grow apace with populations throughout the world. Thermodynamics, Solubility and Environmental Issues highlights some of the problems and shows how chemistry can help to reduce these them. The unifying theme is Solubility – the most basic and important of thermodynamic properties. This informative book looks at the importance and applications of solubility and thermodynamics, in understanding and in reducing chemical pollution in the environment. Written by experts in their respective fields and representing the latest findings in this very important and broad area. A collection of twenty-five chapters cover a wide range of topics including; mining, polymer manufacture and applications, radioactive wastes, industries in general, agro-chemicals, soil pollution and biology, together with the basic theory and recent developments in the modelling of environmental pollutants. Latest research into solving some of the most important environmental problems Covering new technologies, new chemicals and new processes eg, biodegradable polymers, ionic liquids and green chemistry Contains the basic theories and underlying importance of solubility

Basic Organic Chemistry for the Life Sciences

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Author: Hrvoj Vančik

Publisher: Springer

ISBN: 3319076051

Category: Medical

Page: 179

View: 3600

This book is designed for students of biology, molecular biology, ecology, medicine, agriculture, forestry and other professions where the knowledge of organic chemistry plays the important role. The work may also be of interest to non-professionals, as well as to teachers in high schools. The book consists of 11 chapters that cover: - basic principles of structure and constitution of organic compounds, - the elements of the nomenclature, - the concepts of the nature of chemical bond, - introductions in NMR and IR spectroscopy, - the concepts and main classes of the organic reaction mechanisms, - reactions and properties of common classes or organic compounds, - and the introduction to the chemistry of the natural organic products followed by basic principles of the reactions in living cells.